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Assay Guidance Manual for Drug Discovery: Robust or Go Bust
Assay Guidance Manual for Drug Discovery: Robust or Go Bust
1. Freedman, L. P., Cockburn, I. M., Simcoe, T. S. The Economics of Reproducibility in Preclinical Research. PLoS Biol. 20...
Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine
Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine
Malignant tumors are complex tissues composed of malignant cells, vascular cells, structural mesenchymal cells including p...
The Extensive and Expensive Impacts of HEp-2 [HeLa], Intestine 407 [HeLa], and Other False Cell Lines in Journal Publications
The Extensive and Expensive Impacts of HEp-2 [HeLa], Intestine 407 [HeLa], and Other False Cell Lines in Journal Publications
Cell lines are essential models for biomedical research. However, they have a common and important problem that needs to b...
Advances in High-Content Imaging and Informatics: A Joint Special Collection with Society for Biomolecular Imaging and Informatics and SLAS
Advances in High-Content Imaging and Informatics: A Joint Special Collection with Society for Biomolecular Imaging and Informatics and SLAS
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Flexible Fitting of PROTAC Concentration–Response Curves with Changepoint Gaussian Processes
Flexible Fitting of PROTAC Concentration–Response Curves with Changepoint Gaussian Processes
A proteolysis-targeting chimera (PROTAC) is a new technology that marks proteins for degradation in a highly specific mann...
Treating Cells as Reagents to Design Reproducible Assays
Treating Cells as Reagents to Design Reproducible Assays
The reproducibility of high-throughput cell-based assays is dependent on having a consistent source of cells for each expe...
Addressing Unusual Assay Variability with Robust Statistics
Addressing Unusual Assay Variability with Robust Statistics
Well-behaved, in vitro bioassays generally produce normally distributed values in their primary (efficacy) data. According...
Applications of Biophysics in Early Drug Discovery
Applications of Biophysics in Early Drug Discovery
1. Genick, C. C., Barlier, D., Monna, D. Applications of Biophysics in High-Throughput Screening Hit Validation. J. Biomol...
Luminescence Energy Transfer–Based Screening and Target Engagement Approaches for Chemical Biology and Drug Discovery
Luminescence Energy Transfer–Based Screening and Target Engagement Approaches for Chemical Biology and Drug Discovery
Luminescence is characterized by the spontaneous emission of light resulting from either chemical or biological reactions....
Acoustic Ejection Mass Spectrometry: A Fully Automatable Technology for High-Throughput Screening in Drug Discovery
Acoustic Ejection Mass Spectrometry: A Fully Automatable Technology for High-Throughput Screening in Drug Discovery
Acoustic droplet ejection (ADE)–open port interface (OPI)–mass spectrometry (MS) has recently been introduced as a versati...
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