Jeong SH, Jang JH, Lee YB. Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors. J Pharm Investig. 2023;53(1):119–52. https://doi.org/10.1007/s40005-022-00589-5.

Article  PubMed  Google Scholar 

Lee DV, Shen AM, Garbuzenko OB, Minko T. Liposomal formulations of anti-alzheimer drugs and sirna for nose-to-brain delivery: design, safety and efficacy in vitro. AAPS J. 2024;26(5):17. https://doi.org/10.1208/s12248-024-00967-x.

Article  CAS  Google Scholar 

Mardikasari SA, Katona G, Csóka I. Serum albumin in nasal drug delivery systems: exploring the role and application. Pharmaceutics. 2024;16(10):17. https://doi.org/10.3390/pharmaceutics16101322.

Article  CAS  Google Scholar 

Wang M, Ma XY, Zong SY, Su YQ, Su R, Zhang H, et al. The prescription design and key properties of nasal gel for CNS drug delivery: A review. Eur J Pharm Sci. 2024;192:22. https://doi.org/10.1016/j.ejps.2023.106623.

Article  CAS  Google Scholar 

Nakahashi-Ouchida R, Fujihashi K, Kurashima Y, Yuki Y, Kiyono H. Nasal vaccines: solutions for respiratory infectious diseases. Trends Mol Med. 2023;29(2):124–40. https://doi.org/10.1016/j.molmed.2022.10.009.

Article  PubMed  Google Scholar 

Shrewsbury SB. The upper nasal space: option for systemic drug delivery, mucosal vaccines and “nose-to-brain.” Pharmaceutics. 2023;15(6):26. https://doi.org/10.3390/pharmaceutics15061720.

Article  CAS  Google Scholar 

Xu D, Song XJ, Chen X, Wang JW, Cui YL. Advances and future perspectives of intranasal drug delivery: A scientometric review. J Control Release. 2024;367:366–84. https://doi.org/10.1016/j.jconrel.2024.01.053.

Article  CAS  PubMed  Google Scholar 

Aref ZF, Bazeed SEES, Hassan MH, Hassan AS, Rashad A, Hassan RG, et al. Clinical, biochemical and molecular evaluations of ivermectin mucoadhesive nanosuspension nasal spray in reducing upper respiratory symptoms of mild COVID-19. Int J Nanomed. 2021;16:4063–72. https://doi.org/10.2147/ijn.S313093.

Article  CAS  Google Scholar 

Yu Y-S, AboulFotouh K, Xu H, Williams G, Suman J, Cano C, et al. Feasibility of intranasal delivery of thin-film freeze-dried, mucoadhesive vaccine powders. Int J Pharm. 2023;640:122990. https://doi.org/10.1016/j.ijpharm.2023.122990.

Article  CAS  PubMed  Google Scholar 

Baldelli A, Boraey MA, Oguzlu H, Cidem A, Rodriguez AP, Ong HX, et al. Engineered nasal dry powder for the encapsulation of bioactive compounds. Drug Discov Today. 2022;27(8):2300–8. https://doi.org/10.1016/j.drudis.2022.04.012.

Article  CAS  PubMed  Google Scholar 

Trenkel M, Scherließ R. Nasal powder formulations: in-vitro characterisation of the impact of powders on nasal residence time and sensory effects. Pharmaceutics. 2021;13(3):14. https://doi.org/10.3390/pharmaceutics13030385.

Article  CAS  Google Scholar 

Puri V, Kaur VP, Singh A, Singh C. Recent advances on drug delivery applications of mucopenetrative/mucoadhesive particles: A review. J Drug Deliv Sci Technol. 2022;75:25. https://doi.org/10.1016/j.jddst.2022.103712.

Article  Google Scholar 

Muntu CM, Avanti C, Hayun, Surini S. Promising brain biodistribution of insulin via intranasal dry powder for nose-to-brain delivery. Heliyon. 2024;10(13):16. https://doi.org/10.1016/j.heliyon.2024.e33657.

Mieda S, Inoue K, Ito A, Yada S, Miyajima M, Fukami T. Evaluation of the usefulness of hydroxypropyl cellulose and sucrose in the nasal influenza vaccine. J Drug Deliv Sci Technol. 2022;69:8. https://doi.org/10.1016/j.jddst.2022.103165.

Article  CAS  Google Scholar 

Cama ES, Catenacci L, Perteghella S, Sorrenti M, Caira MR, Rassu G, et al. Design and development of a chitosan-based nasal powder of dimethyl fumarate-cyclodextrin binary systems aimed at nose-to-brain administration. A stability study Int J Pharm. 2024;659:14. https://doi.org/10.1016/j.ijpharm.2024.124216.

Article  CAS  Google Scholar 

Fasiolo LT, Manniello MD, Tratta E, Buttini F, Rossi A, Sonvico F, et al. Opportunity and challenges of nasal powders: Drug formulation and delivery. Eur J Pharm Sci. 2018;113:2–17. https://doi.org/10.1016/j.ejps.2017.09.027.

Article  CAS  Google Scholar 

Deruyver L, Rigaut C, Lambert P, Haut B, Goole J. The importance of pre-formulation studies and of 3D-printed nasal casts in the success of a pharmaceutical product intended for nose-to-brain delivery. Adv Drug Deliv Rev. 2021;175:23. https://doi.org/10.1016/j.addr.2021.113826.

Article  CAS  Google Scholar 

Lombardo R, Ruponen M, Rautio J, Lampinen R, Kanninen KM, Koivisto AM, et al. A technological comparison of freeze-dried poly-ε-caprolactone (PCL) and poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with clozapine for nose-to-brain delivery. J Drug Deliv Sci Technol. 2024;93:16. https://doi.org/10.1016/j.jddst.2024.105419.

Article  CAS  Google Scholar 

Gavini E, Rassu G, Ferraro L, Generosi A, Rau JV, Brunetti A, et al. Influence of chitosan glutamate on the in vivo intranasal absorption of rokitamycin from microspheres. J Pharm Sci. 2011;100(4):1488–502. https://doi.org/10.1002/jps.22382.

Article  CAS  PubMed  Google Scholar 

Dalpiaz A, Gavini E, Colombo G, Russo P, Bortolotti F, Ferraro L, et al. Brain uptake of an anti-ischemic agent by nasal administration of microparticles. J Pharm Sci. 2008;97(11):4889–903. https://doi.org/10.1002/jps.21335.

Article  CAS  PubMed  Google Scholar 

Dalpiaz A, Fogagnolo M, Ferraro L, Capuzzo A, Pavan B, Rassu G, et al. Nasal chitosan microparticles target a zidovudine prodrug to brain HIV sanctuaries. Antiviral Res. 2015;123:146–57. https://doi.org/10.1016/j.antiviral.2015.09.013.

Article  CAS  PubMed  Google Scholar 

Fasiolo LT, Manniello MD, Bortolotti F, Buttini F, Rossi A, Sonvico F, et al. Anti-inflammatory flurbiprofen nasal powders for nose-to-brain delivery in Alzheimer’s disease. J Drug Target. 2019;27(9):984–94. https://doi.org/10.1080/1061186x.2019.1574300.

Article  CAS  Google Scholar 

Wong SN, Li S, Low KH, Chan HW, Zhang XY, Chow S, et al. Development of favipiravir dry powders for intranasal delivery: An integrated cocrystal and particle engineering approach via spray freeze drying. Int J Pharm. 2024;653:16. https://doi.org/10.1016/j.ijpharm.2024.123896.

Article  CAS  Google Scholar 

Varga P, Németh A, Zeiringer S, Roblegg E, Budai-Szűcs M, Balla-Bartos C, et al. Formulation and investigation of differently charged (3-cyclodextrin-based meloxicam potassium containing nasal powders. Eur J Pharm Sci. 2024;202:11. https://doi.org/10.1016/j.ejps.2024.106879.

Article  CAS  Google Scholar 

Trenkel M, Scherließ R. Optimising nasal powder drug delivery - Characterisation of the effect of excipients on drug absorption. Int J Pharm. 2023;633:10. https://doi.org/10.1016/j.ijpharm.2023.122630.

Article  CAS  Google Scholar 

Nižić L, Potaś J, Winnicka K, Szekalska M, Erak I, Gretić M, et al. Development, characterisation and nasal deposition of melatonin-loaded pectin/hypromellose microspheres. Eur J Pharm Sci. 2020;141:11. https://doi.org/10.1016/j.ejps.2019.105115.

Article  CAS  Google Scholar 

Van Der Zwaan I, Franek F, Fransson R, Tehler U, Frenning G. Characterization of membrane-type dissolution profiles of clinically available orally inhaled products using a weibull fit and a mechanistic model. Mol Pharm. 2022;19(9):3114–24. https://doi.org/10.1021/acs.molpharmaceut.2c00177.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Amini E, Kurumaddali A, Bhagwat S, Berger SM, Hochhaus G. Optimization of the transwell® system for assessing the dissolution behavior of orally inhaled drug products through in vitro and in silico approaches. Pharmaceutics. 2021;13(8):21. https://doi.org/10.3390/pharmaceutics13081109.

Article  CAS  Google Scholar 

Kumar V, Sethi B, Yanez E, Leung DH, Ghanwatkar YYY, Cheong JAT, et al. Effect of magnesium stearate surface coating method on the aerosol performance and permeability of micronized fluticasone propionate. Int J Pharm. 2022;615:13. https://doi.org/10.1016/j.ijpharm.2022.121470.

Article  CAS  Google Scholar 

Papakyriakopoulou P, Manta K, Kostantini C, Kikionis S, Banella S, Ioannou E, et al. Nasal powders of quercetin-β-cyclodextrin derivatives complexes with mannitol/lecithin microparticles for Nose-to-Brain delivery: In vitro and ex vivo evaluation. Int J Pharm. 2021;607:10. https://doi.org/10.1016/j.ijpharm.2021.121016.

Article  CAS  Google Scholar 

Perkušić M, Nodilo LN, Ugrina I, Špoljarić D, Brala CJ, Pepić I, et al. Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery. Int J Pharm. 2022;624:15. https://doi.org/10.1016/j.ijpharm.2022.122038.

Article