The Dual Role of Hypoxia Inducible Factor-1α (HIF-1α) in Ovarian Physiology and Pathophysiology: Insights from Polycystic Ovarian Syndrome

Zhao Y, Xing C, Deng Y, Ye C, Peng H. HIF-1α signaling: essential roles in tumorigenesis and implications in targeted therapies. Genes Dis. 2024;11(1):234–51.

Article  CAS  PubMed  Google Scholar 

Henríquez S, Kohen P, Muñoz A, Godoy A, Orge F, Strauss JF, et al. In-vitro study of gonadotrophin signaling pathways in human granulosa cells in relation to progesterone receptor expression. Reprod Biomed Online. 2017;35(4):363–71.

Article  PubMed  Google Scholar 

Zhang ZH, Chen LY, Wang F, Wu YQ, Su JQ, Huang XH, et al. Expression of hypoxia-inducible factor-1α during ovarian follicular growth and development in Sprague-Dawley rats. Genet Mol Res. 2015;14(2):5896–909.

Article  CAS  PubMed  Google Scholar 

Duncan WC, van den Driesche S, Fraser HM. Inhibition of vascular endothelial growth factor in the primate ovary up-regulates hypoxia-inducible factor-1α in the follicle and corpus luteum. Endocrinology. 2008;149(7):3313–20.

Article  CAS  PubMed  Google Scholar 

Boonyaprakob U, Gadsby JE, Hedgpeth V, Routh PA, Almond GW. Expression and localization of hypoxia inducible factor-1alpha mRNA in the porcine ovary. Can J Vet Res. 2005;69(3):215–22.

CAS  PubMed  PubMed Central  Google Scholar 

Fadhillah YS, Nishimura R, Yamamoto Y, Kimura K, Okuda K. Hypoxia-inducible factor 1 mediates hypoxia-enhanced synthesis of progesterone during luteinization of granulosa cells. J Reprod Dev. 2017;63(1):75–85.

Article  CAS  PubMed  Google Scholar 

Rolaki A, Drakakis P, Millingos S, Loutradis D, Makrigiannakis A. Novel trends in follicular development, atresia and corpus luteum regression: a role for apoptosis. Reprod Biomed Online. 2005;11(1):93–103.

Article  PubMed  Google Scholar 

Chaudhary H, Patel J, Jain NK, Joshi R. The role of polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis. J Ovarian Res. 2021;14(1):125.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu J, Zhou Y, Ding J, Zhang D, Yu C, Huang H. Characteristics and possible mechanisms of metabolic disorder in overweight women with polycystic ovary syndrome. Front Endocrinol (Lausanne). 2023;12:13.

Google Scholar 

Abdel-Ghani M, Shimizu T, Suzuki H. Expression Pattern of vascular endothelial growth factor in canine folliculogenesis and its effect on the growth and development of follicles after ovarian organ culture. Reprod Domest Anim. 2014;49(5):734–9.

Article  CAS  PubMed  Google Scholar 

Zimmermann RC, Xiao E, Husami N, Sauer MV, Lobo R, Kitajewski J, et al. Short-term administration of antivascular endothelial growth factor antibody in the late follicular phase delays follicular development in the rhesus monkey 1. J Clin Endocrinol Metab. 2001;86(2):768–72.

CAS  PubMed  Google Scholar 

Zimmermann RC, Xiao E, Bohlen P, Ferin M. Administration of antivascular endothelial growth factor receptor 2 antibody in the early follicular phase delays follicular selection and development in the rhesus monkey. Endocrinology. 2002;143(7):2496–502.

Article  CAS  PubMed  Google Scholar 

Wulff C, Wilson H, Wiegand SJ, Rudge JS, Fraser HM. Prevention of thecal angiogenesis, antral follicular growth, and ovulation in the primate by treatment with vascular endothelial Growth factor trap R1R2. Endocrinology. 2002;143(7):2797–807.

Article  CAS  PubMed  Google Scholar 

Celik-Ozenci C, Akkoyunlu G, Kayisli UA, Arici A, Demir R. Localization of vascular endothelial growth factor in the zona pellucida of developing ovarian follicles in the rat: a possible role in destiny of follicles. Histochem Cell Biol. 2003;120(5):383–90.

Article  CAS  PubMed  Google Scholar 

Stouffer RL, Martı́nez-Chequer JC, Molskness TA, Xu F, Hazzard TM. Regulation and action of angiogenic factors in the primate ovary. Arch Med Res. 2001;32(6):567–75.

Article  CAS  PubMed  Google Scholar 

Hibbert ML, Stouffer RL, Wolf DP, Zelinski-Wooten MB. Midcycle administration of a progesterone synthesis inhibitor prevents ovulation in primates. Proc Natl Acad Sci. 1996;93(5):1897–901.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Acosta TJ, Miyamoto A. Vascular control of ovarian function: ovulation, corpus luteum formation and regression. Anim Reprod Sci. 2004;82–83:127–40.

Article  PubMed  Google Scholar 

Hazzard TM. Vascular endothelial growth factor (VEGF) and angiopoietin regulation by gonadotrophin and steroids in macaque granulosa cells during the peri-ovulatory interval. Mol Hum Reprod. 1999;5(12):1115–21.

Article  CAS  PubMed  Google Scholar 

Bender HR, Trau HA, Duffy DM. Placental growth factor is required for ovulation, luteinization, and angiogenesis in primate ovulatory follicles. Endocrinology. 2018;159(2):710–22.

Article  CAS  PubMed  Google Scholar 

Koos RD. Increased expression of vascular endothelial growth/permeability factor in the rat ovary following an ovulatory gonadotropin stimulus: potential roles in follicle rupture. Biol Reprod. 1995;52(6):1426–35.

Article  CAS  PubMed  Google Scholar 

Miyabayashi K, Shimizu T, Kawauchi C, Sasada H, Sato E. Changes of mRNA expression of vascular endothelial growth factor, angiopoietins and their receptors during the periovulatory period in eCG/hCG-treated immature female rats. J Exp Zool A Comp Exp Biol. 2005;303A(7):590–7.

Article  CAS  Google Scholar 

Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci. 1995;92(12):5510–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wlodarczyk J, Leng A, Abadchi SN, Shababi N, Mokhtari-Esbuie F, Gheshlaghi S, et al. Transfection of hypoxia-inducible factor-1α mRNA upregulates the expression of genes encoding angiogenic growth factors. Sci Rep. 2024;14(1):6738.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park JE, Keller GA, Ferrara N. The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell. 1993;4(12):1317–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Semenza GL. Regulation of hypoxia-induced angiogenesis: a chaperone escorts VEGF to the dance. J Clin Investig. 2001;108(1):39–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Quintero-Fabián S, Arreola R, Becerril-Villanueva E, Torres-Romero JC, Arana-Argáez V, Lara-Riegos J, et al. Role of matrix metalloproteinases in angiogenesis and cancer. Front Oncol. 2019;6:9.

Google Scholar 

Fischer B, Künzel W, Kleinstein J, Gips H. Oxygen tension in follicular fluid falls with follicle maturation. Eur J Obstet Gynecol Reprod Biol. 1992;43(1):39–43.

Article  CAS  PubMed  Google Scholar 

Simon M, Tournaire R, Pouyssegur J. The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1. J Cell Physiol. 2008;217(3):809–18.

Article  CAS  PubMed  Google Scholar 

van den Driesche S, Myers M, Gay E, Thong KJ, Duncan WC. HCG up-regulates hypoxia inducible factor-1 alpha in luteinized granulosa cells: implications for the hormonal regulation of vascular endothelial growth factor A in the human corpus luteum. Mol Hum Reprod. 2008;14(8):455–64.

Article  PubMed  Google Scholar 

Tam KKY, Russell DL, Peet DJ, Bracken CP, Rodgers RJ, Thompson JG, et al. Hormonally regulated follicle differentiation and luteinization in the mouse is associated with hypoxia inducible factor activity. Mol Cell Endocrinol. 2010;327(1–2):47–55.

Article  CAS  PubMed  Google Scholar 

Kind KL, Banwell KM, Gebhardt KM, Macpherson A, Gauld A, Russell DL, et al. Microarray analysis of mRNA from cumulus cells following in vivo or in vitro maturation of mouse cumulus–oocyte complexes. Reprod Fertil Dev. 2013;25(2):426–38.

Article  CAS 

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