Aguzzi A, Zhu C (2017) Microglia in prion diseases. J Clin Invest 127(9):3230–3239. https://doi.org/10.1172/JCI90605
Google Scholar
Akshulakov SK, Kerimbayev TT, Biryuchkov MY, Urunbayev YA, Farhadi DS, Byvaltsev VA (2019) Current trends for improving safety of stereotactic brain biopsies: advanced optical methods for vessel avoidance and tumor detection. Front Oncol 9:947. https://doi.org/10.3389/fonc.2019.00947
Google Scholar
Balcerek E, Wlodkowska U, Czajkowski R (2021) Retrosplenial cortex in spatial memory: focus on immediate early genes mapping. Mol Brain 14(1):172. https://doi.org/10.1186/s13041-021-00880-w
Google Scholar
Baldensperger T, Jung T, Heinze T, Schwerdtle T, Hohn A, Grune T (2024) The age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death. Free Radic Biol Med 225:871–880. https://doi.org/10.1016/j.freeradbiomed.2024.10.311
Google Scholar
Banna HU, Slayo M, Armitage JA, Del Rosal B, Vocale L, Spencer SJ (2024) Imaging the eye as a window to brain health: frontier approaches and future directions. J Neuroinflamm 21(1):309. https://doi.org/10.1186/s12974-024-03304-3
Google Scholar
Bartsch T, Dohring J, Rohr A, Jansen O, Deuschl G (2011) CA1 neurons in the human hippocampus are critical for autobiographical memory, mental time travel, and autonoetic consciousness. Proc Natl Acad Sci USA 108(42):17562–17567. https://doi.org/10.1073/pnas.1110266108
Google Scholar
Benavides SH, Monserrat AJ, Farina S, Porta EA (2002) Sequential histochemical studies of neuronal lipofuscin in human cerebral cortex from the first to the ninth decade of life. Arch Gerontol Geriatr 34(3):219–231. https://doi.org/10.1016/s0167-4943(01)00223-0
Google Scholar
Birtel J, Bauer T, Pauleikhoff L, Ruber T, Gliem M, Charbel Issa P (2023) Fundus autofluorescence imaging using red excitation light. Sci Rep 13(1):9916. https://doi.org/10.1038/s41598-023-36217-x
Google Scholar
Bozorg S, Ramirez-Montealegre D, Chung M, Pearce DA (2009) Juvenile neuronal ceroid lipofuscinosis (JNCL) and the eye. Surv Ophthalmol 54(4):463–471. https://doi.org/10.1016/j.survophthal.2009.04.007
Google Scholar
Brandstetter C, Mohr LK, Latz E, Holz FG, Krohne TU (2015) Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage. J Mol Med (Berl) 93(8):905–916. https://doi.org/10.1007/s00109-015-1275-1
Google Scholar
Burns JC, Cotleur B, Walther DM, Bajrami B, Rubino SJ, Wei R, Franchimont N, Cotman SL, Ransohoff RM, Mingueneau M (2020) Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain. Elife. https://doi.org/10.7554/eLife.57495
Google Scholar
Buttini M, Limonta S, Boddeke HW (1996) Peripheral administration of lipopolysaccharide induces activation of microglial cells in rat brain. Neurochem Int 29(1):25–35. https://doi.org/10.1016/0197-0186(95)00141-7
Google Scholar
Campbell JM, Mahbub SB, Habibalahi A, Agha A, Handley S, Anwer AG, Goldys EM (2023) Clinical applications of non‐invasive multi and hyperspectral imaging of cell and tissue autofluorescence beyond oncology. J Biophotonics 16(4):e202200264
Google Scholar
Cataldo AM, Hamilton DJ, Nixon RA (1994) Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease. Brain Res 640(1–2):68–80. https://doi.org/10.1016/0006-8993(94)91858-9
Google Scholar
Chhor V, Moretti R, Le Charpentier T, Sigaut S, Lebon S, Schwendimann L, Ore MV, Zuiani C, Milan V, Josserand J, Vontell R, Pansiot J, Degos V, Ikonomidou C, Titomanlio L, Hagberg H, Gressens P, Fleiss B (2016) Role of microglia in a mouse model of paediatric traumatic brain injury. Brain Behav Immun. https://doi.org/10.1016/j.bbi.2016.11.001
Google Scholar
Chung YG, Schwartz JA, Gardner CM, Sawaya RE, Jacques SL (1997) Diagnostic potential of laser-induced autofluorescence emission in brain tissue. J Korean Med Sci 12(2):135–142. https://doi.org/10.3346/jkms.1997.12.2.135
Google Scholar
Croce AC, Fiorani S, Locatelli D, Nano R, Ceroni M, Tancioni F, Giombelli E, Benericetti E, Bottiroli G (2003) Diagnostic potential of autofluorescence for an assisted intraoperative delineation of glioblastoma resection margins. Photochem Photobiol 77(3):309–318. https://doi.org/10.1562/0031-8655(2003)0770309DPOAFA2.0.CO2
Google Scholar
Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, Littman DR, Dustin ML, Gan WB (2005) ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 8(6):752–758. https://doi.org/10.1038/nn1472
Google Scholar
Davies DS, Ma J, Jegathees T, Goldsbury C (2016) Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer’s disease. Brain Pathol. https://doi.org/10.1111/bpa.12456
Google Scholar
De Luca SN, Sominsky L, Soch A, Wang H, Ziko I, Rank MM, Spencer SJ (2019) Conditional microglial depletion in rats leads to reversible anorexia and weight loss by disrupting gustatory circuitry. Brain Behav Immun 77:77–91. https://doi.org/10.1016/j.bbi.2018.12.008
Google Scholar
del Rosal B, Benayas A (2018) Strategies to overcome autofluorescence in nanoprobe‐driven in vivo fluorescence imaging. Small Methods 2(9):1800075
Google Scholar
Dowson JH, Harris SJ (1981) Quantitative studies of the autofluorescence derived from neuronal lipofuscin. J Microsc 123(Pt 3):249–258. https://doi.org/10.1111/j.1365-2818.1981.tb02469.x
Google Scholar
Duong H, Han M (2013) A multispectral LED array for the reduction of background autofluorescence in brain tissue. J Neurosci Methods 220(1):46–54
Google Scholar
Eikelenboom P, van Gool WA (2004) Neuroinflammatory perspectives on the two faces of Alzheimer’s disease. J Neural Transm 111(3):281–294
Google Scholar
Fan Z, Brooks DJ, Okello A, Edison P (2017) An early and late peak in microglial activation in Alzheimer’s disease trajectory. Brain 140(3):792–803. https://doi.org/10.1093/brain/aww349
Google Scholar
Furube E, Kawai S, Inagaki H, Takagi S, Miyata S (2018) Brain region-dependent heterogeneity and dose-dependent difference in transient microglia population increase during lipopolysaccharide-induced inflammation. Sci Rep 8(1):2203. https://doi.org/10.1038/s41598-018-20643-3
Google Scholar
Gao Y, Liu Q, Xu L, Zheng N, He X, Xu F (2019) Imaging and spectral characteristics of amyloid plaque autofluorescence in brain slices from the APP/PS1 mouse model of Alzheimer’s Disease. Neurosci Bull 35(6):1126–1137. https://doi.org/10.1007/s12264-019-00393-6
Google Scholar
Gosnell ME, Staikopoulos V, Anwer AG, Mahbub SB, Hutchinson MR, Mustafa S, Goldys EM (2021) Autofluorescent imprint of chronic constriction nerve injury identified by deep learning. Neurobiol Dis 160:105528. https://doi.org/10.1016/j.nbd.2021.105528
Google Scholar
Hadoux X, Hui F, Lim JKH, Masters CL, Pebay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Lesage F, Sylvestre JP, Rosa-Neto P, Mathotaarachchi S, Gauthier S, Nasreddine ZS, Arbour JD, Rhéaume M-A, Beaulieu S, Dirani M, Nguyen CTO, Bui BV, Williamson R, Crowston JG, Wijngaarden P (2019) Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease. Nat Commun 10(1):4227. https://doi.org/10.1038/s41467-019-12242-1
Google Scholar
Han X, Chen X, Chen S, Luo Q, Liu X, He A, He S, Qiu J, Chen P, Wu Y, Zhuang J, Yang M, Wu C, Wu N, Yang Y, Ge J, Zhuang J, Yu K (2020) Tetramethylpyrazine attenuates endotoxin-induced retinal inflammation by inhibiting microglial activation via the TLR4/NF-kappaB signalling pathway. Biomed Pharmacother 128:110273. https://doi.org/10.1016/j.biopha.2020.110273
Google Scholar
Hanamsagar R, Alter MD, Block CS, Sullivan H, Bolton JL, Bilbo SD (2017) Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity. Glia 65(9):1504–1520. https://doi.org/10.1002/glia.23176
Google Scholar
Herrando AI, Castillo-Martin M, Galzerano A, Fernández L, Vieira P, Azevedo J, Parvaiz A, Cicchi R, Shcheslavskiy VI, Silva PG (2024) Dual excitation spectral autofluorescence lifetime and reflectance imaging for fast macroscopic characterization of tissues. Biomed Opt Express 15(6):3507–3522
Google Scholar
Hoeijmakers L, Ruigrok SR, Amelianchik A, Ivan D, van Dam AM, Lucassen PJ, Korosi A (2017) Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer’s disease mouse model. Brain Behav Immun 63:160–175. https://doi.org/10.1016/j.bbi.2016.12.023
Google Scholar
Je KH, Ryu WS, Lee SK, Kim EJ, Kim JY, Jang HJ, Park JE, Nahrendorf M, Schellingerhout D, Kim DE (2017) Green-channel autofluorescence imaging: a novel and sensitive technique to delineate infarcts. J Neurosci Methods 279:22–32. https://doi.org/10.1016/j.jneumeth.2017.01.007
Google Scholar
Jeong Y, Huh N, Lee J, Yun I, Lee JW, Lee I, Jung MW (2018) Role of the hippocampal CA1 region in incremental value learning. Sci Rep 8(1):9870. https://doi.org/10.1038/s41598-018-28176-5
Google Scholar
Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, Sher A, Littman DR (2000) Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20(11):4106–4114
Google Scholar
Jung H, Lee D, You H, Lee M, Kim H, Cheong E, Um JW (2023) LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment. Sci Rep 13(1):6547. https://doi.org/10.1038/s41598-023-32798-9
Google Scholar
Legland D, Arganda-Carreras I, Andrey P (2016) MorphoLibJ: integrated library and plugins for mathematical morphology with ImageJ. Bioinformatics 32(22):3532–3534. https://doi.org/10.1093/bioinformatics/btw413
Google Scholar
Loane DJ, Byrnes KR (2010) Role of microglia in neurotrauma. Neurotherapeutics 7(4):366–377. https://doi.org/10.1016/j.nurt.2010.07.002
Google Scholar
London A, Benhar I, Schwartz M (2013) The retina as a window to the brain—from eye research to CNS disorders. Nat Rev Neurol 9(1):44–53
Google Scholar
Malik S, Wang H, Xavier S, Slayo M, Bozinovski S, Sominsky L, Spencer SJ (2023) The role of microglia and monocytes in the generation and resolution of the immune response in female and male rats. Brain Behav Immun 107:179–192. https://doi.org/10.1016/j.bbi.2022.10.011
Google Scholar
McGrory S, Cameron JR, Pellegrini E, Warren C, Doubal FN, Deary IJ, Dhillon B, Wardlaw JM, Trucco E, MacGillivray TJ (2017) The application of retinal fundus camera imaging in dementia: a systematic review. Alzheimers Dement (Amst) 6:91–107. https://doi.org/10.1016/j.dadm.2016.11.001
Google Scholar
Monici M (2005) Cell and tissue autofluorescence research and diagnostic applications. Biotechnol Annu Rev 11:227–256
Google Scholar
Moon M, Kim HG, Hwang L, Seo JH, Kim S, Hwang S, Lee D, Chung H, Oh MS, Lee KT, Park S (2009) Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease by blocking microglial activation. Neurotox Res 15(4):332–347. https://doi.org/10.1007/s12640-009-9037-x
Google Scholar
More SS, Vince R (2015) Hyperspectral imaging signatures detect amyloidopathy in Alzheimer’s mouse retina well before onset of cognitive decline. ACS Chem Neurosci 6(2):306–315. https://doi.org/10.1021/cn500242z
Google Scholar
More SS, Beach JM, Vince R (2016) Early detection of amyloidopathy in Alzheimer’s mice by hyperspectral endoscopy. Invest Ophthalmol vis Sci 57(7):3231–3238. https://doi.org/10.1167/iovs.15-17406
Google Scholar
Murtaj V, Belloli S, Di Grigoli G, Pannese M, Ballarini E, Rodriguez-Menendez V, Marmiroli P, Cappelli A, Masiello V, Monterisi C, Bellelli G, Panina-Bordignon P, Moresco RM (2019) Age and sex influence the neuro-inflammatory response to a peripheral acute LPS challenge. Front Aging Neurosci 11:299. https://doi.org/10.3389/fnagi.2019.00299
Google Scholar
Nociari MM, Lehmann GL, Perez Bay AE, Radu RA, Jiang Z, Goicochea S, Schreiner R
Comments (0)