HIF-1α mediates mitochondrial damage by down-regulating ALKBH7 expression to promote the aberrant activation of FLS in rheumatoid arthritis

Zhang Q, Liu J, Zhang M, Wei S, Li R, Gao Y, et al. Apoptosis induction of fibroblast-like synoviocytes is an important molecular-mechanism for herbal medicine along with its active components in treating rheumatoid arthritis. Biomolecules. 2019;9:795.

PubMed  PubMed Central  Google Scholar 

Petrovská N, Prajzlerová K, Vencovský J, Šenolt LFilková M. The pre-clinical phase of rheumatoid arthritis: From risk factors to prevention of arthritis. Autoimmun Rev. 2021;20:102797.

PubMed  Google Scholar 

Wasserman AM. Diagnosis and management of rheumatoid arthritis. Am Fam Phys. 2011;84:1245–52.

Google Scholar 

Nygaard G, Firestein GS. Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes. Nat Rev Rheumatol. 2020;16:316–33.

PubMed  PubMed Central  Google Scholar 

Bottini NFirestein GS. Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat Rev Rheumatol. 2013;9:24–33.

Google Scholar 

de Oliveira PG, Farinon M, Sanchez-Lopez E, Miyamoto S, Guma M. Fibroblast-like synoviocytes glucose metabolism as a therapeutic target in rheumatoid arthritis. Front Immunol. 2019;10:1743.

PubMed  PubMed Central  Google Scholar 

Sabeh F, Fox D, Weiss SJ. Membrane-type I matrix metalloproteinase-dependent regulation of rheumatoid arthritis synoviocyte function. J Immunol. 2010;184:6396–406.

CAS  PubMed  Google Scholar 

Cornelius MD, Leech SL, Goldschmidt L, Day NL. Is prenatal tobacco exposure a risk factor for early adolescent smoking? A follow-up study. Neurotoxicology Teratol. 2005;27:667–76.

CAS  Google Scholar 

Fearon U, Canavan M, Biniecka M, Veale DJ. Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis. Nat Rev Rheumatol. 2016;12:385–97.

CAS  PubMed  Google Scholar 

Chen J, Cheng W, Li J, Wang Y, Chen J, Shen X, et al. Notch‐1 and notch‐3 mediate hypoxia‐induced activation of synovial fibroblasts in rheumatoid arthritis. Arthritis Rheumatol. 2021;73:1810–9.

CAS  PubMed  Google Scholar 

McGettrick AF, O’Neill LAJ. The role of HIF in immunity and inflammation. Cell Metab. 2020;32:524–36.

CAS  PubMed  Google Scholar 

Fuhrmann DC, Brune B. Mitochondrial composition and function under the control of hypoxia. Redox Biol. 2017;12:208–15.

CAS  PubMed  PubMed Central  Google Scholar 

Gong T, Liu L, Jiang W, Zhou R. DAMP-sensing receptors in sterile inflammation and inflammatory diseases. Nat Rev Immunol. 2020;20:95–112.

CAS  PubMed  Google Scholar 

Hopfner KP, Hornung V. Molecular mechanisms and cellular functions of cGAS-STING signalling. Nat Rev Mol Cell Biol. 2020;21:501–21.

CAS  PubMed  Google Scholar 

Jiang M, Chen P, Wang L, Li W, Chen B, Liu Y, et al. cGAS-STING, an important pathway in cancer immunotherapy. J Hematol Oncol. 2020;13:81.

CAS  PubMed  PubMed Central  Google Scholar 

Bian K, Lenz SAP, Tang Q, Chen F, Qi R, Jost M, et al. DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro. Nucleic Acids Res. 2019;47:5522–9.

CAS  PubMed  PubMed Central  Google Scholar 

Wu TP, Wang T, Seetin MG, Lai Y, Zhu S, Lin K, et al. DNA methylation on N6-adenine in mammalian embryonic stem cells. Nature. 2016;532:329–33.

CAS  PubMed  PubMed Central  Google Scholar 

Perry GS, Das M, Woon ECY. Inhibition of AlkB nucleic acid demethylases: promising new epigenetic targets. J Med Chem. 2021;64:16974–7003.

CAS  PubMed  Google Scholar 

Zhang LS, Xiong QP, Pena Perez S, Liu C, Wei J, Le C, et al. ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing. Nat Cell Biol. 2021;23:684–91.

PubMed  PubMed Central  Google Scholar 

Hong Z, Tie Q, Zhang L. Targeted inhibition of the GRK2/HIF-1α pathway is an effective strategy to alleviate synovial hypoxia and inflammation. Int Immunopharmacol. 2022;113:109271.

CAS  PubMed  Google Scholar 

Nunnari J, Suomalainen A. Mitochondria: in sickness and in health. Cell. 2012;148:1145–59.

CAS  PubMed  PubMed Central  Google Scholar 

Faas MMde, Vos P. Mitochondrial function in immune cells in health and disease. Biochim Biophys Acta. 2020;1866:165845.

CAS  Google Scholar 

Picca A, Calvani R, Coelho-Junior HJ, Landi F, Bernabei R, Marzetti E. Mitochondrial dysfunction, oxidative stress, and neuroinflammation: intertwined roads to neurodegeneration. Antioxidants (Basel). 2020;9:647.

CAS  PubMed  Google Scholar 

Maekawa H, Inoue T, Ouchi H, Jao TM, Inoue R, Nishi H, et al. Mitochondrial damage causes inflammation via cGAS-STING signaling in acute kidney injury. Cell Rep. 2019;29:1261–73.e6.

CAS  PubMed  Google Scholar 

Jedynak-Slyvka M, Jabczynska A, Szczesny RJ. Human mitochondrial RNA processing and modifications: overview. Int J Mol Sci. 2021;22:7999.

CAS  PubMed  PubMed Central  Google Scholar 

Barshad G, Marom S, Cohen T, Mishmar D. Mitochondrial DNA transcription and its regulation: an evolutionary perspective. Trends Genet. 2018;34:682–92.

CAS  PubMed  Google Scholar 

Delaunay S, Pascual G, Feng B, Klann K, Behm M, Hotz-Wagenblatt A, et al. Mitochondrial RNA modifications shape metabolic plasticity in metastasis. Nature. 2022;607:593–603.

CAS  PubMed  PubMed Central  Google Scholar 

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