McGavin JK, Goa KL (2001) Capecitabine. Drugs 61:2309–2326. https://doi.org/10.2165/00003495-200161150-00015

Article  PubMed  CAS  Google Scholar 

Walko CM, Lindley C (2005) Capecitabine: a review. Clin Ther 27:23–44. https://doi.org/https://doi.https://doi.org/10.1016/j.clinthera.2005.01.005

Article  PubMed  CAS  Google Scholar 

Tsukamoto Y, Kato Y, Ura M et al (2001) Investigation of 5-FU disposition after oral administration of capecitabine, a triple-prodrug of 5-FU, using a physiologically based pharmacokinetic model in a human cancer xenograft model: comparison of the simulated 5-FU exposures in the tumour tissue between human and xenograft model. Biopharm Drug Dispos 22:1–14. https://doi.org/10.1002/BDD.250

Article  PubMed  CAS  Google Scholar 

Gieschke R, Burger H-U, Reigner B et al (2003) Population pharmacokinetics and concentration–effect relationships of capecitabine metabolites in colorectal cancer patients. Br J Clin Pharmacol 55:252–263. https://doi.org/10.1046/j.1365-2125.2003.01765.x

Article  PubMed  PubMed Central  CAS  Google Scholar 

Saif MW (2011) Capecitabine and hand–foot syndrome. Expert Opin Drug Saf 10:159–169. https://doi.org/10.1517/14740338.2011.546342

Article  PubMed  CAS  Google Scholar 

Milano G, Etienne-Grimaldi M-C, Mari M et al (2008) Candidate mechanisms for capecitabine-related hand–foot syndrome. Br J Clin Pharmacol 66:88–95. https://doi.org/10.1111/j.1365-2125.2008.03159.x

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lou Y, Wang Q, Zheng J et al (2016) Possible pathways of Capecitabine-induced hand–foot syndrome. Chem Res Toxicol 29:1591–1601. https://doi.org/10.1021/acs.chemrestox.6b00215

Article  PubMed  CAS  Google Scholar 

Bouwstra JA, Gooris GS, Dubbelaar FER, Ponec M (2002) Phase behavior of stratum corneum lipid mixtures based on human ceramides: the role of natural and synthetic ceramide 1. J Invest Dermatol 118:606–617. https://doi.org/10.1046/j.1523-1747.2002.01706.x

Article  PubMed  CAS  Google Scholar 

van Smeden J, Janssens M, Gooris GS, Bouwstra JA (2014) The important role of stratum corneum lipids for the cutaneous barrier function. Biochimica et Biophysica Acta (BBA) 1841:295

Article  PubMed  Google Scholar 

Bouwstra JA, Gooris GS, van der Spek JA, Bras W (1991) Structural investigations of human stratum corneum by small-angle X-ray scattering. J Invest Dermatol 97:1005–1012. https://doi.org/10.1111/1523-1747.ep12492217

Article  PubMed  CAS  Google Scholar 

Bouwstra JA, Gooris GS, Salomonsdevries MA et al (1992) Structure of human Stratum-Corneum as a function of temperature and Hydration - a Wide-Angle X-Ray-Diffraction study. Int J Pharm 84:205–216. https://doi.org/10.1016/0378-5173(92)90158-X

Article  CAS  Google Scholar 

Boncheva M (2014) The physical chemistry of the stratum corneum lipids. Int J Cosmet Sci 36:505–515. https://doi.org/10.1111/ics.12162

Article  PubMed  CAS  Google Scholar 

Weerheim A, Ponec M (2001) Determination of stratum corneum lipid profile by tape stripping in combination with high-performance thin-layer chromatography. Arch Dermatol Res 293:191

Article  PubMed  CAS  Google Scholar 

Suzuki M, Ohno Y, Kihara A (2022) Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases. J Lipid Res. https://doi.org/10.1016/j.jlr.2022.100235

Article  PubMed  PubMed Central  Google Scholar 

Bouwstra JA, Nădăban A, Bras W et al (2023) The skin barrier: an extraordinary interface with an exceptional lipid organization. Prog Lipid Res 92:101252. https://doi.org/10.1016/J.PLIPRES.2023.101252

Article  PubMed  PubMed Central  CAS  Google Scholar 

van Smeden J, Bouwstra JA (2016) Stratum corneum lipids: their role for the skin barrier function in healthy subjects and atopic dermatitis patients. Curr Probl Dermatol 49:8–26. https://doi.org/10.1159/000441540

Article  PubMed  Google Scholar 

Rousel J, Mergen C, Schoones JW et al (2024) Similar alterations of the stratum corneum ceramide profile in atopic dermatitis, psoriasis, and ichthyosis: results from a systematic review and meta-analysis. J Invest Dermatol 144:2311-2314e22. https://doi.org/10.1016/J.JID.2024.02.010

Article  PubMed  CAS  Google Scholar 

van Smeden J, Janssens M, Kaye EC et al (2014) The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients. Exp Dermatol 23:45–52. https://doi.org/10.1111/exd.12293

Article  PubMed  CAS  Google Scholar 

Van Smeden J, Janssens M, Boiten WA et al (2014) Intercellular skin barrier lipid composition and organization in Netherton syndrome patients. J Invest Dermatol 134:1238–1245. https://doi.org/10.1038/jid.2013.517

Article  PubMed  CAS  Google Scholar 

Uchino T, Kamiya D, Yagi H et al (2023) Comparative analysis of intercellular lipid organization and composition between psoriatic and healthy stratum corneum. Chem Phys Lipids 254:105305. https://doi.org/10.1016/j.chemphyslip.2023.105305

Article  PubMed  CAS  Google Scholar 

Uchino T, Fujino H, Kamiya D et al (2020) Association of dry skin with intercellular lipid composition of stratum corneum after erlotinib administration. Cancer Chemother Pharmacol 86:233–243. https://doi.org/10.1007/s00280-020-04095-z

Article  PubMed  CAS  Google Scholar 

Cassidy J, Clarke S, Díaz-Rubio E et al (2008) Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer. J Clin Oncol 26:2006–2012. https://doi.org/10.1200/JCO.2007.14.9898

Article  PubMed  CAS  Google Scholar 

T’Kindt R, Jorge L, Dumont E et al (2012) Profiling and characterizing skin ceramides using reversed-phase liquid chromatography-quadrupole time-of-flight mass spectrometry. Anal Chem 84:403–411. https://doi.org/10.1021/ac202646v

Article  PubMed  CAS  Google Scholar 

Pullmannová P, Pavlíková L, Kováčik A et al (2017) Permeability and microstructure of model stratum corneum lipid membranes containing ceramides with long (C16) and very long (C24) acyl chains. Biophys Chem 224:20–31. https://doi.org/10.1016/j.bpc.2017.03.004

Article  PubMed  CAS  Google Scholar 

Školová B, Kováčik A, Tesař O et al (2017) Phytosphingosine, sphingosine and dihydrosphingosine ceramides in model skin lipid membranes: permeability and biophysics. Biochimica et Biophysica Acta (BBA) 1859:824–834. https://doi.org/10.1016/j.bbamem.2017.01.019

Article  CAS  Google Scholar 

Mizutani Y, Mitsutake S, Tsuji K et al (2009) Ceramide biosynthesis in keratinocyte and its role in skin function. Biochimie 91:784–790. https://doi.org/10.1016/j.biochi.2009.04.001

Article  PubMed  CAS  Google Scholar 

Uchida Y, Hara M, Nishio H et al (2000) Epidermal sphingomyelins are precursors for selected stratum corneum ceramides. J Lipid Res 41:2071–2082. https://doi.org/10.1016/S0022-2275(20)32369-5

Article  PubMed  CAS  Google Scholar 

Hamanaka S, Suzuki A, Hara M et al (2002) Human epidermal glucosylceramides are major precursors of stratum corneum ceramides. J Invest Dermatol 119:416–423. https://doi.org/10.1046/j.1523-1747.2002.01836.x

Article  PubMed  CAS