Systemic Metabolites and Cytokines as Predictive Biomarkers of Metabolic Syndrome in Young Healthy Cohort: A Prospective Study

Guerra JVS, Dias MMG, Brilhante AJVC, Terra MF, García-Arévalo M, Figueira ACM. Multifactorial basis and therapeutic strategies in metabolism-related diseases. Nutrients. 2021;13(8):2830–79. https://doi.org/10.3390/nu13082830.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lipsy RJ. The National Cholesterol Education Program Adult Treatment Panel III guidelines. J Manag Care Pharm. 2003;9(1Suppl):2–5. https://doi.org/10.18553/jmcp.2003.9.s1.2.

Article  PubMed  PubMed Central  Google Scholar 

Khatiwada S, Sah SK, Kc R, Baral N, Lamsal M. Thyroid dysfunction in metabolic syndrome patients and its relationship with components of metabolic syndrome. Clin Diabetes Endocrinol. 2016;2:3–7. https://doi.org/10.1186/s40842-016-0021-0.

Article  PubMed  PubMed Central  Google Scholar 

Chasens ER, Imes CC, Kariuki JK, Luyster FS, Morris JL, DiNardo MM, et al. Sleep and metabolic syndrome. Nurs Clin North Am. 2021;56(2):203–17. https://doi.org/10.1016/j.cnur.2020.10.012.

Article  PubMed  PubMed Central  Google Scholar 

Calcaterra V, Verduci E, Cena H, Magenes VC, Todisco CF, Tenuta E, et al. Polycystic ovary syndrome in insulin-resistant adolescents with obesity: the role of nutrition therapy and food supplements as a strategy to protect fertility. Nutrients. 2021;13(6):1848–79. https://doi.org/10.3390/nu13061848.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tune JD, Goodwill AG, Sassoon DJ, Mather KJ. Cardiovascular consequences of metabolic syndrome. Transl Res. 2017;183:57–70. https://doi.org/10.1016/j.trsl.2017.01.001.

Article  PubMed  PubMed Central  CAS  Google Scholar 

World Health Organization. Available online:https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases (accessed on 15 August 2023)

Krishnamoorthy Y, Rajaa S, Murali S, Rehman T, Sahoo J, Kar SS. Prevalence of metabolic syndrome among adult population in India: a systematic review and meta-analysis. PLoS ONE. 2020;15(10):e0240971–96. https://doi.org/10.1371/journal.pone.0240971.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sundarakumar JS, Stezin A, Menesgere AL, Ravindranath V; SANSCOG, TLSA Collaborators. ‘Rural-urban and gender differences in metabolic syndrome in the aging population from southern India: Two parallel, prospective cohort studies’. EClinicalMedicine.2022;47:101395-101404. Available from: https://doi.org/10.1016/j.eclinm.2022.101395

Harikrishnan S, Sarma S, Sanjay G, Jeemon P, Krishnan MN, Venugopal K, et al. Prevalence of metabolic syndrome and its risk factors in Kerala, South India: analysis of a community based cross-sectional study. PLoS ONE. 2018;13(3):e0192372–87. https://doi.org/10.1371/journal.pone.0192372.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Šoštarič A, Jenko B, Kozjek NR, Ovijač D, Šuput D, Milisav I, et al. Detection of metabolic syndrome burden in healthy young adults may enable timely introduction of disease prevention. Arch Med Sci. 2019;15(5):1184–94. https://doi.org/10.5114/aoms.2019.87462.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Reddy P, Lent-Schochet D, Ramakrishnan N, McLaughlin M, Jialal I. Metabolic syndrome is an inflammatory disorder: a conspiracy between adipose tissue and phagocytes. Clin Chim Acta. 2019;496:35–44. https://doi.org/10.1016/j.cca.2019.06.019.

Article  PubMed  CAS  Google Scholar 

Kany S, Vollrath JT, Relja B. Cytokines in inflammatory disease. Int J Mol Sci. 2019;20(23):6008–38. https://doi.org/10.3390/ijms20236008.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Engvall E, Jonsson K, Perlmann P. Enzyme-linked immunosorbent assay, ELISA. II. Quantitative assay of protein antigen, immunoglobulin G, by means of enzyme-labeled antigen and antibody-coated tubes. Biochim Biophys Acta. 1971;251:427–34. https://doi.org/10.1016/0005-2795(71)90132-2.

Article  PubMed  CAS  Google Scholar 

Wang X, Ji X. Sample size estimation in clinical research: from randomized controlled trials to observational studies. Chest. 2020;158(1):S12–20. https://doi.org/10.1016/j.chest.2020.03.010.

Article  PubMed  Google Scholar 

Robinson O, Carter AR, Ala-Korpela M, Casas JP, Chaturvedi N, Engmann J, et al. Metabolic profiles of socio-economic position: a multi-cohort analysis. Int J Epidemiol. 2021;50(3):768–82. https://doi.org/10.1093/ije/dyaa188.

Article  PubMed  PubMed Central  Google Scholar 

Sauvaget C, Ramadas K, Fayette JM, Thomas G, Thara S, Sankaranarayanan R. Socio-economic factors & longevity in a cohort of Kerala State, India. Indian J Med Res. 2011;133(5):479–86.

PubMed  PubMed Central  Google Scholar 

Che T, Yan C, Tian D, Zhang X, Liu X, Wu Z. The association between sleep and metabolic syndrome: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2021;12:773646–56. https://doi.org/10.3389/fendo.2021.773646.

Article  PubMed  PubMed Central  Google Scholar 

Cao L, Zhou J, Chen Y, Wu Y, Wang Y, Liu T, et al. Effects of body mass index, waist circumference, waist-to-height ratio and their changes on risks of dyslipidemia among Chinese adults: the Guizhou Population Health Cohort Study. Int J Environ Res Public Health. 2021;19(1):341–54. https://doi.org/10.3390/ijerph19010341.

Article  PubMed  PubMed Central  Google Scholar 

Atasoy S, Middeke M, Johar H, Peters A, Heier M, Ladwig KH. Cardiovascular mortality risk in young adults with isolated systolic hypertension: findings from population-based MONICA/KORA cohort study. J Hum Hypertens. 2022;36:1059–65. https://doi.org/10.1038/s41371-023-00804-2.

Article  PubMed  Google Scholar 

Chiu H, Lee MY, Wu PY, Huang JC, Chen SC, Chang JM. Comparison of the effects of sibling and parental history of type 2 diabetes on metabolic syndrome. Sci Rep. 2020;10(1):22131–8. https://doi.org/10.1038/s41598-020-79382-z.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mohanraj S, Velmurugan G, Swaminathan K, Ramakrishnan A. Prevalence and risk factors for dyslipidemia among South Indian adults: a community based-NCD study. Int J Diabetes Dev Ctries. 2023. https://doi.org/10.1007/s13410-023-01202-7.

Article  Google Scholar 

Tang N, Ma J, Tao R, Chen Z, Yang Y, He Q, et al. The effects of the interaction between BMI and dyslipidemia on hypertension in adults. Sci Rep. 2022;12(1):927–33. https://doi.org/10.1038/s41598-022-04968-8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Powell-Wiley TM, Poirier P, Burke LE, Després JP, Gordon-Larsen P, Lavie CJ, et al. Obesity and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2021;143(21):e984–1010. https://doi.org/10.1161/CIR.0000000000000973.

Article  PubMed  PubMed Central  Google Scholar 

Wang X, Cheng S, Lv J, Yu C, Guo Y, Pei P, et al. Liver biomarkers, genetic and lifestyle risk factors in relation to risk of cardiovascular disease in Chinese. Front Cardiovasc Med. 2022;9:938902–12. https://doi.org/10.3389/fcvm.2022.938902.

Article  PubMed  PubMed Central  Google Scholar 

Kamath DY, Xavier D, Sigamani A, Pais P. High sensitivity C-reactive protein (hsCRP) & cardiovascular disease: an Indian perspective. Indian J Med Res. 2015;142(3):261–8. https://doi.org/10.4103/0971-5916.166582.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tian X, Chen S, Zuo Y, Zhang Y, Zhang X, Xu Q, et al. Association of lipid, inflammatory, and metabolic biomarkers with age at onset for incident cardiovascular disease. BMCMed. 2022;20(1):383–94. https://doi.org/10.1186/s12916-022-02592-x.

Article  CAS  Google Scholar 

Kim SH, Cho YK, Kim YJ, Jung CH, Lee WJ, Park JY, et al. Association of the atherogenic index of plasma with cardiovascular risk beyond the traditional risk factors: a nationwide population-based cohort study. Cardiovasc Diabetol. 2022;21(1):81–91. https://doi.org/10.1186/s12933-022-01522-8.

Article  PubMed  PubMed Central  CAS 

Comments (0)

No login
gif