A Facile Way to Enhance the Therapeutic Efficacy of Hydrophobic Drugs via Amorphous Solid Dispersions

Wu YL, Pan X, Xie HX, et al. Research progress of biomineralization for the diagnosis and treatment of malignant tumors. Front Pharmacol. 2023;14:01–6.

Google Scholar 

Sun XN, Zhang YT, Li HY, et al. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023;51(D1):D1263–75.

CAS  PubMed  Google Scholar 

Huang XC, Huang YB. Solubilization of organic compounds by arginine-derived polymers. Chin Chem Lett. 2015;26(6):636–40.

CAS  Google Scholar 

Yang YM, Yue CX, Han Y, et al. Tumor-responsive small molecule self-assembled nanosystem for simultaneous fluorescence imaging and chemotherapy of lung cancer. Adv Func Mater. 2016;26(47):8735–45.

CAS  Google Scholar 

Hermans A, Milsmann J, Li HL, et al. Challenges and strategies for solubility measurements and dissolution method development for amorphous solid dispersion formulations. Aaps Journal. 2022;25(1):1–14.

Google Scholar 

Song W, Zhang M, Huang X, et al. Smart L-borneol-loaded hierarchical hollow polymer nanospheres with antipollution and antibacterial capabilities. Mater Today Chem. 2022;26:1–14.

Google Scholar 

Yu DG, Zhao P. The key elements for biomolecules to biomaterials and to bioapplications. Biomol. 2022;12(9):1–3.

CAS  Google Scholar 

Lu HJ, Zhao Y, Qin SC, et al. Fluorine substitution tunes the nanofiber chirality of supramolecular hydrogels to promote cell adhesion and proliferation. Adv Fiber Mater. 2023;5(1):377–87.

CAS  Google Scholar 

Meng Y, Chen LJ, Chen Y, et al. Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing. Nat Commun. 2022;13(1):1–16.

Google Scholar 

Hamasaki H, Hirahara K. The van der Waals cohesive force between two carbon nanotubes. Appl Phys Express. 2023;16(3):1–4.

Google Scholar 

Iwaki S, Fu BX, Hayakawa K. Behavior of protein aggregates via electrostatic interactions or hydrogen bonds during dough formation. J Cereal Sci. 2023;111:1–7.

Google Scholar 

Oshita H, Shimazaki Y. π-π Stacking interaction of metal phenoxyl radical complexes. Mol. 2022;27(3):1–19.

Google Scholar 

Sun Q. The hydrophobic effects: our current understanding. Mol. 2022;27(20):1–27.

CAS  Google Scholar 

Bai S, Pappas C, Debnath S, et al. Stable emulsions formed by self-assembly of interfacial networks of dipeptide derivatives. ACS Nano. 2014;8(7):7005–13.

CAS  PubMed  Google Scholar 

Mane SR, Sathyan A, Shunmugam R. Synthesis of norbornene derived helical copolymer by simple molecular marriage approach to produce smart nanocarrier. Sci Rep. 2017;7(1):44857.

CAS  PubMed  PubMed Central  Google Scholar 

Wei X, Wang Y, Xiong X, et al. Codelivery of a π–π Stacked Dual Anticancer Drug Combination with Nanocarriers for Overcoming Multidrug Resistance and Tumor Metastasis. 2016:26(45): 8266–80.

Meng LJ, Zhang XK, Lu QH, et al. Single walled carbon nanotubes as drug delivery vehicles: Targeting doxorubicin to tumors. Biomater. 2012;33(6):1689–98.

CAS  Google Scholar 

Kim T, Rothmund T, Kissel T, et al. Bioreducible polymers with cell penetrating and endosome buffering functionality for gene delivery systems [J]. J Control Release. 2011;152(1):110–9.

CAS  PubMed  PubMed Central  Google Scholar 

Shah D, Li JG, Shaikh AR, et al. Arginine-aromatic interactions and their effects on arginine-induced solubilization of aromatic solutes and suppression of protein aggregation. Biotechnol Prog. 2012;28(1):223–31.

CAS  PubMed  Google Scholar 

Shukla D, Trout BL. Interaction of arginine with proteins and the mechanism by which it inhibits aggregation. J Phys Chem B. 2010;114(42):13426–38.

CAS  PubMed  Google Scholar 

Jamialahmadi K, Zahedipour F, Karimi G. The role of microRNAs on doxorubicin drug resistance in breast cancer. J Pharm Pharmacol. 2021;73(8):997–1006.

PubMed  Google Scholar 

Ko NR, Lee SJ, Chandrasekaran AP, et al. Smart vitamin micelles as cancer nanomedicines for enhanced intracellular delivery of doxorubicin. Int J Mol Sci. 2021;22(20):1–19.

CAS  Google Scholar 

Jiang QQ, Zhang MM, Sun QW, et al. Enhancing the antitumor effect of doxorubicin with photosensitive metal-organic framework nanoparticles against breast cancer. Mol Pharm. 2021;18(8):3026–36.

CAS  PubMed  Google Scholar 

Zhan L, Wang XX, Zhang YJ, et al. Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway. Exp Ther Med. 2021;22(4):1–9.

Google Scholar 

Fuhrmann K, Schulz JD, Gauthier MA, et al. PEG nanocages as non-sheddable stabilizers for drug nanocrystals. ACS Nano. 2012;6(2):1667–76.

CAS  PubMed  Google Scholar 

Ceriello A, Cremasco F, Romoli E, et al. Insulin lispro protamine suspension in the treatment of patients with type 1 and type 2 diabetes mellitus: a systematic review of published data. Expert Opin Pharmacother. 2012;13(2):255–81.

CAS  PubMed  Google Scholar 

Frank DS, Matzger AJ. Effect of polymer hydrophobicity on the stability of amorphous solid dispersions and supersaturated solutions of a hydrophobic pharmaceutical. Mol Pharm. 2019;16(2):682–8.

CAS  PubMed  PubMed Central  Google Scholar 

Hirano A, Kameda T, Arakawa T, et al. Arginine-assisted solubilization system for drug substances: solubility experiment and simulation. J Phys Chem B. 2010;114(42):13455–62.

CAS  PubMed  Google Scholar 

Li J, Garg M, Shah D, et al. Solubilization of aromatic and hydrophobic moieties by arginine in aqueous solutions. J Chem Phys. 2010:133(5).

Cui PF, Zhuang WR, Hu X, et al. A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units. Chem Commun. 2018;54(59):8218–21.

CAS  Google Scholar 

Mashru RC, Sutariya VB, Sankalia MG, et al. Characterization of solid dispersions of rofecoxib using differential scanning calorimeter. J Therm Anal Calorim. 2005;82(1):167–70.

CAS  Google Scholar 

Gholizadeh R, Wang YJ. Molecular dynamics simulation of the aggregation phenomenon in the late stages of silica materials preparation. Chem Eng Sci. 2018;184:62–71.

CAS  Google Scholar 

Malekshah RE, Fahimirad B, Aallaei M, et al. Synthesis and toxicity assessment of Fe3O4NPs grafted by ∼ NH2-Schiff base as anticancer drug: modeling and proposed molecular mechanism through docking and molecular dynamic simulation. Drug Delivery. 2020;27(1):1201–17.

Google Scholar 

Malekshah RE, Fahimirad B, Khaleghian A. Synthesis, Characterization, Biomedical Application, Molecular Dynamic Simulation and Molecular Docking of Schiff Base Complex of Cu(II) Supported on Fe3O4/SiO2/APTS. Int J Nanomed. 2020;15:2583–602.

CAS  Google Scholar 

Ahmad ZU, Chao B, Konggidinata MI, et al. Molecular simulation and experimental validation of resorcinol adsorption on Ordered Mesoporous Carbon (OMC). J Hazard Mater. 2018;354:258–65.

PubMed  Google Scholar 

Saini RS, Binduhayyim RIH, Gurumurthy V, et al. Dental biomaterials redefined: molecular docking and dynamics-driven dental resin composite optimization. BMC Oral Health. 2024;24(1):1–18.

Google Scholar 

Ma C, Li ZY, Duan XY, et al. Molecular dynamics simulation and performance analysis of polyimide/aramid blends. J Mol Model. 2024;30(1):1–11.

CAS  Google Scholar 

Zhang XF, Shao XN. π-π binding ability of different carbon nano-materials with aromatic phthalocyanine molecules: comparison between graphene, graphene oxide and carbon nanotubes. J Photochem Photobio a-Chem. 2014;278:69–74.

CAS  Google Scholar 

Tu YJ, Zhao Z, Lam JWY, et al. Aggregate Science: much to explore in the Meso World. Matter. 2021;4(2):338–49.

CAS  Google Scholar 

Jiang N, Zhu CY, Li KX, et al. Recent progress in nonconventional luminescent macromolecules and their applications. Macromol. 2024;57(12):5561–77.

CAS  Google Scholar 

Huang H, Liu L, Wang J, et al. Aggregation caused quenching to aggregation induced emission transformation: a precise tuning based on BN-doped polycyclic aromatic hydrocarbons toward subcellular organelle specific imaging. Chem Sci. 2022;13(11):3129–39.

CAS  PubMed  PubMed Central  Google Scholar 

Huang C, Li B. Two luminescent iridium complexes with phosphorous ligands and their photophysical comparison in solution, solid and electrospun fibers: decreased aggregation-caused emission quenching by Steric Hindrance. Mater (Basel, Switzerland). 2021;14(18):1–17.

CAS  Google Scholar 

Fixler D, Namer Y, Yishay Y, et al. Influence of fluorescence anisotropy on fluorescence intensity and lifetime measurement: Theory, simulations and experiments. IEEE Trans Biomed Eng. 2006;53(6):1141–52.

PubMed  Google Scholar 

Rocha FS, Gomes AJ, Lunardi CN, et al. Experimental methods in chemical engineering: Ultraviolet visible spectroscopy-UV-Vis. Can J Chem Eng. 2018;96(12):2512–7.

CAS  Google Scholar 

Gill P, Moghadam TT, Ranjbar B. Differential scanning calorimetry techniques: applications in biology and nanoscience. J Biomol Tech : JBT. 2010;21(4):167–93.

PubMed  PubMed Central  Google Scholar 

Obireddy SR, Lai WF. ROS-generating amine-functionalized magnetic nanoparticles coupled with carboxymethyl chitosan for pH-responsive release of Doxorubicin. Int J Nanomed. 2022;17:589–601.

CAS  Google Scholar 

Miglietta A, Cavalli R, Bocca C, et al. Cellular uptake and cytotoxicity of solid lipid nanospheres (SLN) incorporating doxorubicin or paclitaxel. Int J Pharm. 2000;210(1–2):61–7.

CAS  PubMed 

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