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RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
The maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a cor...
Protein Crystallization in Microgravity: Commercialization and the Next Chapter
Protein Crystallization in Microgravity: Commercialization and the Next Chapter
The purpose of this review is to describe the benefit of growing crystals in a microgravity environment and the changes we...
New Disruptive Technologies: Early-Stage Funding and Investment Trends
New Disruptive Technologies: Early-Stage Funding and Investment Trends
This paper provides a discussion of the investment climate in the life sciences industry. The authors explore recent and l...
Physiological Relevant 3D Biomanufacturing of Pluripotent Stem Cells for Regenerative Medicine
Physiological Relevant 3D Biomanufacturing of Pluripotent Stem Cells for Regenerative Medicine
Regenerative medicine is transforming modern healthcare by offering personalized approaches to the treatment of diseases a...
Artificial Intelligence in Biotechnology and Pharmaceuticals: Evolution, Applications, and Regulatory Frontiers
Artificial Intelligence in Biotechnology and Pharmaceuticals: Evolution, Applications, and Regulatory Frontiers
This review aims to examine how Artificial Intelligence (AI) is revolutionizing the biotechnology and pharmaceutical indus...
Denosumab Withdrawal and Rebound Bone Resorption: Molecular Mechanisms and Approaches for Treatment
Denosumab Withdrawal and Rebound Bone Resorption: Molecular Mechanisms and Approaches for Treatment
Denosumab (Dmab) is a human monoclonal anti-RANKL antibody that inhibits osteoclast-mediated bone resorption and sequentia...
From Brain Organoids to Organoid Intelligence. Benefits and Ethical-Moral Framework
From Brain Organoids to Organoid Intelligence. Benefits and Ethical-Moral Framework
Organoid intelligence (OI) is an emerging field in biological computing that integrates brain organoids with external inte...
Stem Cell-Based Strategies for Prenatal Treatment of Spina Bifida and the Promise of Cell-Free, Minimally Invasive Approaches
Stem Cell-Based Strategies for Prenatal Treatment of Spina Bifida and the Promise of Cell-Free, Minimally Invasive Approaches
Spina bifida (SB) is a severe birth defect that affects 1400 newborns annually in the USA. SB is often diagnosed before ir...
TRASCET—Transamniotic Stem Cell Therapy
TRASCET—Transamniotic Stem Cell Therapy
This is an overview of the current state of development of transamniotic stem cell therapy (TRASCET) as an emerging therap...
Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Prenatal intervention for congenital diseases could potentially halt or reverse devastating co-morbidities. Particle-based...
Maternal Gene Delivery for the Prevention and Treatment of Obstetric Conditions
Maternal Gene Delivery for the Prevention and Treatment of Obstetric Conditions
There is an urgent unmet clinical need for effective therapies for obstetric complications such as fetal growth restrictio...
Mesenchymal Stromal Cell Immunomodulatory Potential for Orthopedic Applications can be fine-tuned via 3D nano-engineered Scaffolds
Mesenchymal Stromal Cell Immunomodulatory Potential for Orthopedic Applications can be fine-tuned via 3D nano-engineered Scaffolds
This concise review delves into the pivotal role of three-dimensional (3D) nanostructured scaffolds in fostering mesenchym...
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) occupy the summit of the intricate hematopoiesis hierarchy, constituting a mere 0.01% of t...
Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
To review recent research using various stem cell-related therapies, including bone marrow, adipose tissue, hematopoietic ...
Iron-oxide-nanoparticle-tagged Mesenchymal Stem Cell Exosomes in Therapeutics
Iron-oxide-nanoparticle-tagged Mesenchymal Stem Cell Exosomes in Therapeutics
Mesenchymal Stromal/Stem Cells (MSCs) include a population of cells that are predominantly stromal cells with a small frac...
Human Induced Pluripotent Stem Cells for Advancing Regenerative Medicine in Space
Human Induced Pluripotent Stem Cells for Advancing Regenerative Medicine in Space
Space medicine research investigates the effects of microgravity on physiological systems to improve both astronaut health...
Role of Mesenchymal Stem Cells in Skin Aging and Damage: Insights from Recent Preclinical and Clinical Studies
Role of Mesenchymal Stem Cells in Skin Aging and Damage: Insights from Recent Preclinical and Clinical Studies
As interest in healthy lifestyles and youthfulness grows, anti-aging research has become increasingly popular among health...
Review of Disruptive Technologies in 3D Bioprinting
Review of Disruptive Technologies in 3D Bioprinting
The purpose of this review is to share insights from recognized experts in 3D biopriniting on the recent advances in these...
Quantitative Modelling in Stem Cell Biology and Beyond: How to Make Best Use of It
Quantitative Modelling in Stem Cell Biology and Beyond: How to Make Best Use of It
This article gives a broad overview of quantitative modelling approaches in biology and provides guidance on how to employ...
First Clinical Experiences Using Preconditioning Approaches to Improve MSC-Based Therapies
First Clinical Experiences Using Preconditioning Approaches to Improve MSC-Based Therapies
Describe the rationale for preconditioning MSCs prior to use as therapy and the state-of-the-art of using preconditioning ...
MSC-Based Cell Therapy for COVID-19-Associated ARDS and Classical ARDS: Comparative Perspectives
MSC-Based Cell Therapy for COVID-19-Associated ARDS and Classical ARDS: Comparative Perspectives
Despite no general conclusions regarding the therapeutic effect of MSCs on virus-induced acute lung injury in pre-clinical...
Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling
Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling
To explore the advances and future research directions in image analysis and computational modelling of human stem cells (...
Machine Learning Approaches for Stem Cells
Machine Learning Approaches for Stem Cells
Machine learning (ML) enables high-throughput analysis of multimodal data generated from stem cell experiments such as gen...
Transcription Factors and Splice Factors—Interconnected Regulators of Stem Cell Differentiation
Transcription Factors and Splice Factors—Interconnected Regulators of Stem Cell Differentiation
The underlying molecular mechanisms that direct stem cell differentiation into fully functional, mature cells remain an ar...
Understanding Hematopoietic Stem Cell Dynamics—Insights from Mathematical Modelling
Understanding Hematopoietic Stem Cell Dynamics—Insights from Mathematical Modelling
Hematopoietic stem cells (HSCs) drive blood-cell production (hematopoiesis). Out-competition of HSCs by malignant cells oc...
The Efficacy of Intra-articular Umbilical Cord-Mesenchymal Stem Cell Injection for Knee Osteoarthritis: a Systematic Review
The Efficacy of Intra-articular Umbilical Cord-Mesenchymal Stem Cell Injection for Knee Osteoarthritis: a Systematic Review
Previous studies involving various mesenchymal stem cell (MSC) sources have reported osteoarthritis (OA) attenuation benef...
A Review of Stochastic and Deterministic Modeling of Stem Cell Dynamics
A Review of Stochastic and Deterministic Modeling of Stem Cell Dynamics
This paper briefly describes recent mathematical models that use stochastic and deterministic approaches to understand ste...
Stem Cell Banking of Adipose Tissue
Stem Cell Banking of Adipose Tissue
Adult stem cells such as adipose tissue derived cells (ASCs) are often preferred for autologous cellular therapies. Nevert...
Immune Editing: Overcoming Immune Barriers in Stem Cell Transplantation
Immune Editing: Overcoming Immune Barriers in Stem Cell Transplantation
Human pluripotent stem cells have the potential to revolutionize the treatment of inborn and degenerative diseases, includ...
Applying the Cytocentric Principles to Regenerative Medicine for Reproducibility
Applying the Cytocentric Principles to Regenerative Medicine for Reproducibility
Cell and tissue products do not just reflect their present conditions; they are the culmination of all they have encounter...
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