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Sialin-STAT3 axis regulates bone homeostasis in mice
Sialin-STAT3 axis regulates bone homeostasis in mice
Mitochondrial regulation in mesenchymal stem cells (MSCs) serves as a critical determinant of bone formation and skeletal ...
Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network
Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network
Endochondral ossification is a physiological process involving a sequential formation of cartilage and bone tissues. Class...
Pharmacological HIF activation protects against diet-induced obesity, glucose intolerance, and skeletal dysfunction by exerting dual beneficial effects on energy metabolism and bone
Pharmacological HIF activation protects against diet-induced obesity, glucose intolerance, and skeletal dysfunction by exerting dual beneficial effects on energy metabolism and bone
Obesity and type-2 diabetes, two interconnected and increasingly prevalent metabolic disorders, are associated with poor b...
Estradiol regulates osteoclast sialylation via ST3Gal1 in postmenopausal osteoporosis
Estradiol regulates osteoclast sialylation via ST3Gal1 in postmenopausal osteoporosis
Estrogen deficiency after menopause accelerates bone loss by stimulating osteoclast formation and activity, but the molecu...
Advances in the mechanism for steroid-induced osteonecrosis of the femoral head
Advances in the mechanism for steroid-induced osteonecrosis of the femoral head
Steroid-induced osteonecrosis of the femoral head (SONFH) is a debilitating condition resulting from the use of glucocorti...
Smart biomaterials for skeletal aging repair and regeneration
Smart biomaterials for skeletal aging repair and regeneration
Skeletal aging associated with diverse age-related disorders is increasing due to unhealthy diets, stressful lifestyles, a...
HIF-1α and BMAL1 in bone regeneration: crosstalk between hypoxia response and circadian rhythm
HIF-1α and BMAL1 in bone regeneration: crosstalk between hypoxia response and circadian rhythm
Bone regeneration is initiated after a bone injury, such as a bone fracture or tooth extraction. It is a highly complex bi...
Synovial inflammatory macrophage-derived extracellular vesicles exacerbate cartilage lesions with a FMRP-selectively sorted manner in osteoarthritis
Synovial inflammatory macrophage-derived extracellular vesicles exacerbate cartilage lesions with a FMRP-selectively sorted manner in osteoarthritis
Osteoarthritis (OA) is an aging-related degenerative joint disease without effective therapies. In the early stage of OA, ...
RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
The maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a cor...
Protein Crystallization in Microgravity: Commercialization and the Next Chapter
Protein Crystallization in Microgravity: Commercialization and the Next Chapter
The purpose of this review is to describe the benefit of growing crystals in a microgravity environment and the changes we...
New Disruptive Technologies: Early-Stage Funding and Investment Trends
New Disruptive Technologies: Early-Stage Funding and Investment Trends
This paper provides a discussion of the investment climate in the life sciences industry. The authors explore recent and l...
Physiological Relevant 3D Biomanufacturing of Pluripotent Stem Cells for Regenerative Medicine
Physiological Relevant 3D Biomanufacturing of Pluripotent Stem Cells for Regenerative Medicine
Regenerative medicine is transforming modern healthcare by offering personalized approaches to the treatment of diseases a...
Artificial Intelligence in Biotechnology and Pharmaceuticals: Evolution, Applications, and Regulatory Frontiers
Artificial Intelligence in Biotechnology and Pharmaceuticals: Evolution, Applications, and Regulatory Frontiers
This review aims to examine how Artificial Intelligence (AI) is revolutionizing the biotechnology and pharmaceutical indus...
Denosumab Withdrawal and Rebound Bone Resorption: Molecular Mechanisms and Approaches for Treatment
Denosumab Withdrawal and Rebound Bone Resorption: Molecular Mechanisms and Approaches for Treatment
Denosumab (Dmab) is a human monoclonal anti-RANKL antibody that inhibits osteoclast-mediated bone resorption and sequentia...
From Brain Organoids to Organoid Intelligence. Benefits and Ethical-Moral Framework
From Brain Organoids to Organoid Intelligence. Benefits and Ethical-Moral Framework
Organoid intelligence (OI) is an emerging field in biological computing that integrates brain organoids with external inte...
Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis
Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis
Itaconate, a macrophage-specific anti-inflammatory metabolite, has recently emerged as a critical regulator in rheumatoid ...
Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis
Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease in which synovial fibroblasts (SFs) maintain chronic inflammati...
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration
Intervertebral disc degeneration (IDD) is a progressive and dynamic process in which the senescence-associated secretory p...
Different role of the gut microbiota in postmenopausal and senile osteoporosis
Different role of the gut microbiota in postmenopausal and senile osteoporosis
Fan, Y. & Pedersen, O. Gut microbiota in human metabolic health and disease. Nat. Rev. Microbiol. 19, 55–71 (2021).Art...
Pathophysiology of Myopenia in rheumatoid arthritis
Pathophysiology of Myopenia in rheumatoid arthritis
Rheumatoid arthritis (RA) is a prevalent and debilitating inflammatory disease that significantly impairs functional capac...
Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice
Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice
Membrane-initiated estrogen receptor α (mERα) signaling has been shown to affect bone mass in murine models. How...
ER-induced PERK/TFEB cascade sequentially modulates mitochondrial dynamics during cranial suture expansion
ER-induced PERK/TFEB cascade sequentially modulates mitochondrial dynamics during cranial suture expansion
The effectiveness of cranial suture expansion therapy hinges on the timely and adequate regeneration of bone tissue in res...
Reduced somatosensory innervation alters the skeletal transcriptome at a single cell level in a mouse model of type 2 diabetes
Reduced somatosensory innervation alters the skeletal transcriptome at a single cell level in a mouse model of type 2 diabetes
Peripheral neuropathy is a common complication in diabetes, affecting around 50% of the diabetic population. Co-occurrence...
Stem Cell-Based Strategies for Prenatal Treatment of Spina Bifida and the Promise of Cell-Free, Minimally Invasive Approaches
Stem Cell-Based Strategies for Prenatal Treatment of Spina Bifida and the Promise of Cell-Free, Minimally Invasive Approaches
Spina bifida (SB) is a severe birth defect that affects 1400 newborns annually in the USA. SB is often diagnosed before ir...
TRASCET—Transamniotic Stem Cell Therapy
TRASCET—Transamniotic Stem Cell Therapy
This is an overview of the current state of development of transamniotic stem cell therapy (TRASCET) as an emerging therap...
Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Prenatal intervention for congenital diseases could potentially halt or reverse devastating co-morbidities. Particle-based...
Maternal Gene Delivery for the Prevention and Treatment of Obstetric Conditions
Maternal Gene Delivery for the Prevention and Treatment of Obstetric Conditions
There is an urgent unmet clinical need for effective therapies for obstetric complications such as fetal growth restrictio...
Mesenchymal Stromal Cell Immunomodulatory Potential for Orthopedic Applications can be fine-tuned via 3D nano-engineered Scaffolds
Mesenchymal Stromal Cell Immunomodulatory Potential for Orthopedic Applications can be fine-tuned via 3D nano-engineered Scaffolds
This concise review delves into the pivotal role of three-dimensional (3D) nanostructured scaffolds in fostering mesenchym...
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) occupy the summit of the intricate hematopoiesis hierarchy, constituting a mere 0.01% of t...
Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
To review recent research using various stem cell-related therapies, including bone marrow, adipose tissue, hematopoietic ...
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