Identification of Neurite Outgrowth and Synaptic Plasticity-related Genes Showing Sustained Hypermethylation of Promoter Region in the Hippocampal Dentate Gyrus of Rats Exposed Maternally To Neurotoxicants To Induce Persistent Disruption of Hippocampal Neurogenesis

Akane H, Shiraki A, Imatanaka N, Akahori Y, Itahashi M, Ohishi T, Mitsumori K, Shibutani M (2013a) Glycidol induces axonopathy by adult-stage exposure and aberration of hippocampal neurogenesis affecting late-stage differentiation by developmental exposure in rats. Toxicol Sci 134:140–154. https://doi.org/10.1093/toxsci/kft092

Article  CAS  PubMed  Google Scholar 

Akane H, Saito F, Yamanaka H, Shiraki A, Imatanaka N, Akahori Y, Morita R, Mitsumori K, Shibutani M (2013b) Methacarn as a whole brain fixative for gene and protein expression analyses of specific brain regions in rats. J Toxicol Sci 38:431–443. https://doi.org/10.2131/jts.38.431

Article  CAS  PubMed  Google Scholar 

Akane H, Shiraki A, Imatanaka N, Akahori Y, Itahashi M, Abe H, Shibutani M (2014) Glycidol induces axonopathy and aberrations of hippocampal neurogenesis affecting late-stage differentiation by exposure to rats in a framework of 28-day toxicity study. Toxicol Lett 224:424–432. https://doi.org/10.1016/j.toxlet.2013.10.026

Article  CAS  PubMed  Google Scholar 

Basiri A, Izadi S, Kakhki S, Alikahni V, Askarian S, Beheshti F (2024) N-acetylcysteine prevents hypothyroidism-induced impairment of learning and memory in adolescent male rats via affecting oxidative status, inflammatory response and BDNF in hippocampal tissues. Acta Neurobiol Exp (Wars) 84:218–229. https://doi.org/10.55782/ane-2024-2587

Article  PubMed  Google Scholar 

Bernal J Thyroid Hormones in Brain Development and Function. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, Dartmouth S (2022) 2000-. https://www.ncbi.nlm.nih.gov/books/NBK285549/. Accessed 1 June 2025

Brackenbury WJ, Isom LL (2008) Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets. Expert Opin Ther Targets 12:1191–1203. https://doi.org/10.1517/14728222.12.9.1191

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brackenbury WJ, Davis TH, Chen C, Slat EA, Detrow MJ, Dickendesher TL, Ranscht B, Isom LL (2008) Voltage-Gated Na+ channel β1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo. J Neurosci 28:3246–3256. https://doi.org/10.1523/JNEUROSCI.5446-07.2008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brackenbury WJ, Yuan Y, O’Malley HA, Parent JM, Isom LL (2013) Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability. Proc Natl Acad Sci U S A 110:1089–1094. https://doi.org/10.1073/pnas.1208767110

Article  PubMed  Google Scholar 

Bunker SK, Dutta A, Pradhan J, Dandapat J, Chainy GBN (2019) Curcumin restores hepatic epigenetic changes in propylthiouracil (PTU)-induced hypothyroid male rats: a study on DNMTs, MBDs, GADD45a, C/EBP-β and PCNA. Food Chem Toxicol 123:169–180. https://doi.org/10.1016/j.fct.2018.10.050

Article  CAS  PubMed  Google Scholar 

Campo Verde Arbocco F, Pascual LI, García D, Ortiz I, Gamarra-Luques C, Carón RW, Hapon MB (2024) Epigenetic impact of hypothyroidism on the functional differentiation of the mammary gland in rats. Mol Cell Endocrinol 590:112267. https://doi.org/10.1016/j.mce.2024.112267

Article  CAS  PubMed  Google Scholar 

Chen X, Johnston D (2005) Constitutively active G-protein-gated inwardly rectifying K+ channels in dendrites of hippocampal CA1 pyramidal neurons. J Neurosci 25:3787–3792. https://doi.org/10.1523/JNEUROSCI.5312-04.2005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O’Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, Shrager P, Catterall WA, Isom LL (2004) Mice lacking sodium channel β1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci 24:4030–4042. https://doi.org/10.1523/JNEUROSCI.4139-03.2004

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen XJ, Zhang H, Yang F, Liu Y, Chen G (2021) DNA methylation sustains “inflamed” memory of peripheral immune cells aggravating kidney inflammatory response in chronic kidney disease. Front Physiol 12:637480. https://doi.org/10.3389/fphys.2021.637480

Article  PubMed  PubMed Central  Google Scholar 

Clavel Rolland N, Kiehr B, Zhu M, Chen C, Gao P, Pourcher T, Blanck O (2025) Toxicokinetic insights into distinct mechanisms of action of two thyroid toxicants: Propylthiouracil and pregnenolone 16α-carbonitrile. Toxicol Appl Pharmacol 498:117282. https://doi.org/10.1016/j.taap.2025.117282

Article  CAS  PubMed  Google Scholar 

Davis TH, Chen C, Isom LL (2004) Sodium channel β1 subunits promote neurite outgrowth in cerebellar granule neurons. J Biol Chem 279:51424–51432. https://doi.org/10.1074/jbc.M410830200

Article  CAS  PubMed  Google Scholar 

Demeneix BA (2019) Evidence for prenatal exposure to thyroid disruptors and adverse effects on brain development. Eur Thyroid J 8:283–292. https://doi.org/10.1159/000504668

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deng GF, Qin JM, Sun XS, Kuang ZY, Su T, Zhao QH, Shi YW, Liu XR, Yu MJ, Yi YH, Liao WP, Long YS (2011) Promoter analysis of mouse Scn3a gene and regulation of the promoter activity by GC box and CpG methylation. J Mol Neurosci 44:115–121. https://doi.org/10.1007/s12031-011-9492-8

Article  CAS  PubMed  Google Scholar 

Dieni CV, Chancey JH, Overstreet-Wadiche LS (2013) Dynamic functions of GABA signaling during granule cell maturation. Front Neural Circuits 6:113. https://doi.org/10.3389/fncir.2012.00113

Article  PubMed  PubMed Central  Google Scholar 

Gilbert ME, Ramos RL, McCloskey DP, Goodman JH (2014) Subcortical band heterotopia in rat offspring following maternal hypothyroxinaemia: structural and functional characteristics. J Neuroendocrinol 26:528–541. https://doi.org/10.1111/jne.12169

Article  CAS  PubMed  Google Scholar 

Harashima C, Jacobowitz DM, Witta J, Borke RC, Best TK, Siarey RJ, Galdzicki Z (2006) Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia Nigra of Ts65Dn mouse: a model of down syndrome. J Comp Neurol 494:815–833. https://doi.org/10.1002/cne.20844

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang DW, Sherman BT, Lempicki RA (2009a) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37:1–13. https://academic.oup.com/nar/article-abstract/37/1/1/1026684

Article  PubMed  Google Scholar 

Huang DW, Sherman BT, Lempicki RA (2009b) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44–57. https://doi.org/10.1038/nprot.2008.211

Article  CAS  PubMed  Google Scholar 

Inohana M, Eguchi A, Nakamura M, Nagahara R, Onda N, Nakajima K, Saegusa Y, Yoshida T, Shibutani M (2018) Developmental exposure to aluminum chloride irreversibly affects postnatal hippocampal neurogenesis involving multiple functions in mice. Toxicol Sci 164:264–277. https://doi.org/10.1093/toxsci/kfy081

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jena S (2015) Effect of persistent and transient hypothyroidism on histoarchitecture and antioxidant defence system in rat brain. Neurol Sci 36:953–959. https://doi.org/10.1007/s10072-015-2199-9

Article  PubMed  Google Scholar 

Jena S, Chainy GB, Dandapat J (2012) Hypothyroidism modulates renal antioxidant gene expression during postnatal development and maturation in rat. Gen Comp Endocrinol 178:8–18. https://doi.org/10.1016/j.ygcen.2012.03.012

Article  CAS  PubMed  Google Scholar 

Kawahori K, Hashimoto K, Yuan X, Tsujimoto K, Hanzawa N, Hamaguchi M, Kase S, Fujita K, Tagawa K, Okazawa H, Nakajima Y, Shibusawa N, Yamada M, Ogawa Y (2018) Mild maternal hypothyroxinemia during pregnancy induces persistent DNA hypermethylation in the hippocampal Brain-Derived neurotrophic factor gene in mouse offspring. Thyroid 28:395–406. https://doi.org/10.1089/thy.2017.0331

Article  CAS  PubMed  Google Scholar 

Kempermann G, Jessberger S, Steiner B, Kronenberg G (2004) Milestones of neuronal development in the adult hippocampus. Trends Neurosci 27:447–452. https://doi.org/10.1016/j.tins.2004.05.013

Article  CAS 

Comments (0)

No login
gif