SCI Abstract

search
+
β-Catenin stabilization protects against alveolar hemorrhage through amphiregulin- and BATF-mediated Tregs
β-Catenin stabilization alters the CD8+ T cell phenotype. β-Catenin is required for both αβ and γδ T cell development (21...
Cardiac conduction system malformations in heterotaxy result from dysregulated Pitx2 expression
Disposition of CCS in Cryptic–/– embryos at E18.5. To investigate CCS disposition in mouse heterotaxy, we first examined ...
Targeting PI3Kγ anchoring enhances CFTR membrane localization and modulator efficacy via PKD1
Research ArticleCell biologyPulmonology Open Access | 10.1172/jci.insight.198846 Alessandra M...
Ex vivo–expanded allogeneic Vδ2 T cells specifically reduce reservoirs of HIV-1 following latency reversal
Sex as a biological variable. Self-reported biological sex of study participants was included as a variable for the analy...
Splicing variants in MYRF cause partial loss of function in the retinal pigment epithelium leading to nanophthalmos
Research ArticleGeneticsOphthalmology Open Access | 10.1172/jci.insight.194681 Gabrielle M. R...
CD9 regulates macrophage-mediated remodeling of adipose tissue in obesity
Research ArticleImmunologyMetabolism Open Access | 10.1172/jci.insight.193837 Julia Chini,1,2...
Reduced late endosome/lysosome function promotes SLE through chronic PI3K activity and SHP-1/SHIP-1 defects
Multiple hematopoietic cell types exhibit LEL dysfunction. Previous studies showed that bone marrow–derived Mφs (BMMφs) f...
Hypothyroidism impairs skeletal muscle regeneration after injury by altering myogenic and nonmyogenic pathways
Skeletal muscle regeneration after injury is impaired during hypothyroidism. To assess the impact of thyroid hormone defi...
Extracellular vesicle miR-93-5p cargo regulates glomerular endothelial cell damage in Alport syndrome
Research ArticleCell biologyNephrology Open Access | 10.1172/jci.insight.197643 Charmi Dedhia...
Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke
Research ArticleInflammationNephrology Open Access | 10.1172/jci.insight.189825 Min Zhang,1,2...
Endothelial oncogenic KRAS mutation drives the dynamics of microglia and macrophages in brain arteriovenous malformation
ECs carrying mutant KRAS lead to bAVM genesis. We previously showed that ECs carrying mutant human KRAS (KRAS-ECs) are su...
DAB2 in LGMD R2: a molecular link between disease progression and lipid dysregulation
Research ArticleCell biologyMuscle biology Open Access | 10.1172/jci.insight.200054 Celine Br...
DNA delivered by lipid nanoparticles induces CD8+ T cell–dependent antitumor responses and enhances anti–PD-L1 therapy
DNA delivered by LNPs induces an antitumor effect in mouse models of HCC. HCC is an optimal target for DNA-LNP therapy gi...
IFN-γ–induced trained immunity enhances killing of priority pathogens in healthy and genetically vulnerable individuals
Research ArticleImmunologyInfectious disease Open Access | 10.1172/jci.insight.195866 Dearbhl...
Consideration of spatial companion biomarkers for targeted therapeutics in cancer: depatuxizumab mafodotin in glioblastoma
Research LetterNeuroscienceOncology Open Access | 10.1172/jci.insight.198475 Rimas V. Lukas,1...
Heterozygous NFKB1 variant causes inflammatory dysregulation shaped by broader genetic context in common variable immunodeficiency
Research ArticleImmunologyInflammation Open Access | 10.1172/jci.insight.198703 Kevin M. Haye...
Epidermal NAD+ deficiency induces IL-36–mediated skin inflammation and acanthosis
Research ArticleDermatologyMetabolism Open Access | 10.1172/jci.insight.189177 Taiki Seki,1,2...
PI3K regulates TAZ/YAP and mTORC1 axes that can be synergistically targeted
PI3K is activated in sarcomas. To evaluate the mutational landscape of the PI3K signaling pathway, we analyzed publicly a...
Nrf2 activator peptide protects the brain from cerebral vascular dysfunction in alcohol ingestion
Determination of optimal dose and evaluation of drug safety. The peptide sequences used in this study, including the Nrf2...
Dietary palmitic acid inhibits colorectal cancer progression through enhancing bisecting GlcNAc
Bisecting GlcNAc levels are reduced in CRC tissues. We previously reported the downregulation of MGAT3 expression and bis...
Spread through air spaces (STAS) in lung adenocarcinoma: Prognostic impact of morphologic patterns, density, and extent
According to the World Health Organization (WHO), lung cancer is among the most common malignancies worldwide and remains ...
Clinicopathological characterization of gastric amphicrine carcinoma: A case series
Gastric amphicrine carcinoma (GAC) is a rare malignancy exhibiting dual neuroendocrine and exocrine differentiation. Claud...
Pulmonary intravascular mononuclear cell accumulation in cases of mechanical asphyxia due to external neck compression
Pulmonary intravascular mononuclear cell accumulations have been described in mechanical asphyxia, but their diagnostic va...
Interval appendicitis
There are a few studies that have focused on histopathologic findings in interval appendectomies compared to acute appendi...
Novel RUNX1/2 fusions in unclassified cystic squamous salivary gland tumors: Possible expansion of the keratocystoma family
Keratocystoma is a salivary gland tumor which was described by Nagao, et al. in a two-case report in 2002 [1], likely the ...
Diagnostic value of dystrophin immunostaining for histopathologic diagnosis of uterine smooth muscle tumors
Uterine smooth muscle tumors (USMT) are the most common neoplasms of the uterus, categorized into benign, uncertain malign...
From the archives of MD Anderson Cancer Center: Paraneoplastic autoimmune multiorgan syndrome (PAMS) associated with stroma-rich Castleman disease
Paraneoplastic autoimmune multiorgan syndrome (PAMS) is a heterogeneous autoimmune condition that can occur as a complicat...
“Letter to the editor: Comparative analysis of MIB1 and SP6 antibodies for Ki-67 assessment in breast carcinoma with focus on the influence of molecular subtyping”
This letter evaluates the study by Milev and Ivanov (2025) comparing MIB1 and SP6 antibodies for Ki-67 assessment in breas...
Percutaneous renal mass biopsies with no viable lesional cells – Recognizing different histologic patterns can help predict nondiagnostic vs. true negative biopsy and guide clinical management
Percutaneous core needle biopsy for renal mass is increasingly utilized to provide histological diagnoses, helping to avoi...
H3-3A gene mutation analysis in giant cell tumor of bone and its histologic mimics: A single institutional study from India
Though the diagnostic utility of H3.3G34W immunohistochemistry (IHC) for giant cell tumor of bone (GCTB) is well establish...
Load More
format_indent_increase