Markiewicz-Gospodarek A, Kozioł M, Tobiasz M, Baj J, et al. Burn wound healing: clinical Complications, medical Care, Treatment, and dressing types: the current state of knowledge for clinical practice. Int J Environ Res Public Health. 2022;19:3.

Article  Google Scholar 

Jeschke MG, van Baar ME, Choudhry MA, et al. Burn injury. Nat Rev Dis Prim. 2020;6:1.

Google Scholar 

Singer AJ, Boyce ST. Burn wound healing and tissue engineering. J Burn Care Res. 2017;38(3):e605–13.

Article  PubMed  PubMed Central  Google Scholar 

Saku K, Zhang B, Noda K. Randomized head-to-head comparison of pitavastatin, atorvastatin, and Rosuvastatin for safety and efficacy (quantity and quality of LDL)-The PATROL trial. Circ. 2011;75 6:1493–505.

Google Scholar 

Taylor F, Huffman MD, Macedo AF, et al. Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2013;1:1.

Google Scholar 

- Zhou Q, Liao JK. Pleiotropic effects of statins. - Basic research and clinical perspectives. Circ J. 2010;74(5):818–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

DuBroff R, de Lorgeril M. Cholesterol confusion and Statin controversy. World J Cardiol. 2015;7:404–9.

Article  PubMed  PubMed Central  Google Scholar 

Mohammadkhani N, Gharbi S, Rajani HF. A. Statins: complex outcomes but increasingly helpful treatment options for patients. Eur J Pharmacol 863, pp.172704, 2019.

Davignon J. Beneficial cardiovascular pleiotropic effects of Statins. Circulation. 2004;109:39–43.

Article  Google Scholar 

Tousoulis D, Papageorgiou N, Androulakis E, et al. Diabetes mellitus-associated vascular impairment: novel Circulating biomarkers and therapeutic approaches. J Am Coll Cardiol. 2013;62(8):667–76.

Article  CAS  PubMed  Google Scholar 

Maged A, Abdelkhalek AA, Mahmoud AA, Salah S, Ammar MM, Ghorab MM. September. Mesenchymal stem cells associated with chitosan scaffolds loaded with rosuvastatin to improve wound healing, Eur. J. Pharm. Sci. 2019;127(2018):185–198

Schachter M. Chemical, Pharmacokinetic and pharmacodynamic properties of statins: an update. Fundam Clin Pharmacol. 2005;19:117–25.

Article  CAS  PubMed  Google Scholar 

Sikorski JA. Atherosclerosis/Lipoprotein/Cholesterol metabolism. In: Taylor JB, Triggle DJ, editors. Current medicinal chemistry II. Amsterdam, Netherlands: Elsevier; 2007. pp. 459–94.

Google Scholar 

Husain I, Khan S, Khan S, et al. Unfolding the pleiotropic facades of Rosuvastatin in therapeutic intervention of myriads of neurodegenerative disorders. Clin Exp Pharmacol Physiol. 2019;46(4):283–91.

Article  CAS  PubMed  Google Scholar 

Moeini A, Masi M, Zonno MC, et al. Encapsulation of inuloxin A, a plant germacrane sesquiterpene with potential herbicidal activity, in -cyclodextrins. Org Biomol Chem. 2019;17:2508–15.

Article  CAS  PubMed  Google Scholar 

Tabatabaei SM, et al. The effect of Sesame oil and cucurbita on healing wounds caused by Third-degree burn. J Ski Stem Cell. 2017;4:3–4.

Google Scholar 

Sidibe M, Williams JT. Baobab – Adansonia digitata. Fruits for the future 4. Southampton: International centre for underutilised crops, United Kingdom; 2002.

Google Scholar 

Zimba N, Wren S, Stucki A. Three major tree nut oils of Southern cen-tral africa: their uses and future as commercial base oils. Int J Aromather. 2005;15:177–82.

Article  CAS  Google Scholar 

Chindo IY, Gushit JS, Olotu PN, et al. Comparison of thequality parameters of the seed and condiment oil of Adansonia digitata. J Am Sci. 2010;6:990–4.

Google Scholar 

Murthy SK. Nanoparticles in modern medicine: state of the Art and future challenges. Int J Nanomed. 2007;2(2):129–41.

CAS  Google Scholar 

Yu L, Li C, Xu J, et al. Highly stable concentrated nanoemulsions by the phase inversion composition method at elevated temperature. Langmuir. 2012;28(41):14547–52.

Article  CAS  PubMed  Google Scholar 

Bouchemal K, Briançon S, Perrier E, et al. Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimization. Int J Pharm. 2004;280(1–2):241–51.

Article  CAS  PubMed  Google Scholar 

Zhao L, Zhu Z, Ma L, Li Y. O/W nanoemulsion as an adjuvant for an inactivated H3N2 influenza vaccine: based on particle properties and mode of carrying. Int J Nanomed. 2020;15:2071–83.

Article  CAS  Google Scholar 

Knight KL, Ingersoll CD. Structure of a scholarly manuscript: 66 tips for what goes where. J Athl Train. 1996;31(3):201–6.

CAS  PubMed  PubMed Central  Google Scholar 

Khallaf RA, Aboud HM, Sayed OM. Surface modified niosomes of olanzapine for brain targeting via nasal route; preparation, optimization, and in vivo evaluation. J Lip Res. 2020;30:163–73.

Article  CAS  Google Scholar 

Sindi AM, Hosny KM, Rizg WY, et al. Utilization of experimental design in the formulation and optimization of hyaluronic acid-based nanoemulgel loaded with a turmeric-curry leaf oil nanoemulsion for gingivitis. Drug Deliv. 2023;30(1):2184311.

Article  PubMed  PubMed Central  Google Scholar 

Ngan CL, Basri M, Tripathy M, et al. Physicochemical characterization and thermodynamic studies of Nanoemulsion-Based transdermal delivery system for fullerene. Sci World J. 2014;2014:1–12.

Article  Google Scholar 

Njunda AL, Nsagha DS, Assob JC, et al. In vitro antifungal susceptibility patterns of Candida albicans from HIV and AIDS patients attending the nylon health district hospital in Douala, Cameroon. J Public Health Afr. 2013;3(1):e2.

Article  Google Scholar 

Hosny KM, Alhakamy NA, Almodhwahi MA, et al. Self-Nanoemulsifying system loaded with sildenafil citrate and incorporated within oral lyophilized flash tablets: Preparation, Optimization, and in. Vivo Evaluation Pharm. 2020;12(11):1124.

CAS  Google Scholar 

Abdelbary A, Salem HF, Khallaf RA, Ali AM. Mucoadhesive niosomal in situ gel for ocular tissue targeting: in vitro and in vivo evaluation of lomefloxacin hydrochloride. Pharm Dev Technol. 2017;22(3):409–17.

Article  CAS  PubMed  Google Scholar 

Salem HF, El-Menshawe SF, Khallaf RA, Rabea YK. A novel transdermal nanoethosomal gel of lercanidipine HCl for treatment of hypertension: optimization using box-benkhen design, in vitro and in vivo characterization. Drug Deliv Transl Res. 2020;10(1):227–40.

Article  PubMed  Google Scholar 

Salem HF, Nafady MM, Ewees MGE, Hassan H, Khallaf RA. Rosuvastatin calcium-based novel nanocubic vesicles capped with silver nanoparticles-loaded hydrogel for wound healing management: optimization employing box-behnken design: in vitro and in vivo assessment. J Liposome Res. 2021;32(1):45–61.

Article  PubMed  Google Scholar 

El Yahyaoui O, Bouabid B, Ouaaziz NA. The antibacterial activity and biochemical composition of Adansonia digitata edible parts. Arab Gulf J Sci ResearchVol. 2023;41:91–106.

Google Scholar 

Peng C-YJ, Long H, Abaci S. Power analysis software for educational researchers. J Experimental Educ. 2012;80(2):113–36.

Article  Google Scholar 

Amini M, Younesi H, Bahramifar N, et al. Application of response surface methodology for optimization of lead biosorption in an aqueous solution by Aspergillus Niger. J Hazard Mater. 2008;154(1–3):694–702.

Article  CAS  PubMed  Google Scholar 

Kim HJ, Kim JK, Cho JD, et al. Optimization and characterization of UV-curable adhesives for optical communications by response surface methodology. Polym Test. 2003;22:899–906.

Article  CAS  Google Scholar 

Sakeena MHF, Elrashid SM, Munavvar AS, Azmin MN. Effects of oil and drug concentrations on droplets size of palm oil esters (POEs) nanoemulsion. J Oleo Sci. 2011;60:155–8.

Article  CAS  PubMed  Google Scholar 

Tsai M-J, Fu Y-S, Lin Y-H, et al. The effect of nanoemulsion as a carrier of hydrophilic compound for transdermal delivery. PLoS ONE. 2014;9:e102850.

Article  PubMed  PubMed Central  Google Scholar 

Hosny K, Asfour H, Rizg W, et al. Formulation, Optimization, and evaluation of oregano oil nanoemulsions for the treatment of infections due to oral microbiota. Int J Nanomed. 2021;16:5465–78.

Article  Google Scholar 

Bhardwaj S, Bhatia S, Gupta PS, Singh S. Thiazole derivative based topical nanoemulgel for Inhibition of bacterial virulence in surface infections. Iran J Basic Med Sci. 2022;25(3):352–63.

PubMed  PubMed Central  Google Scholar 

Silva RR, Shrestha-Bajracharya D, Almeida-Leite CM, et al. Short-term therapy with Simvastatin reduces inflammatory mediators and heart inflammation during the acute phase of experimental Chagas disease. Memórias Do Instituto Oswaldo Cruz. 2012;107:513–21.