Zhang, Y. et al. A system hierarchy for brain-inspired computing. Nature 586, 378–384 (2020).

Article  CAS  PubMed  Google Scholar 

Dolmetsch, R. & Geschwind, D. H. The human brain in a dish: the promise of iPSC-derived neurons. Cell 145, 831–834 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khakh, B. S. & Lester, H. A. Dynamic selectivity filters in ion channels. Neuron 23, 653–658 (1999).

Article  CAS  PubMed  Google Scholar 

Keramidas, A., Moorhouse, A. J., Schofield, P. R. & Barry, P. H. Ligand-gated ion channels: mechanisms underlying ion selectivity. Prog. Biophys. Mol. Biol. 86, 161–204 (2004).

Article  CAS  PubMed  Google Scholar 

Kato, H. E. et al. Structural mechanisms of selectivity and gating in anion channelrhodopsins. Nature 561, 349–354 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhorov, B. S. & Tikhonov, D. B. Potassium, sodium, calcium and glutamate‐gated channels: pore architecture and ligand action. J. Neurochem. 88, 782–799 (2004).

Article  CAS  PubMed  Google Scholar 

Lee, Y., Park, H.-L., Kim, Y. & Lee, T.-W. Organic electronic synapses with low energy consumption. Joule 5, 794–810 (2021).

Article  CAS  Google Scholar 

Abedelhady, S. Neuron’s power. Int. J. Appl. Energy Syst. 7, 50–60 (2025).

Article  Google Scholar 

Sun, L. et al. Synaptic computation enabled by joule heating of single-layered semiconductors for sound localization. Nano Lett. 18, 3229–3234 (2018).

Article  CAS  PubMed  Google Scholar 

Hodgkin, A. L. & Huxley, A. F. Action potentials recorded from inside a nerve fibre. Nature 144, 710–711 (1939).

Article  Google Scholar 

Hebb, D. O. The Organization of Behavior (1949) Ch. 4 (eds Anderson, J. A. & Rosenfeld, E.) (MIT Press, 1988).

Hodgkin, A. L. & Huxley, A. F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 117, 500 (1952).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chua, L. Memristor — the missing circuit element. IEEE Transact. Circuit Theory 18, 507–519 (1971).

Article  Google Scholar 

Strukov, D. B., Snider, G. S., Stewart, D. R. & Williams, R. S. The missing memristor found. Nature 453, 80–83 (2008).

Article  CAS  PubMed  Google Scholar 

Chua, L. If it’s pinched it’s a memristor. Semicond. Sci. Technol.  29, 104001 (2014).

Article  Google Scholar 

Park, S.-O. et al. Phase-change memory via a phase-changeable self-confined nano-filament. Nature 628, 293–298 (2024).

Article  CAS  PubMed  Google Scholar 

Chanthbouala, A. et al. A ferroelectric memristor. Nat. Mater. 11, 860–864 (2012).

Article  CAS  PubMed  Google Scholar 

Kim, K.-H., Hyun Jo, S., Gaba, S. & Lu, W. Nanoscale resistive memory with intrinsic diode characteristics and long endurance. Appl. Phys. Lett. 96, 053106 (2010).

Article  Google Scholar 

Chen, S. et al. Wafer-scale integration of two-dimensional materials in high-density memristive crossbar arrays for artificial neural networks. Nat. Electron. 3, 638–645 (2020).

Article  CAS  Google Scholar 

Choi, B. J. et al. High‐speed and low‐energy nitride memristors. Adv. Funct. Mater. 26, 5290–5296 (2016).

Article  CAS  Google Scholar 

Zhao, H. et al. Atomically thin femtojoule memristive device. Adv. Mater. 29, 1703232 (2017).

Article  Google Scholar 

Ismail, A. & Radha, B. Mechano-ionic memristors for nanofluidic logic. Nat. Electron. 7, 258–259 (2024).

Article  Google Scholar 

Ismail, A. et al. When does nanofluidic memory disappear? Understanding and reinstating memristive behavior of ionic liquids in two-dimensional nanochannels. Faraday Discuss. https://doi.org/10.1039/D5FD00142K (2026).

Robin, P. et al. Long-term memory and synapse-like dynamics in two-dimensional nanofluidic channels. Science 379, 161–167 (2023).

Article  CAS  PubMed  Google Scholar 

Ling, Y. et al. Single-pore nanofluidic logic memristor with reconfigurable synaptic functions and designable combinations. J. Am. Chem. Soc. 146, 14558–14565 (2024).

Article  CAS  PubMed  Google Scholar 

Emmerich, T. et al. Nanofluidic logic with mechano–ionic memristive switches. Nat. Electron. 7, 271–278 (2024).

Article  PubMed  PubMed Central  Google Scholar 

Ismail, A. et al. Programmable memristors with two-dimensional nanofluidic channels. Nat. Commun. 16, 7008 (2025).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pandey, S. V. et al. Ionic memory or electrode artefacts? A systematic assessment of nanofluidic memristors. Faraday Discuss. https://doi.org/10.1039/D5FD00135H (2026).

Liu, W. et al. Bioinspired carbon nanotube–based nanofluidic ionic transistor with ultrahigh switching capabilities for logic circuits. Sci. Adv. 10, 7867 (2024).

Article  Google Scholar 

Goutham, S. et al. Beyond steric selectivity of ions using ångström-scale capillaries. Nat. Nanotechnol. 18, 596–601 (2023).

Article  CAS  PubMed  Google Scholar 

Gopinadhan, K. et al. Complete steric exclusion of ions and proton transport through confined monolayer water. Science 363, 145–148 (2019).

Article  CAS  PubMed  Google Scholar 

Esfandiar, A. et al. Size effect in ion transport through angstrom-scale slits. Science 358, 511–513 (2017).

Article  CAS  PubMed  Google Scholar 

Müller-Caspary, K. et al. Atomic-scale quantification of charge densities in two-dimensional materials. Phys. Rev. B 98, 121408 (2018).

Article  Google Scholar 

Gogoi, R. K., Neog, A. B., Konch, T. J., Sarmah, N. & Raidongia, K. A two-dimensional ion-pump of a vanadium pentoxide nanofluidic membrane. J. Mater. Chem. A 7, 10552–10560 (2019).

Article  CAS  Google Scholar 

Chen, X. et al. How universal is the wetting aging in 2D materials. Nano Lett. 20, 5670–5677 (2020).

Article  CAS  PubMed  Google Scholar 

Kühne, M. et al. Wettability engineering for studying ion transport in 2D layered materials. Adv. Mater. Interfaces 8, 2001453 (2021).

Article  Google Scholar 

Snapp, P. et al. Interaction of 2D materials with liquids: wettability, electrochemical properties, friction, and emerging directions. NPG Asia Mater. 12, 22 (2020).

Article  Google Scholar 

Si, L. et al. A superstable, flexible, and scalable nanofluidic ion regulation composite membrane. Sci. Bull. 68, 2344–2353 (2023).

Article  CAS  Google Scholar 

Thakur, M. et al. High durability and stability of 2D nanofluidic devices for long-term single-molecule sensing. npj 2D Mater. Appl. 7, 11 (2023).

Article  CAS  PubMed  PubMed Central