Microplastics, Nanoplastics, and Cancer: A Narrative Review

Thompson RC, Olsen Y, Mitchell RP, Davis A, Rowland SJ, John AWG, et al. Lost at Sea: Where Is All the Plastic? Science. 2004;304(5672):838–838. https://doi.org/10.1126/science.1094559.

Article  PubMed  CAS  Google Scholar 

Geyer R, Jambeck JR, Law KL. Production, use, and fate of all plastics ever made. Sci Adv. 2017;3(7):e1700782. https://doi.org/10.1126/sciadv.1700782.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hartmann NB, Hüffer T, Thompson RC, Hassellöv M, Verschoor A, Daugaard AE, et al. Are We Speaking the Same Language? Recommendations for a Definition and Categorization Framework for Plastic Debris. Environ Sci Technol. 2019;53(3):1039–47. https://doi.org/10.1021/acs.est.8b05297 . PubMed PMID: 30608663.

Article  PubMed  CAS  Google Scholar 

Prata JC, da Costa JP, Lopes I, Duarte AC, Rocha-Santos T. Environmental exposure to microplastics: An overview on possible human health effects. Sci Total Environ. 2020;702:134455. https://doi.org/10.1016/j.scitotenv.2019.134455 . PubMed PMID: 31733547.

Article  PubMed  CAS  Google Scholar 

Vethaak AD, Legler J. Microplastics and human health. Science. 2021;371(6530):672–4. https://doi.org/10.1126/science.abe5041.

Article  PubMed  CAS  Google Scholar 

Rahman A, Sarkar A, Yadav OP, Achari G, Slobodnik J. Potential human health risks due to environmental exposure to nano- and microplastics and knowledge gaps: A scoping review. Sci Total Environ. 2021;757:143872. https://doi.org/10.1016/j.scitotenv.2020.143872.

Article  PubMed  CAS  Google Scholar 

Yee MSL, Hii LW, Looi CK, Lim WM, Wong SF, Kok YY, et al. Impact of Microplastics and Nanoplastics on Human Health. Nanomaterials. 2021;11(2):496. https://doi.org/10.3390/nano11020496.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mohamed Nor NH, Kooi M, Diepens NJ, Koelmans AA. Lifetime Accumulation of Microplastic in Children and Adults. Environ Sci Technol. 2021;55(8):5084–96. https://doi.org/10.1021/acs.est.0c07384 . PubMed PMID: 33724830; PubMed Central PMCID: PMC8154366.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cox KD, Covernton GA, Davies HL, Dower JF, Juanes F, Dudas SE. Human Consumption of Microplastics. Environ Sci Technol. 2019;53(12):7068–74. https://doi.org/10.1021/acs.est.9b01517 . PubMed PMID: 31184127.

Article  PubMed  CAS  Google Scholar 

Hanahan D. Hallmarks of Cancer: New Dimensions. Cancer Discov. 2022;12(1):31–46. https://doi.org/10.1158/2159-8290.CD-21-1059.

Article  PubMed  CAS  Google Scholar 

Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436–44. https://doi.org/10.1038/nature07205.

Article  PubMed  CAS  Google Scholar 

Grivennikov SI, Greten FR, Karin M. Immunity, Inflammation, and Cancer. Cell. 2010;140(6):883–99. https://doi.org/10.1016/j.cell. .2010.01.025 PubMed PMID: 20303878; PubMed Central PMCID: PMC2866629.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420(6917):860–7. https://doi.org/10.1038/nature01322 . PubMed PMID: 12490959; PubMed Central PMCID: PMC2803035.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Garrett WS. Cancer and the microbiota. Science. 2015;348(6230):80–6. https://doi.org/10.1126/science.aaa4972.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Louis P, Hold GL, Flint HJ. The gut microbiota, bacterial metabolites and colorectal cancer. Nat Rev Microbiol. 2014;12(10):661–72. https://doi.org/10.1038/nrmicro3344.

Article  PubMed  CAS  Google Scholar 

Wong SH, Yu J. Gut microbiota in colorectal cancer: mechanisms of action and clinical applications. Nat Rev Gastroenterol Hepatol. 2019;16(11):690–704. https://doi.org/10.1038/s41575-019-0209-8.

Article  PubMed  CAS  Google Scholar 

Cirillo F, Gianì F, Sergi V, Scordamaglia D, Giallongo S, Tibullo D, et al. The hidden threat: Microplastics and cancer biology. J Hazard Mater. 2026;505:141332. https://doi.org/10.1016/j.jhazmat.2026.141332.

Article  PubMed  CAS  Google Scholar 

Bogani G, Trimarchi E, Chiappa V, Vizzielli G, Raspagliesi F, La Vecchia C et al. Microplastics and cancer. Eur J Cancer Prev. https://doi.org/10.1097/CEJ.0000000000000999

Casella C, Dondi D, Vadivel D. Do microplastics (MPs) and nanoplastics (NPs) directly contribute to human carcinogenesis? Environ Pollut. 2026;388:127343. https://doi.org/10.1016/j.envpol.2025.127343.

Article  PubMed  CAS  Google Scholar 

Chartres N, Cooper CB, Bland G, Pelch KE, Gandhi SA, BakenRa A, et al. Effects of Microplastic Exposure on Human Digestive, Reproductive, and Respiratory Health: A Rapid Systematic Review. Environ Sci Technol. 2024;58(52):22843–64. https://doi.org/10.1021/acs.est.3c09524 . PubMed PMID: 39692326; PubMed Central PMCID: PMC11697325.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lamoree MH, van Boxel J, Nardella F, Houthuijs KJ, Brandsma SH, Béen F, et al. Health impacts of microplastic and nanoplastic exposure. Nat Med. 2025;31(9):2873–87. https://doi.org/10.1038/s41591-025-03902-5.

Article  PubMed  CAS  Google Scholar 

Cowger W, Gray A, Christiansen SH, DeFrond H, Deshpande AD, Hemabessiere L, et al. Critical Review of Processing and Classification Techniques for Images and Spectra in Microplastic Research. Appl Spectrosc. 2020;74(9):989–1010. https://doi.org/10.1177/0003702820929064.

Article  PubMed  CAS  Google Scholar 

Primpke S, Christiansen SH, Cowger W, De Frond H, Deshpande A, Fischer M, et al. Critical Assessment of Analytical Methods for the Harmonized and Cost-Efficient Analysis of Microplastics. Appl Spectrosc. 2020;74(9):1012–47. https://doi.org/10.1177/0003702820921465.

Article  PubMed  CAS  Google Scholar 

Koelmans AA, Bakir A, Burton GA, Janssen CR. Microplastic as a Vector for Chemicals in the Aquatic Environment: Critical Review and Model-Supported Reinterpretation of Empirical Studies. Environ Sci Technol. 2016;50(7):3315–26. https://doi.org/10.1021/acs.est.5b06069 . PubMed PMID: 26946978; PubMed Central PMCID: PMC6863595.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kutralam-Muniasamy G, Shruti VC, Pérez-Guevara F, Roy PD. Microplastic diagnostics in humans: The 3Ps Progress, problems, and prospects. Sci Total Environ. 2023;856:159164. https://doi.org/10.1016/j.scitotenv.2022.159164.

Article  PubMed  CAS  Google Scholar 

Mason SA, Welch VG, Neratko J. Synthetic Polymer Contamination in Bottled Water. Front Chem. 2018;6:407. https://doi.org/10.3389/fchem. 2018.00407 PubMed PMID: 30255015; PubMed Central PMCID: PMC6141690.

Article  PubMed  PubMed Central  Google Scholar 

Hagelskjær O, Hagelskjær F, Margenat H, Yakovenko N, Sonke JE, Roux GL. Majority of potable water microplastics are smaller than the 20 µm EU methodology limit for consumable water quality. PLOS Water. 2025;4(1):e0000250. https://doi.org/10.1371/journal.pwat.0000250.

Article  Google Scholar 

Chen H, Xu L, Yu K, Wei F, Zhang M. Release of microplastics from disposable cups in daily use. Sci Total Environ. 2023;854:158606. https://doi.org/10.1016/j.scitotenv.2022.158606.

Article  PubMed  CAS 

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