Gil G, Tosin MHS, Ferraz HB. The impact of the socioeconomic factor on Parkinson’s disease medication adherence: a scoping review. Arq Neuropsiquiatr. 2024;82(2):1–8.

PubMed  PubMed Central  Google Scholar 

Dovonou A, Bolduc C, Soto Linan V, Gora C, Peralta Iii MR, Lévesque M. Animal models of Parkinson's disease: bridging the gap between disease hallmarks and research questions. Transl Neurodegener. 2023;12(1):36.

Dorsey ER, Elbaz A, Nichols E, Abd-Allah F, Abdelalim A, Adsuar JC, et al. Global, regional, and national burden of Parkinson’s disease, 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet Neurol. 2018;17(11):939–53.

Article  Google Scholar 

Kim DJ, Rodriguez-Salgado AM, Llibre-Rodriguez JJ, Acosta I, Sosa AL, Acosta D, et al. Burden of parkinsonism and Parkinson’s disease on health service use and outcomes in Latin America. J Parkinsons Dis. 2023;13(7):1199–211.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chaudhuri KR, Azulay JP, Odin P, Lindvall S, Domingos J, Alobaidi A, et al. Economic burden of Parkinson’s disease: a multinational, real-world, cost-of-illness study. Drugs. 2024;11(1):1–11.

Google Scholar 

Schneider RB, Iourinets J, Richard IH. Parkinson’s disease psychosis: presentation, diagnosis and management. Neurodegener Dis Manag. 2017;7:365–76.

Article  PubMed  Google Scholar 

Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, et al. Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease. J Biol Chem. 2013;288(6):4436–51.

Article  CAS  PubMed  Google Scholar 

Goloborshcheva VV, Kucheryanu VG, Voronina NA, Teterina EV, Ustyugov AA, Morozov SG. Synuclein proteins in MPTP-induced death of substantia nigra pars compacta dopaminergic neurons. Biomedicines. 2022;10:2278.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nonnekes J, Timmer MHM, de Vries NM, Rascol O, Helmich RC, Bloem BR. Unmasking levodopa resistance in Parkinson’s disease: unmasking levodopa resistance in PD. Mov Disord. 2016;31(11):1602–9.

Article  CAS  PubMed  Google Scholar 

Bhusal CK, Uti DE, Mukherjee D, Alqahtani T, Alqahtani S, Bhattacharya A, et al. Unveiling nature’s potential: promising natural compounds in Parkinson’s disease management. Parkinsonism Relat Disord. 2023;115:105799.

Article  CAS  PubMed  Google Scholar 

Rijo P, Simões MF, Duarte A, Rodríguez B. Isopimarane diterpenoids from Aeollanthus rydingianus and their antimicrobial activity. Phytochemistry. 2009;70:1161–5.

Article  CAS  PubMed  Google Scholar 

Pathak G, Singh S, Kumari P, Raza W, Hussain Y, Meena A. Cirsimaritin, a lung squamous carcinoma cells (NCIH-520) proliferation inhibitor. J Biomol Struct Dyn. 2020;39:3312–23.

PubMed  Google Scholar 

Ibañez E, Kubátová A, Señoráns FJ, Cavero S, Reglero U, Hawthorne SB. Subcritical water extraction of antioxidant compounds from rosemary plants. J Agric Food Chem. 2002;51:375–82.

Article  Google Scholar 

Shin MS, Park JY, Lee J, Yoo HH, Hahm DH, Lee SC, et al. Anti-inflammatory effects and corresponding mechanisms of Cirsimaritin extracted from Cirsium japonicum var. Maackii maxim. Bioorg Med Chem Lett. 2017;27:3076–80.

Article  CAS  PubMed  Google Scholar 

Alqudah A, Athamneh RY, Qnais E, Gammoh O, Oqal M, AbuDalo R, Alshaikh HA, Al-Hashimi N, Alqudah M. The emerging importance of Cirsimaritin in type 2 diabetes treatment. Int J Mol Sci. 2023;24(6):5749.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ielciu I, Sevastre B, Olah NK, Turdean A, Chișe E, Marica R, et al. Evaluation of hepatoprotective activity and oxidative stress reduction of Rosmarinus officinalis L. shoots tincture in rats with experimentally induced hepatotoxicity. Molecules. 2021;26(6):1737.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan H, Wang B, Zhang Y, et al. A cryo-electron microscopy support film formed by 2D crystals of hydrophobin HFBI. Nat Commun. 2021;12(1):7257.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kavanagh, K.L., Oppermann, U. Crystal structure of human glutathione peroxidase 7. 2007. https://www.rcsb.org/structure/2P31.

Google Scholar 

Manjula R, Wright GSA, Strange RW, Padmanabhan B. Assessment of ligand binding at a site relevant to SOD1 oxidation and aggregation. FEBS Lett. 2018;592(10):1725–37.

Article  CAS  PubMed  Google Scholar 

Suzuki M, Youle RJ, Tjandra N. Structure of Bax: coregulation of dimer formation and intracellular localization. Cell. 2000;103(4):645–54.

Article  CAS  PubMed  Google Scholar 

Petros AM, Medek A, Nettesheim DG, Kim DH, Yoon HS, Swift K, Matayoshi ED, Oltersdorf T, Fesik SW. Solution structure of the antiapoptotic protein bcl-2. Proc Natl Acad Sci USA. 2001;98(6):3012–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang K, Peng T, Tao X, Tian M, Li Y, Wang Z, Ma S, Hu S, Pan X, Xue J, Luo J, Wu Q, Fu Y, Li S. Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. Mol Cell. 2022;82(24):4712–26.

Article  CAS  PubMed  Google Scholar 

Vickers CJ, González-Páez GE, Litwin KM, Umotoy JC, Coutsias EA, Wolan DW. Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids. ACS Chem Biol. 2014;9(10):2194–8.

Article  CAS  PubMed  Google Scholar 

Moertl M, Maskos K, Steuber H. Human caspase 9 in complex with bacterial effector protein. PLoS One. 2013; https://www.rcsb.org/structure/3V3K

Nold SM, Lei H, Mou TC, Bowler BE. Effect of a K72A mutation on the structure, stability, dynamics, and peroxidase activity of human cytochrome c. Biochemistry. 2017;56(26):3358–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, Li Q, Shoemaker BA, Thiessen PA, Yu B, Zaslavsky L, Zhang J, Bolton EE. PubChem 2023 update. Nucleic Acids Res. 2023;51(D1):D1373–80.

Article  PubMed  PubMed Central  Google Scholar 

Polák L, Škoda P, Riedlová K, Krivák R, Novotný M, Hoksza D. PrankWeb 4: a modular web server for protein–ligand binding site prediction and downstream analysis. Nucleic Acids Res. 2025. https://doi.org/10.1093/nar/gkaf421.

Article  PubMed  PubMed Central  Google Scholar 

Eberhardt J, Santos-Martins D, Tillack AF, Forli S. AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings. J Chem Inf Model. 2021;61(8):3891–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brown RE, Corey SC, Moore AK. Differences in measures of exploration and fear in MHC-cogenic C57BL/6J and B6-H-2K mice. Behav Genet. 1999;29:263–71.

Article  Google Scholar 

Perez-Villalba A, Sirerol-Piquer MS, Soriano-Cantón R, Folgado V, Pérez-Cañamás A, Kirstein M, et al. Dopaminergic neuron loss in mice due to increased levels of wild-type human α-Synuclein only takes place under conditions of accelerated aging. Sci Rep. 2024;14(1):2490.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poewe W, Seppi K, Tanner CM, Halliday GM, Brundin P, Volkmann J, et al. Parkinson disease. Nat Rev Dis Primers. 2017;3:17013.

Article  PubMed  Google Scholar 

Homayoun H. Parkinson disease. Ann Intern Med. 2018;169:ITC33–48.

Article  PubMed  Google Scholar 

Han NR, Kim YK, Ahn S, Hwang TY, Lee H, Park HJ. A comprehensive phenotype of non-motor impairments and distribution of alpha-Synuclein deposition in parkinsonism-induced mice by a combination injection of MPTP and probenecid. Front Aging Neurosci. 2020;12:599045.

Article  CAS