Abreu IA, Cabelli DE (2010) Superoxide dismutases-a review of the metal-associated mechanistic variations. Biochim Biophys Acta 2:263–274. https://doi.org/10.1016/j.bbapap.2009.11.005

Article  CAS  Google Scholar 

Açar Y, Ağagündüz D, De Cicco P, Capasso R (2023) Flavonoids: Their putative neurologic roles, epigenetic changes, and gut microbiota alterations in Parkinson's disease. Biomed Pharmacother 168:115788. https://doi.org/10.1016/j.biopha.2023.115788

Article  CAS  PubMed  Google Scholar 

Acuña AI, Esparza M, Kramm C, Beltrán FA, Parra AV, Cepeda C, Toro CA, Vidal RL, Hetz C, Concha II, Brauchi S, Levine MS, Castro MA (2013) A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington’s disease in mice. Nat Commun 4:2917. https://doi.org/10.1038/ncomms3917

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahn JH, Hu Y, Hernandez M, Kim JR (2011) Crocetin inhibits beta- amyloid fibrillization and stabilizes beta- amyloid oligomers. Biochem Biophys Res Commun 414(1):79–83 10. 1016/j. bbrc.2011.09.025. 09. 025

Article  CAS  PubMed  Google Scholar 

Akbaraly TN, Hininger-Favier I, Carrière I, Arnaud J, Gourlet V, Roussel AM, Berr C (2007) Plasma selenium over time and cognitive decline in the elderly. Epidemiology 18(1):52–58. https://doi.org/10.1097/01.ede.0000248202.83695.4e

Article  PubMed  Google Scholar 

Akundi RS, Huang Z, Eason J, Pandya JD, Zhi L, Cass WA, Sullivan PG, Büeler H (2011) Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. PLoS ONE 6(1):e16038. https://doi.org/10.1371/journal.pone.0016038

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al-Khayri JM, Sahana GR, Nagella P, Joseph BV, Alessa FM, Al-Mssallem MQ (2022) Flavonoids as potential anti-inflammatory molecules: a review. Molecules 27(9):2901. https://doi.org/10.3390/molecules27092901

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alexeyev M, Shokolenko I, Wilson G, LeDoux S (2013) The maintenance of mitochondrial DNA integrity–critical analysis and update. Cold Spring Harb Perspect Biol 5(5):a012641. https://doi.org/10.1101/cshperspect.a012641

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alhumaydhi FA, Younus H, Khan MA (2025) Catalase functions and glycation: their central roles in oxidative stress, metabolic disorders, and neurodegeneration. Catalysts 15(9):817. https://doi.org/10.3390/catal15090817

Article  CAS  Google Scholar 

Ali ZK, Baker DE (2017) Formulary drug review: edaravone. Hosp Pharm 52(11):732–736. https://doi.org/10.1177/0018578717734877

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali F, Manzoor U, Bhattacharya R, Bansal AK, Chandrashekharaiah KS, Singh LR, Saraswati SM, Uversky V, Dar TA (2022) Brain metabolite, myo-inositol, inhibits catalase activity: a mechanism of the distortion of the antioxidant defense system in Alzheimer’s disease. ACS Omega 7(15):12690–12700. https://doi.org/10.1021/acsomega.1c06990

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alies B, Badei B, Faller P, Hureau C (2012a) Reevaluation of copper(I) affinity for amyloid-beta peptides by competition with ferrozine—an unusual copper(I) indicator. Chemistry 18(4):1161–1167. https://doi.org/10.1002/chem.201102746

Article  CAS  PubMed  Google Scholar 

Alies B, Badei B, Faller P, Hureau C (2012b) Reevaluation of copper(I) affinity for amyloid-β peptides by competition with ferrozine–an unusual copper(I) indicator. Chemistry 18(4):1161–1167. https://doi.org/10.1002/chem.201102746

Article  CAS  PubMed  Google Scholar 

Alies B, Conte-Daban A, Sayen S, Collin F, Kieffer I, Guillon E, Faller P, Hureau C (2016) Zinc(II) Binding Site to the Amyloid-β Peptide: Insights from Spectroscopic Studies with a Wide Series of Modified Peptides. Inorg Chem 55(20):10499–10509. https://doi.org/10.1021/acs.inorgchem.6b01733

Article  CAS  PubMed  PubMed Central  Google Scholar 

Amara AW, Memon AA (2018) Effects of exercise on non-motor symptoms in Parkinson’s disease. Clin Ther 40:8–15. https://doi.org/10.1016/j.clinthera.2017.11.004

Article  PubMed  Google Scholar 

Andreassen OA, Ferrante RJ, Dedeoglu A, Beal MF (2001) Lipoic acid improves survival in transgenic mouse models of Huntington’s disease. NeuroReport 12(15):3371–3373. https://doi.org/10.1097/00001756-200110290-00044

Article  CAS  PubMed  Google Scholar 

Andrews SJ, Renton AE, Fulton-Howard B, Podlesny-Drabiniok A, Marcora E, Goate AM (2023) The complex genetic architecture of Alzheimer’s disease: novel insights and future directions. EBioMedicine 90:104511. https://doi.org/10.1016/j.ebiom.2023.2023.104511

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ansari A, Maffioletti E, Milanesi E, Marizzoni M et al (2019) PharmaCog Consortium. miR-146a and miR-181a are involved in the progression of mild cognitive impairment to Alzheimer’s disease. Neurobiol Aging 82:102–109. https://doi.org/10.1016/j.neurobiolaging.2019.06.005

Article  CAS  PubMed  Google Scholar 

Antico O, Thompson PW, Hertz NT, Muqit MMK, Parton LE (2025) Targeting mitophagy in neurodegenerative diseases. Nat Rev Drug Discov 24(4):276–299. https://doi.org/10.1038/s41573-024-01105-0

Article  CAS  PubMed  Google Scholar 

Appel SH, Zhao W, Beers DR, Henkel JS (2011) The microglial-motoneuron dialogue in ALS. Acta Myol 30(1):4–8

CAS  PubMed  PubMed Central  Google Scholar 

Appiah D, Ingabire-Gasana E, Appiah L, Yang J (2024) The relation of serum vitamin C concentrations with Alzheimer’s disease mortality in a national cohort of community-dwelling elderly adults. Nutrients 16(11):1672. https://doi.org/10.3390/nu16111672

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arutyunyan A, Seuma M, Faure AJ, Bolognesi B, Lehner B (2025) Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state. Sci Adv 11(24):eadv1422. https://doi.org/10.1126/sciadv.adv1422

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ascherio A, Zhang SM, Hernán MA, Kawachi I, Colditz GA, Speizer FE, Willett WC (2001) Prospective study of caffeine consumption and risk of Parkinson’s disease in men and women. Ann Neurol 50(1):56–63. https://doi.org/10.1002/ana.1052

Article  CAS  PubMed  Google Scholar 

Ashkenazi A, Salvesen G (2014) Regulated cell death: signaling and mechanisms. Annu Rev Cell Dev Biol 30:337–356. https://doi.org/10.1146/annurev-cellbio-100913-013226

Article  CAS  PubMed  Google Scholar 

Atiq A, Lee HJ, Khan A, Kang MH, Rehman IU, Ahmad R, Tahir M, Ali J, Choe K, Park JS, Kim MO (2023) Vitamin E analog trolox attenuates MPTP-induced Parkinson’s disease in mice, mitigating oxidative stress, neuroinflammation, and motor impairment. Int J Mol Sci 24(12):9942. https://doi.org/10.3390/ijms24129942

Article  CAS  PubMed  PubMed Central  Google Scholar 

Atrián-Blasco E, Gonzalez P, Santoro A, Alies B, Faller P, Hureau C (2018) Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance. Coord Chem Rev 375:38–55. https://doi.org/10.1016/j.ccr.2018.04.007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ayala A, Muñoz MF, Argüelles S (2014) Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev 2014:360438. https://doi.org/10.1155/2014/360438