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PCSK9 in the liver metastatic niche: From cholesterol homeostasis to tumor microenvironment reprogramming
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Mitophagy in lymph node metastasis: Mechanisms, immune consequences and therapeutic opportunities
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Dendritic cell-driven immune rebalancing as a systemic regulator of tumor and neurodegenerative microenvironments
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Harnessing myeloid plasticity in CAR macrophages for solid tumor immunotherapy
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Hybrid membrane nanosystems for cancer immunotherapy: Biomimetic design, immune activation, and translational potential
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Immune checkpoint inhibitor resistance in non-small cell lung cancer: An updated view through the cancer-immunity cycle
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Macrophages in colorectal cancer: Origin, function and significance of targeted therapy
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Translational aspects of Desmoplastic small round cell tumor (DSRCT): An expert consensus paper from the OCTOPUS group
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Molecular understanding and clinical aspects of adoptive cellular immunotherapy in prostate cancer
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From bone alterations to tumours: Genetic drivers linking Paget’s disease of bone to cancer
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Targeting KRAS G12C in non-small cell lung cancer: Breakthrough inhibitors and combination approaches
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Gut microbiome dysbiosis and cancer: A systematic review on the emerging role of probiotics in oncology
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Brain tumor susceptibility: From genetic predisposition syndromes to extended characterization of genomic determinants
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Research advances in dual-conversion therapy for hepatocellular carcinoma
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Myelodysplastic syndromes: Updates on Genomic Landscape, Molecular Subtypes, & Targeted Therapies
Myelodysplastic syndromes: Updates on Genomic Landscape, Molecular Subtypes, & Targeted Therapies
Advances in modern molecular and genomic testing have spurred tremendous progress in our understanding of MDS pathogenesis...
From MRD To Match: the Role of Allogeneic Hematopoietic Cell Transplant in Philadelphia-Negative B-ALL
From MRD To Match: the Role of Allogeneic Hematopoietic Cell Transplant in Philadelphia-Negative B-ALL
Given the high risk of relapse for Philadelphia-negative (Ph-negative) B-cell acute lymphoblastic leukemia (ALL), allogene...
Targeting RUNX1 Germline Variants: Agents Under Investigation
Targeting RUNX1 Germline Variants: Agents Under Investigation
Despite increased recognition of FPDMM and advancements in genetic technologies that have improved carrier identification ...
Impact of Germline DNA Repair Mutations on Clonal Hematopoiesis and Myeloid Neoplasm Development
Impact of Germline DNA Repair Mutations on Clonal Hematopoiesis and Myeloid Neoplasm Development
Clonal hematopoiesis (CH) arises from the expansion of a single hematopoietic stem cell harboring somatic mutations that c...
Understanding Triple Negative Myeloproliferative Neoplasms and Identifying Molecular Drivers
Understanding Triple Negative Myeloproliferative Neoplasms and Identifying Molecular Drivers
Triple-negative (TN) myeloproliferative neoplasms (MPNs), defined by the absence of canonical driver JAK2, CALR and MPL mu...
When Targeted Therapy Falls Short: Unraveling Resistance Mechanisms in Chronic Lymphocytic Leukemia
When Targeted Therapy Falls Short: Unraveling Resistance Mechanisms in Chronic Lymphocytic Leukemia
Targeted therapies have revolutionized the treatment of chronic lymphocytic leukemia (CLL), however the disease remains in...
Molecular Pathogenesis and Targeted Therapies for Myeloproliferative Hypereosinophilic Neoplasms
Molecular Pathogenesis and Targeted Therapies for Myeloproliferative Hypereosinophilic Neoplasms
This review examines the rapidly evolving landscape of myeloproliferative hypereosinophilic syndromes (HES) and related ne...
Clonal Signatures of Telomere Biology Disorders
Clonal Signatures of Telomere Biology Disorders
In inherited bone marrow failure syndromes (IBMFS), clonal hematopoiesis (CH) has been increasingly recognized as a molecu...