Moore VC (2012) Spirometry: step by step. Breathe 8:233–240

Article  Google Scholar 

Graham BL, Steenbruggen I, Miller MR, Barjaktarevic IZ, Cooper BG, Hall GL et al (2019) Standardization of spirometry 2019 Update. An official American thoracic society and European respiratory society technical statement. Am J Respir Crit Care Med 200:e70–e88

Article  PubMed  PubMed Central  Google Scholar 

Bourke SJ, Burns GP, Chalmers JD, De Soyza A (2022) Respiratory medicine: lecture notes, 10th edn. Wiley-Blackwell, Hoboken, NJ

Google Scholar 

Hess DR (2014) Respiratory mechanics in mechanically ventilated patients. Respir Care 59:96–108

Article  Google Scholar 

Shevade MS (2019) Time constant: what do we need to know to use it? Indian J Respir Care 8:4–7

Article  Google Scholar 

Depta F, Kallet RH, Gentile MA et al (2025) Expiratory time constants in mechanically ventilated patients: rethinking the old concept—a narrative review. ICMx 13:40

Article  PubMed  PubMed Central  Google Scholar 

McIlroy MB, Tierney DF, Nadel JA (1963) A new method for measurement of compliance and resistance of lungs and thorax. J Appl Physiol 18(2):424–427

Article  Google Scholar 

Pierce JA (1959) Studies of free collapse in the intact human lung. J Lab Clin Med 54:96–106

CAS  PubMed  Google Scholar 

Bodduluri S, Nakhmani A, Bhatt SP (2024) Spirometric time constant for detection of early and mild airflow obstruction. Am J Respir Crit Care Med 209:A4680

Google Scholar 

Ikeda T, Yamauchi Y, Uchida K et al (2019) Reference value for expiratory time constant calculated from the maximal expiratory flow–volume curve. BMC Pulm Med 19:208

Article  PubMed  PubMed Central  Google Scholar 

Aerts JG, van den Berg B, Lourens MS, Bogaard JM (1999) Expiratory flow–volume curves in mechanically ventilated patients with chronic obstructive pulmonary disease. Acta Anaesthesiol Scand 43:322–327

Article  CAS  PubMed  Google Scholar 

Brunner JX, Laubscher TP, Banner MJ, Iotti G, Braschi A (1995) Simple method to measure total expiratory time constant based on the passive expiratory flow–volume curve. Crit Care Med 23:1117–1122

Article  CAS  PubMed  Google Scholar 

Guttmann J, Eberhard L, Fabry B, Bertschmann W, Zeravik J, Adolph M et al (1995) Time constant/volume relationship of passive expiration in mechanically ventilated ARDS patients. Eur Respir J 8:114–120

Article  CAS  PubMed  Google Scholar 

Lourens MS, van den Berg B, Aerts JG, Verbraak AF, Hoogsteden HC, Bogaard JM (2000) Expiratory time constants in mechanically ventilated patients with and without COPD. Intensive Care Med 26:1612–1618

Article  CAS  PubMed  Google Scholar 

Kondili E, Prinianakis G, Athanasakis H, Georgopoulos D (2002) Lung emptying in patients with acute respiratory distress syndrome: effects of positive end-expiratory pressure. Eur Respir J 19:811–819

Article  CAS  PubMed  Google Scholar 

Depta F, Chiofolo CM, Chbat NW et al (2024) Six methods to determine expiratory time constants in mechanically ventilated patients: a prospective observational physiology study. Intensive Care Med Exp 12:25

Article  PubMed  PubMed Central  Google Scholar 

Stanojevic S, Kaminsky DA, Miller MR et al (2022) ERS/ATS technical standard on interpretive strategies for routine lung function tests. Eur Respir J 60:2101499

Article  PubMed  Google Scholar 

Depta F, Bodnárová S, Šurinová K, Paraničová I, Sokolová E, Lombartová E et al (2025) Expiratory time constants in patients undergoing routine spirometry. CHEST Pulm https://doi.org/10.1016/j.chpulm.2025.100181

Book  Google Scholar 

Neuberger N, Levison H, Bryan AC, Kruger K (1976) Transit time analysis of the forced expiratory spirogram in growth. J Appl Physiol 40:329–335

Article  Google Scholar 

Webster PM, Zamel N, Bryan AC, Kruger K (1977) Volume dependence of instantaneous time constants derived from the maximal expiratory flow–volume curve. A new approach to the analysis of forced expiration. Am Rev Respir Dis 115:805–810

CAS  PubMed  Google Scholar 

McDonough JE, Yuan R, Suzuki M, Seyednejad N, Elliott WM, Sanchez PG et al (2011) Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. N Engl J Med 365:1567–1575

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hogg JC, Macklem PT, Thurlbeck WM (1968) Site and nature of airway obstruction in chronic obstructive lung disease. N Engl J Med 278:1355–1360

Article  CAS  PubMed  Google Scholar 

Mead J, Turner JM, Macklem PT, Little JB (1967) Significance of the relationship between lung recoil and maximum expiratory flow. J Appl Physiol 22:95–108

Article  CAS  PubMed  Google Scholar 

Kondili E, Alexopoulou C, Prinianakis G, Xirouchaki N, Georgopoulos D (2004) Pattern of lung emptying and expiratory resistance in mechanically ventilated patients with chronic obstructive pulmonary disease. Intensive Care Med 30:1311–1318

Article  PubMed  Google Scholar 

Al-Rawas N, Banner MJ, Euliano NR, Tams CG, Brown J, Martin AD et al (2013) Expiratory time constant for determinations of plateau pressure, respiratory system compliance, and total resistance. Crit Care 17:R23

Article  PubMed  PubMed Central  Google Scholar 

Pride NB, Permutt S, Riley RL, Bromberger-Barnea B (1967) Determinants of maximal expiratory flow from the lungs. J Appl Physiol 23:646–662

Article  CAS  PubMed  Google Scholar 

Gold WM, Koth LL (2016) Pulmonary function testing. In: Broaddus VC, Mason RJ, Ernst JD, King TE Jr, Lazarus SC, Murray JF (eds) Murray and Nadel’s textbook of respiratory medicine. Elsevier, New York, pp 407–435.e18

Chapter  Google Scholar 

Higbee DH, Granell R, Davey Smith G, Dodd JW (2022) Prevalence, risk factors, and clinical implications of preserved ratio impaired spirometry: a UK biobank cohort analysis. Lancet Respir Med 10:149–157

Article  CAS  PubMed  Google Scholar 

Kanetake R, Takamatsu K, Park K, Yokoyama A (2022) Prevalence and risk factors for COPD in subjects with preserved ratio impaired spirometry. BMJ Open Respir Res 9:e001298

Article  PubMed  PubMed Central  Google Scholar