Ajani JA, D’Amico TA, Bentrem DJ, Cooke D, Corvera C, Das P et al (2023) Esophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 21(4):393–422. https://doi.org/10.6004/jnccn.2023.0019

Article  PubMed  CAS  Google Scholar 

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229–263. https://doi.org/10.3322/caac.21834

Article  PubMed  Google Scholar 

Buas MF, Vaughan Vaughan TL. (2012) Epidemiology and risk factors for gastroesophageal junction tumors: understanding the rising incidence of this disease. Semin Radiat Oncol 23(1):3–9. https://doi.org/10.1016/j.semradonc.2012.09.008

Article  Google Scholar 

Chen Y, Mi Y, Tan S, Chen Y, Liu S, Lin S et al (2025) CEA-induced PI3K/AKT pathway activation through the binding of CEA to KRT1 contributes to oxaliplatin resistance in gastric cancer. Drug Resist Updat 78:101179. https://doi.org/10.1016/j.drup.2024.101179

Article  PubMed  CAS  Google Scholar 

El Jabbour T, Misyura M, Cowzer D, Zimmermann M, Rimkunas V, Marra A et al (2022) ATM Germline-Mutated Gastroesophageal Junction Adenocarcinomas: Clinical Descriptors, Molecular Characteristics, and Potential Therapeutic Implications. Natl Cancer Inst 114(5):761–770. https://doi.org/10.1093/jnci/djac024

Article  CAS  Google Scholar 

Gao S, Gang J, Yu M, Xin G, Tan H (2021) Computational analysis for identification of early diagnostic biomarkers and prognostic biomarkers of liver cancer based on GEO and TCGA databases and studies on pathways and biological functions affecting the survival time of liver cancer. BMC Cancer 21(1):791. https://doi.org/10.1186/s12885-021-08520-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

Giacometti C, Gusella A, Cassaro M (2023) Gastro-Esophageal Junction Precancerosis: Histological Diagnostic Approach and Pathogenetic Insights. Cancers (Basel) 15(24):5725. https://doi.org/10.3390/cancers15245725

Article  PubMed  CAS  Google Scholar 

Groen-van Schooten TS, Harrasser M, Seidel J, Bos EN, Fleitas T, van Mourik M et al (2024) Phenotypic immune characterization of gastric and esophageal adenocarcinomas reveals profound immune suppression in esophageal tumor locations. Front Immunol 15:1372272. https://doi.org/10.3389/fimmu.2024.1372272

Article  PubMed  PubMed Central  CAS  Google Scholar 

Han W, Hu C, Fan ZJ, Shen GL (2021) Transcript levels of keratin 1/5/6/14/15/16/17 as potential prognostic indicators in melanoma patients. Sci Rep 11(1):1023. https://doi.org/10.1038/s41598-020-80336-8

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ho M, Thompson B, Fisk JN, Nebert DW, Bruford EA, Vasiliou V et al (2022) Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders. Hum Genomics 16(1):1. https://doi.org/10.1186/s40246-021-00374-9

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hong K, Yang Q, Yin H, Wei N, Wang W, Yu B (2023) Comprehensive analysis of ZNF family genes in prognosis, immunity, and treatment of esophageal cancer. BMC Cancer 23(1):301. https://doi.org/10.1186/s12885-023-10779-5

Article  PubMed  PubMed Central  CAS  Google Scholar 

Huang Q, Shen YJ, Hsueh CY, Zhang YF, Guo Y, Yuan XH et al (2023) Tetraspanin CD63 reduces the progression and metastasis of head and neck squamous cell carcinoma via KRT1-mediated cell cycle arrest. Heliyon 9(7):e17711. https://doi.org/10.1016/j.heliyon.2023.e17711

Article  PubMed  PubMed Central  CAS  Google Scholar 

Japanese Gastric Cancer Association (2023) Japanese Gastric Cancer Treatment Guidelines 2021 (6th edition). Gastric Cancer 26(1):1-25. https://doi.org/10.1007/s10120-022-01331-8

Joshi SS, Badgwell BD (2021) Current treatment and recent progress in gastric cancer. CA Cancer J Clin 71(3):264–279. https://doi.org/10.3322/caac.21657

Article  PubMed  PubMed Central  Google Scholar 

Ke L, Li S, Huang D (2023) The predictive value of tumor mutation burden on survival of gastric cancer patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis. Int Immunopharmacol 124(Pt B):110986. https://doi.org/10.1016/j.intimp.2023.110986

Article  PubMed  CAS  Google Scholar 

Li N, Sohal D (2023) Current state of the art: immunotherapy in esophageal cancer and gastroesophageal junction cancer. Cancer Immunol Immunother 72(12):3939–3952. https://doi.org/10.1007/s00262-023-03566-5

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li S, Yuan L, Xu ZY, Xu JL, Chen GP, Guan X et al (2023) Integrative proteomic characterization of adenocarcinoma of esophagogastric junction. Nat Commun 14(1):778. https://doi.org/10.1038/s41467-023-36462-8

Article  PubMed  PubMed Central  CAS  Google Scholar 

Luo Q, Du R, Liu W, Huang G, Dong Z, Li X (2022) PI3K/Akt/mTOR Signaling pathway: role in esophageal squamous cell carcinoma, regulatory mechanisms and opportunities for targeted therapy. Front Oncol 12:852383. https://doi.org/10.3389/fonc.2022.852383

Article  PubMed  PubMed Central  CAS  Google Scholar 

Matula K, Collie-Duguid E, Murray G, Parikh K, Grabsch H, Tan P et al (2015) Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer. BMC Cancer 15:762. https://doi.org/10.1186/s12885-015-1718-7

Article  PubMed  PubMed Central  CAS  Google Scholar 

Morgos DT, Stefani C, Miricescu D, Greabu M, Stanciu S, Nica S et al (2024) Targeting PI3K/AKT/mTOR and MAPK signaling pathways in gastric cancer. Int J Mol Sci 25(3):1848. https://doi.org/10.3390/ijms25031848

Article  PubMed  PubMed Central  CAS  Google Scholar 

Oberoi M, Noor MS, Abdelfatah E (2024) The Multidisciplinary approach and surgical management of GE junction adenocarcinoma. Cancers (Basel) 16(2):288. https://doi.org/10.3390/cancers16020288

Article  PubMed  CAS  Google Scholar 

Ogunnigbagbe O, Bunick CG, Kaur K (2022) Keratin 1 as a cell-surface receptor in cancer. Biochim Biophys Acta Rev Cancer 1877(1):188664. https://doi.org/10.1016/j.bbcan.2021.188664

Article  PubMed  CAS  Google Scholar 

Peng L, Zhao M, Liu T, Chen J, Gao P, Chen L et al (2022) A stop-gain mutation in GXYLT1 promotes metastasis of colorectal cancer via the MAPK pathway. Cell Death Dis 13(4):395. https://doi.org/10.1038/s41419-022-04844-3

Article  PubMed  PubMed Central  CAS  Google Scholar 

Qin Q, Zhou Y, Guo J, Chen Q, Tang W, Li Y et al (2024) Conserved methylation signatures associate with the tumor immune microenvironment and immunotherapy response. Genome Med 16(1):47. https://doi.org/10.1186/s13073-024-01318-3

Article  PubMed  PubMed Central  CAS  Google Scholar 

Quante M, Bhagat G, Abrams JA, Marache F, Good P, Lee MD et al (2012) Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia. Cancer Cell 21(1):36–51. https://doi.org/10.1016/j.ccr.2011.12.004

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ren Y, Dong H, Jin R, Jiang J, Zhang X (2022) TRIM22 actives PI3K/Akt/mTOR pathway to promote psoriasis through enhancing cell proliferation and inflammation and inhibiting autophagy. Cutan Ocul Toxicol 41(4):304–309. https://doi.org/10.1080/15569527.2022.2127750

Article  PubMed  CAS  Google Scholar 

Rhee H, Kim H, Park YN (2020) Clinico-Radio-Pathological and Molecular Features of Hepatocellular Carcinomas with Keratin 19 Expression. Liver Cancer 9(6):663–681. https://doi.org/10.1159/000510522

Article