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Multicenter Validation of Cerebellar Motor Learning Biomarker for Spinocerebellar Degenerations
Multicenter Validation of Cerebellar Motor Learning Biomarker for Spinocerebellar Degenerations
Objectively quantifying cerebellar motor dysfunction remains a challenge in clinical trials. The Adaptability Index, deriv...
Generation and Validation of an Acan-Cre Mouse Line to Selectively Label Class-B Excitatory Neurons of the Cerebellar Nuclei
Generation and Validation of an Acan-Cre Mouse Line to Selectively Label Class-B Excitatory Neurons of the Cerebellar Nuclei
The cerebellar nuclei form the main output structures of the cerebellum and are composed of a deeply conserved set of cell...
Cerebellar Cognitive Affective Syndrome in Spinocerebellar Ataxia Type 6
Cerebellar Cognitive Affective Syndrome in Spinocerebellar Ataxia Type 6
Background: Spinocerebellar ataxia type 6 (SCA6) has traditionally been classified as a "pure" cerebellar syndro...
Multimodal PET Findings in -Related Primary familial Brain Calcification Caused by a Novel Homozygous Frameshift Mutation
Multimodal PET Findings in -Related Primary familial Brain Calcification Caused by a Novel Homozygous Frameshift Mutation
Primary familial brain calcification (PFBC) is a rare inherited neurological disorder characterized by bilateral intracran...
Chiari I Malformation as a Human Disease Model of Cerebellar Cognitive–Affective Dysfunction
Chiari I Malformation as a Human Disease Model of Cerebellar Cognitive–Affective Dysfunction
Chiari malformation type I (CM1) is traditionally viewed as a structural disorder of the posterior fossa characterized by ...
The CCAS-Scale in Chiari Malformation Type I: A Cerebellar-Focused Cognitive Assessment with Clinical Utility
The CCAS-Scale in Chiari Malformation Type I: A Cerebellar-Focused Cognitive Assessment with Clinical Utility
Background/Objectives: The Cerebellar Cognitive-Affective Syndrome (CCAS) scale, introduced by Schmahmann, was prospective...
The Real Life of Ataxia Patients Without a Vertical Family History: a Twenty-year Experience in South Brazil
The Real Life of Ataxia Patients Without a Vertical Family History: a Twenty-year Experience in South Brazil
Studies of hereditary ataxias (HA) without vertical family history are necessary for designing diagnostic protocols. We de...
EEG-ECeG Coherence Mapping of Human Cerebro-cerebellar Projections: An Exploratory Study
EEG-ECeG Coherence Mapping of Human Cerebro-cerebellar Projections: An Exploratory Study
The cerebellar and cerebral cortices are powerfully connected via reciprocal, crossed projections which mediate their coor...
Preoperative Speech Impairments as Precursors of Posterior Fossa Syndrome in Children with Brain Tumours
Preoperative Speech Impairments as Precursors of Posterior Fossa Syndrome in Children with Brain Tumours
Preoperative speech deficits in children with posterior fossa tumours (PFTs) may be linked to postoperative speech impairm...
Low-Titer Anti-GAD Cerebellar Ataxia: Evidence That Diagnosis Should Extend Beyond Serum Antibody Levels – A Case Report and Systematic Review
Low-Titer Anti-GAD Cerebellar Ataxia: Evidence That Diagnosis Should Extend Beyond Serum Antibody Levels – A Case Report and Systematic Review
Anti-glutamic acid decarboxylase (anti-GAD) antibodies are associated with cerebellar ataxia. Although high antibody titer...
Purkinje Cell Loss and Changes in Basket Cell Morphology in Essential Tremor and Other Cerebellar Degenerative Diseases: A Postmortem Study of 332 Brains
Purkinje Cell Loss and Changes in Basket Cell Morphology in Essential Tremor and Other Cerebellar Degenerative Diseases: A Postmortem Study of 332 Brains
Essential tremor (ET) is among the most prevalent neurological diseases. Postmortem studies have demonstrated Purkinje cel...
Multimodal PET Imaging Unveils Early Metabolic Compensation Mechanisms and Dopaminergic Degeneration in Parkinson’s Disease
Multimodal PET Imaging Unveils Early Metabolic Compensation Mechanisms and Dopaminergic Degeneration in Parkinson’s Disease
This study aimed to elucidate the interplay between cerebral glucose metabolism and dopaminergic degeneration in Parkinson...
Post-Infectious Cerebellitis: A Systematic Review of Aetiology, Clinical Presentation, Treatment, and Outcomes
Post-Infectious Cerebellitis: A Systematic Review of Aetiology, Clinical Presentation, Treatment, and Outcomes
Post-infectious cerebellitis is an immune-mediated cerebellar inflammatory syndrome that follows a preceding infection (or...
Blood Glucose Homeostasis is Preserved in Patients with Mild-to-moderate Spinocerebellar Ataxia Type 2
Blood Glucose Homeostasis is Preserved in Patients with Mild-to-moderate Spinocerebellar Ataxia Type 2
Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disorder that shows cerebellar glucose hypometabolism, systemi...
Target Interpretability and Functional Mapping of rTMS and Theta-Burst Stimulation of the Cerebellar Vermis and Midline Cerebellum: A Scoping Review
Target Interpretability and Functional Mapping of rTMS and Theta-Burst Stimulation of the Cerebellar Vermis and Midline Cerebellum: A Scoping Review
The cerebellar vermis and midline cerebellum contribute to motor, oculomotor, vestibular, cognitive, affective, autonomic,...
TNIP1 As A Potential Factor In Neuronal Survival, Growth and Differentiation in the Cerebellar Cortex
TNIP1 As A Potential Factor In Neuronal Survival, Growth and Differentiation in the Cerebellar Cortex
Tumor Necrosis Factor-Induced Protein 1 (TNIP1) is a well-known ubiquitin-binding signaling molecule involved in innate an...
Motor Improvements Following Non-Invasive Brain Stimulation with kTMP: A Case Study of Cerebellar Stroke
Motor Improvements Following Non-Invasive Brain Stimulation with kTMP: A Case Study of Cerebellar Stroke
Cerebellar ataxia results in debilitating impairments in balance, gait, and cognition, with no established effective treat...
Age-Related Volumetric Changes of the Posterior Cranial Fossa and its Structures in Stroke Patients
Age-Related Volumetric Changes of the Posterior Cranial Fossa and its Structures in Stroke Patients
The posterior cranial fossa (PCF) contains critical neural structures, including the cerebellum and brainstem, whose volum...
Anatomy of Cerebro-cerebellar Circuits in Motor Control
Anatomy of Cerebro-cerebellar Circuits in Motor Control
Cerebral cortex and cerebellum are intimately connected enabling them to perform their functions in learning, controlling ...
Cost Effectiveness of the Adjuvanted Recombinant Zoster Vaccine in Older Adults in Portugal
Cost Effectiveness of the Adjuvanted Recombinant Zoster Vaccine in Older Adults in Portugal
Herpes zoster (HZ) and associated complications comprise a considerable public health burden in older adults. This study a...
Trial-Based Economic Evaluations Conducted alongside Studies Embedded in Australian Healthcare Services and Programs: A Scoping Review
Trial-Based Economic Evaluations Conducted alongside Studies Embedded in Australian Healthcare Services and Programs: A Scoping Review
The objective of this study was to map the literature and provide an overview of economic evaluations (EEs) conducted alon...
Updated Health Economics Simulation Model of the Lifetime Progression of Multiple Sclerosis in an Australian Setting
Updated Health Economics Simulation Model of the Lifetime Progression of Multiple Sclerosis in an Australian Setting
Multiple sclerosis (MS) is a progressive disease leading to increasing disability. Our previous simulation model estimated...
Advancing Lost Productivity Measurement in Economic Evaluations: Evidence Priorities from a Targeted Literature Review and Expert Workshop
Advancing Lost Productivity Measurement in Economic Evaluations: Evidence Priorities from a Targeted Literature Review and Expert Workshop
Productivity losses from illness, treatment, and informal caregiving impose a substantial economic burden on patients, car...
Adverse Drug Reaction Costs and Study Quality in Africa: A Systematic Review of Cost-of-Illness Studies
Adverse Drug Reaction Costs and Study Quality in Africa: A Systematic Review of Cost-of-Illness Studies
An adverse drug reaction (ADR) is a harmful, unwanted patient response to a drug that happens at doses normally used for p...
Validation of the Obesity Lifecycle Model Built to Assess the Cost Effectiveness of Novel Therapies in the Management of Obesity
Validation of the Obesity Lifecycle Model Built to Assess the Cost Effectiveness of Novel Therapies in the Management of Obesity
Economic models support healthcare decision makers to efficiently assess value and allocate resources; formal validation i...
A Micro-costing Study of Community-Based Primary HPV Self-Sampling and Triage Test for Cervical Cancer Screening in Rural Cambodia
A Micro-costing Study of Community-Based Primary HPV Self-Sampling and Triage Test for Cervical Cancer Screening in Rural Cambodia
Community-based human papillomavirus (HPV) self-sampling can expand cervical cancer screening coverage in rural settings, ...
Integrating Structured Expert Elicitation with External Evidence to Inform Earlier Reimbursement Decisions: A Norwegian Case Study of Selpercatinib for Non-Small Cell Lung Cancer
Integrating Structured Expert Elicitation with External Evidence to Inform Earlier Reimbursement Decisions: A Norwegian Case Study of Selpercatinib for Non-Small Cell Lung Cancer
The Norwegian public–private partnership, CONNECT, identified the reimbursement submission case of selpercatinibR...
A Scoping Review of Methods for Extrapolating Costs and Effects in Economic Evaluations of Remote Monitoring
A Scoping Review of Methods for Extrapolating Costs and Effects in Economic Evaluations of Remote Monitoring
Telehealth, including remote monitoring, has the potential to reduce healthcare resource use. However, economic evaluation...
Economic Impact of PromarkerD In Vitro Diagnostic Testing on the Management of Chronic Kidney Disease in Type 2 Diabetes: A Budget Impact Analysis
Economic Impact of PromarkerD In Vitro Diagnostic Testing on the Management of Chronic Kidney Disease in Type 2 Diabetes: A Budget Impact Analysis
This study evaluated the clinical and economic impact of integrating Promarker®D, a validated biomarker-based blood t...
AMPLIFY: Estimating Clinical and Humanistic Benefits of Pembrolizumab in Portugal
AMPLIFY: Estimating Clinical and Humanistic Benefits of Pembrolizumab in Portugal
Pembrolizumab has become a cornerstone in the treatment of multiple tumor types. In Portugal, it is currently reimbursed a...
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