Dynamic regulation of H3K9 dimethylation drives mouse minor zygotic genome activation

Jukam, D., Shariati, S. A. M. & Skotheim, J. M. Zygotic genome activation in vertebrates. Dev. Cell 42, 316–332 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abe, K. et al. Minor zygotic gene activation is essential for mouse preimplantation development. Proc. Natl. Acad. Sci. USA 115, E6780–E6788 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peaston, A. E. et al. Retrotransposons regulate host genes in mouse oocytes and preimplantation embryos. Dev. Cell 7, 597–606 (2004).

Article  CAS  PubMed  Google Scholar 

De Iaco, A. et al. DUX-family transcription factors regulate zygotic genome activation in placental mammals. Nat. Genet. 49, 941–945 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Hendrickson, P. G. et al. Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons. Nat. Genet. 49, 925–934 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Whiddon, J. L., Langford, A. T., Wong, C. J., Zhong, J. W. & Tapscott, S. J. Conservation and innovation in the DUX4-family gene network. Nat. Genet. 49, 935–940 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grow, E. J. et al. p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models. Nat. Genet. 53, 1207–1220 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji, S. et al. OBOX regulates mouse zygotic genome activation and early development. Nature 620, 1047–1053 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo, Y. et al. Obox4 promotes zygotic genome activation upon loss of Dux. eLife 13, 1–25 (2024).

Article  Google Scholar 

Macfarlan, T. S. et al. Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature 487, 57–63 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sakashita, A. et al. Transcription of MERVL retrotransposons is required for preimplantation embryo development. Nat. Genet. 55, 484–495 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Padeken, J., Methot, S. P. & Gasser, S. M. Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance. Nat. Rev. Mol. Cell Biol. 23, 623–640 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peters, A. H. et al. Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell 107, 323–337 (2001).

Article  CAS  PubMed  Google Scholar 

Matsui, T. et al. Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET. Nature 464, 927–931 (2010).

Article  CAS  PubMed  Google Scholar 

Tachibana, M. et al. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev. 16, 1779–1791 (2002).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tachibana, M. et al. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev. 19, 815–826 (2005).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuroki, S. et al. Combined loss of JMJD1A and JMJD1B reveals critical roles for H3K9 demethylation in the maintenance of embryonic stem cells and early embryogenesis. Stem Cell Rep. 10, 1340–1354 (2018).

Article  CAS  Google Scholar 

Wang, C. et al. Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development. Nat. Cell Biol. 20, 620–631 (2018).

Article  CAS  PubMed  Google Scholar 

Deng, M. et al. Exchanges of histone methylation and variants during mouse zygotic genome activation. Zygote 28, 51–58 (2020).

Article  CAS  PubMed  Google Scholar 

Burton, A. et al. Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3. Nat. Cell Biol. 22, 767–778 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sankar, A. et al. KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes. Nat. Cell Biol. 22, 380–388 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zylicz, J. J. et al. G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst. eLife 7, 1–12 (2018).

Article  Google Scholar 

Wu, J. et al. The landscape of accessible chromatin in mammalian preimplantation embryos. Nature 534, 652–657 (2016).

Article  CAS  PubMed  Google Scholar 

Chen, K. et al. Pivotal role for long noncoding RNAs in zygotic genome activation in mice. Sci. China Life Sci. 67, 958–969 (2024).

Article  CAS  PubMed  Google Scholar 

Liu, B. et al. The landscape of RNA Pol II binding reveals a stepwise transition during ZGA. Nature 587, 139–144 (2020).

Article  CAS  PubMed  Google Scholar 

Zhu, Y. et al. Genomewide decoupling of H2AK119ub1 and H3K27me3 in early mouse development. Sci. Bull. 66, 2489–2497 (2021).

Article  CAS  Google Scholar 

Matsuwaka, M., Kumon, M. & Inoue, A. H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos. Nat. Cell Biol. 27, 28–38 (2024).

Article  PubMed  Google Scholar 

Liu, N. et al. Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability. Genes Dev. 29, 379–393 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Au Yeung, W. K. et al. Histone H3K9 methyltransferase G9a in oocytes is essential for preimplantation development but dispensable for CG methylation protection. Cell Rep. 27, 282–293 (2019).

Article  CAS  PubMed  Google Scholar 

Mei, H. et al. H2A.Z reinforces maternal H3K4me3 formation and is essential for meiotic progression in mouse oocytes. Nat. Struct. Mol. Biol. 32, 1883–1893 (2025).

Article  CAS  PubMed  Google Scholar 

Xiong, Z. et al. Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development. Nat. Cell Biol. 24, 968–980 (2022).

Article  CAS  PubMed 

Comments (0)

No login
gif