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Can the molecular and transgenic breeding of crops be an alternative and sustainable technology to meet food demand?
Can the molecular and transgenic breeding of crops be an alternative and sustainable technology to meet food demand?
The gradual increase in the worldwide population represents various challenges, and one of the most alarming being the foo...
Roles of Immunity and Endogenous Retroelements in the Pathogenesis of Rheumatoid Arthritis and Treatment Strategies
Roles of Immunity and Endogenous Retroelements in the Pathogenesis of Rheumatoid Arthritis and Treatment Strategies
Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disease that primarily affects the joints. RA usually res...
Epigenetic profiles integrated with transcriptomic reveal the difference between COPD and PRISm in KOCOSS-NIH
Epigenetic profiles integrated with transcriptomic reveal the difference between COPD and PRISm in KOCOSS-NIH
In 2023, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) introduced a provision regarding preserved rati...
EXO1 as a potential biomarker for prognosis, immune infiltration, and immunotherapy in pan-cancer analysis
EXO1 as a potential biomarker for prognosis, immune infiltration, and immunotherapy in pan-cancer analysis
Human EXO1 is a 5' → 3' exonuclease that plays a critical role in regulating cell cycle checkpoi...
Exploring the molecular pathways of miRNAs in testicular cancer: from diagnosis to therapeutic innovations
Exploring the molecular pathways of miRNAs in testicular cancer: from diagnosis to therapeutic innovations
Cancer diagnostics highlight the critical requirement for sensitive and accurate tools with functional biomarkers for earl...
Multi-omic profiling identifies as a predictor of immune infiltration and prognosis in gastroesophageal junction cancer
Multi-omic profiling identifies as a predictor of immune infiltration and prognosis in gastroesophageal junction cancer
Gastroesophageal junction cancer (GEJ) is typically investigated alongside gastric or esophageal cancers. However, separat...
Identification and mechanistic analysis of shared biomarkers and pathogenesis in acute pancreatitis and sepsis based on differential gene expression and protein interaction networks
Identification and mechanistic analysis of shared biomarkers and pathogenesis in acute pancreatitis and sepsis based on differential gene expression and protein interaction networks
Acute pancreatitis (AP) is a common gastrointestinal inflammatory disease that requires hospitalization, with 40–70%...
Identification of a NEK7-related pyroptosis gene signature against pancreatic cancer and evaluation of its potential in tumor microenvironment remodeling via regulating inflammasome complex
Identification of a NEK7-related pyroptosis gene signature against pancreatic cancer and evaluation of its potential in tumor microenvironment remodeling via regulating inflammasome complex
The treatment options for pancreatic ductal adenocarcinoma (PDAC) remain limited. It is therefore important to explore new...
A Multi-omics approach to identify and validate shared genetic architecture in rheumatoid arthritis, multiple sclerosis, and type 1 diabetes: integrating GWAS, GEO, MSigDB, and scRNA-seq data
A Multi-omics approach to identify and validate shared genetic architecture in rheumatoid arthritis, multiple sclerosis, and type 1 diabetes: integrating GWAS, GEO, MSigDB, and scRNA-seq data
The notable comorbidity among autoimmune diseases underscores their shared genetic underpinnings, particularly evident in ...
SNP’s use as a potential chemotoxicity stratification tool in breast cancer: from bench to clinic
SNP’s use as a potential chemotoxicity stratification tool in breast cancer: from bench to clinic
Breast cancer (BC) remains one of the most prevalent malignancies affecting women worldwide, necessitating ongoing researc...
Multi-omics integration reveals YWHAE as a key mediator of ferroptosis in ARDS
Multi-omics integration reveals YWHAE as a key mediator of ferroptosis in ARDS
Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by severe hypoxemia and high mort...
RNA-binding protein HuR interacts with UFM1 mRNA to ameliorate chondrocyte inflammation, apoptosis and extracellular matrix degradation
RNA-binding protein HuR interacts with UFM1 mRNA to ameliorate chondrocyte inflammation, apoptosis and extracellular matrix degradation
To investigate the mechanisms by which the RNA-binding protein HuR /ELAVL1 interacts with UFM1 mRNA to ameliorate chondroc...
Mitochondrial genome evolution in the orchid subfamily Cypripedioideae (Orchidaceae)
Mitochondrial genome evolution in the orchid subfamily Cypripedioideae (Orchidaceae)
In this study, the mitogenomes of nine species in the subfamily Cypripedioideae were newly sequenced and assembled using b...
Integration of metabolite and transcriptome profiles of cultivated and wild rice to unveil gene regulatory networks and key genes determining rice source and sink strength
Integration of metabolite and transcriptome profiles of cultivated and wild rice to unveil gene regulatory networks and key genes determining rice source and sink strength
Targeting source and sink strength for crop yield increase requires a comprehensive genetic and metabolic understanding of...
Genomic dissection of terminal heat tolerance in synthetic hexaploid derived nested introgression libraries of wheat ( L.)
Genomic dissection of terminal heat tolerance in synthetic hexaploid derived nested introgression libraries of wheat ( L.)
The terminal heat stress during grain filling period is major threat to wheat productivity. Heat tolerant QTLs were harnes...
Establishment of a rapid RAA-CRISPR/Cas12a system targeting the gene for on-site detection of in livestock and fresh pork meat
Establishment of a rapid RAA-CRISPR/Cas12a system targeting the gene for on-site detection of in livestock and fresh pork meat
Streptococcus suis is a major bacterial pathogen in the swine industry, causing meningitis, arthritis, and other diseases ...
Twenty-five years of WWOX insight in cancer: a treasure trove of knowledge
Twenty-five years of WWOX insight in cancer: a treasure trove of knowledge
More than two decades ago, MD Anderson Cancer group discovered, characterised, and identified the WW domain-containing oxi...
sc-MULTI-omics approach in nano-rare diseases: understanding the pathophysiological mechanism of Mulvihill-Smith Syndrome
sc-MULTI-omics approach in nano-rare diseases: understanding the pathophysiological mechanism of Mulvihill-Smith Syndrome
Mulvihill-Smith Syndrome (MSS) is a clinically complex and genetically unsolved nano-rare disorder with only 12 patients r...
Durum wheat nuclear factor Y (NF-Y) a subfamily: structure, phylogeny, and expression analysis in response to hormones and abiotic stresses
Durum wheat nuclear factor Y (NF-Y) a subfamily: structure, phylogeny, and expression analysis in response to hormones and abiotic stresses
Nuclear factor-Y (NF-Y) transcription factors are heterotrimeric complexes that are widely distributed in eukaryotes and p...
3’UTR RNA editing driven by ADAR1 modulates MDM2 expression in breast cancer cells
3’UTR RNA editing driven by ADAR1 modulates MDM2 expression in breast cancer cells
Epitranscriptomic changes in the transcripts of cancer related genes could modulate protein levels. RNA editing, particula...
Identification of flowering genes in Camellia perpetua by comparative transcriptome analysis
Identification of flowering genes in Camellia perpetua by comparative transcriptome analysis
Camellia perpetua has the excellent characteristic of flowering multiple times throughout the year, which is of great impo...
Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression
Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression
This study was designed to investigate the role of a disintegrin and metalloproteinase domain-like protein decysin 1 (ADAM...
Hypoxia-induced circRTN4IP1 promotes progression and glycolysis of hepatocellular carcinoma cells
Hypoxia-induced circRTN4IP1 promotes progression and glycolysis of hepatocellular carcinoma cells
Hypoxia is one of the hallmarks of solid tumors, especially in hepatocellular carcinoma (HCC). CircRNAs are reported to be...
IGF2 is upregulated by its antisense RNA to potentiate pancreatic cancer progression
IGF2 is upregulated by its antisense RNA to potentiate pancreatic cancer progression
Pancreatic cancer is a deadly cancer. More and more long noncoding RNAs (lncRNAs) have received confirmation to be dysregu...
Benchmarking of bioinformatics tools for NGS-based microRNA profiling with RT-qPCR method
Benchmarking of bioinformatics tools for NGS-based microRNA profiling with RT-qPCR method
MicroRNAs are vital gene expression regulators, extensively studied worldwide. The large-scale characterization of miRNAom...
CFAP61 knockdown aggravates male infertility by inhibiting testosterone secretion by Leydig cells via the MAPK/COX-2 pathway
CFAP61 knockdown aggravates male infertility by inhibiting testosterone secretion by Leydig cells via the MAPK/COX-2 pathway
This study aimed to elucidate the roles of cilia- and flagella-associated protein 61 (CFAP61) in male infertility and its ...
3′-tRF-CysGCA overexpression in HEK-293 cells alters the global expression profile and modulates cellular processes and pathways
3′-tRF-CysGCA overexpression in HEK-293 cells alters the global expression profile and modulates cellular processes and pathways
tRNA fragments (tRFs) are small non-coding RNAs generated through specific cleavage of tRNAs and involved in various biolo...
NLRP3/miR-223-3p axis attenuates neuroinflammation induced by chronic intermittent hypoxia
NLRP3/miR-223-3p axis attenuates neuroinflammation induced by chronic intermittent hypoxia
Obstructive sleep apnea (OSA) is mainly characterized by chronic intermittent hypoxia (CIH) with multiple brain injuries. ...
The cellular trajectories of tumor-associated macrophages decipher the heterogeneity of pancreatic cancer
The cellular trajectories of tumor-associated macrophages decipher the heterogeneity of pancreatic cancer
Emerging evidence indicates that the interactions and dynamic changes among tumor-associated macrophages (TAMs) are pivota...
Comparative transcriptome analysis reveals candidate genes related to the sex differentiation of Schisandra chinensis
Comparative transcriptome analysis reveals candidate genes related to the sex differentiation of Schisandra chinensis
Schisandra chinensis is a monoecious plant with unisex flowers. The fruit of S. chinensis is of high medical with economic...
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