Abd-Elmawla MA, Abdelalim E, Ahmed KA, Rizk SM (2023) The neuroprotective effect of pterostilbene on oxaliplatin-induced peripheral neuropathy via its anti-inflammatory, anti-oxidative and anti-apoptotic effects: comparative study with celecoxib. Life Sci 315:121364. https://doi.org/10.1016/j.lfs.2022.121364

Article  PubMed  CAS  Google Scholar 

Afridi R, Tsuda M, Ryu H, Suk K (2022) The function of glial cells in the neuroinflammatory and neuroimmunological responses. Cells. https://doi.org/10.3390/cells11040659

Article  PubMed  PubMed Central  Google Scholar 

Agnes JP, Santos VWD, das Neves RN, Gonçalves RM, Delgobo M, Girardi CS, Lückemeyer DD, Ferreira MA, Macedo-Júnior SJ, Lopes SC, Spiller F, Gelain DP, Moreira JCF, Prediger RD, Ferreira J, Zanotto-Filho A (2021) Antioxidants improve Oxaliplatin-induced peripheral neuropathy in Tumor-bearing mice model: role of spinal cord oxidative stress and inflammation. J Pain 22(8):996–1013. https://doi.org/10.1016/j.jpain.2021.03.142

Article  PubMed  CAS  Google Scholar 

Álvarez-Tosco K, González-Fernández R, González-Nicolás M, Martín-Ramírez R, Morales M, Gutiérrez R, Díaz-Flores L, Arnau MR, Machín F, Ávila J, Lázaro A, Martín-Vasallo P (2024) Dorsal root ganglion inflammation by oxaliplatin toxicity: DPEP1 as possible target for peripheral neuropathy prevention. BMC Neurosci 25(1):44. https://doi.org/10.1186/s12868-024-00891-y

Article  PubMed  PubMed Central  CAS  Google Scholar 

Araldi D, Khomula EV, Bonet IJM, Bogen O, Green PG, Levine JD (2024) Role of pattern recognition receptors in chemotherapy-induced neuropathic pain. Brain 147(3):1025–1042. https://doi.org/10.1093/brain/awad339

Article  PubMed  Google Scholar 

Aydemir E, Yetkin D, Ayaz F (2025) Immunostimulatory and immunomodulatory effects of duloxetine and venlafaxine on p38 MAPK and PI3K pathways. J Neuroimmunol 408:578728. https://doi.org/10.1016/j.jneuroim.2025.578728

Article  PubMed  CAS  Google Scholar 

Branca JJV, Carrino D, Gulisano M, Ghelardini C, Di Cesare Mannelli L, Pacini A (2021) Oxaliplatin-induced neuropathy: genetic and epigenetic profile to better understand how to ameliorate this side effect. Front Mol Biosci 8:643824. https://doi.org/10.3389/fmolb.2021.643824

Article  PubMed  PubMed Central  CAS  Google Scholar 

Campolo M, Paterniti I, Siracusa R, Filippone A, Esposito E, Cuzzocrea S (2019) TLR4 absence reduces neuroinflammation and inflammasome activation in parkinson’s diseases in vivo model. Brain Behav Immun 76:236–247. https://doi.org/10.1016/j.bbi.2018.12.003

Article  PubMed  CAS  Google Scholar 

Campolo M, Lanza M, Paterniti I, Filippone A, Ardizzone A, Casili G, Scuderi SA, Puglisi C, Mare M, Memeo L, Cuzzocrea S, Esposito E (2021) PEA-OXA mitigates oxaliplatin-induced painful neuropathy through NF-κB/Nrf-2 axis. Int J Mol Sci. https://doi.org/10.3390/ijms22083927

Article  PubMed  PubMed Central  Google Scholar 

Canta A, Pozzi E, Carozzi VA (2015) Mitochondrial dysfunction in Chemotherapy-induced peripheral neuropathy (CIPN). Toxics 3(2):198–223. https://doi.org/10.3390/toxics3020198

Article  PubMed  PubMed Central  CAS  Google Scholar 

Carabotti M, Scirocco A, Maselli MA, Severi C (2015) The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol 28(2):203–209

PubMed  PubMed Central  Google Scholar 

Celik H, Kucukler S, Ozdemir S, Comakli S, Gur C, Kandemir FM, Yardim A (2020) Lycopene protects against central and peripheral neuropathy by inhibiting oxaliplatin-induced ATF-6 pathway, apoptosis, inflammation and oxidative stress in brains and sciatic tissues of rats. Neurotoxicology 80:29–40. https://doi.org/10.1016/j.neuro.2020.06.005

Article  PubMed  CAS  Google Scholar 

Chaves de Souza JA, Nogueira AVB, Chaves de Souza PP, Kim YJ, Silva Lobo C, Pimentel Lopes de Oliveira GJ, Cirelli JA, Garlet GP, Rossa C Jr. (2013) SOCS3 expression correlates with severity of inflammation, expression of Proinflammatory Cytokines, and activation of STAT3 and p38 MAPK in LPS-Induced inflammation in vivo. Mediat Inflamm 2013(1):650812. https://doi.org/10.1155/2013/650812

Article  CAS  Google Scholar 

Chen L, Huang J, Zhao P, Persson A-K, Dib-Hajj FB, Cheng X, Tan A, Waxman SG, Dib-Hajj SD (2018) Conditional knockout of NaV1.6 in adult mice ameliorates neuropathic pain. Sci Rep 8(1):3845. https://doi.org/10.1038/s41598-018-22216-w

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen L, Hu Y, Wang S, Cao K, Mai W, Sha W, Ma H, Zeng LH, Xu ZZ, Gao YJ, Duan S, Wang Y, Gao Z (2022) mTOR-neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain. JCI Insight. https://doi.org/10.1172/jci.insight.159247

Article  PubMed  PubMed Central  Google Scholar 

Chen X, Gan Y, Au NPB, Ma CHE (2024) Current understanding of the molecular mechanisms of chemotherapy-induced peripheral neuropathy. Front Mol Neurosci. https://doi.org/10.3389/fnmol.2024.1345811

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Yu Y, Kou J, Qi H, Zhang C, Wang F, Zhou L, Liang X, Xu K, Zhang C, Zhang A, Liu X, Zhang C, Gan G, Sun J, Zhu X (2025) Astrocytic AEG-1 drives neuroinflammation and enhances seizure susceptibility. Neurobiol Dis 212:106957. https://doi.org/10.1016/j.nbd.2025.106957

Article  PubMed  CAS  Google Scholar 

Cheng X, Huo J, Wang D, Cai X, Sun X, Lu W, Yang Y, Hu C, Wang X, Cao P (2017) Herbal medicine AC591 prevents Oxaliplatin-Induced peripheral neuropathy in animal model and cancer patients. Front Pharmacol 8:344. https://doi.org/10.3389/fphar.2017.00344

Article  PubMed  PubMed Central  CAS  Google Scholar 

Colvin LA (2019) Chemotherapy-induced peripheral neuropathy: where are we now? Pain 160(1):S1-s10. https://doi.org/10.1097/j.pain.0000000000001540

Article  PubMed  PubMed Central  CAS  Google Scholar 

D’Andre S, McAllister S, Nagi J, Giridhar KV, Ruiz-Macias E, Loprinzi C (2021) Topical cannabinoids for treating Chemotherapy-Induced neuropathy: a case series. Integr Cancer Ther 20:15347354211061740. https://doi.org/10.1177/15347354211061739

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dai C, Zhen F, Yu L, Xin S (2024) Puerarin alleviates oxaliplatin-induced neuropathic pain by promoting Nrf2/GPX4-mediated antioxidative response. PLoS ONE 19(8):e0308872. https://doi.org/10.1371/journal.pone.0308872

Article  PubMed  PubMed Central  CAS  Google Scholar 

de Souza Monteiro Araujo D, Nassini R, Geppetti P, De Logu F (2020) TRPA1 as a therapeutic target for nociceptive pain. Expert Opin Ther Targets 24(10):997–1008. https://doi.org/10.1080/14728222.2020.1815191

Article  CAS  Google Scholar 

Desforges AD, Hebert CM, Spence AL, Reid B, Dhaibar HA, Cruz-Topete D, Cornett EM, Kaye AD, Urits I, Viswanath O (2022) Treatment and diagnosis of chemotherapy-induced peripheral neuropathy: an update. Biomed Pharmacother 147:112671. https://doi.org/10.1016/j.biopha.2022.112671

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dong ZB, Wang YJ, Cheng ML, Wang BJ, Lu H, Zhu HL, Liu L, Xie M (2022) 2-bromopalmitate decreases spinal inflammation and attenuates oxaliplatin-induced neuropathic pain via reducing Drp1-mediated mitochondrial dysfunction. PLoS One 17(10):e0275428. https://doi.org/10.1371/journal.pone.0275428

Article  PubMed  PubMed Central  CAS  Google Scholar 

Doyle TM, Salvemini D (2021) Mini-review: mitochondrial dysfunction and chemotherapy-induced neuropathic pain. Neurosci Lett 760:136087. https://doi.org/10.1016/j.neulet.2021.136087

Article  PubMed  PubMed Central  CAS  Google Scholar 

Duan Z, Su Z, Wang H, Pang X (2018) Involvement of pro-inflammation signal pathway in inhibitory effects of Rapamycin on oxaliplatin-induced neuropathic pain. Mol Pain 14:1744806918769426. https://doi.org/10.1177/1744806918769426

Article  PubMed  PubMed Central