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A PIVOT towards single-cell functional genetic screening in plants
A PIVOT towards single-cell functional genetic screening in plants
We developed PIVOT, a single-cell screening platform for functional characterization of plant genes. PIVOT enables deliver...
Newcomer anti-IL-33 makes strides in COPD
Newcomer anti-IL-33 makes strides in COPD
AstraZeneca’s IL-33 antibody tozorakimab targets two distinct signaling pathways engaged in COPD: inflammation and e...
Circling back to RNA vaccines
While circRNA is often framed as a more stable, longer-lasting alternative to linear mRNA, its real-world advantages remai...
Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models
Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models
Although immunotherapy has benefited a subset of persons with cancer, its broader efficacy remains limited, primarily beca...
Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery
Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery
Predicting T cell receptor (TCR) specificity on the basis of sequence is challenging because TCRs of similar sequence can ...
Guide DNA — not RNA — expands the CRISPR toolkit
Guide DNA — not RNA — expands the CRISPR toolkit
Cas12 nucleases can use guide DNA instead of guide RNA, which switches their targets from DNA to RNA.
DNA-guided CRISPR–Cas12 for cellular RNA targeting
DNA-guided CRISPR–Cas12 for cellular RNA targeting
Here, we present ΨDNA, a DNA-based guide that enables RNA targeting by Cas12 nucleases, overcoming the traditional re...
Widespread DNA off-targeting confounds RNA chromatin occupancy studies
Widespread DNA off-targeting confounds RNA chromatin occupancy studies
Several high-throughput sequencing methods have been used to study the genome-wide chromatin occupancy of long noncoding R...
Improving lipid production by for renewable fuel production based on machine learning
Improving lipid production by for renewable fuel production based on machine learning
Microbial lipid fermentation encompasses intricate complex cell growth processes and heavily relies on expert experience f...
Revisiting soil fungal biomarkers and conversion factors: Interspecific variability in phospholipid fatty acids, ergosterol and rDNA copy numbers
Revisiting soil fungal biomarkers and conversion factors: Interspecific variability in phospholipid fatty acids, ergosterol and rDNA copy numbers
The abundances of fungi and bacteria in soil are used as simple predictors for carbon dynamics, and represent widely avail...
Notes, outline, systematics and phylogeny of hyaline-spored hyphomycetes
Notes, outline, systematics and phylogeny of hyaline-spored hyphomycetes
Hyphomycetes is an artificial group of asexual fungi with an estimated 2200 recognizable genera. These fungi have crucial ...
The silent cleanup arsenal: microbial biofertilizers and their enzymatic pathways for arsenic decontamination in agricultural soils
The silent cleanup arsenal: microbial biofertilizers and their enzymatic pathways for arsenic decontamination in agricultural soils
Arsenic (As) contamination in agricultural soils endangers environmental health and food security by inducing phytotoxicit...
Lab Scale Closed-Loop Recycling of Polycarbonate Bioreactors for Sustainable Process Development
Lab Scale Closed-Loop Recycling of Polycarbonate Bioreactors for Sustainable Process Development
Despite well-known benefits, the increasing use of single-use technology (SUT) in biopharmaceutical processes has raised c...
Reusability of immobilised lipase in the production of omega-3 oils from squid viscera
Reusability of immobilised lipase in the production of omega-3 oils from squid viscera
Squid viscera, a waste product from squid processing, is a marine source of omega-3 fatty acid–rich oil suitable for...
Co-expression, purification, and characterization of an acidophilic and n-hexane-tolerant lipase with its foldase from Bsp-1
Co-expression, purification, and characterization of an acidophilic and n-hexane-tolerant lipase with its foldase from Bsp-1
Lipases are versatile biocatalysts widely applied in hydrolysis and synthesis reactions, yet bacterial acidophilic and sol...
Physiological characterization of anaerobic cometabolic transformation of sulfamethoxazole by Hildenborough
Physiological characterization of anaerobic cometabolic transformation of sulfamethoxazole by Hildenborough
Sulfonamide antibiotics are widely used in medicine and farming and residual amounts end up in wastewater effluents and so...
Research progress on nucleic acid amplification–based detection technologies for phytopathogenic fungi
Research progress on nucleic acid amplification–based detection technologies for phytopathogenic fungi
Phytopathogenic fungi are highly diverse and globally distributed, posing a major threat to agricultural production worldw...
Foot-and-mouth disease virus-like particle mRNA vaccine induces strong humoral and cellular immunity
Foot-and-mouth disease virus-like particle mRNA vaccine induces strong humoral and cellular immunity
Foot-and-mouth disease (FMD) is a major animal infectious disease that has garnered significant international attention. C...
Identification and characterization of prostaglandin F 9-dehydrogenase from
Identification and characterization of prostaglandin F 9-dehydrogenase from
Prostaglandin F2α (PGF2α) is one of the most important bioactive lipids in mammals. Developing a bioproduction s...
Enhanced biomass and desulfurization by recombinant IGTS8 in bioreactor cultures
Enhanced biomass and desulfurization by recombinant IGTS8 in bioreactor cultures
Rhodococcus qingshengii IGTS8 is a model strain well-known for its ability to remove sulfur from dibenzothiophene (DBT) an...
Investigation of regioselectivity and thermostability of free and immobilized lipase
Investigation of regioselectivity and thermostability of free and immobilized lipase
A fungal lipase from the Basidiomycete Pleurotus citrinopileatus (PCI_Lip) has been investigated for its regioselectivity....
Optimized expression and antimicrobial activity of rainbow trout defensin 3 in
Optimized expression and antimicrobial activity of rainbow trout defensin 3 in
Rainbow trout β-defensin 3 (rtDefb3) is identified as a small cationic antimicrobial peptide, but its recombinant exp...
Retraction notice to “Identification and recombinant expression of a novel defluorinase from Rhodococcus jostii RHA1, for defluorination and biotransformation of the PFAS compound 6:2 fluorotelomer carboxylic acid” [Enzyme Microb. Technol. 191 (2025) 110724]
Available online 9 February 2026, 110823Author links open overlay panelEustace Y. FernandoShow moreRecommended articlesVie...
Biochemical characterization of heterologously expressed Thiomonas delicata arsenite oxidase subunits (AioA and AioB)
Arsenite oxidase (Aio) plays a central role in the microbial oxidation of As(III) to the generally less toxic and more eas...
The potential and innovative applications of CRISPR gene editing technology in enzyme gene development
This review innovatively proposes for the first time that CRISPR gene editing technology can be used for site specific fus...
Naringinase: A comprehensive review on its characteristics, production, and biotechnological applications
Naringinase (E.C. 3.2.1.40) is an enzyme complex that's recently garnered significant attention due to its enzymatic activ...
Cellulose biosynthesis in nature and In Vitro: mechanisms and challenges
Cellulose is a polysaccharide predominantly found in the extracellular matrices of plants, algae and bacteria [1], with ur...
Enzymatic synthesis of sucrose esters: Advances and challenges in high-efficiency and regioselective catalysis
Sucrose esters (SEs), commonly referred to as fatty acid sucrose esters, are amphiphilic compounds synthesized via the est...
Levansucrase from Gluconacetobacter diazotrophicus. Key residues involved in levan synthesis
The polysaccharide levan is a homopolymer that reaches 104 fructose units and is structured in β-(2→6) linked main chains,...
Efficient production of active recombinant cholesterol oxidase from Rhodococcus erythropolis in Escherichia coli via his-tag assisted refolding strategy for cholesterol oxidation
Cholesterol oxidase (ChOx) is a flavoprotein enzyme that catalyzes the oxidation of cholesterol to 4-cholesten-3-one with ...
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