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Ivonescimab Plus Chemotherapy versus Bevacizumab Plus Chemotherapy in EGFR-Mutant Lung Adenocarcinoma After EGFR-TKI Failure: A Two-Center Retrospective Real-World Propensity Score-Matched Study
Ivonescimab Plus Chemotherapy versus Bevacizumab Plus Chemotherapy in EGFR-Mutant Lung Adenocarcinoma After EGFR-TKI Failure: A Two-Center Retrospective Real-World Propensity Score-Matched Study
Compared with bevacizumab plus chemotherapy, ivonescimab plus chemotherapy prolongs survival with manageable safety in thi...
First-in-Human Phase I Trial of HRS-2129, a Selective Nav1.8 Inhibitor: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Healthy Subjects
First-in-Human Phase I Trial of HRS-2129, a Selective Nav1.8 Inhibitor: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Healthy Subjects
Within the evaluated dose range, HRS-2129 demonstrated a favorable safety profile, predictable PK with low accumulation, a...
Assessment: An Unresolved Intercurrent Event in a Randomized Trial of Ciprofol versus Propofol [Response to Letter]
Assessment: An Unresolved Intercurrent Event in a Randomized Trial of Ciprofol versus Propofol [Response to Letter]
Response to Letter in regards to Assessment: An Unresolved Intercurrent Event in a Randomized Trial of Ciprofol versus Pro...
Ultrasound-Guided Infraspinatus-Teres Minor Interfascial Block versus Interscalene Brachial Plexus Block for Analgesia After Arthroscopic Shoulder Surgery: A Randomized Non-Inferiority Clinical Trial
Ultrasound-Guided Infraspinatus-Teres Minor Interfascial Block versus Interscalene Brachial Plexus Block for Analgesia After Arthroscopic Shoulder Surgery: A Randomized Non-Inferiority Clinical Trial
This trial compares ultrasound-guided ITMB vs ISB for postoperative analgesia, respiratory safety, and adverse events in a...
Assessment of the Cytotoxic and Apoptotic Impacts of Bimetallic Zinc Iron Oxide Nanoparticles on HuH-7 Cell Line
Assessment of the Cytotoxic and Apoptotic Impacts of Bimetallic Zinc Iron Oxide Nanoparticles on HuH-7 Cell Line
ZnFe2O4NPs as a cytotoxic agent via oxidative stress could be useful in various cancer treatments
Interpreting Perineural Esketamine for Analgesia After Total Knee Arthroplasty: Methodological and Reporting Considerations [Response to Letter]
Interpreting Perineural Esketamine for Analgesia After Total Knee Arthroplasty: Methodological and Reporting Considerations [Response to Letter]
Response to Letter in regards to Interpreting Perineural Esketamine for Analgesia After Total Knee Arthroplasty: Methodolo...
Letter to the Editor Regarding "Effects of Desflurane and Propofol General Anesthesia on Postoperative Recovery Quality in Elderly Patients Undergoing Spinal Surgery: A Randomized Non-Inferiority Trial” [Letter]
Letter to the Editor Regarding "Effects of Desflurane and Propofol General Anesthesia on Postoperative Recovery Quality in Elderly Patients Undergoing Spinal Surgery: A Randomized Non-Inferiority Trial” [Letter]
Letter for the article Effects of Desflurane and Propofol General Anesthesia on Postoperative Recovery Quality in Elderly ...
Matrine Alleviates Sepsis-Induced Acute Lung Injury by Reinforcing NQO1/SLC7A11/GPX4-Associated Anti-Ferroptotic Defenses and Attenuating NF-κB-Driven Inflammation
Matrine Alleviates Sepsis-Induced Acute Lung Injury by Reinforcing NQO1/SLC7A11/GPX4-Associated Anti-Ferroptotic Defenses and Attenuating NF-κB-Driven Inflammation
Matrine alleviates SALI by reinforcing NQO1/SLC7A11/GPX4-associated anti-ferroptotic defenses and attenuating NF-κB-...
Anti-Lung Cancer Agent Discovery and Development: A Review of Cross-Platform Correlation Across in silico, Network Pharmacology, in vitro, and in vivo Assessments
Anti-Lung Cancer Agent Discovery and Development: A Review of Cross-Platform Correlation Across in silico, Network Pharmacology, in vitro, and in vivo Assessments
Synthesising reports evaluating anti–lung cancer agents across computational, cellular, and organism-level platforms...
Esketamine for Postoperative Anxiety After Major Abdominal Tumor Surgery: A Randomized Clinical Trial
Esketamine for Postoperative Anxiety After Major Abdominal Tumor Surgery: A Randomized Clinical Trial
Esketamine did not reduce postoperative anxiety versus placebo in patients with preoperative anxiety undergoing major abdo...
Monkeypox Virus Countermeasures: Vaccines, Antibodies, Drugs and Traditional Chinese Medicine
Monkeypox Virus Countermeasures: Vaccines, Antibodies, Drugs and Traditional Chinese Medicine
To explore mpox measures, therapies, and drug development including vaccines, antibodies, chemicals, natural monomers, TCM...
Integrated Metabolomic and Transcriptomic Analysis Suggests Potential Therapeutic Mechanism of Shengxian Decoction in Hypobaric Hypoxia-Induced Pulmonary Hypertension in SD Rats
Integrated Metabolomic and Transcriptomic Analysis Suggests Potential Therapeutic Mechanism of Shengxian Decoction in Hypobaric Hypoxia-Induced Pulmonary Hypertension in SD Rats
These findings suggest that Shengxian Decoction may ameliorate HPH partly through coordinated regulation of metabolic path...
Development and Validation of a UPLC–MS/MS Method for Simultaneous Quantification of Ensartinib and Its Major Metabolite M465 in Rat Plasma and Application to Pharmacokinetic Studies
Development and Validation of a UPLC–MS/MS Method for Simultaneous Quantification of Ensartinib and Its Major Metabolite M465 in Rat Plasma and Application to Pharmacokinetic Studies
This study developed a UPLC-MS/MS method for quantifying ensartinib and M465 in rat plasma and applied it to pharmacokinet...
First-in-Human Study of the PARP Inhibitor HWH340 in Advanced Solid Tumors with Enrichment for Homologous Recombination Repair Gene Mutations
First-in-Human Study of the PARP Inhibitor HWH340 in Advanced Solid Tumors with Enrichment for Homologous Recombination Repair Gene Mutations
Evaluating the safety, tolerability, pharmacokinetics, and clinical profiles of HWH340 tablets in patients with advanced s...
Folic Acid Therapy is Associated with a Lower Risk of Incident Diabetes and Better Glycemic Status in Patients with Coronary Heart Disease: Findings from a Multicenter Propensity Score–Matched Analysis
Folic Acid Therapy is Associated with a Lower Risk of Incident Diabetes and Better Glycemic Status in Patients with Coronary Heart Disease: Findings from a Multicenter Propensity Score–Matched Analysis
FA use was significantly associated with reduced new-onset diabetes risk and improved long-term glycemic status in CHD pat...
Key Experimental Therapeutics and Knowledge Gaps in Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Key Experimental Therapeutics and Knowledge Gaps in Metabolic Dysfunction-Associated Steatohepatitis (MASH)
MASH therapeutics reviewed via liver cell-centered framework: hepatocyte, immune, stellate, niche, systemic targets demand...
Mechanism of Ferroptosis in Cardiovascular Disease and Its Regulation by Natural Compounds: A Narrative Review
Mechanism of Ferroptosis in Cardiovascular Disease and Its Regulation by Natural Compounds: A Narrative Review
Ferroptosis drives CVD pathology; 35 natural compounds and 19 TCM formulas modulate Nrf2/GPX4/iron pathways, yet clinical ...
Oliceridine versus Hydromorphone for Postoperative Analgesia: Interpreting the PONV Signal and the Limitations of Resting Pain as a Primary Endpoint [Response to Letter]
Oliceridine versus Hydromorphone for Postoperative Analgesia: Interpreting the PONV Signal and the Limitations of Resting Pain as a Primary Endpoint [Response to Letter]
Response to Letter in regards to Oliceridine Versus Hydromorphone for Postoperative Analgesia: Interpreting the PONV Signa...
Analgesic Efficacy of Continuous Bupivacaine Infusion versus Liposomal Bupivacaine in Parasacral Ischial Plane Block After Total Knee Arthroplasty: An Open-Label, Randomized, Controlled, Non-Inferiority Study
Analgesic Efficacy of Continuous Bupivacaine Infusion versus Liposomal Bupivacaine in Parasacral Ischial Plane Block After Total Knee Arthroplasty: An Open-Label, Randomized, Controlled, Non-Inferiority Study
A single-shot PIPB with LB met the prespecified non-inferiority criterion for pain relief compared with CPIPB after TKA, w...
Dose-Finding of Alfentanil for Hysteroscopy Under Remimazolam Sedation in Obese and Normal-Weight Patients: An Up-and-Down Trial
Dose-Finding of Alfentanil for Hysteroscopy Under Remimazolam Sedation in Obese and Normal-Weight Patients: An Up-and-Down Trial
Explored the 95% effective dose (ED95) of alfentanil for suppressing predefined procedural responses during hysteroscopy
Synergistic effects of herbal extracts and nanoparticles in skin damage repair: A comprehensive review
Objective: Today, applying herbal extracts to treat skin damage has become widespread and it is supported by numerous stud...
Evaluation of the effects of Asparagus racemosus extract (ARova5X) supplementation on postmenopausal discomfort
Objective: Menopause is a critical physiological transition often associated with a spectrum of health challenges such as ...
Impact of green tea on obesity-related hormones in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials
Objective: Menopause leads to hormonal changes that increase visceral fat, raising risks for metabolic disorders and breas...
Therapeutic effects of Zataria multiflora Boiss. extract-loaded chitosan nanoparticles against asthma in rats
Objective: Asthma is one of the most common chronic inflammatory disorders worldwide. Zataria multiflora Boiss., widely us...
Lycopene suppresses α-cypermethrin nephrotoxicity: An insight into its modulatory effect on oxidative stress-mediated pro-inflammation, DNA damage and caspase apoptosis in Wistar rats
Objective: Cypermethrin (CPM) is a synthetic pyrethroid pesticide with ubiquitous use in agriculture, but well associated ...
Effect of hydroalcoholic extracts of Quercus brantii and Salvia officinalis on the expression of wound healing and anti-inflammatory factors in human fibroblast cells
Objective: Based on research regarding the regenerative properties of Quercus brantii in wound healing and the anti-inflam...
Beneficial effects of berberine and 6-gingerol against global cerebral ischemia: Insights from stereological, behavioral, and antioxidant enzyme activity
Objective: Global cerebral ischemia (GCI) severely impacts brain function, leading to cognitive impairments and neuronal d...
Investigation of the co-administration of flaxseed supplementation with high-intensity interval training, resistance training, or combined training on hematological indices and kidney health in fructose/CCl4-induced NAFLD in rats
Objective: Types of exercise training and flaxseed are beneficial approaches to improve non-alcoholic fatty liver disease ...
The hepatoprotective impacts of Citrullus colocynthis seeds extract on type 1 diabetes-induced liver inflammation and oxidative stress in rats: The role of nrf2/keap1 pathway
Objective: Type 1 Diabetes (T1D) induces several consequences including hepatic damage resulting from oxidative stress and...
Mistletoe extract (Iscador®) in cancer patients undergoing chemotherapy for prostate and bladder tumors: A prospective observational study
Objective: While mistletoe (a semi-parasitic evergreen plant) extract is commonly used as a complementary therapy in Europ...
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