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Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs following 4 weeks of daily dermal administration

ATB1651 gel is an antifungal drug candidate that enhances antifungal activity through substitution of several aryl rings, ...

Toxicological Research

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Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from and

HemoHIM G is a functional food ingredient composed of a triple herbal combination of Angelica sinensis, Ligusticum chuanxi...

Toxicological Research

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$Evaluation of acute, repeated dose 28-day and 13-week oral toxicity and genotoxicity of a standardized fraction (HemoHIM) from$

Evaluation of acute, repeated dose 28-day and 13-week oral toxicity and genotoxicity of a standardized fraction (HemoHIM) from

HemoHIM is a functional food ingredient comprising a triple herbal combination of extracts from Angelica gigas Nakai, Cnid...

Toxicological Research

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Short-term health effects of tear agents chlorobenzylidenemalononitrile and oleoresin capsicum during the civil riots of Santiago de Chile in 2019–2020

Chlorobenzylidenemalononitrile (CS) and Oleoresin Capsicum (OC) were tear gasses used as anti-riot control agents during s...

Toxicological Research

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Advancing hepatotoxicity assessment: current advances and future directions

During drug development, it is crucial to ensure that a drug exhibits effective activity in its target cells and organs. H...

Toxicological Research

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Effect of red yeast rice on the growth of male SD rats: a 90-day feeding study

Red yeast rice (RYR) is commonly used as colouring and flavouring agent in foods throughout East Asia. RYR contains monaco...

Toxicological Research

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Artificial intelligence‑based quantitative analysis of hepatic fibrosis in carbon tetrachloride-induced mouse model of metabolic dysfunction-associated steatohepatitis

Liver fibrosis, a major histopathological indicator of chronic liver injury, is also a key feature of metabolic dysfunctio...

Toxicological Research

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Validation of a B cell acute lymphoblastic leukemia xenograft rat model for integrated efficacy, pharmacokinetics and safety of CD19 CAR-T

In preclinical studies of B cell acute lymphoblastic leukemia (B-ALL), mouse models have limitations related to their smal...

Toxicological Research

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Molecular modulation of cholinergic and neuromuscular signaling following long-term acetaminophen administration

Acetaminophen is widely used as an analgesic and antipyretic; however, its long-term neurochemical actions remain incomple...

Toxicological Research

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The oncogenic signalosome: SQSTM1/p62 as a master integrator of signaling, metabolism, and autophagy in cancer

Sequestosome 1 (SQSTM1/p62), long established as a selective autophagy receptor and ubiquitin-binding scaffold, is now rec...

Toxicological Research

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Development of in vitro skin corrosion test using KeraSkin™

Skin corrosion and irritation are critical local toxicological endpoints associated with chemical exposure. OECD has appro...

Toxicological Research

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Skin absorption and metabolism of [C]-labeled C12-benzalkonium chloride (C12-BKC) in ex vivo porcine ear skin using UPLC-β-RAM analysis

Benzalkonium chloride is a quaternary ammonium disinfectant widely used in pharmaceutical, cosmetic, and household product...

Toxicological Research

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In vitro studies on curcumin-chitosan-Multiwalled Carbon Nanotubes (MWCNT) cytotoxicity against A549 (lung cancer cell line) HCT 116 (colorectal cancer cell line) and PANC1 (pancreatic cancer cell line)

Toxicology Reports

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Self-nanoemulsifying drug delivery system (SNEDDS) enhances the antidiabetic potential of Averrhoa bilimbi L. leaf extract: Integrated LC–MS/MS metabolomics, network pharmacology, and alpha-amylase inhibition

Toxicology Reports

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Acute 2,4-dichlorophenoxyacetic acid herbicide poisoning in rural India: clinical spectrum, multiorgan toxicity, and outcomes in an eight-patient observational study

Toxicology Reports

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Presence of glyphosate in endometrial cancer tissue: A cross-sectional study

Toxicology Reports

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In silico evaluation of soursop (Annona muricata) leaf compound interactions with CYP450 and their potential impact on systemic cancer therapies

Toxicology Reports

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Toxicological evaluation of bioengineered salidroside produced by a novel method

Toxicology Reports

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Characteristics and prognostic factors of adult poisoning patients in the intensive care unit: A retrospective cohort study using the Japanese intensive care patient database

Toxicology Reports

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L-carvone protects against myoglobinuric acute tubular necrosis via inhibition of NF-κB and caspase-dependent apoptotic pathways

Toxicology Reports

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Knowledge structure and thematic organization of PFAS-associated cardiac toxicity: A bibliometric analysis

Toxicology Reports

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Phloridzin mitigates bleomycin-elicited lung fibrosis in Wistar rats: The interplay between antioxidant defenses, inflammatory processes, transforming growth factor beta 1, and autophagy

Toxicology Reports

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Neuroprotective effects of agomelatine in a D-galactose-induced hippocampal aging model

Toxicology Reports

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Toxicological profiling and health hazard characterization of pesticides widely used in Tanzania unmarked

Toxicology Reports

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Phytochemical composition and subacute toxicity of ethanolic extract of Eucheuma denticulatum on male Wistar albino rats

Toxicology Reports

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Chronic exposure to aerosolized Arizona test dust reduces visual acuity in mice

Toxicology Reports

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Fatal pediatric paraquat poisoning following scalp application for head lice treatment: Public health implications for pesticide regulation and emergency care — A case series

Toxicology Reports

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Acute liver injury linked to an adulterated weight-loss product: Integrated clinical, chemical, and toxicological evidence supporting a highly probable causality as assessed by updated RUCAM (2016)

Toxicology Reports

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Intoxication with nutmeg: A case presentation and analysis of Swiss poisons information center (Tox Info Suisse) enquiries 2014–2023

Toxicology Reports

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Integrated LC–MS/MS profiling, network pharmacology, molecular docking, and enzyme inhibition assays reveal the antidiabetic potential of Mitragyna speciosa

Toxicology Reports

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