Evaluation of Essential Micronutrients in Patients with Tropical Diseases

World Health Organization. Global report on neglected tropical diseases 2025 Internet].Geneva: WHO;2025. Disponible en: [https://www.who.int/es](https://www.who.int/es)

Molyneux DH, Hotez PJ, Fenwick A. The role of nutrition in integrated programs to control neglected tropical diseases. PLoS Negl Trop Dis. 2012;6(5):e1570.

Google Scholar 

Sankar J, Srivastava R, Kumar V, Maroof M, Yadav J, Lodh M. Interactions of nutrition and infection: the role of micronutrient deficiencies in the immune response to pathogens and implications for child health. Annu Rev Nutr. 2024;44:113–41.

Google Scholar 

Gombart AF, Pierre A, Maggini S. A review of micronutrients and the immune System–Working in harmony to reduce the risk of infection. Nutrients. 2020;12(1):236.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sankar J, Srivastava R, Kumar V, Maroof M, Yadav J, Lodh M. Interactions of nutrition and infection: the role of micronutrient deficiencies in the immune response to pathogens and implications for child health. Annu Rev Nutr. 2024;44:113–41.

Google Scholar 

Costa-Da-silva AC, Nascimento DO, Ferreira JRM, Guimarães-Pinto K, Freire-De-lima L, Morrot A, et al. Immune responses in leishmaniasis: an overview. Trop Med Infect Dis. 2022;7(4):54. https://doi.org/10.3390/TROPICALMED7040054.

Article  PubMed  PubMed Central  Google Scholar 

Singh N, Chawla HV, Kumar A, Singh S. Role of vitamin A supplementation in prevention and control of coronavirus disease-19: A narrative review. Int J Prev Med. 2022;13(1):122. https://doi.org/10.4103/IJPVM.IJPVM_683_20.

Article  PubMed  PubMed Central  Google Scholar 

Owusu-Agyei S, Newton S, Mahama E, Febir LG, Ali M, Adjei K, et al. Impact of vitamin A with zinc supplementation on malaria morbidity in Ghana. Nutr J. 2013;12(1):131. https://doi.org/10.1186/1475-2891-12-131.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hanna M, Jaqua E, Nguyen V, Clay JB, Vitamins. Functions and uses in medicine. Perm J. 2022;26(2):89. https://doi.org/10.7812/TPP/21.204.

Article  PubMed  PubMed Central  Google Scholar 

Ciccarelli AB, Frank FM, Puente V, Malchiodi EL, Batlle A, Lombardo ME. Antiparasitic effect of vitamin B12 on trypanosoma Cruzi. Antimicrob Agents Chemother. 2012;56(9):4825–30. https://doi.org/10.1128/AAC.00481-12.

Article  CAS  Google Scholar 

Kronenberger T, Lindner J, Meissner KA, Zimbres FM, Coronado MA, Sauer FM, et al. Vitamin B6-Dependent enzymes in the human malaria parasite plasmodium falciparum: A druggable target? BioMed Res Int. 2014;2014:108516. https://doi.org/10.1155/2014/108516.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Srivastava VK, Khattar D, Shukla A, Bhanarkar U. Systematic review: role of vitamin D3 in immune system regulation. Eur J Cardiovasc Med. 2025;15:102–9. https://doi.org/10.5083/EJCM/25-03-18.

Article  Google Scholar 

Setto JMA, Libonati RMF, Ventura RMS, Chaves TS, Sequeira CG, Martins Filho AJ, et al. Association between vitamin D serum levels and clinical, laboratory, and parasitological parameters in patients with malaria from an endemic area of the Amazon. J Braz Soc Trop Med. 2022;55:e00772021. https://doi.org/10.1590/0037-8682-0077-2021.

Article  Google Scholar 

Middelkoop K, Stewart J, Walker N, Delport C, Jolliffe DA, Coussens AK, et al. Vitamin D supplementation to prevent tuberculosis infection in South African schoolchildren: multicenter phase 3 double-blind randomized placebo-controlled trial (ViDiKids). Int J Infect Dis. 2023;134:63–70. https://doi.org/10.1016/j.ijid.2023.05.010.

Article  CAS  PubMed  Google Scholar 

Taghipour A, Abdoli A, Ramezani A, Abolghazi A, Mofazzal Jahromi MA, Maani S, et al. Leishmaniasis and trace element alterations: a systematic review. Biol Trace Elem Res. 2021;199(10):3918–38. https://doi.org/10.1007/s12011-020-02505-0.

Article  CAS  PubMed  Google Scholar 

Sandalinas F, Joy EJM, Hopkins H, Likoswe BH, Blake T, Luo H, et al. Malaria infection confounds inflammation-adjusted micronutrient biomarker concentrations in children and women in malawi: a secondary analysis of the 2015/2016 Malawi micronutrient survey. Br J Nutr. 2025;133(9):1276–86. https://doi.org/10.1017/S0007114525000820.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Achieng MN. Integrating nutritional interventions in malaria and anemia management: strategies for effective public health initiatives. Res Invent J Biol Appl Sci. 2025;5(2):48–53. https://doi.org/10.59298/rijbas/2025/524853.

Article  Google Scholar 

Kotepui M, Wilairatana P, Mala W, Kotepui KU, Masangkay FR, Wangdi K. Effects of daily zinc alone or in combination with other nutrient supplements on the risk of malaria parasitaemia: A systematic review and Meta-Analysis of randomised controlled trials. Nutrients. 2023;15(13):2855. https://doi.org/10.3390/NU15132855.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martín-Escolano R, Etxebeste-Mitxeltorena M, Martín-Escolano J, Plano D, Rosales MJ, Espuelas S, et al. Selenium derivatives as promising therapy for Chagas disease: in vitro and in vivo studies. ACS Infect Dis. 2021;7(6):1727–41. https://doi.org/10.1021/ACSINFECDIS.1C00048.

Article  PubMed  PubMed Central  Google Scholar 

Rashidi S, Fernández-Rubio C, Mansouri R, Ali-Hassanzadeh M, Ghani E, Karimazar M, et al. Selenium and protozoan parasitic infections: Selenocompounds and selenoproteins potential. Parasitol Res. 2022;121(1):49–60. https://doi.org/10.1007/S00436-021-07400-8.

Article  PubMed  PubMed Central  Google Scholar 

Mcdonald CM, Suchdev PS, Krebs NF, Hess SY, Wessells KR, Ismaily S, et al. Adjusting plasma or serum zinc concentrations for inflammation: biomarkers reflecting inflammation and nutritional determinants of anemia (BRINDA) project. Am J Clin Nutr. 2020;111(4):927–37. https://doi.org/10.1093/AJCN/NQZ304.

Article  PubMed  PubMed Central  Google Scholar 

Locks LM, Parekh A, Newell K, Dauphinais MR, Cintron C, Maloomian K, et al. The ABCDs of nutritional assessment in infectious diseases research. J Infect Dis. 2024;231(3):562. https://doi.org/10.1093/INFDIS/JIAE540.

Article  Google Scholar 

Combs GF. Biomarkers of selenium status. Nutrients. 2015;7(4):2209. https://doi.org/10.3390/nu7042209.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sheftel J, Tanumihardjo SA. Systematic review and Meta-Analysis of the relative Dose-Response tests to assess vitamin A status. Adv Nutr. 2021;12(3):904–41. https://doi.org/10.1093/ADVANCES/NMAA136.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo H, Geng J, Zeiler M, Nieckula E, Sandalinas F, Williams A, et al. A practical guide to adjust micronutrient biomarkers for inflammation using the BRINDA method. J Nutr. 2023;153(4):1265. https://doi.org/10.1016/J.TJNUT.2023.02.016.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Layden AJ, Täse K, Finkelstein JL. Neglected tropical diseases and vitamin B12: a review of the current evidence. Trans R Soc Trop Med Hyg. 2018;112(10):423–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Linus Pauling Institute, Oregon State University. Thiamin [Internet]. Corvallis (OR): Oregon State University. 2022. Disponible en: https://lpi.oregonstate.edu/es/mic

Perica VS, Huda M, Kadiu N, Gashi S, Nuri D, et al. Diagnosis, treatment and Long-Term management of vitamin B12 deficiency in adults: A Delphi expert consensus. Nutrients. 2024;16(8):2176.

Google Scholar 

Linus Pauling Institute, Oregon State University. Vitamin B12 [Internet]. Corvallis (OR): Oregon State University. 2015. Disponible en: https://lpi.oregonstate.edu/es/mic

Squillacioti G, Sherbiny S, El, Lettico V, Ghelli F, Panizzolo M, Scaioli G, et al. The quantification of vitamin D in humans: A Promising, Non-Invasive and Cost-Effective method to measure 25-Hydroxyvitamin D. Biomolecules. 2025;15(4):1–15. https://doi.org/10.3390/BIOM15040560.

Article  Google Scholar 

El-Gendy FM, El-Hawy MA, Rizk MS, El-Hefnawy SM, Mahmoud MZ. Value of soluble transferrin receptors and sTfR/log ferritin in the diagnosis of iron deficiency accompanied by acute infection. Indian J Hematol Blood Transfus. 2017. https://doi.org/10.1007/s12288-017-0836-6.

Article  PubMed  PubMed Central  Google Scholar 

Nipanal AV, Kumar MHM. Utility of sTFR/Ferritin index to differentiate iron deficiency anaemia and anaemia of chronic disease. IP J Nutr Metab Health Sci. 2021;3(4):119–23. https://doi.org/10.18231/J.IJNMHS.2020.024.

Article  Google Scholar 

Cebal

Comments (0)

No login
gif