We gratefully thank all NAPKON sites who contributed patient data and/or biosamples for this analysis. The representatives of NAPKON sites contributing at least 5 per mille to this analysis are (alphabetical order): Bielefeld University, Medical School and University Medical Center OWL, Bielefeld (Alsaad K, Hamelmann E, Heidenreich H, Hornberg C, Kulamadayil-Heidenreich NSA, Maasjosthusmann P, Muna A, Ruwe M, Stellbrink C, Tebbe J), Klinikum Dortmund Hospital of Universitiy Witten-Herdecke, Dortmund (Azzaui H, Graeske M, Hower M, Kremling J, Landsiedel-Mechenbier E, Riepe A, Schaaf B), University Hospital Augsburg, Augsburg (Bader S, Engelmann M, Fuchs A, Langer A, Maerkl B, Messmann H, Muzalyova A, Roemmele C), University Hospital Carl Gustav Carus, Dresden (Altmann H, Berner R, Dressen S, Koch T, Lindemann D, Seele K, Spieth P, Tausche K, Toepfner N, v. Bonin S), University Hospital Erlangen, Erlangen (Kraska D, Kremer AE, Leppkes M, Mang J, Neurath MF, Prokosch HU, Schmid J, Vetter M, Willam C, Wolf K), University Hospital Frankfurt, Frankfurt am Main (Arendt< a0> C, Bellinghausen C, Cremer S, Groh A, Gruenewaldt A, Khodamoradi Y, Klinsing S, Rohde G, Vehreschild M, Vogl T), University Hospital Hamburg-Eppendorf, Hamburg (Addo M, Almahfoud M, Engels ALF, Jarczak D, Kerinn M, Kluge S, Kobbe R, Petereit S, Schlesner C, Zeller T), University Hospital Leipzig, Leipzig (Baber R, Bercker S, Krug N, Mueller SD, Wirtz H), University Hospital Muenster, Muenster (Boeckel G, Meier JA, Nowacki T, Tepasse PR, Vollenberg R, Wilms C), University Hospital Regensburg, Regensburg (Albig H, Burkhardt R, Feustel M, Fisser C, Hansch S, Hanses F, Hitzenbichler F, Niedermair T, Schuster P, Tran T), University Hospital RWTH Aachen, Aachen (Dahl E, Dreher M, Marx N, Mueller-Wieland D, Wipperfuerth J), University Hospital Schleswig-Holstein Kiel, Kiel (Cleef S, Friedrichs A, Kujat C, Pape D, Schunk D), University Hospital Schleswig-Holstein Luebeck, Luebeck (Kaeding N, Nissen M, Rupp J), University Hospital Technical University Munich, Munich (Barkey W, Erber J, Fricke L, Gladis S, Michler T, Mueller L, Schneider J, Spinner C, Winter C), University Hospital Tuebingen, Tuebingen (Bitzer M, Bunk S, Goepel S, Haeberle H, Kienzle K, Mahrhofer H, Malek N, Rosenberger P, Struemper C, Trauner F), University Hospital Wuerzburg, Wuerzburg (Einsele H, Frantz S, Frey A, Haas K, Haertel C, Herrmann J, Meybohm P, Schmidt J, Schulze P, Volkmann J), University Hospitals of the Ruhr University Bochum, Bochum (Brinkmann F, Brueggemann Y, Gambichler T, Hellwig K, Luecke T, Reinacher-Schick A, Schmidt WE, Schuette C, Steinmann E, Torres Reyes C), University Medical Center Goettingen, Central Biobank, Goettingen (Nussbeck SY), University Medical Center Goettingen, Central Laboratory, Goettingen (Hafke A), University Medical Center Goettingen, Emergency Department, Goettingen (Blaschke S, Hermanns G, Santibanez-Santana M, Zeh S), University Medicine Essen, Essen (Brochhagen L, Dolff S, Elsner C, Krawczyk A, Madel RJ, Otte M, Thuemmler L, Witzke O), University Medicine Greifswald, Greifswald (Becker K, Doerr M, Lehnert K, Nauck M, Piasta N, Schaefer C, Schaefer E, Schattschneider M, Scheer C, Stahl D), University Medicine Oldenburg, Oldenburg (Arlt A, Griesinger F, Guenther U, Hamprecht A, Juergens K, Kluge A, Meinhardt C, Meinhardt K, Petersmann A, Prenzel R).We gratefully thank all participating NAPKON and NUKLEUS infrastructures that contributed to this analysis. The representatives of these NAPKON and NUKLEUS infrastructures are (alphabetical order): Charite - Universitaetsmedizin Berlin, Berlin (Lorbeer R, Schaller J), Helmholtz Center Munich, Munich (Kraus M, Lorenz-Depiereux B), University Hospital Frankfurt, Frankfurt (Appel K, Brechtel M, Broehl I, Fiedler K, Geisler R, Hopff SM, Knaub K, Lee C, Nunes de Miranda S, Raquib S, Sauer G, Scherer M, Vehreschild JJ, Wagner P, Wolf L), University Hospital Wuerzburg, Wuerzburg (Guenther K, Haug F, Haug J), University Hospital Wuerzburg and University of Wuerzburg, Wuerzburg (Fiessler C, Heuschmann PU, Miljukov O, Nuernberger C, Reese JP, Schmidbauer L), University Medicine Goettingen, Goettingen (Chaplinskaya I, Hanss S, Krefting D, Pape C, Rainers M, Schoneberg A, Weinert N), University Medicine Greifswald, Greifswald (Bahls T, Hoffmann W, Nauck M, Schaefer C, Schattschneider M, Stahl D, Valentin H), University of Wuerzburg, Wuerzburg (Jiru-Hillmann S).We gratefully thank the NAPKON Steering Committee: University Hospital Giessen and Marburg, Giessen (Herold S), University of Würzburg, Würzburg (Heuschmann P), Charité - Universitätsmedizin Berlin, Berlin (Heyder R), University Medicine Greifswald, Greifswald (Hoffmann W), Hannover Unified Biobank, Hannover Medical School, Hannover (Illig T), University Hospital Schleswig-Holstein, Kiel (Schreiber S), University Hospital Cologne and University Hospital Frankfurt, Cologne and Frankfurt (Vehreschild JJ), Charité - Universitätsmedizin Berlin, Berlin (Witzenrath M).