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RNA modifications: one ring to map them all
RNA modifications: one ring to map them all
Direct RNA sequencing by the Oxford nanopore technology enabled simultaneous mapping of different RNA modifications on the...
Elucidating structure–function relationships in the mammalian nucleolus
Elucidating structure–function relationships in the mammalian nucleolus
The nucleolus is the site of ribosomal RNA synthesis and ribosome biogenesis. Advances in high-resolution imaging and next...
Emerging evidence for a cooperative pathway of Hedgehog release
Emerging evidence for a cooperative pathway of Hedgehog release
All Hedgehog (Hh) morphogens undergo dual lipidation during biosynthesis. This process renders them insoluble; however, wi...
Principles and mechanisms of plant acclimation to heat stress
Principles and mechanisms of plant acclimation to heat stress
Plants are able to acclimate to heat stress (HS) at the level of individual cells and the whole organism. With extreme tem...
Overview of circular RNA databases and other resources
Overview of circular RNA databases and other resources
Circular RNAs (circRNAs) form a distinct class of RNA molecules with roles in diverse biological processes. The characteri...
Effortless immortalization of primary mouse fibroblasts
Effortless immortalization of primary mouse fibroblasts
A 2003 study established that oxidative DNA damage can drive cell senescence of mouse fibroblasts, and that culturing thes...
Caveolae mechanics in cellular functions and disease
Caveolae mechanics in cellular functions and disease
Caveolae are small, cup-shaped invaginations of the plasma membrane that are enriched in caveolin and cavin proteins, chol...
Tight junction structure, assembly and (dys)function
Tight junction structure, assembly and (dys)function
Tight junctions (TJs) regulate paracellular permeability, cell polarity and cell mechanics of barrier-forming tissues. Thi...
Sialin-STAT3 axis regulates bone homeostasis in mice
Sialin-STAT3 axis regulates bone homeostasis in mice
Mitochondrial regulation in mesenchymal stem cells (MSCs) serves as a critical determinant of bone formation and skeletal ...
Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network
Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network
Endochondral ossification is a physiological process involving a sequential formation of cartilage and bone tissues. Class...
Pharmacological HIF activation protects against diet-induced obesity, glucose intolerance, and skeletal dysfunction by exerting dual beneficial effects on energy metabolism and bone
Pharmacological HIF activation protects against diet-induced obesity, glucose intolerance, and skeletal dysfunction by exerting dual beneficial effects on energy metabolism and bone
Obesity and type-2 diabetes, two interconnected and increasingly prevalent metabolic disorders, are associated with poor b...
Estradiol regulates osteoclast sialylation via ST3Gal1 in postmenopausal osteoporosis
Estradiol regulates osteoclast sialylation via ST3Gal1 in postmenopausal osteoporosis
Estrogen deficiency after menopause accelerates bone loss by stimulating osteoclast formation and activity, but the molecu...
Advances in the mechanism for steroid-induced osteonecrosis of the femoral head
Advances in the mechanism for steroid-induced osteonecrosis of the femoral head
Steroid-induced osteonecrosis of the femoral head (SONFH) is a debilitating condition resulting from the use of glucocorti...
Smart biomaterials for skeletal aging repair and regeneration
Smart biomaterials for skeletal aging repair and regeneration
Skeletal aging associated with diverse age-related disorders is increasing due to unhealthy diets, stressful lifestyles, a...
HIF-1α and BMAL1 in bone regeneration: crosstalk between hypoxia response and circadian rhythm
HIF-1α and BMAL1 in bone regeneration: crosstalk between hypoxia response and circadian rhythm
Bone regeneration is initiated after a bone injury, such as a bone fracture or tooth extraction. It is a highly complex bi...
Synovial inflammatory macrophage-derived extracellular vesicles exacerbate cartilage lesions with a FMRP-selectively sorted manner in osteoarthritis
Synovial inflammatory macrophage-derived extracellular vesicles exacerbate cartilage lesions with a FMRP-selectively sorted manner in osteoarthritis
Osteoarthritis (OA) is an aging-related degenerative joint disease without effective therapies. In the early stage of OA, ...
RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
The maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a cor...
Protein Crystallization in Microgravity: Commercialization and the Next Chapter
Protein Crystallization in Microgravity: Commercialization and the Next Chapter
The purpose of this review is to describe the benefit of growing crystals in a microgravity environment and the changes we...
New Disruptive Technologies: Early-Stage Funding and Investment Trends
New Disruptive Technologies: Early-Stage Funding and Investment Trends
This paper provides a discussion of the investment climate in the life sciences industry. The authors explore recent and l...
Physiological Relevant 3D Biomanufacturing of Pluripotent Stem Cells for Regenerative Medicine
Physiological Relevant 3D Biomanufacturing of Pluripotent Stem Cells for Regenerative Medicine
Regenerative medicine is transforming modern healthcare by offering personalized approaches to the treatment of diseases a...
Artificial Intelligence in Biotechnology and Pharmaceuticals: Evolution, Applications, and Regulatory Frontiers
Artificial Intelligence in Biotechnology and Pharmaceuticals: Evolution, Applications, and Regulatory Frontiers
This review aims to examine how Artificial Intelligence (AI) is revolutionizing the biotechnology and pharmaceutical indus...
Denosumab Withdrawal and Rebound Bone Resorption: Molecular Mechanisms and Approaches for Treatment
Denosumab Withdrawal and Rebound Bone Resorption: Molecular Mechanisms and Approaches for Treatment
Denosumab (Dmab) is a human monoclonal anti-RANKL antibody that inhibits osteoclast-mediated bone resorption and sequentia...
From Brain Organoids to Organoid Intelligence. Benefits and Ethical-Moral Framework
From Brain Organoids to Organoid Intelligence. Benefits and Ethical-Moral Framework
Organoid intelligence (OI) is an emerging field in biological computing that integrates brain organoids with external inte...
Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis
Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis
Itaconate, a macrophage-specific anti-inflammatory metabolite, has recently emerged as a critical regulator in rheumatoid ...
Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis
Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease in which synovial fibroblasts (SFs) maintain chronic inflammati...
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration
Intervertebral disc degeneration (IDD) is a progressive and dynamic process in which the senescence-associated secretory p...
Different role of the gut microbiota in postmenopausal and senile osteoporosis
Different role of the gut microbiota in postmenopausal and senile osteoporosis
Fan, Y. & Pedersen, O. Gut microbiota in human metabolic health and disease. Nat. Rev. Microbiol. 19, 55–71 (2021).Art...
Pathophysiology of Myopenia in rheumatoid arthritis
Pathophysiology of Myopenia in rheumatoid arthritis
Rheumatoid arthritis (RA) is a prevalent and debilitating inflammatory disease that significantly impairs functional capac...
Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice
Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice
Membrane-initiated estrogen receptor α (mERα) signaling has been shown to affect bone mass in murine models. How...
ER-induced PERK/TFEB cascade sequentially modulates mitochondrial dynamics during cranial suture expansion
ER-induced PERK/TFEB cascade sequentially modulates mitochondrial dynamics during cranial suture expansion
The effectiveness of cranial suture expansion therapy hinges on the timely and adequate regeneration of bone tissue in res...
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