Konopka-Filippow M, Politynska B, Wojtukiewicz AM, Wojtukiewicz MZ. Cancer Pain: Radiotherapy as a Double-Edged Sword. Int J Mol Sci. 2025;26(11).
Andolino DL, Forquer JA, Henderson MA, Barriger RB, Shapiro RH, Brabham JG, et al. Chest wall toxicity after stereotactic body radiotherapy for malignant lesions of the lung and liver. Int J Radiat Oncol Biol Phys. 2011;80(3):692–7.
Bongers EM, Haasbeek CJ, Lagerwaard FJ, Slotman BJ, Senan S. Incidence and risk factors for chest wall toxicity after risk-adapted stereotactic radiotherapy for early-stage lung cancer. J Thorac Oncol. 2011;6(12):2052–7.
Chipko C, Ojwang J, Gharai LR, Deng X, Mukhopadhyay N, Weiss E. Characterization of Chest Wall Toxicity During Long-term Follow Up After Thoracic Stereotactic Body Radiation Therapy. Pract Radiat Oncol. 2019;9(3):e338–46.
Article PubMed PubMed Central Google Scholar
Creach KM, El Naqa I, Bradley JD, Olsen JR, Parikh PJ, Drzymala RE, et al. Dosimetric predictors of chest wall pain after lung stereotactic body radiotherapy. Radiother Oncol. 2012;104(1):23–7.
Dunlap NE, Cai J, Biedermann GB, Yang W, Benedict SH, Sheng K, et al. Chest wall volume receiving > 30 Gy predicts risk of severe pain and/or rib fracture after lung stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2010;76(3):796–801.
Aoki M, Sato M, Hirose K, Akimoto H, Kawaguchi H, Hatayama Y, et al. Radiation-induced rib fracture after stereotactic body radiotherapy with a total dose of 54–56 Gy given in 9 – 7 fractions for patients with peripheral lung tumor: impact of maximum dose and fraction size. Radiat Oncol. 2015;10:99.
Article PubMed PubMed Central Google Scholar
Carducci MP, Sundaram B, Greenberger BA, Werner-Wasik M, Kane GC. Predictors and characteristics of Rib fracture following SBRT for lung tumors. BMC Cancer. 2023;23(1):337.
Article PubMed PubMed Central Google Scholar
Kim SS, Song SY, Kwak J, Ahn SD, Kim JH, Lee JS, et al. Clinical prognostic factors and grading system for rib fracture following stereotactic body radiation therapy (SBRT) in patients with peripheral lung tumors. Lung Cancer. 2013;79(2):161–6.
Farris MK, Helis CA, Hughes RT, LeCompte MC, Borg AM, Nieto K et al. Bench to Bedside: Animal Models of Radiation Induced Musculoskeletal Toxicity. Cancers (Basel). 2020;12(2).
Farris M, Hughes RT, Pacholke HD, Levine B, Black PJ, Razavian N, et al. The Impact of Prophylactic Bisphosphonates on Radiation-Induced Rib Fractures and Chest Wall Pain in Peripheral Lung Tumor SBRT: A Randomized, Double-Blind, Placebo-Controlled Study. Int J Radiation Oncology*Biology*Physics. 2024;120(2):S85–6.
Park SH, Peters M, Aguayo C, Farris MK, Hughes RT, Moore J et al. Preclinical Study of Pain Neuropeptide Expression in Murine Sensory Neurons Induced by Irradiated Osteoclasts in the Context of Stereotactic Body Radiation Therapy. Cells. 2025;14(17).
Lloyd S, Decker RH, Evans SB. Bone scan findings of chest wall pain syndrome after stereotactic body radiation therapy: implications for the pathophysiology of the syndrome. J Thorac Dis. 2013;5(2):E41–4.
PubMed PubMed Central Google Scholar
Woody NM, Videtic GM, Stephans KL, Djemil T, Kim Y, Xia P. Predicting chest wall pain from lung stereotactic body radiotherapy for different fractionation schemes. Int J Radiat Oncol Biol Phys. 2012;83(1):427–34.
Willey JS, Lloyd SA, Robbins ME, Bourland JD, Smith-Sielicki H, Bowman LC, et al. Early increase in osteoclast number in mice after whole-body irradiation with 2 Gy X rays. Radiat Res. 2008;170(3):388–92.
Article CAS PubMed PubMed Central Google Scholar
Zhang J, Qiu X, Xi K, Hu W, Pei H, Nie J, et al. Therapeutic ionizing radiation induced bone loss: a review of in vivo and in vitro findings. Connect Tissue Res. 2018;59(6):509–22.
Donaubauer AJ, Deloch L, Becker I, Fietkau R, Frey B, Gaipl US. The Influence of Radiation on Bone and Bone Cells-Differential Effects on Osteoclasts and Osteoblasts. Int J Mol Sci. 2020;21(17).
Wright LE, Buijs JT, Kim HS, Coats LE, Scheidler AM, John SK, et al. Single-Limb Irradiation Induces Local and Systemic Bone Loss in a Murine Model. J Bone Min Res. 2015;30(7):1268–79.
Alwood JS, Shahnazari M, Chicana B, Schreurs AS, Kumar A, Bartolini A, et al. Ionizing Radiation Stimulates Expression of Pro-Osteoclastogenic Genes in Marrow and Skeletal Tissue. J Interferon Cytokine Res. 2015;35(6):480–7.
Article CAS PubMed PubMed Central Google Scholar
Yumoto K, Globus RK, Mojarrab R, Arakaki J, Wang A, Searby ND, et al. Short-term effects of whole-body exposure to (56)fe ions in combination with musculoskeletal disuse on bone cells. Radiat Res. 2010;173(4):494–504.
Article CAS PubMed Google Scholar
Berk L. The effects of high-dose radiation therapy on bone: a scoping review. Radiat Oncol J. 2024;42(2):95–103.
Article PubMed PubMed Central Google Scholar
Farris M, McTyre ER, Okoukoni C, Dugan G, Johnson BJ, Blackstock AW, et al. Cortical Thinning and Structural Bone Changes in Non-Human Primates after Single-Fraction Whole-Chest Irradiation. Radiat Res. 2018;190(1):63–71.
Article CAS PubMed PubMed Central Google Scholar
Keenawinna L, Oest ME, Mann KA, Spadaro J, Damron TA. Zoledronic acid prevents loss of trabecular bone after focal irradiation in mice. Radiat Res. 2013;180(1):89–99.
Article CAS PubMed Google Scholar
Willey JS, Livingston EW, Robbins ME, Bourland JD, Tirado-Lee L, Smith-Sielicki H, et al. Risedronate prevents early radiation-induced osteoporosis in mice at multiple skeletal locations. Bone. 2010;46(1):101–11.
Article CAS PubMed Google Scholar
Pacheco R, Stock H. Effects of radiation on bone. Curr Osteoporos Rep. 2013;11(4):299–304.
Mutter RW, Liu F, Abreu A, Yorke E, Jackson A, Rosenzweig KE. Dose-volume parameters predict for the development of chest wall pain after stereotactic body radiation for lung cancer. Int J Radiat Oncol Biol Phys. 2012;82(5):1783–90.
Cun-Jin S, Jian-Hao X, Xu L, Feng-Lun Z, Jie P, Ai-Ming S, et al. X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation. Mol Pain. 2019;15:1744806919849201.
Article PubMed PubMed Central Google Scholar
Utreras E, Keller J, Terse A, Prochazkova M, Iadarola MJ, Kulkarni AB. Transforming growth factor-beta1 regulates Cdk5 activity in primary sensory neurons. J Biol Chem. 2012;287(20):16917–29.
Article CAS PubMed PubMed Central Google Scholar
Rakici SY, Yilmaz A, Karakas SM. The Relationship Between Radiotherapy-Induced Pain Response Score and Pain Biomarkers TRPV1, beta-Endorphin (bEP), Neurotensin (NT), and Orexin A (OXA) in Patients with Bone Metastases. Life (Basel). 2025;15(9).
Xu Q, Zhang XM, Duan KZ, Gu XY, Han M, Liu BL, et al. Peripheral TGF-beta1 signaling is a critical event in bone cancer-induced hyperalgesia in rodents. J Neurosci. 2013;33(49):19099–111.
Article CAS PubMed PubMed Central Google Scholar
Regan JN, Trivedi T, Guise TA, Waning DL. The Role of TGFbeta in Bone-Muscle Crosstalk. Curr Osteoporos Rep. 2017;15(1):18–23.
Article PubMed PubMed Central Google Scholar
Lantero A, Tramullas M, Diaz A, Hurle MA. Transforming growth factor-beta in normal nociceptive processing and pathological pain models. Mol Neurobiol. 2012;45(1):76–86.
Article CAS PubMed Google Scholar
Trivedi T, Pagnotti GM, Guise TA, Mohammad KS. The Role of TGF-beta in Bone Metastases. Biomolecules. 2021;11(11).
Andriessen AS, Donnelly CR, Ji RR. Reciprocal interactions between osteoclasts and nociceptive sensory neurons in bone cancer pain. Pain Rep. 2021;6(1):e867.
Article PubMed PubMed Central Google Scholar
Yoneda T, Hiasa M, Nagata Y, Okui T, White FA. Acidic microenvironment and bone pain in cancer-colonized bone. Bonekey Rep. 2015;4:690.
Article CAS PubMed PubMed Central Google Scholar
Neto E, Leitao L, Mateus JC, Sousa DM, Alves CJ, Aroso M, et al. Osteoclast-derived extracellular vesicles are implicated in sensory neurons sprouting through the activation of epidermal growth factor signaling. Cell Biosci. 2022;12(1):127.
Comments (0)