Dohner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H et al (2022) Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood 140(12):1345–77
Levis MJ, Hamadani M, Logan B, Jones RJ, Singh AK, Litzow M et al (2024) Gilteritinib as post-transplant maintenance for AML with internal tandem duplication mutation of FLT3. J Clin Oncol 42(15):1766–75
Article PubMed CAS Google Scholar
Maziarz RT, Levis M, Patnaik MM, Scott BL, Mohan SR, Deol A et al (2021) Midostaurin after allogeneic stem cell transplant in patients with FLT3-internal tandem duplication-positive acute myeloid leukemia. Bone Marrow Transplant 56(5):1180–9
Article PubMed CAS Google Scholar
Xuan L, Wang Y, Huang F, Fan Z, Xu Y, Sun J et al (2020) Sorafenib maintenance in patients with FLT3-ITD acute myeloid leukaemia undergoing allogeneic haematopoietic stem-cell transplantation: an open-label, multicentre, randomised phase 3 trial. Lancet Oncol 21(9):1201–12
Article PubMed CAS Google Scholar
Usuki K, Sakura T, Kobayashi Y, Miyamoto T, Iida H, Morita S et al (2018) Clinical profile of gilteritinib in Japanese patients with relapsed/refractory acute myeloid leukemia: an open-label phase 1 study. Cancer Sci 109(10):3235–44
Article PubMed PubMed Central CAS Google Scholar
James AJ, Smith CC, Litzow M, Perl AE, Altman JK, Shepard D et al (2020) Pharmacokinetic profile of gilteritinib: a novel FLT-3 tyrosine kinase inhibitor. Clin Pharmacokinet 59(10):1273–1290
Article PubMed PubMed Central CAS Google Scholar
Wang J, Jiang B, Li J, Liu L, Du X, Jiang H et al (2024) Phase 3 study of gilteritinib versus salvage chemotherapy in predominantly Asian patients with relapsed/refractory FLT3-mutated acute myeloid leukemia. Leukemia 38(11):2410–2418
Article PubMed PubMed Central CAS Google Scholar
McCall D, Roth M, Mahadeo KM, Toepfer L, Nunez C, Short NJ et al (2021) Gilteritinib combination therapies in pediatric patients with FLT3-mutated acute myeloid leukemia. Blood Adv 5(23):5215–9
Article PubMed PubMed Central CAS Google Scholar
Sexauer AN, Tasian SK (2017) Targeting FLT3 signaling in childhood acute myeloid leukemia. Front Pediatr 5:248
Article PubMed PubMed Central Google Scholar
Terao T, Matsuoka KI, Ueda H, Matsumura A, Matsubara C, Kondo K et al (2023) Early initiation of low-dose gilteritinib maintenance improves posttransplant outcomes in patients with R/R FLT3mut AML. Blood Adv 7(5):681–6
Article PubMed CAS Google Scholar
FDA (2017) Gilteritinib for Treatment of Pediatric Patients with FLT3/ITD AML. https://www.fda.gov/media/106162/download
Tomizawa D, Tawa A, Watanabe T, Saito AM, Kudo K, Taga T et al (2013) Appropriate dose reduction in induction therapy is essential for the treatment of infants with acute myeloid leukemia: a report from the Japanese pediatric Leukemia/Lymphoma study group. Int J Hematol 98(5):578–588
Article PubMed PubMed Central CAS Google Scholar
Negotei C, Colita A, Mitu I, Lupu AR, Lapadat ME, Popovici CE et al (2023) A review of FLT3 kinase inhibitors in AML. J Clin Med 12(20):6429
Perl AE, Altman JK, Cortes J, Smith C, Litzow M, Baer MR et al (2017) Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1–2 study. Lancet Oncol 18(8):1061–75
Article PubMed PubMed Central CAS Google Scholar
Abematsu T, Nishikawa T, Shiba N, Iijima-Yamashita Y, Inaba Y, Takahashi Y et al (2021) Pediatric acute myeloid leukemia co-expressing FLT3/ITD and NUP98/NSD1 treated with gilteritinib plus allogenic peripheral blood stem cell transplantation: a case report. Pediatr Blood Cancer 68(11):e29216
Leger KJ, Robison N, Narayan HK, Smith AM, Tsega T, Chung J et al (2023) Rationale and design of the Children’s Oncology Group study AAML1831 integrated cardiac substudies in pediatric acute myeloid leukemia therapy. Front Cardiovasc Med 10:1286241
Article PubMed PubMed Central Google Scholar
Perl AE, Larson RA, Podoltsev NA, Strickland S, Wang ES, Atallah E et al (2023) Outcomes in patients with FLT3-Mutated Relapsed/ refractory acute myelogenous leukemia who underwent transplantation in the phase 3 ADMIRAL trial of gilteritinib versus salvage chemotherapy. Transpl Cell Ther 29(4):265 e1- e10
Tamefusa K, Ishida H, Kanamitsu K, Ochi M, Fujiwara K, Tatebe Y et al (2023) Posttransplant gilteritinib maintenance therapy for pediatric acute myeloid leukemia with myelodysplasia-related changes with FLT3-internal tandem duplication. Pediatr Blood Cancer 70(4):e30108
Tasaka K, Kato I, Takeshita S, Yoshioka Y, Usami A, Uchihara Y et al (2023) Second relapse of FLT3-ITD-positive acute myeloid leukemia after discontinuation of 3-year post-transplant maintenance therapy with gilteritinib. Pediatr Blood Cancer 70(5):e30185
Article PubMed CAS Google Scholar
Ata F, Benkhadra M, Ghasoub R, Fernyhough LJ, Omar NE, Nashwan AJ et al (2023) Tyrosine kinase inhibitors in pediatric chronic myeloid leukemia: a focused review of clinical trials. Front Oncol 13:1285346
Article PubMed PubMed Central CAS Google Scholar
Jamaladdin N, Sigaud R, Kocher D, Kolodziejczak AS, Nonnenbroich LF, Ecker J et al (2023) Key pharmacokinetic parameters of 74 pediatric anticancer drugs providing assistance in preclinical studies. Clin Pharmacol Ther 114(4):904–13
Comments (0)