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The Dual Role of Hypoxia Inducible Factor-1α (HIF-1α) in Ovarian Physiology and Pathophysiology: Insights from Polycystic Ovarian Syndrome
The Dual Role of Hypoxia Inducible Factor-1α (HIF-1α) in Ovarian Physiology and Pathophysiology: Insights from Polycystic Ovarian Syndrome
Hypoxia-Inducible Factor-1α (HIF-1α) is a fundamental transcriptional regulator of cellular adaptation to low ox...
Plasma MicroRNA Expression Differentiates Individuals with Isolated Impaired Fasting Glycaemia from Normal Glucose Tolerance and Type 2 Diabetes Mellitus
Plasma MicroRNA Expression Differentiates Individuals with Isolated Impaired Fasting Glycaemia from Normal Glucose Tolerance and Type 2 Diabetes Mellitus
There are multiple studies exploring the role of circulatory micro RNAs (miRNAs) in prediabetes. However there were no stu...
Modulatory Effects of Interleukin 1-alpha (IL-1α) in Lung Cancer Cell Line A549
Modulatory Effects of Interleukin 1-alpha (IL-1α) in Lung Cancer Cell Line A549
Lung cancer is the leading cause of cancer-related deaths worldwide, with a high mortality rate due to late-stage diagnosi...
External Quality Assurance Scheme in Clinical Biochemistry: Experience of CMC EQAS on the Continuous Improvement in Indian Medical Laboratories
External Quality Assurance Scheme in Clinical Biochemistry: Experience of CMC EQAS on the Continuous Improvement in Indian Medical Laboratories
External quality assurance schemes (EQAS) are invaluable tools used by medical laboratories to assess the performance of t...
Oxidative Stress–Mediated Endothelial Dysfunction and Cell-Free Fetal DNA Release in Preeclampsia
Oxidative Stress–Mediated Endothelial Dysfunction and Cell-Free Fetal DNA Release in Preeclampsia
In normal pregnancy, systemic inflammation, oxidative stress, and angiogenic balance are tightly regulated. However, in pr...
Debate on Measurement Uncertainty Verses Total Error: A Take by Tertiary Care Hospital Laboratory
Debate on Measurement Uncertainty Verses Total Error: A Take by Tertiary Care Hospital Laboratory
Nearly 70% medical decisions are related to diagnosis, and their treatment revolves around laboratory results, emphasizing...
Interleukin 18 Gene Promoter Polymorphisms in Children with Celiac Disease and in Their First-Degree Relatives: Is There an Association?
Interleukin 18 Gene Promoter Polymorphisms in Children with Celiac Disease and in Their First-Degree Relatives: Is There an Association?
Interleukin 18 (IL18) induce severe inflammation, promotes Th1 cells and express in the small intestinal mucosa in patient...
Quantitative Proteomic Analysis of Serum-Derived Exosomes from Patients with and Without Human Immunodeficiency Virus–Tuberculosis Coinfection
Quantitative Proteomic Analysis of Serum-Derived Exosomes from Patients with and Without Human Immunodeficiency Virus–Tuberculosis Coinfection
Human immunodeficiency virus (HIV) associated tuberculosis (TB) poses significant diagnostic challenges due to atypical cl...
Systemic Metabolites and Cytokines as Predictive Biomarkers of Metabolic Syndrome in Young Healthy Cohort: A Prospective Study
Systemic Metabolites and Cytokines as Predictive Biomarkers of Metabolic Syndrome in Young Healthy Cohort: A Prospective Study
Nearly one billion people are suffering from disabilities of metabolic syndrome. It is essential to identify the occurrenc...
Targeting GnRHR and ESR-1 Receptors with Natural Bioactive Compounds: A Network Pharmacology and Molecular Docking Approach to Endometriosis Therapy
Targeting GnRHR and ESR-1 Receptors with Natural Bioactive Compounds: A Network Pharmacology and Molecular Docking Approach to Endometriosis Therapy
Endometriosis is a chronic inflammatory disorder linked to ectopic endometrial tissue and increased estradiol, resulting i...
New Crossover Scratch Assay (COS Assay) Method for Quantifying Cell Migration at Marked Locations Identified Role of miR-186 and Temozolomide (TMZ) in Glioblastoma Cells
New Crossover Scratch Assay (COS Assay) Method for Quantifying Cell Migration at Marked Locations Identified Role of miR-186 and Temozolomide (TMZ) in Glioblastoma Cells
The scratch assay, also known as the wound healing assay, is a widely used in vitro method to study two-dimensional cell m...
The Effects of Cigarette Smoking and Chronic Alcohol Consumption on Seminal Quality in Young Adults: A Cross-Sectional Study
The Effects of Cigarette Smoking and Chronic Alcohol Consumption on Seminal Quality in Young Adults: A Cross-Sectional Study
Lifestyle factors such as cigarette smoking and chronic alcohol consumption are increasingly recognized as major contribut...
Molecular Perspective of GPNMB in the Progression of End-Stage Liver Disease
Molecular Perspective of GPNMB in the Progression of End-Stage Liver Disease
Glycoprotein Non-Metastatic Melanoma Protein B (GPNMB) is an emerging transmembrane glycoprotein involved in inflammation,...
Glutathione at the Crossroads of Redox Homeostasis and Glucose Metabolism in Diabetes Mellitus
Glutathione at the Crossroads of Redox Homeostasis and Glucose Metabolism in Diabetes Mellitus
Type 2 diabetes (T2D) has been a serious health concern as its effects about 6.2% of world population. Glutathione (GSH) i...
Tracking the Trail: Linking Reported Biomarkers of MetS to its Severity Using NHANES Data
Tracking the Trail: Linking Reported Biomarkers of MetS to its Severity Using NHANES Data
A cluster of metabolic abnormalities, including obesity, hyperglycemia, hypertension, and dyslipidemia known as metabolic ...
Inflammatory Markers as Predictors of Atherosclerotic Plaque Burden and Future Major Adverse Cardiovascular Events: Insights from a Tertiary Care Centre of Southeast Asia
Inflammatory Markers as Predictors of Atherosclerotic Plaque Burden and Future Major Adverse Cardiovascular Events: Insights from a Tertiary Care Centre of Southeast Asia
Globally, coronary artery disease (CAD) remains the principal cause of death and disability, with India accounting for one...
Carcinogenic Link to Diabetes, Obesity and Atherosclerosis—A Focus on Differently Programmed Cholesterol Homeostasis
Carcinogenic Link to Diabetes, Obesity and Atherosclerosis—A Focus on Differently Programmed Cholesterol Homeostasis
Diabetes and obesity are the known partners of metabolic syndrome having co-morbidities of atherosclerosis and hypercholes...
The Role of L-Arginine Metabolism and Endogenous Dimethylarginine in Chronic Venous Insufficiency
The Role of L-Arginine Metabolism and Endogenous Dimethylarginine in Chronic Venous Insufficiency
Our knowledge about the possible effects of inflammatory factors, oxidative stress, and coagulation factors on the venous ...
Combined Effects of Lipoic Acid and Dimercaptosuccinic Acid in Improving Lead-Induced Alterations on Glucose Metabolism, Energy Metabolism and Tissue Histology
Combined Effects of Lipoic Acid and Dimercaptosuccinic Acid in Improving Lead-Induced Alterations on Glucose Metabolism, Energy Metabolism and Tissue Histology
The research highlights the protective effects of DL-α-Lipoic acid (LA) at a dosage of 25 mg/kg body weight,...
Association Between Vitamin D Receptor Gene Polymorphism and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus
Association Between Vitamin D Receptor Gene Polymorphism and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus
This study investigates the link between low vitamin D (Vit D) levels, FokI polymorphism in the vitamin D receptor (VDR) g...
Coumarins at the Crossroads of Drug Development: Enzyme Modulation for Clinical Advances
Coumarins at the Crossroads of Drug Development: Enzyme Modulation for Clinical Advances
Coumarins, a diverse class of naturally occurring and synthetic compounds, have garnered significant attention in drug dev...
Genetic Determinants of Apoptosis Regulate Liver Cirrhosis Risk: The FAS/FASL Polymorphism Connection in Iraqi Population
Genetic Determinants of Apoptosis Regulate Liver Cirrhosis Risk: The FAS/FASL Polymorphism Connection in Iraqi Population
A number of chronic liver illnesses often culminate in liver cirrhosis. It is typically brought on by long-term liver cond...
Identification of Deleterious Missense Single Nucleotide Polymorphisms in Human Gene: An In Silico Study
Identification of Deleterious Missense Single Nucleotide Polymorphisms in Human Gene: An In Silico Study
Interleukin-2-inducible T-cell kinase (ITK), a mammalian non-receptor tyrosine kinase, shows the highest level of expressi...
Polygenic Risk Scores for Predicting Type 2 Diabetes Using Whole-Exome Sequencing and Global Screening Array
Polygenic Risk Scores for Predicting Type 2 Diabetes Using Whole-Exome Sequencing and Global Screening Array
This study investigated the predictability of type 2 diabetes (T2D) using genetic risk factors identified through Genome-w...
Exploring the Prognostic and Diagnostic Value of miR-497-5p and miR-17-5p in Breast Cancer: In Silico and Experimental Analysis
Exploring the Prognostic and Diagnostic Value of miR-497-5p and miR-17-5p in Breast Cancer: In Silico and Experimental Analysis
Breast cancer ranks as the most prevalent cancer worldwide. MicroRNAs (miRNAs) play dual roles as oncogenes and tumor supp...
Frequency and Associations of the Gilbert Syndrome (*28/*28) in Patients with Non–alcoholic Fatty Liver Disease
Frequency and Associations of the Gilbert Syndrome (*28/*28) in Patients with Non–alcoholic Fatty Liver Disease
Interrelationship of non-alcoholic fatty liver disease (NAFLD) with Gilbert syndrome (GS, homozygous UGT1A1*28/*28 or TA7/...
Genetic Variation in the Receptor for Advanced Glycation End Product (1704G > T) and Matrix Metalloproteinase-9 (-1562 C/T) in Type 2 Diabetic Patients with Nephropathy in Western Rajasthan
Genetic Variation in the Receptor for Advanced Glycation End Product (1704G > T) and Matrix Metalloproteinase-9 (-1562 C/T) in Type 2 Diabetic Patients with Nephropathy in Western Rajasthan
The receptor for Advanced Glycation End Products (RAGE) gene polymorphism influences matrix metalloproteinase 9 (MMP-9) le...
Therapeutic Potential of High Dose Vitamin C in Cancer: Mechanisms, Clinical Evidence and Future Directions
Therapeutic Potential of High Dose Vitamin C in Cancer: Mechanisms, Clinical Evidence and Future Directions
High-dose vitamin C (HDVC) has emerged as a potential adjunct for cancer treatment because of its selective toxicity again...
Exploring the Association of MMP-7 Promoter Site Single Nucleotide Polymorphism with Risk of Diabetic Nephropathy
Exploring the Association of MMP-7 Promoter Site Single Nucleotide Polymorphism with Risk of Diabetic Nephropathy
Diabetic nephropathy (DN), a leading cause of end-stage renal disease, has a substantial impact on the global health burde...
Genetic Polymorphisms in FAS/FASL Apoptotic Pathway Genes Modulate Beta-Thalassemia Susceptibility and Oxidative Stress Response: A Case–Control Study
Genetic Polymorphisms in FAS/FASL Apoptotic Pathway Genes Modulate Beta-Thalassemia Susceptibility and Oxidative Stress Response: A Case–Control Study
Beta-thalassemia is an inherited disorder of hemoglobin which leads to severe anemia and the complications of oxidative st...
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