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Evaluation of the Neuroprotective Efficacies and Related Mechanisms of Cirsimaritin in MPTP-Induced Parkinson in Mice with Following the Molecular Docking Studies
Evaluation of the Neuroprotective Efficacies and Related Mechanisms of Cirsimaritin in MPTP-Induced Parkinson in Mice with Following the Molecular Docking Studies
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuronal loss and...
Composition-dependent Effects of Nano-emulsions on the Antibacterial Activity of Ciprofloxacin Against and
Composition-dependent Effects of Nano-emulsions on the Antibacterial Activity of Ciprofloxacin Against and
The widespread emergence of antibiotic resistance presents a growing global health challenge, with Pseudomonas aeruginosa ...
A New Validated Stability Indicating RP-HPLC Method for the Simultaneous Estimation of Xanomeline and Trospium Chloride in Bulk and in its Pharmaceutical Formulation
A New Validated Stability Indicating RP-HPLC Method for the Simultaneous Estimation of Xanomeline and Trospium Chloride in Bulk and in its Pharmaceutical Formulation
A stability-indicating RP-HPLC method was developed and validated for the simultaneous estimation of Xanomeline (XAE) and ...
Mannosylated Chitosan–Coated Berberine Hydrochloride Cubosomal Hydrogel for Targeted Macrophage-Mediated Wound Healing
Mannosylated Chitosan–Coated Berberine Hydrochloride Cubosomal Hydrogel for Targeted Macrophage-Mediated Wound Healing
Wounds are breaks in the skin or tissues caused by trauma or surgery and require a complex healing process to restore inte...
Non Polar Fraction from Selectively Inhibit Hep-2 C Cancer Cell Proliferation; Insights from GCMS and HRLCMS-QTOFS Profiling
Non Polar Fraction from Selectively Inhibit Hep-2 C Cancer Cell Proliferation; Insights from GCMS and HRLCMS-QTOFS Profiling
The objective of current study encompasses to evaluate the phytochemical composition of hexane extract (IRK-H) from the fl...
Inhalable Sildenafil-Loaded Novasomes for Targeted Pulmonary Delivery in Pulmonary Arterial Hypertension: Formulation Optimization, Safety Evaluation, and Pharmacokinetic Assessment
Inhalable Sildenafil-Loaded Novasomes for Targeted Pulmonary Delivery in Pulmonary Arterial Hypertension: Formulation Optimization, Safety Evaluation, and Pharmacokinetic Assessment
Pulmonary arterial hypertension (PAH) remains a life-threatening disorder requiring innovative therapies to overcome the l...
Supramolecular nanosystems for rutin topical application
Supramolecular nanosystems for rutin topical application
This study presents the development of supramolecular nanosystems for the topical administration of rutin (RU), focusing o...
Preparation, Chemical Characterization and Determination of the Antioxidant, Cytotoxicity and Anti-Breast Properties of Plant Extract Green-Synthesized Iron Nanoparticles
Preparation, Chemical Characterization and Determination of the Antioxidant, Cytotoxicity and Anti-Breast Properties of Plant Extract Green-Synthesized Iron Nanoparticles
Iron nanoparticles are used in cancer treatment mainly as multifunctional platforms for magnetic hyperthermia, radiosensit...
Development and Validation of a Novel and Green RP-HPLC Method for the Simultaneous Analysis of Chloride, Sodium Citrate, Glycine, Niacinamide, D-Panthenol, and Pyridoxine in ORT LRG Liquid
Development and Validation of a Novel and Green RP-HPLC Method for the Simultaneous Analysis of Chloride, Sodium Citrate, Glycine, Niacinamide, D-Panthenol, and Pyridoxine in ORT LRG Liquid
The present study aimed to develop a novel and green analytical method for the simultaneous analysis of Chloride, Sodium C...
Phytoprotective Effects of Linn against Crystalline Damage: Examining the Renal Protective Role in Ethylene Glycol-Induced Urolithiasis in Rats
Phytoprotective Effects of Linn against Crystalline Damage: Examining the Renal Protective Role in Ethylene Glycol-Induced Urolithiasis in Rats
The wood apple Limonia acidissima Linn has long been used in Ayurveda to treat urinary and renal conditions. Despite its w...
O-Butyryl Chitosan Nanoparticles Enhance Baicalin Efficacy: A Study on Transdermal Penetration, Antioxidant, Anti-inflammatory, and Melanogenesis-Inhibiting Activities
O-Butyryl Chitosan Nanoparticles Enhance Baicalin Efficacy: A Study on Transdermal Penetration, Antioxidant, Anti-inflammatory, and Melanogenesis-Inhibiting Activities
The study aimed to develop an O-butyryl chitosan nanoparticles (O-CTS/BAI NPs) delivery system to enhance the transdermal ...
Rosuvastatin‒Natural Oil Self Nanosized Emulsion Incorporated into Hyaluronic Acid‒Based Hydrogel for Wound Healing
Rosuvastatin‒Natural Oil Self Nanosized Emulsion Incorporated into Hyaluronic Acid‒Based Hydrogel for Wound Healing
Remodeling damaged tissues and managing infection are two crucial steps in the intricate process of the healing of chronic...
Development of a Novel 1,8-Naphthyridine–Thiazolidinone Derivative: Synthesis, Spectral Characterization, Antimicrobial Profiling, and ADME Prediction
Development of a Novel 1,8-Naphthyridine–Thiazolidinone Derivative: Synthesis, Spectral Characterization, Antimicrobial Profiling, and ADME Prediction
A novel series of 1,8-naphthyridine–thiazolidinone hybrid derivatives, namely (Z)-2-(5-benzylidene-2,4-dioxothiazoli...
Evaluation of Dual Effect of Sodium Borohydride (NaBH) as a Reducing and Crosslinking Agent for Development of Novel Silver Nanoparticles (AgNPs) Loaded Chitosan-Poly (Vinyl Alcohol) (CS-PVA) Hydrogels for Wound Healing Activity
Evaluation of Dual Effect of Sodium Borohydride (NaBH) as a Reducing and Crosslinking Agent for Development of Novel Silver Nanoparticles (AgNPs) Loaded Chitosan-Poly (Vinyl Alcohol) (CS-PVA) Hydrogels for Wound Healing Activity
Hydrogels are three-dimensional, crosslinked polymeric systems with high hydrophilicity and biocompatibility, making them ...
Revealing the Immunomodulatory Targets and Mechanisms of Sijing Pill for Postmenopausal Osteoporosis: A UHPLC-MS-Based Bioinformatics and Machine Learning Study
Revealing the Immunomodulatory Targets and Mechanisms of Sijing Pill for Postmenopausal Osteoporosis: A UHPLC-MS-Based Bioinformatics and Machine Learning Study
This study aimed to elucidate the pharmacological mechanisms of Sijing Pill (SJP) in treating postmenopausal osteoporosis ...
AQbD enabled analytical method development and validation for simultaneous estimation of Asiaticoside (AC) and Chlorhexidine (CHX) in nanostructured lipid carriers
AQbD enabled analytical method development and validation for simultaneous estimation of Asiaticoside (AC) and Chlorhexidine (CHX) in nanostructured lipid carriers
The purpose of current study was to develop a sensitive, rapid, cost-effective, and precise Reverse Phase High Performance...
QbD-Guided RP-HPLC Method for Luteolin Featuring Full Factorial Design and Response Surface Optimization
QbD-Guided RP-HPLC Method for Luteolin Featuring Full Factorial Design and Response Surface Optimization
This study aimed to develop and optimize a rapid, robust, and efficient reversed-phase HPLC (RP-HPLC) method for luteolin ...
Machine Learning-guided Virtual Screening and Molecular Dynamics Simulations for Identifying Potent FGFR1 Inhibitors as Anti-neoplastic Agents
Machine Learning-guided Virtual Screening and Molecular Dynamics Simulations for Identifying Potent FGFR1 Inhibitors as Anti-neoplastic Agents
Quick identification of new molecules against protein involved in cancer pathogenesis by machine learning (ML) ap...
Development and Optimization of 3D-Printed Orally Dissolving Films of Vitamin D₃ Using a Quality by Design Approach
Development and Optimization of 3D-Printed Orally Dissolving Films of Vitamin D₃ Using a Quality by Design Approach
Vitamin D₃ (cholecalciferol) deficiency remains a global health concern, exacerbated by poor patient compliance with...
Fabrication of Centrifugally Spun Microfibers for Quick Release of Flurbiprofen; a Characterization and Process Optimization Study
Fabrication of Centrifugally Spun Microfibers for Quick Release of Flurbiprofen; a Characterization and Process Optimization Study
Despite the recent pharmaceutical advancements and dosage form modifications, the poor dissolution rates of BCS class II d...
Formulation, Evaluation, Factorial Optimization, and In-Silico Study of Eplerenone Loaded Pectin Nanoparticles: A New Approach to the Proliferation of Human Skin Fibroblasts for Wound Healing
Formulation, Evaluation, Factorial Optimization, and In-Silico Study of Eplerenone Loaded Pectin Nanoparticles: A New Approach to the Proliferation of Human Skin Fibroblasts for Wound Healing
Repurposing Eplerenone (EPL) for wound healing through in silico molecular docking to explore its therapeutic potential be...
An Analysis of FDA Warning Letter Citations from 2019-2023
An Analysis of FDA Warning Letter Citations from 2019-2023
This study investigates trends in the issuance of FDA warning letters from 2019 to 2023. The paper aims to assess past and...
An Investigation into the Preparation, Characterization, and Therapeutic Applications of Novel Gefitinib/Capric Acid Deep Eutectic Systems
An Investigation into the Preparation, Characterization, and Therapeutic Applications of Novel Gefitinib/Capric Acid Deep Eutectic Systems
In this work, we sought to report and fully characterise novel therapeutic deep eutectic systems (THEDESs) formed between ...
Synthesis, Structural Characterization, and Antimicrobial Evaluation of Silver Nanoparticle-embedded Layered Double Hydroxides for Delivery in Polymeric Hydrogel Matrices
Synthesis, Structural Characterization, and Antimicrobial Evaluation of Silver Nanoparticle-embedded Layered Double Hydroxides for Delivery in Polymeric Hydrogel Matrices
This study aimed to synthesize and characterize silver nanoparticle-embedded layered double hydroxides (Ag-LDH) nanohybrid...
Veracity of In Silico Approach for Designing Rivastigmine-Polymer Nano Complexes for Intranasal Delivery: Prediction and In Vitro Validation
Veracity of In Silico Approach for Designing Rivastigmine-Polymer Nano Complexes for Intranasal Delivery: Prediction and In Vitro Validation
Rivastigmine (RT), exhibits low oral availability (40%) and high hepatic first-pass (36%). Circumventing the blood-brain b...
The Synergistic Effect of Butter Oil and Capsaicin in the Microemulsion Based gel Formulation for Anti-Inflammatory Effect in Treatment of Arthritis
The Synergistic Effect of Butter Oil and Capsaicin in the Microemulsion Based gel Formulation for Anti-Inflammatory Effect in Treatment of Arthritis
Certain oils like butter oil and sesame oil have been traditionally used to reduce inflammation. The objective of the stud...
Formulation and Packaging Considerations in Developing Pediatric Oral Liquid Medication: A Caregiver-Reported Cross-Sectional Study Focusing on Excipient Selectivity and Packaging Design
Formulation and Packaging Considerations in Developing Pediatric Oral Liquid Medication: A Caregiver-Reported Cross-Sectional Study Focusing on Excipient Selectivity and Packaging Design
The acceptability of oral medication by children is crucial for ensuring compliance and therapeutic effectiveness while de...
Formulation Optimization of Metformin-Loaded Propyl Moringa Gum Beads
Formulation Optimization of Metformin-Loaded Propyl Moringa Gum Beads
The purpose of the present work was to optimize the formulation of extended-release, metformin-loaded ionically-gelled pro...
Implementing Quality by Design for Development and Optimization of Sublingual Tablet of Valsartan
Implementing Quality by Design for Development and Optimization of Sublingual Tablet of Valsartan
Heart failure, a progressive cardiovascular disorder, significantly affects patient morbidity and mortality. Valsartan, an...
Design of a Pharmaceutical 3D Printer Using Quality-by-Design Approach
Design of a Pharmaceutical 3D Printer Using Quality-by-Design Approach
Pharmaceutical three-dimensional (3D) printing is an innovative production technique which enables the manufacturing of pe...
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