Samadder NJ, Valentine JF, Guthery S, Singh H, Bernstein CN, Leighton JA et al (2019) Family history associates with increased risk of colorectal cancer in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol 17(9):1807–13e1

Article  PubMed  Google Scholar 

Hossain MS, Karuniawati H, Jairoun AA, Urbi Z, Ooi DJ, John A et al (2022) Colorectal cancer: a review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies. Cancers (Basel). https://doi.org/10.3390/cancers14071732

Article  PubMed  PubMed Central  Google Scholar 

Rebuzzi F, Ulivi P, Tedaldi G (2023) Genetic predisposition to colorectal cancer: how many and which genes to test? Int J Mol Sci. https://doi.org/10.3390/ijms24032137

Article  PubMed  PubMed Central  Google Scholar 

Outtaleb FZ, Alami A, Serbati N, Benchakroun N, Bouchbika Z, Jouhadi H et al (2021) Lynch syndrome or hereditary non polyposis colorectal cancer (HNPCC) in a Moroccan family: case report. Ann Med Surg (Lond) 62:123–126

Article  PubMed  Google Scholar 

Yu GH, Li SF, Wei R, Jiang Z (2022) Diabetes and colorectal cancer risk: clinical and therapeutic implications. J Diabetes Res 2022:1747326

Article  PubMed  PubMed Central  Google Scholar 

Sawicki T, Ruszkowska M, Danielewicz A, Niedźwiedzka E, Arłukowicz T, Przybyłowicz KE (2021) A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis. Cancers (Basel). https://doi.org/10.3390/cancers13092025

Article  PubMed  Google Scholar 

Aune D, Chan DS, Lau R, Vieira R, Greenwood DC, Kampman E et al (2011) Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies. BMJ 343:d6617

Article  PubMed  PubMed Central  Google Scholar 

Grothey A, Sobrero AF, Shields AF, Yoshino T, Paul J, Taieb J et al (2018) Duration of adjuvant chemotherapy for stage III colon cancer. N Engl J Med 378(13):1177–1188

Article  PubMed  PubMed Central  Google Scholar 

Anand U, Dey A, Chandel AKS, Sanyal R, Mishra A, Pandey DK et al (2023) Cancer chemotherapy and beyond: current status, drug candidates, associated risks and progress in targeted therapeutics. Genes Dis 10(4):1367–1401

Article  PubMed  Google Scholar 

Shaham SH, Vij P, Tripathi MK (2025) Advances in targeted and chemotherapeutic strategies for colorectal cancer: current insights and future directions. Biomedicines. https://doi.org/10.3390/biomedicines13030642

Article  PubMed  PubMed Central  Google Scholar 

Shanmugam MK, Rane G, Kanchi MM, Arfuso F, Chinnathambi A, Zayed ME et al (2015) The multifaceted role of curcumin in cancer prevention and treatment. Molecules 20(2):2728–2769

Article  PubMed  PubMed Central  Google Scholar 

Dehelean CA, Marcovici I, Soica C, Mioc M, Coricovac D, Iurciuc S et al (2021) Plant-derived anticancer compounds as new perspectives in drug discovery and alternative therapy. Molecules. https://doi.org/10.3390/molecules26041109

Article  PubMed  PubMed Central  Google Scholar 

Patel BB, Sengupta R, Qazi S, Vachhani H, Yu Y, Rishi AK et al (2008) Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R. Int J Cancer 122(2):267–273

Article  PubMed  Google Scholar 

Weng W, Goel A (2022) Curcumin and colorectal cancer: an update and current perspective on this natural medicine. Semin Cancer Biol 80:73–86

Article  PubMed  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249

PubMed  Google Scholar 

Sharma R, Abbasi-Kangevari M, Abd-Rabu R, Abidi H, Abu-Gharbieh E, Acuna JM et al (2022) Global, regional, and National burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the global burden of disease study 2019. The lancet Gastroenterology & hepatology

Huang J, Patel H, Lucero-Prisno D, Boakye D, Chandrasekar V, Lok V et al (2020) IDDF2020-ABS-0181 Disease burden, risk factors, and recent trends of colorectal cancer: a global analysis of data from 186 countries. Abstracts

Li J, Zhang Y, Ji Y, Wu J, Jin Q, Feng Z et al (2025) [Comparison analyses of global burden of colorectal cancer]. Zhonghua Zhong Liu Za Zhi [Chinese journal of oncology]. 47 4:308–315

Asadi A, Ghahramani Y (2025) Gold nanoparticles: a powerful biosensor in oral medicine and dentistry. J Oral Dent Health Nexus 1:1–4

Article  Google Scholar 

Deng Y, Wang Y, Yang J, Luo X, Qiu J, Long R et al (2025) Global, regional, and national disease burden and prediction analysis of colorectal cancer attributable to tobacco, alcohol, and obesity from 1990 to 2030. Front Oncol. https://doi.org/10.3389/fonc.2025.1524308

Article  PubMed  PubMed Central  Google Scholar 

He M, Gu R, Huang X, Zhao A, Tian S, Zheng Y (2025) Global burden of colorectal cancer attributable to metabolic risks from 1990 to 2021, with projections of mortality to 2035. Int J Colorectal Dis. https://doi.org/10.1007/s00384-025-04817-w

Article  PubMed  PubMed Central  Google Scholar 

Ryu HS, Kim HJ, Ji WB, Kim BC, Kim JH, Moon SK et al (2024) Colon cancer: the 2023 Korean clinical practice guidelines for diagnosis and treatment. Ann Coloproctol 40(2):89–113

Article  PubMed  PubMed Central  Google Scholar 

Morgan E, Arnold M, Gini A, Lorenzoni V, Cabasag CJ, Laversanne M et al (2023) Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN. Gut 72(2):338–344

Article  PubMed  Google Scholar 

Ahmad I, Hoque M, Alam SSM, Zughaibi T, Tabrez S (2023) Curcumin and Plumbagin synergistically target the PI3K/Akt/mTOR pathway: a prospective role in cancer treatment. Int J Mol Sci. https://doi.org/10.3390/ijms24076651

Article  PubMed  PubMed Central  Google Scholar 

Soroush A, Pourhossein S, Hosseingholizadeh D, Hjazi A, Shahhosseini R, Kavoosi H, Kermanshahi N, Behnamrad P, Ghavamikia N, Dadashpour M, Karkon Shayan S (2024) Anti-cancer potential of Zerumbone in cancer and glioma: current trends and future perspectives. Med Oncol 41(5):125

Article  PubMed  Google Scholar 

Atwan QS, Al-Ogaidi I (2024) Enhancing the therapeutic potential of curcumin: a novel nanoformulation for targeted anticancer therapy to colorectal cancer with reduced miR20a and miR21 expression. Biomed Mater. ;19(2)

Azeez HJ, Neri F, Hosseinpour Feizi MA, Babaei E (2022) Transcriptome profiling of HCT-116 colorectal cancer cells with RNA sequencing reveals novel targets for polyphenol nano Curcumin. Molecules. https://doi.org/10.3390/molecules27113470

Article  PubMed  PubMed Central  Google Scholar 

Bernardo A, Plumitallo C, De Nuccio C, Visentin S, Minghetti L (2021) Curcumin promotes oligodendrocyte differentiation and their protection against TNF-α through the activation of the nuclear receptor PPAR-γ. Sci Rep 11(1):4952

Article  PubMed  PubMed Central  Google Scholar 

Brockmueller A, Ruiz de Porras V, Shakibaei M (2024) Curcumin and its anti-colorectal cancer potential: from mechanisms of action to autophagy. Phytother Res 38(7):3525–3551

Article  PubMed  Google Scholar 

Chen M, Tan AH, Li J (2023) Curcumin represses colorectal cancer cell proliferation by triggering ferroptosis via PI3K/Akt/mTOR signaling. Nutr Cancer 75(2):726–733

Article  PubMed  Google Scholar 

Noraldeen SA, Rasulova I, Lalitha R, Hussin F, Alsaab HO, Alawadi AH, Alsaalamy A, Sayyid NH, Alkhafaji AT, Mustafa YF, Shayan SK (2023) Involving stemness factors to improve CAR T-cell-based cancer immunotherapy. Med Oncol 40(11):313

Article  PubMed  Google Scholar 

Chuang HY, Chan HW, Shih KC (2025) Suppression of colorectal cancer growth: interplay between Curcumin and Metformin through DMT1 downregulation and ROS-mediated pathways. Biofactors 51(1):e2137

Article  PubMed  Google Scholar 

Dal Z A, Aru B (2023) The role of curcumin on apoptosis and NLRP3 inflammasome-dependent pyroptosis on colorectal cancer in vitro. Turk J Med Sci 53(4):883–893

Article  PubMed  PubMed Central  Google Scholar 

Das L, Vinayak M (2019) Curcumin modulates glycolytic metabolism and inflammatory cytokines via Nrf 2 in dalton’s lymphoma ascites cells in vivo. Anti-Cancer Agents Med Chem 18(12):1779–1791

Article  Google Scholar 

Ming T, Lei J, Peng Y, Wang M, Liang Y, Tang S et al (2024) Curcumin suppresses colorectal cancer by induction of ferroptosis via regulation of p53 and solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 signaling axis. Phytother Res. https://doi.org/10.1002/ptr.8258

Article  PubMed