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MS1-96 induces HIP1R-dependent PD-L1 degradation and promotes antitumor immunity in colorectal cancer
MS1-96 induces HIP1R-dependent PD-L1 degradation and promotes antitumor immunity in colorectal cancer
The programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway, a pivotal immune checkpoint, enables...
Deguelin inhibits growth and prolactin synthesis in prolactinomas by targeting the PI3K/AKT/CREB3L1 pathway and ornithine decarboxylase
Deguelin inhibits growth and prolactin synthesis in prolactinomas by targeting the PI3K/AKT/CREB3L1 pathway and ornithine decarboxylase
Dopamine receptor agonist (DA)-resistant prolactinoma presents a significant clinical challenge, highlighting the need for...
Structure-activity relationship of prevalent synthetic cannabinoid metabolites on hCB1 in vitro and in silico dynamics
Structure-activity relationship of prevalent synthetic cannabinoid metabolites on hCB1 in vitro and in silico dynamics
Synthetic cannabinoids (SC) target the human cannabinoid receptor 1 (hCB1) and are extensively metabolized, but the metabo...
The mGluR2/3 agonist xanthurenic acid improves memory, attention, and synaptic deficits by modulating glutamate release in Alzheimer’s disease model
The mGluR2/3 agonist xanthurenic acid improves memory, attention, and synaptic deficits by modulating glutamate release in Alzheimer’s disease model
Amyloid-beta (Aβ) aggregation is the key component of neuritic plaques that drives Alzheimer’s disease (AD) pro...
Correction: GluN2A-NMDA receptor inhibition disinhibits the prefrontal cortex, reduces forced swim immobility, and impairs sensorimotor gating
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
New advances in small molecule drugs targeting NMDA receptors
New advances in small molecule drugs targeting NMDA receptors
N-methyl-D-aspartate (NMDA) receptors are glutamate-gated ion channels that are ubiquitously expressed throughout the cent...
Mup3 ameliorates the dysregulation of glucose and lipid metabolism in MAFLD
Mup3 ameliorates the dysregulation of glucose and lipid metabolism in MAFLD
Major urinary protein 3 (Mup3), belonging to the Mup family, is involved in metabolic regulation, but the exact regulatory...
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis
Cerebral ischemia-reperfusion injury (CIRI) represents a significant clinical challenge, with microglial homeostasis playi...
Genetic and pharmacological targeting of Snail inhibits atherosclerosis by relieving intraplaque endothelium dysfunction and associated inflammation
Genetic and pharmacological targeting of Snail inhibits atherosclerosis by relieving intraplaque endothelium dysfunction and associated inflammation
The intraplaque endothelium dysfunction and associated inflammation contribute to the progression of atherosclerosis. We p...
HIF-1α mediates mitochondrial damage by down-regulating ALKBH7 expression to promote the aberrant activation of FLS in rheumatoid arthritis
HIF-1α mediates mitochondrial damage by down-regulating ALKBH7 expression to promote the aberrant activation of FLS in rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and progressive joint destructio...
KLX ameliorates liver cancer progression by mediating ZBP1 transcription and ubiquitination and increasing ZBP1-induced PANoptosis
KLX ameliorates liver cancer progression by mediating ZBP1 transcription and ubiquitination and increasing ZBP1-induced PANoptosis
Liver cancer is a highly aggressive malignancy with poor survival rates. Current treatments, including liver transplantati...
Endothelial histone deacetylase 9 promotes diabetic retinopathy in mice by regulating endothelial–mesenchymal transition
Endothelial histone deacetylase 9 promotes diabetic retinopathy in mice by regulating endothelial–mesenchymal transition
Diabetic retinopathy (DR) is a common and specific microvascular complication of diabetes and the leading cause of blindne...
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with a high fatality rate. Currently no ap...
Nicotine promotes the progression and metastasis of non-small cell lung cancer by modulating the OTUB1-c-Myc-EZH2 axis
Nicotine promotes the progression and metastasis of non-small cell lung cancer by modulating the OTUB1-c-Myc-EZH2 axis
Smoking has been identified as a major risk factor for the development and progression of non-small cell lung cancer (NSCL...
PU.1/Spi1 exacerbates ischemia-reperfusion induced acute kidney injury via upregulating Gata2 and promoting fibroblast activation
PU.1/Spi1 exacerbates ischemia-reperfusion induced acute kidney injury via upregulating Gata2 and promoting fibroblast activation
Previous studies on acute kidney injury (AKI) have predominantly focused on renal tubular cells, while the specif...
Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy
Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy
Among the numerous complications of diabetes mellitus, diabetic wounds seriously affect patients’ quality of life an...
E3 ubiquitin ligase NEDD4L inhibits epithelial-mesenchymal transition by suppressing the β-catenin/HIF-1α positive feedback loop in chronic rhinosinusitis with nasal polyps
E3 ubiquitin ligase NEDD4L inhibits epithelial-mesenchymal transition by suppressing the β-catenin/HIF-1α positive feedback loop in chronic rhinosinusitis with nasal polyps
Chronic rhinosinusitis with nasal polyp (CRSwNP) is a refractory inflammatory disease with epithelial-mesenchymal transiti...
SMAD4 endows TGF-β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer
SMAD4 endows TGF-β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy prone to recurrence and metastasis. Studies ...
From bench to bedside: current development and emerging trend of KRAS-targeted therapy
From bench to bedside: current development and emerging trend of KRAS-targeted therapy
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most frequently mutated oncogene in human cancers with mutation...
A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity
A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity
Leveraging the specificity of antibody to deliver cytotoxic agent into tumor, antibody-drug conjugates (ADCs) have become ...
Colon-targeted S100A8/A9-specific peptide systems ameliorate colitis and colitis-associated colorectal cancer in mouse models
Colon-targeted S100A8/A9-specific peptide systems ameliorate colitis and colitis-associated colorectal cancer in mouse models
The link between chronic inflammation and cancer development is well acknowledged. Inflammatory bowel disease including ul...
Author Correction: DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer
Author Correction: DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer
Authors and AffiliationsShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, ChinaXiang-li...
Amuc_1100 pretreatment alleviates acute pancreatitis in a mouse model through regulating gut microbiota and inhibiting inflammatory infiltration
Amuc_1100 pretreatment alleviates acute pancreatitis in a mouse model through regulating gut microbiota and inhibiting inflammatory infiltration
Amuc_1100 is a membrane protein from Akkermansia muciniphila, which has been found to play a role in host immunological ho...
Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models
Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models
Epilepsy is a prevalent and severe neurological disorder and approximately 30% of patients are resistant to existing medic...
Combination of eriocalyxin B and homoharringtonine exerts synergistic anti-tumor effects against t(8;21) AML
Combination of eriocalyxin B and homoharringtonine exerts synergistic anti-tumor effects against t(8;21) AML
Understanding the molecular pathogenesis of acute myeloid leukemia (AML) with well-defined genomic abnormalities has facil...
Lipid droplets in pathogen infection and host immunity
Lipid droplets in pathogen infection and host immunity
As the hub of cellular lipid metabolism, lipid droplets (LDs) have been linked to a variety of biological processes. Durin...
Baicalein attenuates rotenone-induced SH-SY5Y cell apoptosis through binding to SUR1 and activating ATP-sensitive potassium channels
Baicalein attenuates rotenone-induced SH-SY5Y cell apoptosis through binding to SUR1 and activating ATP-sensitive potassium channels
Dopaminergic neurons in the substantia nigra (SN) expressing SUR1/Kir6.2 type ATP-sensitive potassium channels (K-ATP) are...
Blocking reverse electron transfer-mediated mitochondrial DNA oxidation rescues cells from PANoptosis
Blocking reverse electron transfer-mediated mitochondrial DNA oxidation rescues cells from PANoptosis
PANoptosis is a new type of cell death featured with pyroptosis, apoptosis and necroptosis, and is implicated in organ inj...
Reexamining the effects of drug loading on the in vivo performance of PEGylated liposomal doxorubicin
Reexamining the effects of drug loading on the in vivo performance of PEGylated liposomal doxorubicin
Higher drug loading employed in nanoscale delivery platforms is a goal that researchers have long sought after. But such v...
Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification
Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification
N6-methyladenosine (m6A) modification is a prevalent RNA epigenetic modification, which plays a crucial role in tumor prog...
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