Revolutionizing cancer treatment with senotherapeutics: a current perspective

Cancer Accessed: Feb. 05, 2025. [Online]. Available: https://www.who.int/health-topics/cancer#tab=tab_1

Cancer Development | CancerQuest Accessed: Feb. 05, 2025. [Online]. Available: https://cancerquest.org/cancer-biology/cancer-development

Cancer Overview, causes, treatments, and types. Accessed: Feb. 05, 2025. [Online]. Available: https://www.medicalnewstoday.com/articles/323648

Cancer treatment - Mayo Clinic., Accessed Feb. 05, 2025. [Online]. Available: https://www.mayoclinic.org/tests-procedures/cancer-treatment/about/pac-20393344

Cancer treatments MedlinePlus Medical Encyclopedia. Accessed: Feb. 05, 2025. [Online]. Available: https://medlineplus.gov/ency/patientinstructions/000901.htm

Overview of Cancer Therapy - Hematology and Oncology - MSD Manual Professional Edition Accessed: Feb. 05, 2025. [Online]. Available: https://www.msdmanuals.com/professional/hematology-and-oncology/principles-of-cancer-therapy/overview-of-cancer-therapy

Naser R, Dilabazian H, Bahr H, Barakat A, El-Sibai M (2022) A guide through conventional and modern cancer treatment modalities: a specific focus on glioblastoma cancer therapy (Review). Oncol Rep. https://doi.org/10.3892/OR.2022.8405

Article  PubMed  Google Scholar 

Liu B, Zhou H, Tan L, Siu KTH, Guan XY Exploring treatment options in cancer: tumor treatment strategies. Dec 01 2024 Springer Nature. https://doi.org/10.1038/s41392-024-01856-7

Gorgoulis V et al (2019) Cellular Senescence: Defining a Path Forward, Oct. 31, Cell Press. https://doi.org/10.1016/j.cell.2019.10.005

Czajkowski K, Herbet M, Murias M, Piątkowska-Chmiel I (2024) Senolytics: charting a new course or enhancing existing anti-tumor therapies. Springer Sci Bus Media B V. https://doi.org/10.1007/s13402-024-01018-5

Article  Google Scholar 

Hayflick L, Moorhead PS (1961) THE SERIAL CULTIVATION OF HUMAN DIPLOID CELL STRAINS’

Fossel M (2018) Cell senescence, telomerase, and senolytic therapy. OBM Geriat 3(1):1–1. https://doi.org/10.21926/obm.geriatr.1901034

Article  Google Scholar 

Kudlova N, De Sanctis JB, Hajduch M (2022) Cellular senescence: molecular targets, biomarkers, and senolytic drugs. MDPI. https://doi.org/10.3390/ijms23084168

Article  Google Scholar 

Bousset L, Gil J (2022) Targeting senescence as an anticancer therapy. Mol Oncol. https://doi.org/10.1002/1878-0261.13312

Article  PubMed  PubMed Central  Google Scholar 

Zhang JW, Zhang D, Yu BP (2021) Senescent cells in cancer therapy: why and how to remove them. Cancer Lett. https://doi.org/10.1016/j.canlet.2021.07.002

Article  PubMed  PubMed Central  Google Scholar 

Young ARJ, Narita M (2009) SASP reflects senescence. EMBO Rep. https://doi.org/10.1038/embor.2009.22

Article  PubMed  PubMed Central  Google Scholar 

Kaur P et al (2018) Formulation, systematic optimization, in vitro, ex vivo, and stability assessment of transethosome based gel of curcumin. Asian J Pharm Clin Res 11(Special Issue 2):41–47. https://doi.org/10.22159/ajpcr.2018.v11s2.28563

Article  CAS  Google Scholar 

Kirkland JL, Tchkonia T (2020) Senolytic drugs: from discovery to translation. J Intern Med. https://doi.org/10.1111/joim.13141

Article  PubMed  PubMed Central  Google Scholar 

Zhang L, Pitcher LE, Prahalad V, Niedernhofer LJ, Robbins PD (2023) Targeting cellular senescence with senotherapeutics: senolytics and senomorphics. FEBS J. https://doi.org/10.1111/febs.16350

Article  PubMed  Google Scholar 

Zhu Y et al (2015) The achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 14(4):644–658. https://doi.org/10.1111/acel.12344

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carpenter VJ, Saleh T, Gewirtz DA (2021) Senolytics for cancer therapy: is all that glitters really gold? Cancers. https://doi.org/10.3390/cancers13040723

Article  PubMed  PubMed Central  Google Scholar 

Luís C, Maduro AT, Pereira P, Mendes JJ, Soares R, Ramalho R (2022) Nutritional senolytics and senomorphics: implications to immune cells metabolism and aging – from theory to practice. Front Nutr. https://doi.org/10.3389/fnut.2022.958563

Article  PubMed  PubMed Central  Google Scholar 

Malayaperumal S et al (2023) The emerging role of senotherapy in cancer: a comprehensive review. Clin Pract. https://doi.org/10.3390/clinpract13040076

Article  PubMed  PubMed Central  Google Scholar 

van Deursen JM (2019) Senolytic therapies for healthy longevity. Science. https://doi.org/10.1126/science.aaw1299

Article  PubMed  PubMed Central  Google Scholar 

Power H, Valtchev P, Dehghani F, Schindeler A (2023) Strategies for senolytic drug discovery. Aging Cell. https://doi.org/10.1111/acel.13948

Article  PubMed  PubMed Central  Google Scholar 

Shi Y et al (2024) Advances in nanotherapy for targeting senescent cells. Int J Nanomedicine. https://doi.org/10.2147/IJN.S469110

Article  PubMed  PubMed Central  Google Scholar 

Davan-Wetton CSA, Pessolano E, Perretti M, Montero-Melendez T (2021) Senescence under appraisal: hopes and challenges revisited. Cell Mol Life Sci. https://doi.org/10.1007/s00018-020-03746-x

Article  PubMed  PubMed Central  Google Scholar 

Zhu Y, Doornebal EJ, Pirtskhalava T, Giorgadze N, Wentworth M, Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD, Tchkonia T, Kirkland JL (2017) New agents that target senescent cells: The flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging (Albany NY, 9(3):955–963. https://doi.org/10.18632/aging.101202

Billimoria R, Bhatt P (2023) Senescence in cancer: advances in detection and treatment modalities. Biochem Pharmacol 215:115739. https://doi.org/10.1016/J.BCP.2023.115739

Article  CAS  PubMed  Google Scholar 

Rachmian N, Krizhanovsky V (2023) Senescent cells in the brain and where to find them. FEBS J. https://doi.org/10.1111/febs.16649

Article  PubMed  Google Scholar 

Riviere-Cazaux C et al (2023) An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence. NPJ Precis Oncol. https://doi.org/10.1038/s41698-023-00476-8

Budamagunta V et al (2024) Senolytic treatment alleviates doxorubicin-induced chemobrain. Aging Cell. https://doi.org/10.1111/acel.14037

Article  PubMed  PubMed Central  Google Scholar 

Johnson M et al (2023) Advanced age in humans and mouse models of glioblastoma show decreased survival from extratumoral influence. Clin Cancer Res 29(23):4973–4989. https://doi.org/10.1158/1078-0432.CCR-23-0834

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gulej R et al (2023) Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brain. Geroscience 45(5):2983–3002. https://doi.org/10.1007/s11357-023-00870-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Selt F et al (2023) BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma. Neuro Oncol 25(4):735–747. https://doi.org/10.1093/neuonc/noac199

Article  CAS  PubMed  Google Scholar 

Yamamoto M et al (2021) Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax. Neuro-Oncol Adv. https://doi.org/10.1093/noajnl/vdab148

Article  Google Scholar 

Fletcher-Sananikone E et al (2021) Elimination of radiation-induced senescence in the brain tumor microenvironment attenuates glioblastoma recurrence. Cancer Res 81(23):5935–5947. https://doi.org/10.1158/0008-5472.CAN-21-0752

Article  CAS  PubMed  PubMed Central  Google Scholar 

Milczarek M (2020) The premature senescence in breast cancer treatment strategy. Cancers. https://doi.org/10.3390/cancers12071815

Article  PubMed  PubMed Central  Google Scholar 

de Paula B, Kieran R, Koh SSY, Crocamo S, Abdelhay E, Muñoz-Espín D (2023) Targeting senescence as a therapeutic opportunity for triple-negative breast cancer. Mol Cancer Ther. https://doi.org/10.1158/1535-7163.MCT-22-0643

Article 

Comments (0)

No login
gif