Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63.

PubMed  Google Scholar 

Nasim F, Sabath BF, Eapen GA. Lung cancer. Med Clin North Am. 2019;103:463–73.

PubMed  Google Scholar 

Nooreldeen R, Bach H. Current and future development in lung cancer diagnosis. Int J Mol Sci. 2021;22:8661.

CAS  PubMed  PubMed Central  Google Scholar 

Tammemagi MC, Berg CD, Riley TL, Cunningham CR, Taylor KL. Impact of lung cancer screening results on smoking cessation. J Natl Cancer Inst. 2014;106:dju084.

PubMed  PubMed Central  Google Scholar 

Ambrose JA, Barua RS. The pathophysiology of cigarette smoking and cardiovascular disease: an update. J Am Coll Cardiol. 2004;43:1731–7.

CAS  PubMed  Google Scholar 

McEvoy CT, Spindel ER. Pulmonary effects of maternal smoking on the fetus and child: effects on lung development, respiratory morbidities, and life long lung health. Paediatr Respir Rev. 2017;21:27–33.

PubMed  Google Scholar 

Saint-Andre V, Charbit B, Biton A, Rouilly V, Posseme C, Bertrand A, et al. Smoking changes adaptive immunity with persistent effects. Nature. 2024;626:827–35.

CAS  PubMed  PubMed Central  Google Scholar 

McGrath-Morrow SA, Gorzkowski J, Groner JA, Rule AM, Wilson K, Tanski SE, et al. The effects of nicotine on development. Pediatrics. 2020;145:e20191346.

PubMed  Google Scholar 

Milhorn HT Jr. Nicotine dependence. Am Fam Physician. 1989;39:214–24.

PubMed  Google Scholar 

Rose JE. Disrupting nicotine reinforcement: from cigarette to brain. Ann N Y Acad Sci. 2008;1141:233–56.

PubMed  Google Scholar 

Fan Y, Wang K. Nicotine induces EP4 receptor expression in lung carcinoma cells by acting on AP-2alpha: The intersection between cholinergic and prostanoid signaling. Oncotarget. 2017;8:75854–63.

PubMed  PubMed Central  Google Scholar 

Ochirbat S, Kan TC, Hsu CC, Huang TH, Chuang KH, Chen M, et al. The angiogenic role of the alpha 9-nicotinic acetylcholine receptor in triple-negative breast cancers. Angiogenesis. 2024;27:827–43.

Deng X. Bcl2 family functions as signaling target in nicotine-/NNK-induced survival of human lung cancer cells. Scientifica. 2014;2014:215426.

PubMed  PubMed Central  Google Scholar 

Tang MS, Lee HW, Weng MW, Wang HT, Hu Y, Chen LC, et al. DNA damage, DNA repair and carcinogenicity: Tobacco smoke versus electronic cigarette aerosol. Mutat Res Rev Mutat Res. 2022;789:108409.

CAS  PubMed  Google Scholar 

Wang M, Li Y, Xiao Y, Yang M, Chen J, Jian Y, et al. Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer. Nat Commun. 2021;12:7006.

CAS  PubMed  PubMed Central  Google Scholar 

Xiang T, Fei R, Wang Z, Shen Z, Qian J, Chen W. Nicotine enhances invasion and metastasis of human colorectal cancer cells through the nicotinic acetylcholine receptor downstream p38 MAPK signaling pathway. Oncol Rep. 2016;35:205–10.

CAS  PubMed  Google Scholar 

Cardoso C, Mignon C, Hetet G, Grandchamps B, Fontes M, Colleaux L. The human EZH2 gene: genomic organisation and revised mapping in 7q35 within the critical region for malignant myeloid disorders. Eur J Hum Genet. 2000;8:174–80.

CAS  PubMed  Google Scholar 

Simon JA, Lange CA. Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res. 2008;647:21–9.

CAS  PubMed  Google Scholar 

Kim KH, Roberts CW. Targeting EZH2 in cancer. Nat Med. 2016;22:128–34.

CAS  PubMed  PubMed Central  Google Scholar 

Duan R, Du W, Guo W. EZH2: a novel target for cancer treatment. J Hematol Oncol. 2020;13:104.

CAS  PubMed  PubMed Central  Google Scholar 

Zeng J, Zhang J, Sun Y, Wang J, Ren C, Banerjee S, et al. Targeting EZH2 for cancer therapy: From current progress to novel strategies. Eur J Med Chem. 2022;238:114419.

CAS  PubMed  Google Scholar 

Kumari K, Das B, Adhya A, Chaudhary S, Senapati S, Mishra SK. Nicotine associated breast cancer in smokers is mediated through high level of EZH2 expression which can be reversed by methyltransferase inhibitor DZNepA. Cell Death Dis. 2018;9:152.

PubMed  PubMed Central  Google Scholar 

Jin Z, Gao F, Flagg T, Deng X. Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation. J Biol Chem. 2004;279:40209–19.

CAS  PubMed  Google Scholar 

Guo M, Li X, Tao W, Teng F, Li C. Vibrio splendidus infection promotes circRNA-FGL1-regulated coelomocyte apoptosis via competitive binding to Myc with the deubiquitinase OTUB1 in Apostichopus japonicus. PLoS Pathog. 2024;20:e1012463.

CAS  PubMed  PubMed Central  Google Scholar 

Xu F, Zang T, Chen H, Zhou C, Wang R, Yu Y, et al. Deubiquitinase OTUB1 regulates doxorubicin-induced cardiotoxicity via deubiquitinating c-MYC. Cell Signal. 2024;113:110937.

CAS  PubMed  Google Scholar 

Hecht SS, Hatsukami DK. Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention. Nat Rev Cancer. 2022;22:143–55.

CAS  PubMed  PubMed Central  Google Scholar 

Kim K, Picciotto MR. Nicotine addiction: more than just dopamine. Curr Opin Neurobiol. 2023;83:102797.

CAS  PubMed  PubMed Central  Google Scholar 

Wittenberg RE, Wolfman SL, De Biasi M, Dani JA. Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction. Neuropharmacology. 2020;177:108256.

CAS  PubMed  PubMed Central  Google Scholar 

Zhang Q, Ganapathy S, Avraham H, Nishioka T, Chen C. Nicotine exposure potentiates lung tumorigenesis by perturbing cellular surveillance. Br J Cancer. 2020;122:904–11.

CAS  PubMed  PubMed Central  Google Scholar 

Behrens C, Solis LM, Lin H, Yuan P, Tang X, Kadara H, et al. EZH2 protein expression associates with the early pathogenesis, tumor progression, and prognosis of non-small cell lung carcinoma. Clin Cancer Res. 2013;19:6556–65.

CAS  PubMed  PubMed Central  Google Scholar 

Kim NY, Pyo JS. Clinicopathological significance and prognostic role of EZH2 expression in non-small cell lung cancer. Pathol Res Pract. 2017;213:778–82.

CAS  PubMed  Google Scholar 

Wang B, Liu Y, Luo F, Xu Y, Qin Y, Lu X, et al. Epigenetic silencing of microRNA-218 via EZH2-mediated H3K27 trimethylation is involved in malignant transformation of HBE cells induced by cigarette smoke extract. Arch Toxicol. 2016;90:449–61.

CAS  PubMed  Google Scholar 

Dang CV. MYC on the path to cancer. Cell. 2012;149:22–35.

CAS  PubMed  PubMed Central  Google Scholar 

Fatma H, Maurya SK, Siddique HR. Epigenetic modifications of c-MYC: role in cancer cell reprogramming, progression and chemoresistance. Semin Cancer Biol. 2022;83:166–76.

CAS  PubMed  Google Scholar 

Li D, Wang Y, Dong C, Chen T, Dong A, Ren J, et al. CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1. Oncogene. 2023;42:83–98.

CAS  PubMed  Google Scholar 

Liu T, Jiang L, Tavana O, Gu W. The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11. Cancer Res. 2019;79:1913–24.

CAS  PubMed  PubMed Central  Google Scholar 

Gong H, Li Y, Yuan Y, Li W, Zhang H, Zhang Z, et al. EZH2 inhibitors reverse resistance to gefitinib in primary EGFR wild-type lung cancer cells. BMC Cancer. 2020;20:1189.

CAS  PubMed  PubMed Central  Google Scholar 

Lee JK, Kim KC. DZNep, inhibitor of S-adenosylhomocysteine hydrolase, down-regulates expression of SETDB1 H3K9me3 HMTase in human lung cancer cells. Biochem Biophys Res Commun. 2013;438:647–52.

CAS  PubMed