Abdel-Rahman Mohamed A, Abdel Rahman AN, Salem GA, Deib MME, Nassan MA, Rhouma NR, Khater SI (2021) The antioxidant role of a taurine-enriched diet in combating the immunotoxic and inflammatory effects of pyrethroids and/or carbamates in Oreochromis niloticus. Animals 11(5):1318
Article PubMed PubMed Central Google Scholar
Amenotie AJ, Ben-Azu B, Esuku DT, Chijioke BS, Abo E, Ozah EO, Lawrence EO, Efejene OI, Onyeukwu OB, Alabi BA, Ajayi AM (2025) Sabinene inhibits Lipopolysaccharide-Induced memory decline by enhancing cholinergic Function, decreasing molybdenum Enzymes, and suppressing oxidative stress and neuroinflammation. Neurotox Res 43(3):26. https://doi.org/10.1007/s12640-025-00750-6
Article PubMed CAS Google Scholar
An L, Zhang T (2016) Comparison impairments of Spatial cognition and hippocampal synaptic plasticity between prenatal and postnatal melamine exposure in male adult rats. Neurotox Res 29:218–229
Article PubMed CAS Google Scholar
An L, Li Z, Yang Z, Zhang T (2011) Cognitive deficits induced by melamine in rats. Toxicol Lett 206(3):276–280
Article PubMed CAS Google Scholar
An L, Yang Z, Zhang T (2013) Melamine induced Spatial cognitive deficits associated with impairments of hippocampal long-term depression and cholinergic system in Wistar rats. Neurobiol Learn Mem 100:18–24
Article PubMed CAS Google Scholar
An L, Fu J, Zhang T (2015) Reversible effects of vitamins C and E combination on cognitive deficits and oxidative stress in the hippocampus of melamine-exposed rats. Pharmacol Biochem Behav 132:152–159
Article PubMed CAS Google Scholar
Bellomo G, Paciotti S, Gatticchi L, Parnetti L (2020) The vicious cycle between α-synuclein aggregation and autophagic‐lysosomal dysfunction. Mov Disord 35(1):34–44
Article PubMed CAS Google Scholar
Ben-Azu B, Aderibigbe AO, Omogbiya IA, Ajayi AM, Owoeye O, Olonode ET, Iwalewa EO (2018) Probable mechanisms involved in the antipsychotic-like activity of Morin in mice. Biomed Pharmacother 105:1079–1090
Article PubMed CAS Google Scholar
Ben-Azu B, Aderibigbe AO, Ajayi AM, Eneni A-EO, Omogbiya IA, Owoeye O, Umukoro S, Iwalewa EO (2019) Morin decreases cortical pyramidal neuron degeneration via Inhibition of neuroinflammation in mouse model of schizophrenia. Int Immunopharmacol 70:338–353. https://doi.org/10.1016/j.intimp.2019.02.052
Article PubMed CAS Google Scholar
Ben-Azu B, Adebayo OG, Jarikre TA, Oyovwi MO, Edje KE, Omogbiya IA, Eduviere AT, Moke EG, Chijioke BS, Odili OS, Omondiabge OP, Oyovbaire A, Esuku DT, Ozah EO, Japhet K (2021) Taurine, an essential β-amino acid insulates against ketamine-induced experimental psychosis by enhancement of cholinergic neurotransmission, Inhibition of oxidative/nitrergic imbalances, and suppression of COX-2/iNOS immunoreactions in mice. Metab Brain Dis. https://doi.org/10.1007/s11011-022-01075-5
Ben-Azu B, Uruaka CI, Ajayi AM, Jarikre TA, Nwangwa KE, Chilaka KC, Chijioke BS, Omonyeme MG, Ozege CB, Ofili EC, Warekoromor EB, Edigbue NL, Esiekpe UV, Akaenyi DE, Agu GO (2022) Reversal and preventive pleiotropic mechanisms involved in the Antipsychotic-Like effect of Taurine, an essential β-Amino acid in Ketamine-Induced experimental schizophrenia in mice. Neurochem Res. https://doi.org/10.1007/s11064-022-03808-5
Ben-Azu B, Chidebe EO, Toloyai P-EY, Annafi OS, Oritsemuelebi B, Asiwe J, Moke GE, Ajayi AM, Chukwuebuka NB, Onuelu JE, Utomi CW, Iregbeyen UF, Raheem DO (2024a) Adaptogenic action of Diosgenin againsts chronic unpredictable mild stress-induced neuroimmune dysfunction of HPA axis reverses psychiatric behavior in mice. Clin Traditional Med Pharmacol 5:200148. https://doi.org/10.1016/j.ctmp.2024.200148
Ben-Azu B, Adebayo OG, Fokoua AR, Oritsemuelebi B, Chidebe EO, Nwogueze CB, Kumanwee L, Uyere GE, Emuakpeje MT (2024b) Antipsychotic effect of Diosgenin in ketamine-induced murine model of schizophrenia: involvement of oxidative stress and cholinergic transmission. IBRO Neurosci Rep 16:86–97. https://doi.org/10.1016/j.ibneur.2023.12.008
Article PubMed PubMed Central CAS Google Scholar
Ben-Azu B, Oritsemuelebi B, Oghorodi AM, Adebesin A, Isibor H, Eduviere AT, Otuacha OS, Akudo M, Ekereya S, Maidoh IF, Iyayi JO, Uzochukwu-Godfrey FC (2024c) Psychopharmacological interaction of alcohol and posttraumatic stress disorder: effective action of naringin. Eur J Pharmacol 978:176791. https://doi.org/10.1016/j.ejphar.2024.176791
Article PubMed CAS Google Scholar
Bhat MA, Ahmad K, Khan MSA, Bhat MA, Almatroudi A, Rahman S, Jan AT (2020) Expedition into taurine biology: structural insights and therapeutic perspective of taurine in neurodegenerative diseases. Biomolecules 10(6):863
Article PubMed PubMed Central CAS Google Scholar
Bhatia S, Singh V, Singh M, Singh R, Shri R, Singh TG (2025) Expatiating the pivotal role of matrix metalloproteinases and Blood-Brain barrier disruption in ischemic stroke: molecular insights and therapeutic targets. Ischemic injury. Apple Academic, pp 163–179
Bolden AL, Rochester JR, Kwiatkowski CF (2017) Melamine, beyond the kidney: A ubiquitous endocrine disruptor and neurotoxicant? Toxicol Lett 280:181–189
Article PubMed CAS Google Scholar
Castellazzi M, Trentini A, Romani A, Valacchi G, Bellini T, Bonaccorsi G, Cervellati C (2016) Decreased arylesterase activity of paraoxonase-1 (PON-1) might be a common denominator of neuroinflammatory and neurodegenerative diseases. Int J Biochem Cell Biol 81:356–363
Article PubMed CAS Google Scholar
Chakraborty S, Rao BS, Tripathi SJ (2025) The neuroprotective effects of N-acetylcysteine in psychiatric and neurodegenerative disorders: from modulation of glutamatergic transmission to restoration of synaptic plasticity. Neuropharmacology 278:110527
Article PubMed CAS Google Scholar
Chidebe EO, Ben-Azu B, Oritsemuelebi B, Moke EG, Omogbiya IA, Ezedom T (2025) Diosgenin mitigates oxidative stress and inflammation within the hepatorenal system associated with epilepsy and alcohol use disorders in murine models. Phytomedicine Plus 5:100833
Chupel MU, Minuzzi LG, Furtado G, Santos ML, Hogervorst E, Filaire E, Teixeira AM (2018) Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women. Appl Physiol Nutr Metab 43(7):733–741
Article PubMed CAS Google Scholar
Dai XX, Duan X, Cui XS, Kim NH, Xiong B, Sun SC (2015) Melamine induces oxidative stress in mouse ovary. PLoS ONE, 10(11), e0142564
Das J, Ghosh J, Manna P, Sil PC (2010) Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the Inhibition of PKCδ-JNK pathway. PLoS ONE, 5(9), e12602
Di Penta A, Moreno B, Reix S, Fernandez-Diez B, Villanueva M, Errea O, Villoslada P (2013) Oxidative stress and Proinflammatory cytokines contribute to demyelination and axonal damage in a cerebellar culture model of neuroinflammation. PLoS ONE, 8(2), e54722
Duan Y, Zhao Y, Wang T, Sun J, Ali W, Ma Y, Zou H (2023) Taurine alleviates cadmium-induced hepatotoxicity by regulating autophagy flux. Int J Mol Sci 24(2):1205
Article PubMed PubMed Central CAS Google Scholar
Ellman GL, Courtney KD, Andres Jr V, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7(2):88–95
Article PubMed CAS Google Scholar
Ennaceur A, Delacour J (1988) A new one-trial test for Neurobiological studies of memory in rats. 1: behavioral data. Behav Brain Res 31:47–59. https://doi.org/10.1016/0166-4328(88)90157-x
Article PubMed CAS Google Scholar
Geier EG, Chen EC, Webb A, Papp AC, Yee SW, Sadee W, Giacomini KM (2013) Profiling solute carrier transporters in the human blood-brain barrier. Clin Pharmacol Ther 94(6):636–639. https://doi.org/10.1038/clpt.2013.175
Article PubMed CAS Google Scholar
Goyal J, Jain P, Jain V, Banerjee D, Bhattacharyya R, Dey S, Rai N (2023) Melamine exacerbates neurotoxicity in D-Galactose‐Induced neuronal SH‐SY5Y cells. J Aging Res 2023(1):6635370
PubMed PubMed Central Google Scholar
Gupta R, Ambasta RK, Kumar P (2021) Autophagy and apoptosis cascade: which is more prominent in neuronal death? Cell Mol Life Sci 78(24):8001–8047
Article PubMed PubMed Central CAS Google Scholar
Gürer H, Özgünes H, Saygin E, Ercal N (2001) Antioxidant effect of taurine against lead-induced oxidative stress. Arch Environ Contam Toxicol 41:397–402
Habotta OA, Abdeen A, El-Hanafy AA, Yassin N, Elgameel D, Ibrahim SF, El-Mosallamy SA (2023) Sesquiterpene Nootkatone counteracted the melamine-induced neurotoxicity via repressing of oxidative stress, inflammatory, and apoptotic trajectories. Biomed Pharmacother 165:115133
Comments (0)