Biswas T, Mittal RK, Sharma V, Kanupriya, Mishra I. Nitrogen-fused heterocycles: empowering anticancer drug discovery. Med Chem. 2024;20:369–84. https://doi.org/10.2174/0115734064278334231211054053.
Article CAS PubMed Google Scholar
Kanupriya, Mittal RK, Sharma V, Biswas T, Mishra I. Recent advances in nitrogen-containing heterocyclic scaffolds as antiviral agents. Med Chem. 2024;20:487–502. https://doi.org/10.2174/0115734064280150231212113012.
Article CAS PubMed Google Scholar
Grygorenko OO, Volochnyuk DM, Vashchenko BV. Emerging building blocks for medicinal chemistry: recent synthetic advances. Eur J Org Chem. 2021;47:6478–510. https://doi.org/10.1002/ejoc.202100857.
Fuertes M, Masdeu C, Martin-Encinas E, Selas A, Rubiales G, Palacios F, Alonso C. Synthetic strategies, reactivity and applications of 1,5-naphthyridines. Molecules. 2020;25:3252. https://doi.org/10.3390/molecules25143252.
Article CAS PubMed PubMed Central Google Scholar
Brown LD, Girgis AS, Patel S, Samir N, Said MF, Baidya ATK, Kumar R, et al. Novel isatin conjugates endowed with analgesic and anti-inflammatory properties: design, synthesis and biological evaluation. Future Med Chem. 2025;17:59–73. https://doi.org/10.1080/17568919.2024.2437981.
Article CAS PubMed Google Scholar
Ali F, Hussain S, Qazi NG, Wahab A, Pirzada AS, Ikram M. Investigating the anti-leishmanial potential of phytoconstituents derived from Anchusa arvensis: in vitro and network pharmacology study. J Health Wellness Community Res. 2025;e824. https://doi.org/10.61919/0tgkzm06.
Nagoor Meeran MF, Goyal SN, Suchal K, Sharma C, Patil CR, Ojha SK. Pharmacological properties, molecular mechanisms, and pharmaceutical development of asiatic acid. Front Pharmacol. 2018;9:892. https://doi.org/10.3389/fphar.2018.00892.
Article CAS PubMed PubMed Central Google Scholar
Luo X, Deng Y, Li X, Zhang Y, Deng C, Zhang W. Application of carboxylic acid bioisosteres in drug structure optimization. Eur J Med Chem. 2025;118104. https://doi.org/10.1016/j.ejmech.2025.118104.
Mithula S, Nandikolla A, Murugesan S, Kondapalli VGCS. 1,8-Naphthyridine derivatives: recent advancements of their biological activities. Future Med Chem. 2021;13:1591–618. https://doi.org/10.4155/fmc-2021-0086.
Article CAS PubMed Google Scholar
Shireesha K, Siddoju K, Velidandi A, Jella KS. Design and synthesis of biologically active 1,8-naphthyridine amine scaffolds. J Mol Struct. 2025;143422. https://doi.org/10.1016/j.molstruc.2025.143422.
Adhikari S, Nath S, Sen T, Raza R, Sahin O, Eftekhari-Sis B, Mahmoudi G, et al. Tetrazole–1,8-naphthyridine–amide hybrid: structural characterization and anticancer potential. J Mol Struct. 2025;1321:139803. https://doi.org/10.1016/j.molstruc.2024.139803.
Nielsen MT, Mihrin D, Jørgensen MSB, Yan X, Berg RW, Xiao X, Larsen RW, Nielsen M. Paddlewheel complex of 1,8-naphthyridine and palladium(II). Polyhedron. 2025;267:117310. https://doi.org/10.1016/j.poly.2024.117310.
Kataoka Y, Tada N, Masamori N, Yano N, Moriyoshi C, Handa M. Diruthenium complexes with 1,8-naphthyridine-2-carboxylate. Dalton Trans. 2025;54:3047–56. https://doi.org/10.1039/D4DT03321C.
Article CAS PubMed Google Scholar
Surender Reddy S, Shireesha K, Jella KS. Synthesis and biological evaluation of [1,8]-naphthyridine derivatives. Polycycl Aromat Compd. 2025;1–14. https://doi.org/10.1080/10406638.2025.xxxx.
Srilekha A, Shireesha K, Jella KS. N-Phenyl-1,8-naphthyridine-thiazole derivatives. J Mol Struct. 2025;142335. https://doi.org/10.1016/j.molstruc.2025.142335.
Luo W, Zheng X, Lin H, Fu L, Long L, Yu D, Chen Z, Yang M, Wang ZX. Cascade annulation for dihydrobenzo[1,8]naphthyridines. Chem Sci. 2025;16:4119–26. https://doi.org/10.1039/D4SC07999J.
Article CAS PubMed PubMed Central Google Scholar
Simran, Tansky M, Trabulsi S, Deng L, Chu CW, Ozarowski A, Comito RJ. Cooperative redox catalysis in divanadium complexes. Dalton Trans. 2025;54:15400–5. https://doi.org/10.1039/D5DT01296A.
Ahmed NS, Abuzahra M, Sarhan M, Zaghary WA. 1,8-Naphthyridine analogues: anticancer potential. Egypt J Chem. 2023;66:331–53. https://doi.org/10.21608/ejchem.2023.183386.7384.
Saleh MY, Al-barwari ASMO, Ayoob AI. Novel 1,8-naphthyridine chalcones as antibacterial agents. J Nanostruct. 2022;12:598–606. https://doi.org/10.22052/JNS.2022.03.013. 8-Naphthyridine Chalcones as.
Choudhury SS, Jena S, Sahoo DK, Shekh S, Kar RK, Dhakad A, Gowd KH, Biswal HS. Gram-scale synthesis of 1,8-naphthyridines. ACS Omega. 2021;6:19304–13. https://doi.org/10.1021/acsomega.1c02798.
Article CAS PubMed PubMed Central Google Scholar
Dai L, Zhou X, Guo J, Huang Q, Lu Y. Copper-catalyzed atroposelective synthesis enabled by 1,8-naphthyridine ligands. Chem Sci. 2024;15:5993–6001. https://doi.org/10.1039/D4SC01074D.
Article CAS PubMed PubMed Central Google Scholar
Khetmalis YM, Shobha S, Nandikolla A, Chandu A, Murugesan S, Kumar MMK, Sekhar KVGCS. Anti-mycobacterial evaluation of 1,8-naphthyridine-3-carbonitriles. RSC Adv. 2024;14:22676–89. https://doi.org/10.1039/D4RA04262J.
Article CAS PubMed PubMed Central Google Scholar
Trivedi A, Kumar A, Singh AK, Prajapati V, Kalsi AS, Verma A, Kumar P. Medicinal chemistry perspective of 1,8-naphthyridines. Chem Biodivers. 2025;e01396. https://doi.org/10.1002/cbdv.202501396.
Elkanzi NAA, Hrichi H, Alsirhani AM, Bakr RB. Antioxidant and antimicrobial potential of 1,8-naphthyridine scaffolds. Chem Biodivers. 2024;21:e202301746. https://doi.org/10.1002/cbdv.202301746.
Article CAS PubMed Google Scholar
Pandya KM, Battula S, Kumar KAA, Patel RJ, Patel NB. Hybrid pharmacophore of β-lactam and 1,8-naphthyridine. Med Chem Res. 2023;32:1098–108. https://doi.org/10.1007/s00044-023-03058-2.
Comments (0)