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CREB2 Functions as a Central Mediator of Oxidative Neuronal Death Triggered by Microglial Glutamate Release Under Neuroinflammatory Conditions
CREB2 Functions as a Central Mediator of Oxidative Neuronal Death Triggered by Microglial Glutamate Release Under Neuroinflammatory Conditions
Glutamate-induced oxidative cytotoxicity is a major driver of neuronal loss in neurodegenerative diseases, yet the upstrea...
Entorhinal Cholecystokinin in Alzheimer’s Disease: Its Earliest Vulnerability and Rescue Effects Across Different Disease Stages in a Mouse Model
Entorhinal Cholecystokinin in Alzheimer’s Disease: Its Earliest Vulnerability and Rescue Effects Across Different Disease Stages in a Mouse Model
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline. The entorhi...
Cooperation of Transcription Factor PAX6 with Chromatin-Remodeling Complex BAF During Embryonic Development in Mammals
Cooperation of Transcription Factor PAX6 with Chromatin-Remodeling Complex BAF During Embryonic Development in Mammals
The transcription factor Pax6, a member of the Pax family class IV, is a key regulator of multiple developmental processes...
Interactions Between Perioperative Anesthesia Management and Gut Microbiota: Current Research Advances
Interactions Between Perioperative Anesthesia Management and Gut Microbiota: Current Research Advances
The gut microbiota (GM), a complex and diverse microbial community residing in the digestive tract, plays a pivotal role i...
Digging Deep into Alzheimer Disease: How Electron Microscopy Helps Elucidating Its Pathogenesis
Digging Deep into Alzheimer Disease: How Electron Microscopy Helps Elucidating Its Pathogenesis
Alzheimer disease (AD), first described by Alzheimer and Perusini in the early twentieth century, is a devastating neurode...
Identification of Biomarkers Associated With Copper Metabolism in Ischemic Stroke Through Bulk RNA Sequencing and Mendelian Randomization Analysis
Identification of Biomarkers Associated With Copper Metabolism in Ischemic Stroke Through Bulk RNA Sequencing and Mendelian Randomization Analysis
Research has shown that impaired copper metabolism is a key factor in the onset and progression of ischemic stroke (IS). T...
Regional Molecular Diversity in Chronic Spinal Cord Injury
Regional Molecular Diversity in Chronic Spinal Cord Injury
The development of next generation cellular and acellular therapies for regenerative repair of the injured spinal cord wil...
Unravelling Synaptic and Metabolic Mechanisms of Cognitive Resilience in Asymptomatic Alzheimer’s Disease Across Two Alzheimer’s Disease Cohorts
Unravelling Synaptic and Metabolic Mechanisms of Cognitive Resilience in Asymptomatic Alzheimer’s Disease Across Two Alzheimer’s Disease Cohorts
Asymptomatic Alzheimer’s Disease (AsymAD) is a preclinical stage of Alzheimer’s Disease (AD) identified by amy...
Microglial Autofluorescence in the Brain and Retina is Dynamically Modulated by Systemic Inflammation
Microglial Autofluorescence in the Brain and Retina is Dynamically Modulated by Systemic Inflammation
The retina—an extension of the central nervous system—contains microglia that survey and respond to injury or ...
Cerebral Hypoperfusion Causes Behavioral Changes and Impairs the Rod Photoreceptor Pathway in the Retina of Aged Mice
Cerebral Hypoperfusion Causes Behavioral Changes and Impairs the Rod Photoreceptor Pathway in the Retina of Aged Mice
Gradual reduction of cerebral blood flow occurs with aging, and it is a major cause of vascular dementia, a group of demen...
D-serine: A Multitalented Neuromodulator in Brain Function, Systemic Homeostasis, and Disease
D-serine: A Multitalented Neuromodulator in Brain Function, Systemic Homeostasis, and Disease
D-serine is an endogenous D-amino acid and a crucial co-agonist for the N-methyl-D-aspartate (NMDA) receptor, well known a...
Neuroradiological Phenotype Expansion of the Siddiqi Syndrome: A Case Report
Neuroradiological Phenotype Expansion of the Siddiqi Syndrome: A Case Report
Siddiqi syndrome is a rare autosomal recessive deafness-dystonia disorder caused by pathogenic variants in the FITM2 gene....
The Double-Edged Sword Effect of the Fibrinolytic System in Alzheimer’s Disease
The Double-Edged Sword Effect of the Fibrinolytic System in Alzheimer’s Disease
Alzheimer’s disease (AD), the most prevalent neurodegenerative disorder, is fundamentally driven by dysregulation be...
A Dopamine D1-Like Receptor Agonist Ameliorates Traumatic Brain Injury Through its Immunosuppressive Effects
A Dopamine D1-Like Receptor Agonist Ameliorates Traumatic Brain Injury Through its Immunosuppressive Effects
Traumatic brain injury (TBI) causes progressive nervous tissue degeneration long after the initial injury due to secondary...
Sex-Dependent Dynamics of Behavioural and Neuropathological Changes in an A53T Alpha-Synuclein Mouse Model of Parkinson’s Disease
Sex-Dependent Dynamics of Behavioural and Neuropathological Changes in an A53T Alpha-Synuclein Mouse Model of Parkinson’s Disease
Parkinson’s disease (PD) is characterised by progressive dopaminergic neurodegeneration, alpha-synuclein (α-syn...
Decoding the Glioblastoma Microenvironment: AI-Driven Analysis of Cellular MRI Signatures for Targeted Therapy
Decoding the Glioblastoma Microenvironment: AI-Driven Analysis of Cellular MRI Signatures for Targeted Therapy
Glioblastoma (GB), the most aggressive primary brain tumor, is characterized by profound inter- and intratumoral heterogen...
Nitric Oxide Donor Alleviates Cardiac Arrest Induced Blood Brain Barrier Injury by Inhibiting HMGB1-ATG5 Mediated Endothelial
Nitric Oxide Donor Alleviates Cardiac Arrest Induced Blood Brain Barrier Injury by Inhibiting HMGB1-ATG5 Mediated Endothelial
Cardiac arrest (CA) and subsequent cardiopulmonary resuscitation (CPR) often cause severe neurological deficits due to isc...
Interplay Between Autophagy, Cellular Senescence, and Brain Aging: Neuroprotective Implications of Intermittent Fasting
Interplay Between Autophagy, Cellular Senescence, and Brain Aging: Neuroprotective Implications of Intermittent Fasting
Aging is characterized by progressive deterioration in cellular function and molecular integrity, which in turn increases ...
Role of Nuclear Receptors on the Progression of Multiple Sclerosis: A Review
Role of Nuclear Receptors on the Progression of Multiple Sclerosis: A Review
Multiple sclerosis (MS) is the consequence of early-onset inflammatory demyelination and progressive neurodegenerative les...
Pyroptosis in Alzheimer’s Disease: Mechanisms and Therapeutic Potential
Pyroptosis in Alzheimer’s Disease: Mechanisms and Therapeutic Potential
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by amyloid plaques, neurofibrillary tangles (...
Senolytic Treatment Attenuates Global Ischemic Brain Injury and Enhances Cognitive Recovery by Targeting Mitochondria
Senolytic Treatment Attenuates Global Ischemic Brain Injury and Enhances Cognitive Recovery by Targeting Mitochondria
The benefits of senolytic therapy have been known in a series of age-related diseases, whereas its potential roles in glob...
Association of Emotional Stress and Adaptive Behavior with Stroke Risk: A Mendelian Randomization Study
Association of Emotional Stress and Adaptive Behavior with Stroke Risk: A Mendelian Randomization Study
Although emotional stress and adaptive behavior are known to influence cardiovascular health, direct evidence linking them...
Druggable Targets for Postpartum Depression: A Mendelian Randomization and Colocalization Study
Druggable Targets for Postpartum Depression: A Mendelian Randomization and Colocalization Study
Postpartum depression (PPD) remains a complex disorder with poorly understood genetic underpinnings. This study systematic...
Molecular Mechanisms of Perivascular Macrophages in Alzheimer’s Disease: Insights from Single-Cell Sequencing and Mendelian Randomization
Molecular Mechanisms of Perivascular Macrophages in Alzheimer’s Disease: Insights from Single-Cell Sequencing and Mendelian Randomization
Alzheimer’s disease (AD) is a leading cause of dementia characterized by neuroinflammation and immune dysregulation....
MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis
MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease associated with demyelination and microglial activation. Signifi...
Molecular Consequences of a Missense Variant, c.1285G > A, Associated With Syndromic Neurodevelopmental Disorder
Molecular Consequences of a Missense Variant, c.1285G > A, Associated With Syndromic Neurodevelopmental Disorder
PHF21A is a histone reader protein that recognizes unmethylated H3 lysine 4 and binds to DNA through its AT-hook motif. PH...
Causal Effects of the Plasma Proteome on Vascular Dementia Risk: A Mendelian Randomization Study with Experimental Validation
Causal Effects of the Plasma Proteome on Vascular Dementia Risk: A Mendelian Randomization Study with Experimental Validation
Vascular dementia (VaD) is a prevalent form of dementia caused by cerebrovascular disease, leading to cognitive impairment...
Elevated Plasma m6A Demethylase FTO Levels Predict Favorable Outcomes Following Acute Ischemic Stroke
Elevated Plasma m6A Demethylase FTO Levels Predict Favorable Outcomes Following Acute Ischemic Stroke
N6-methyladenosine (m6A) modification is prevalent in the mammalian brain and functions as a significant epigenetic regula...
Inhibition of P2Y6 Receptor-Mediated Microglia Phagocytosis Aggravates Brain Injury in Mice of Intracerebral Hemorrhage
Inhibition of P2Y6 Receptor-Mediated Microglia Phagocytosis Aggravates Brain Injury in Mice of Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a devastating stroke subtype leading to severe sensorimotor dysfunction. Many studies sh...
The Role of Estrogen in Mitochondrial Disease
The Role of Estrogen in Mitochondrial Disease
This review aims to investigate the potential role of estrogen in various mitochondrial diseases, such as Leber’s He...
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