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HUWE1 regulates mitophagy to protect dopaminergic neurons from 6-OHDA- and MPP⁺-induced neurotoxicity
HUWE1 regulates mitophagy to protect dopaminergic neurons from 6-OHDA- and MPP⁺-induced neurotoxicity
Parkinson’s disease (PD) is characterized by dopaminergic neuronal loss, often associated with mitochondrial dysfunc...
METTL7B-stabilized lncRNA-MIR22HG to drive p53-mediated neuronal apoptosis via the ubiquitinating JARID2 in cerebral ischemia/reperfusion injury
METTL7B-stabilized lncRNA-MIR22HG to drive p53-mediated neuronal apoptosis via the ubiquitinating JARID2 in cerebral ischemia/reperfusion injury
Ischemic stroke (IS) constitutes a leading driver of mortality and morbidity worldwide, with neuronal apoptosis representi...
EGR1/miR-4306/MAT2A axis aggravates pyroptosis and extracellular matrix degradation of nucleus pulposus cells in intervertebral disc degeneration
EGR1/miR-4306/MAT2A axis aggravates pyroptosis and extracellular matrix degradation of nucleus pulposus cells in intervertebral disc degeneration
Intervertebral disc degeneration (IVDD) acts as the prerequisite and pathological basis for a series of spinal degenerativ...
Mycotoxins, gut microbiota alterations and liver disease in animals: A scoping review
Mycotoxins, gut microbiota alterations and liver disease in animals: A scoping review
Mycotoxins are fungal secondary metabolites widely detected in up to eighty percent of frequently consumed foods, strongly...
Sublethal heat stress synergizes with the tumor microenvironment to drive recurrence of hepatocellular carcinoma after thermal ablation: mechanisms, molecular predictors, and targeted interventions
Sublethal heat stress synergizes with the tumor microenvironment to drive recurrence of hepatocellular carcinoma after thermal ablation: mechanisms, molecular predictors, and targeted interventions
Although thermal ablation has emerged as a minimally invasive and effective local treatment for hepatocellular carcinoma (...
Single-cell RNA-Seq reveals transcriptional heterogeneity in sepsis and down-regulation of SNHG5/miR-324-5p/CDK16 axis in T cells
Single-cell RNA-Seq reveals transcriptional heterogeneity in sepsis and down-regulation of SNHG5/miR-324-5p/CDK16 axis in T cells
T lymphopenia is a common phenomenon in the sepsis patients, closely related with secondary infection and patients death, ...
Inhibition of acalabrutinib metabolism by finerenone and its molecular docking studies
Inhibition of acalabrutinib metabolism by finerenone and its molecular docking studies
Acalabrutinib is a frontline agent for chronic lymphocytic leukemia (CLL). The objective of this experiment was to screen ...
Lipocalin 2: a double-edged sword in cellular ferroptosis
Lipocalin 2: a double-edged sword in cellular ferroptosis
Ferroptosis is a novel form of programmed cell death that is distinct from apoptosis, necrosis, and autophagy (macroautoph...
Overloaded mitochondrial stress drives reproductive damage in GC-1 mouse spermatogonia cells exposed to nickel nanoparticle
Overloaded mitochondrial stress drives reproductive damage in GC-1 mouse spermatogonia cells exposed to nickel nanoparticle
Nickel nanoparticles (Ni NPs) are widely used in industrial and commercial sectors, raising concerns about their potential...
Targeting ADAMTS1/HDAC6 alleviates TGF-β1/SMAD2-associated cardiac fibrosis in cardiac fibrosis post-myocardial infarction
Targeting ADAMTS1/HDAC6 alleviates TGF-β1/SMAD2-associated cardiac fibrosis in cardiac fibrosis post-myocardial infarction
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) is involved in the occurrence and development o...
Linc-ROR orchestrates autophagy suppression and marks gastric cancer via the miR-145-5p/CARMIL1 axis
Linc-ROR orchestrates autophagy suppression and marks gastric cancer via the miR-145-5p/CARMIL1 axis
Long non-coding RNAs (lncRNAs) have been considered the main regulators of cancer progression through their regulation of ...
Brain organoids in environmental neurotoxicology: applications, mechanisms, and future perspectives
Brain organoids in environmental neurotoxicology: applications, mechanisms, and future perspectives
The advent of human induced pluripotent stem cell (hiPSC)-derived brain organoids represents a significant advance in envi...
Toxicogenomic Characterization of Perfluorooctanoic Acid–Associated Bladder Carcinogenesis
Toxicogenomic Characterization of Perfluorooctanoic Acid–Associated Bladder Carcinogenesis
This study aims to bridge toxicological target prediction and bladder cancer transcriptomics by systematically identifying...
Chronic cadmium exposure promotes TRPM7-dependent acquisition of a myofibroblast-like phenotype in pancreatic stellate cells
Chronic cadmium exposure promotes TRPM7-dependent acquisition of a myofibroblast-like phenotype in pancreatic stellate cells
Cadmium (Cd) is a metallic pollutant which has been classified as a possible pancreatic carcinogen. Cd uses similar ion ch...
Lactate Dehydrogenase B delactylation promotes gastric cancer metastasis via enhancing glutathione-mediated resistance to ferroptosis
Lactate Dehydrogenase B delactylation promotes gastric cancer metastasis via enhancing glutathione-mediated resistance to ferroptosis
To elucidate the role of protein lactylation in gastric adenocarcinoma progression, focusing on lactate dehydrogenase B (L...
RNA mA modification is a driver and therapeutic target in gastric cancer
RNA mA modification is a driver and therapeutic target in gastric cancer
N6-methyladenosine (m6A), the most abundant modification in eukaryotic RNAs, plays a critical role in regulating RNA stabi...
Indoor dust, immune activation, and household exposure risk after Hurricane Maria: a two-year pilot prospective cohort study in Puerto Rico
Indoor dust, immune activation, and household exposure risk after Hurricane Maria: a two-year pilot prospective cohort study in Puerto Rico
Hurricane Maria left many homes in Puerto Rico with prolonged flooding, structural damage, and indoor microbial growth, co...
Sociodemographic predictors of PFAS exposure among a combined sample of U.S. pregnant women: an Environmental influences on Child Health Outcomes (ECHO) public-use dataset analysis
Sociodemographic predictors of PFAS exposure among a combined sample of U.S. pregnant women: an Environmental influences on Child Health Outcomes (ECHO) public-use dataset analysis
Per- and polyfluoroalkyl substances (PFAS) are chemicals widely used in manufacturing since the 1940s and are associated w...
A comparative study of urinary mycotoxin biomarkers co-occurrence patterns and cumulative risk assessment in population from three typical areas in China
A comparative study of urinary mycotoxin biomarkers co-occurrence patterns and cumulative risk assessment in population from three typical areas in China
This biomonitoring study investigated levels of multi-mycotoxin biomarkers in the urine of subjects living in three differ...
Co-exposure to environmental cadmium and arsenic leads to kidney damage even at lower concentrations
Co-exposure to environmental cadmium and arsenic leads to kidney damage even at lower concentrations
While many studies have examined the effects of single heavy metal exposure, the impact of combined exposure to multiple h...
Comparison of residential and mobility-integrated air pollution exposures from tracking campaigns and agent-based modelling in Switzerland and the Netherlands
Comparison of residential and mobility-integrated air pollution exposures from tracking campaigns and agent-based modelling in Switzerland and the Netherlands
Studies investigating the health effects of long-term exposure to air pollution generally rely on the outdoor air pollutio...
A transdisciplinary process-oriented approach to evaluate infant exposure to indoor dust
A transdisciplinary process-oriented approach to evaluate infant exposure to indoor dust
Infants are uniquely vulnerable to indoor dust exposure due to behaviors such as mouthing (hand- or object-to-mouth), craw...
Unravelling airborne complexities: the role of spider webs and indoor dust in assessing human exposure to indoor organic micropollutants
Unravelling airborne complexities: the role of spider webs and indoor dust in assessing human exposure to indoor organic micropollutants
Indoor environments serve as critical exposure pathways for airborne micropollutants, yet traditional sampling methods oft...
Analysis of 18 mercapturic acids in urine samples from the German Environmental Specimen Bank—tackling the data gap in the human biomonitoring of VOCs in Europe
Analysis of 18 mercapturic acids in urine samples from the German Environmental Specimen Bank—tackling the data gap in the human biomonitoring of VOCs in Europe
Human biomonitoring (HBM) plays a pivotal role in assessing exposure to toxicologically relevant chemicals, with urinary m...
DNA G-quadruplexes: Structural and functional insights
It has been over a century since Ivar Bang first noted the unusual self-aggregating property of the guanylic acid-forming ...
Recent advances in understanding the molecular mechanisms of SLX4 recruitment in the replication stress response
Although DNA replication is tightly regulated, various impediments can stall DNA replication forks. SLX4 is a scaffold pro...
Fueling for the finish line: Control of human telomerase activity by nucleotide metabolism
Telomeres are comprised of repetitive sequences at the ends of chromosomes that promote genome stability [1], [2]. Telomer...
How DNA secondary structures drive replication fork instability
DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic feature...
Cutting edge perspectives in genome maintenance XII
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Stepwise DNA damage and repair mechanisms at replication forks in response to topoisomerase I inhibition
DNA replication ensures the precise duplication of the genome during the S phase. The replisome, a complex molecular machi...
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