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Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics
Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics
THIK-1 (KCNK13) is a halothane-inhibited and anionic-lipid-activated two-pore domain (K2P) K+ channel implicated in microg...
A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC
A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC
The apical–basal polarity of epithelial cells depends on mutual antagonism between the apical aPKC and lateral LGL p...
Structures of a natural circularly permuted group II intron reveal mechanisms of branching and backsplicing
Structures of a natural circularly permuted group II intron reveal mechanisms of branching and backsplicing
Circularly permuted (CP) group II introns, identified in various bacteria phyla, swap domains D5 and D6 near the 5′ ...
Human polymerase θ helicase positions DNA microhomologies for double-strand break repair
Human polymerase θ helicase positions DNA microhomologies for double-strand break repair
DNA double-strand breaks occur daily in all human cells and must be repaired with high fidelity to minimize genomic instab...
A chromatin mesh model for compaction of chromatin by PRC1 in condensates
A chromatin mesh model for compaction of chromatin by PRC1 in condensates
The structure of chromatin bound by Polycomb repressive complex 1 (PRC1) and how it contributes to transcription repressio...
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)
Dual reporters encoding two distinct proteins within the same mRNA have had a crucial role in identifying and characterizi...
CTCF-mediated 3D chromatin sets up the gene expression program in the male germline
CTCF-mediated 3D chromatin sets up the gene expression program in the male germline
Spermatogenesis is a unidirectional differentiation process that generates haploid sperm, but how the gene expression prog...
Structural insights into the iron nitrogenase complex
Structural insights into the iron nitrogenase complex
Nitrogenases are best known for catalyzing the reduction of dinitrogen to ammonia at a complex metallic cofactor. Recently...
Structural organization of the retriever–CCC endosomal recycling complex
Structural organization of the retriever–CCC endosomal recycling complex
The recycling of membrane proteins from endosomes to the cell surface is vital for cell signaling and survival. Retriever,...
Rational optimization of a transcription factor activation domain inhibitor
Rational optimization of a transcription factor activation domain inhibitor
Transcription factors are among the most attractive therapeutic targets but are considered largely ‘undruggable̵...
3D Enhancer–promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages
3D Enhancer–promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages
Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that give rise to three essential lineag...
Transient protein folding in condensates reveals ways to target disordered oncoproteins
Transient protein folding in condensates reveals ways to target disordered oncoproteins
The androgen receptor forms nuclear condensates associated with gene transcription. Investigating the molecular basis of c...
Structural basis of branching during RNA splicing
Structural basis of branching during RNA splicing
Branching is a critical step in RNA splicing that is essential for 5′ splice site selection. Recent spliceosome stru...
Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter
Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter
Sodium–glucose cotransporter 2 (SGLT2) is imporant in glucose reabsorption. SGLT2 inhibitors suppress renal glucose ...
Complete set of the Atg8–E1–E2–E3 conjugation machinery forms an interaction web that mediates membrane shaping
Complete set of the Atg8–E1–E2–E3 conjugation machinery forms an interaction web that mediates membrane shaping
Atg8, a ubiquitin-like protein, is conjugated with phosphatidylethanolamine (PE) via Atg7 (E1), Atg3 (E2) and Atg12–...
The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts
The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts
Alternative splicing affects more than 95% of multi-exon genes in the human genome. These changes affect the proteome in a...
Author Correction: In vivo tracking of functionally tagged Rad51 unveils a robust strategy of homology search
Author notesThese authors contributed equally: Judith Miné-Hattab, Marie Villemeur.Authors and AffiliationsInstitut Curie,...
AGO2 localizes to the nucleus in quiescence and represses transposon expression
AGO2 localizes to the nucleus in quiescence and represses transposon expression
An Ago2HA/HA mouse model combined with super-resolution microscopy, molecular and biochemical assays allowed us to stringe...
POLQ to the rescue for double-strand break repair during mitosis
POLQ to the rescue for double-strand break repair during mitosis
DNA polymerase θ (POLQ) repairs mitotic DNA breaks; this requires RHINO and PLK1, averts genomic instability and may ...
Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism
Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism
Global changes in transcriptional regulation and RNA metabolism are crucial features of cancer development. However, littl...
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior
We describe how transcription start site (TSS) choice of thousands of genes results in transcript isoforms with potential ...
Multidomain interactions and ring opening of the p97 ATPase by the UBXD1 adapter
Multidomain interactions and ring opening of the p97 ATPase by the UBXD1 adapter
The human ATPase p97 (also known as VCP) unfolds protein substrates by translocating them through its central channel. Thi...
AGO2 silences mobile transposons in the nucleus of quiescent cells
AGO2 silences mobile transposons in the nucleus of quiescent cells
Argonaute 2 (AGO2) is a cytoplasmic component of the miRNA pathway, with essential roles in development and disease. Yet l...
MOF acetylates COX17 to preserve functional mitochondria: a KAT with two lives
MOF acetylates COX17 to preserve functional mitochondria: a KAT with two lives
Writing in Nature Metabolism, Guhathakurta et al. provide pertinent functional and mechanistic insight about this elusive ...
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor
Hsp90 is an essential molecular chaperone responsible for the folding and activation of hundreds of ‘client’ p...
The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions
The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions
p97, also known as valosin-containing protein, is an essential cytosolic AAA+ (ATPases associated with diverse cellular ac...
FSP1 inhibition: pick your pocket
FSP1 inhibition: pick your pocket
Ferroptosis suppressor protein 1 (FSP1, or AIFM2), an NADPH quinone reductase noted to protect cancer cells from ferroptos...
OAT1 structures reveal insights into drug transport in the kidney
OAT1 structures reveal insights into drug transport in the kidney
OAT1 has a fundamental role in the kidney by facilitating the urinary excretion of various drugs and endogenous metabolite...
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation
A translating ribosome is typically thought to follow the reading frame defined by the selected start codon. Using super-r...
Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation
Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation
Ferroptosis, marked by iron-dependent lipid peroxidation, may present an Achilles heel for the treatment of cancers. Ferro...
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