Metabolic and genetic spectrum of pediatric nephrolithiasis: insights from high-prevalence desert belt in India

Deepthi B, Krishnamurthy S (2025) Kidney Stones in Children: Causes, Consequences, and Concerns. Indian Pediatr 62:151–162. https://doi.org/10.1007/s13312-025-3382-6

Article  PubMed  Google Scholar 

Sorokin I, Mamoulakis C, Miyazawa K, Rodgers A, Talati J, Lotan Y (2017) Epidemiology of stone disease across the world. World J Urol 35:1301–1320. https://doi.org/10.1007/s00345-017-2008-6

Article  PubMed  Google Scholar 

Pecoraro L, Zuccato A, Vitella R, Pietrobelli A, Piacentini G, Brugnara M (2024) Pediatric Nephrolithiasis: A Changing Landscape Through Time and Space. Med (Mex) 60:1993. https://doi.org/10.3390/medicina60121993

Article  Google Scholar 

Reusz GS, Hosszu A, Kis E (2020) Evaluation of a child with suspected nephrolithiasis. Curr Opin Pediatr 32:265–272. https://doi.org/10.1097/MOP.0000000000000880

Article  PubMed  Google Scholar 

Cao B, Daniel R, McGregor R, Tasian GE (2023) Pediatr Nephrolithiasis Healthc 11:552. https://doi.org/10.3390/healthcare11040552

Article  Google Scholar 

Hoppe B, Martin-Higueras C (2020) Inherited conditions resulting in nephrolithiasis. Curr Opin Pediatr 32:273–283. https://doi.org/10.1097/MOP.0000000000000848

Article  PubMed  Google Scholar 

Yang J, Ni J, Zhou Y, Liu X (2025) Association between body mass index, urine metabolic disturbances, and nephrolithiasis in pediatric patients. Pediatr Nephrol Berl Ger. https://doi.org/10.1007/s00467-025-06865-4

Article  Google Scholar 

Ramya K, Krishnamurthy S, Manikandan R, Sivamurukan P, Naredi BK, Karunakar P (2021) Metabolic and Clinical Characteristics of Children with Urolithiasis from Southern India. Indian J Pediatr 88:345–350. https://doi.org/10.1007/s12098-020-03455-0

Article  PubMed  Google Scholar 

Mandal A, Khandelwal P, Geetha TS, Murugan S, Meena J, Jana M et al (2022) Metabolic and Genetic Evaluation in Children with Nephrolithiasis. Indian J Pediatr 89:1243–1250. https://doi.org/10.1007/s12098-022-04234-9

Article  PubMed  Google Scholar 

Hari P, Bagga A, Vasudev V, Singh M, Srivastava RN (1995) Aetiology of nephrolithiasis in north Indian children. Pediatr Nephrol Berl Ger 9:474–475. https://doi.org/10.1007/BF00866731

Article  CAS  Google Scholar 

Abhishek, Kumar J, Mandhani A, Srivastava A, Kapoor R, Ansari MS (2013) Pediatric urolithiasis: Experience from a tertiary referral center. J Pediatr Urol 9:825–830. https://doi.org/10.1016/j.jpurol.2012.11.003

Article  Google Scholar 

Liu Y, Chen Y, Liao B, Luo D, Wang K, Li H, Zeng G (2018) Epidemiology of urolithiasis in Asia. Asian J Urol 5(4):205–214. https://doi.org/10.1016/j.ajur.2018.08.007Epub 2018 Sep 6. PMID: 30364478; PMCID: PMC6197415

Article  PubMed  PubMed Central  Google Scholar 

Emma F, Goldstein SL, Bagga A, Bates CM, Shroff R (eds) (2022) Pediatric Nephrology [Internet]. Springer International Publishing, Cham. [cited 2026 Jan 6]https://doi.org/10.1007/978-3-030-52719-8

Book  Google Scholar 

Bennett RL, Motulsky AG, Bittles A, Hudgins L, Uhrich S, Doyle DL et al (2002) Genetic counseling and screening of consanguineous couples and their offspring: Recommendations of the National Society of Genetic Counselors. J Genet Couns 11(2):97–119

Article  PubMed  Google Scholar 

Gajengi AKR, Wagaskar VG, Tanwar HV, Mhaske S, Patwardhan SK (2016) Metabolic Evaluation in Paediatric Urolithiasis: A 4-Year Open Prospective Study. J Clin Diagn Res JCDR 10:PC04–06. https://doi.org/10.7860/JCDR/2016/17265.7251

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gouru VR, Pogula VR, Vaddi SP, Manne V, Byram R, Kadiyala LS (2018) Metabolic evaluation of children with urolithiasis. Urol Ann 10:94–99. https://doi.org/10.4103/UA.UA_98_17

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bevill M, Kattula A, Cooper CS, Storm DW (2017) The Modern Metabolic Stone Evaluation in Children. Urology 101:15–20. https://doi.org/10.1016/j.urology.2016.09.058

Article  PubMed  Google Scholar 

Gefen AM, Sethna CB, Cil O, Perwad F, Schoettler M, Michael M et al (2023) Genetic testing in children with nephrolithiasis and nephrocalcinosis. Pediatr Nephrol Berl Ger 38:2615–2622. https://doi.org/10.1007/s00467-023-05879-0

Article  Google Scholar 

Dwyer ME, Krambeck AE, Bergstralh EJ, Milliner DS, Lieske JC, Rule AD (2012) Temporal trends in incidence of kidney stones among children: a 25-year population based study. J Urol 188:247–252. https://doi.org/10.1016/j.juro.2012.03.021

Article  PubMed  PubMed Central  Google Scholar 

Tasian GE, Ross ME, Song L, Sas DJ, Keren R, Denburg MR et al (2016) Annual Incidence of Nephrolithiasis among Children and Adults in South Carolina from 1997 to 2012. Clin J Am Soc Nephrol CJASN 11:488–496. https://doi.org/10.2215/CJN.07610715

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prezioso D, Strazzullo P, Lotti T, Bianchi G, Borghi L, Caione P et al (2015) Dietary treatment of urinary risk factors for renal stone formation. A review of CLU Working Group. Arch Ital Urol Androl Organo Uff Soc Ital Ecogr Urol E Nefrol 87:105–120. https://doi.org/10.4081/aiua.2015.2.105

Article  CAS  Google Scholar 

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