Ma Y, Cheng C, Jian Z et al (2024) Risk factors for nephrolithiasis formation: an umbrella review. Int J Surg 110:5733–5744. https://doi.org/10.1097/JS9.0000000000001719

Article  PubMed  PubMed Central  Google Scholar 

Khan SR, Canales BK, Dominguez-Gutierrez PR (2021) Randall’s plaque and calcium oxalate stone formation: role for immunity and inflammation. Nat Rev Nephrol 17:417–433. https://doi.org/10.1038/s41581-020-00392-1

Article  CAS  PubMed  Google Scholar 

Liu H, Duan C, Yang X et al (2023) Metformin suppresses calcium oxalate crystal-induced kidney injury by promoting Sirt1 and M2 macrophage-mediated anti-inflammatory activation. Signal Transduct Target Ther 8:38. https://doi.org/10.1038/s41392-022-01232-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun Y, Liu Y, Guan X et al (2020) Atorvastatin inhibits renal inflammatory response induced by calcium oxalate crystals via inhibiting the activation of TLR4/NF-κB and NLRP3 inflammasome. IUBMB Life 72:1065–1074. https://doi.org/10.1002/iub.2250

Article  CAS  PubMed  Google Scholar 

Liu Y, Sun Y, Kang J et al (2022) Role of ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis. Front Immunol 13:818625. https://doi.org/10.3389/fimmu.2022.818625

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma L-J, Fogo AB (2009) PAI-1 and kidney fibrosis. Front Biosci (Landmark Ed) 14:2028–2041. https://doi.org/10.2741/3361

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tanaka K, Harada H, Kamuro H et al (2023) Arid5a/IL-6/PAI-1 Signaling Is Involved in the Pathogenesis of Lipopolysaccharide-Induced Kidney Injury. Biol Pharm Bull 46:1753–1760. https://doi.org/10.1248/bpb.b23-00482

Article  CAS  PubMed  Google Scholar 

Liu Y, Wang M, Wang D et al (2021) Elevated postischemic tissue injury and leukocyte-endothelial adhesive interactions in mice with global deficiency in caveolin-2: role of PAI-1. Am J Physiol Heart Circ Physiol 320:H1185–H1198. https://doi.org/10.1152/ajpheart.00682.2020

Article  PubMed  PubMed Central  Google Scholar 

Ge K, F C, Cw L et al (2019) PAI-1 augments mucosal damage in colitis. Sci Transl Med. https://doi.org/10.1126/scitranslmed.aat0852. 11:

Article  PubMed  PubMed Central  Google Scholar 

Thapa B, Kim YH, Kwon H-J, Kim D-S (2014) The LRP1-independent mechanism of PAI-1-induced migration in CpG-ODN activated macrophages. Int J Biochem Cell Biol 49:17–25. https://doi.org/10.1016/j.biocel.2014.01.008

Article  CAS  PubMed  Google Scholar 

Zhang X-X, Zuo J-Q, Wang Y-T et al (2022) Paeoniflorin in Paeoniaceae: Distribution, influencing factors, and biosynthesis. Front Plant Sci 13:980854. https://doi.org/10.3389/fpls.2022.980854

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang L, Wei W (2020) Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony. Pharmacol Ther 207:107452. https://doi.org/10.1016/j.pharmthera.2019.107452

Article  CAS  PubMed  Google Scholar 

Cao Y, Xiong J, Guan X et al (2023) Paeoniflorin suppresses kidney inflammation by regulating macrophage polarization via KLF4-mediated mitophagy. Phytomedicine 116:154901. https://doi.org/10.1016/j.phymed.2023.154901

Article  CAS  PubMed  Google Scholar 

Zhang X-E, Pang Y-B, Bo Q et al (2023) Protective effect of paeoniflorin in diabetic nephropathy: A preclinical systematic review revealing the mechanism of action. PLoS ONE 18:e0282275. https://doi.org/10.1371/journal.pone.0282275

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li H, Jiao Y, Xie M (2017) Paeoniflorin Ameliorates Atherosclerosis by Suppressing TLR4-Mediated NF-κB Activation. Inflammation 40:2042–2051. https://doi.org/10.1007/s10753-017-0644-z

Article  CAS  PubMed  Google Scholar 

Shi D, Wang Q, Zheng H et al (2016) Paeoniflorin suppresses IL-6/Stat3 pathway via upregulation of Socs3 in dendritic cells in response to 1-chloro-2,4-dinitrobenze. Int Immunopharmacol 38:45–53. https://doi.org/10.1016/j.intimp.2016.05.013

Article  CAS  PubMed  Google Scholar 

Ju Y, Du M, Wang Z et al (2024) Kukoamine A alleviates nephrolithiasis by inhibiting endogenous oxalate synthesis via the IL-6/JAK/STAT3/DAO signaling pathway. Phytomedicine 135:156145. https://doi.org/10.1016/j.phymed.2024.156145

Article  CAS  PubMed  Google Scholar 

Ming S, Tian J, Ma K et al (2022) Oxalate-induced apoptosis through ERS-ROS-NF-κB signalling pathway in renal tubular epithelial cell. Mol Med 28:88. https://doi.org/10.1186/s10020-022-00494-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun Y, Kang J, Guan X et al (2021) Regulation of endoplasmic reticulum stress on the damage and apoptosis of renal tubular epithelial cells induced by calcium oxalate crystals. Urolithiasis 49:291–299. https://doi.org/10.1007/s00240-021-01261-7

Article  CAS  PubMed  Google Scholar 

Khan SR, Pearle MS, Robertson WG et al (2016) Kidney stones. Nat Rev Dis Primers 2:16008. https://doi.org/10.1038/nrdp.2016.8

Article  PubMed  PubMed Central  Google Scholar 

Su B, Ren Y, Yao W et al (2024) Mitochondrial dysfunction and NLRP3 inflammasome: key players in kidney stone formation. BJU Int 134:696–713. https://doi.org/10.1111/bju.16454

Article  CAS  PubMed  Google Scholar 

Song Q, Song C, Chen X et al (2023) FKBP5 deficiency attenuates calcium oxalate kidney stone formation by suppressing cell-crystal adhesion, apoptosis and macrophage M1 polarization via inhibition of NF-κB signaling. Cell Mol Life Sci 80:301. https://doi.org/10.1007/s00018-023-04958-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu Y, Liang H, Mao X et al (2024) Puerarin alleviates apoptosis and inflammation in kidney stone cells via the PI3K/AKT pathway: Network pharmacology and experimental verification. J Cell Mol Med 28:e70180. https://doi.org/10.1111/jcmm.70180

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen BH, Lu XQ, Liang XH, Wang P (2023) Serpin E1 mediates the induction of renal tubular degeneration and premature senescence upon diabetic insult. Sci Rep 13:16210. https://doi.org/10.1038/s41598-023-43411-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hong S-Y, Qin B-L (2024) The Altered Proteomic Landscape in Renal Tubular Epithelial Cells under High Oxalate Stimulation. Biology (Basel) 13:814. https://doi.org/10.3390/biology13100814

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang D, Zhang J-W, Xu H et al (2024) Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation. Mol Cancer 23:70. https://doi.org/10.1186/s12943-024-01985-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kubala MH, Punj V, Placencio-Hickok VR et al (2018) Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer. Cell Rep 25:2177–2191e7. https://doi.org/10.1016/j.celrep.2018.10.082

Article