Abdel-Magied N, Abdel-Aziz N, Shedid SM, Ahmed AG (2019) Modulating effect of Tiron on the capability of mitochondrial oxidative phosphorylation in the brain of rats exposed to radiation or manganese toxicity. Environ Sci Pollut Res 26:12550–12562. https://doi.org/10.1007/s11356-019-04644-x

Article  CAS  Google Scholar 

Advani VM, Ivanov P (2019) Translational control under stress: reshaping the translatome. BioEssays 41:e1900009. https://doi.org/10.1002/bies.201900009

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahmadi N, Ghanbarinejad V, Ommati MM, Jamshidzadeh A, Heidari R (2018) Taurine prevents mitochondrial membrane permeabilization and swelling upon interaction with manganese: implication in the treatment of cirrhosis-associated central nervous system complications. J Biochem Mol Toxicol 32:e22216. https://doi.org/10.1002/jbt.22216

Article  CAS  PubMed  Google Scholar 

Akingbade GT, Ijomone OM, Imam A, Aschner M, Ajao MS (2021) D-ribose-l-cysteine improves glutathione levels, neuronal and mitochondrial ultrastructural damage, caspase-3 and GFAP expressions following manganese-induced neurotoxicity. Neurotox Res 39:1846–1858. https://doi.org/10.1007/s12640-021-00387-1

Article  CAS  PubMed  Google Scholar 

Alaimo A, Gorojod RM, Miglietta EA, Villarreal A, Ramos AJ, Kotler ML (2013) Manganese induces mitochondrial dynamics impairment and apoptotic cell death: a study in human Gli36 cells. Neurosci Lett 554:76–81. https://doi.org/10.1016/j.neulet.2013.08.061

Article  CAS  PubMed  Google Scholar 

Alaimo A, Gorojod RM, Beauquis J, Muñoz MJ, Saravia F, Kotler ML (2014) Deregulation of mitochondria-shaping proteins Opa-1 and Drp-1 in manganese-induced apoptosis. PLoS ONE 9:e91848. https://doi.org/10.1371/journal.pone.0091848

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alarifi S, Ali D, Alkahtani S (2017) Oxidative Stress-Induced DNA damage by manganese dioxide nanoparticles in human neuronal cells. Biomed Res Int 2017:5478790. https://doi.org/10.1155/2017/5478790

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anand RS, Ganesan D, Rajasekaran S, Jayavelu T (2020) Astrocytes resolve ER stress through mitochondrial fusion facilitated by biotin availability. Cell Stress Chaperones 25:945–953. https://doi.org/10.1007/s12192-020-01129-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anderson NS, Haynes CM (2020) Folding the mitochondrial UPR into the integrated stress response. Trends Cell Biol 30:428–439. https://doi.org/10.1016/j.tcb.2020.03.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Angeli S, Barhydt T, Jacobs R, Killilea DW, Lithgow GJ, Andersen JK (2014) Manganese disturbs metal and protein homeostasis in caenorhabditis elegans. Metallomics 6:1816–1823. https://doi.org/10.1039/c4mt00168k

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aschner M, Skalny AV, Rongzhu L, Santamaria A, Lee E, Bowman AB, Tizabi Y, Zhou JC, Tinkov AA (2025) The role of epigenetics in manganese neurotoxicity: an update with a focus on Non-Coding RNAs and histone modifications. Neurochem Res 50:195. https://doi.org/10.1007/s11064-024-04126-8

Article  CAS  PubMed  Google Scholar 

Avila DS, Puntel RL, Aschner M (2013) Manganese in health and disease. Met Ions Life Sci 11:199–227. https://doi.org/10.1007/978-94-007-7500-8_7

Article  Google Scholar 

Avila DS, Benedetto A, Au C, Bornhorst J, Aschner M (2016) Involvement of heat shock proteins on Mn-induced toxicity in caenorhabditis elegans. BMC Pharmacol Toxicol 17:54. https://doi.org/10.1186/s40360-016-0095-4

Article  PubMed  PubMed Central  Google Scholar 

Bai F, Long Z, Yang J, Liu P, Wu Z, Chen H, Deng Y, Ying M, Zhang S, Li J, Chen Y (2025) Induction of mitochondrial biogenesis enhances neurogenesis and cognitive recovery following ischaemic stroke. Anesthesiol Perioper Sci 3:1–23. https://doi.org/10.1007/s44254-025-00135-0

Article  CAS  Google Scholar 

Bantle CM, French CT, Cummings JE, Sadasivan S, Tran K, Slayden RA, Smeyne RJ, Tjalkens RB (2021) Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia Nigra following infection with H1N1 influenza virus. PLoS ONE 16:e0245171. https://doi.org/10.1371/journal.pone.0245171

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barhoumi R, Faske J, Liu X, Tjalkens RB (2004) Manganese potentiates lipopolysaccharide-induced expression of NOS2 in C6 glioma cells through mitochondrial-dependent activation of nuclear factor kappab. Brain Res Mol Brain Res 122:167–179. https://doi.org/10.1016/j.molbrainres.2003.12.011

Article  CAS  PubMed  Google Scholar 

Biffo S, Ruggero D, Santoro MM (2024) The crosstalk between metabolism and translation. Cell Metab 36:1945–1962. https://doi.org/10.1016/j.cmet.2024.07.022

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bornhorst J, Chakraborty S, Meyer S, Lohren H, Große Brinkhaus S, Knight AL, Aschner M (2014) The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans. Metallomics 6:476–490. https://doi.org/10.1039/c3mt00325f

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bowler RM, Kornblith ES, Gocheva VV, Colledge MA, Bollweg G, Kim Y, Wright RO, Adams WG, Weisskopf MG, Lobdell DT (2015) Environmental exposure to manganese in air: associations with cognitive functions. Neurotoxicology 49:139–148. https://doi.org/10.1016/j.neuro.2015.06.004

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bowman AB, Aschner M (2014) Considerations on manganese (Mn) treatments for in vitro studies. Neurotoxicology 41:141–142. https://doi.org/10.1016/j.neuro.2014.01.010

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brenmoehl J, Hoeflich A (2013) Dual control of mitochondrial biogenesis by Sirtuin 1 and Sirtuin 3. Mitochondrion 13:755–761. https://doi.org/10.1016/j.mito.2013.04.002

Article  CAS  PubMed  Google Scholar 

Brinkhaus SG, Bornhorst J, Chakraborty S, Wehe CA, Niehaus R, Reifschneider O, Aschner M, Karst U (2014) Elemental bioimaging of manganese uptake in C. elegans. Metallomics 6(3):617–621. https://doi.org/10.1039/c3mt00334e

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brown S, Taylor NL (1999) Could mitochondrial dysfunction play a role in manganese toxicity? Environ Toxicol Pharmacol 7:49–57. https://doi.org/10.1016/S1382-6689(99)00009-4

Article  CAS  PubMed  Google Scholar 

Bryan MR, O’Brien MT, Nordham KD, Rose DIR, Foshage AM, Joshi P, Nitin R, Uhouse MA, Di Pardo A, Zhang Z, Maglione V, Aschner M, Bowman AB (2019) Acute manganese treatment restores defective autophagic cargo loading in huntington’s disease cell lines. Hum Mol Genet 28:3825–3841. https://doi.org/10.1093/hmg/ddz209

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai H, He J, Zheng W, Cheng H, Ge X, Bao Y, Wei Y, Zhou Y, Liang X, Chen X, Liu C, Wang F, Yang X (2025) Zinc mitigates the combined neurotoxicity of binary metal mixtures via mitophagy and mitochondrial fusion. Mol Neurobiol 62:5961–5976. https://doi.org/10.1007/s12035-024-04648-w

Article  CAS  PubMed  Google Scholar 

Calakos N, Caffall ZF (2024) The integrated stress response pathway and neuromodulator signaling in the brain: lessons learned from dystonia. J Clin Invest 134:e177833. https://doi.org/10.1172/JCI177833

Article  CAS  PubMed  PubMed Central