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Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration
Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration
Enamel, the hardest mineralized material in the human body, protects the underlying living tissues, the dentin and pulp of...
KDM6B/Pdk1 glycolytic pathway-driven ZEB2 lactylation promotes cellular cementum formation
KDM6B/Pdk1 glycolytic pathway-driven ZEB2 lactylation promotes cellular cementum formation
Periodontitis is a common chronic inflammatory disease that ultimately results in irreversible tooth loss. Cementum, a bon...
Correction: Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux
Correction: Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Bioengineered α-Hairpin peptide TKH with GKG linker: a LLPS-mediated biomimetic mineralization system for intrafibrillar remineralization and deep dentin tubule occlusion
Bioengineered α-Hairpin peptide TKH with GKG linker: a LLPS-mediated biomimetic mineralization system for intrafibrillar remineralization and deep dentin tubule occlusion
Dentin hypersensitivity (DH) originates from collagen exposure and dentinal tubules (DTs) patency caused by mechanical abr...
JAK-STAT signaling: molecular mechanism and targeted treatment in dento-maxillofacial abnormalities
JAK-STAT signaling: molecular mechanism and targeted treatment in dento-maxillofacial abnormalities
Dento-maxillofacial abnormalities are highly prevalent and arise as a result of a variety of etiological factors, presenti...
Defining subcellular synovial responses in TMJ osteoarthritis onset via mechanical stress and articular disk derangement models
Defining subcellular synovial responses in TMJ osteoarthritis onset via mechanical stress and articular disk derangement models
Temporomandibular joint osteoarthritis (TMJ-OA), the most common degenerative disease of the TMJ, is influenced by various...
Gli2 and Gli3 synergistically mediate HH-TGF-β crosstalk in mesenchymal progenitor cells to orchestrate tooth root morphogenesis
Gli2 and Gli3 synergistically mediate HH-TGF-β crosstalk in mesenchymal progenitor cells to orchestrate tooth root morphogenesis
Hedgehog (HH) signaling is essential in directing the fate determination of postmigratory cranial neural crest cells (CNCC...
Expert consensus on orthodontic-associated alveolar ridge augmentation for adult patients
Expert consensus on orthodontic-associated alveolar ridge augmentation for adult patients
Alveolar bone defects, including dehiscence and fenestration, are commonly encountered in adult patients seeking orthodont...
Author Correction: Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation
Author Correction: Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation
Correction to: International Journal of Oral Science https://doi.org/10.1038...
Expert consensus on the prevention and treatment of radiochemotherapy-induced oral mucositis
Expert consensus on the prevention and treatment of radiochemotherapy-induced oral mucositis
Radiochemotherapy-induced oral mucositis (OM) is a common oral complication in patients with tumors following head and nec...
Saliva as a non-invasive matrix for assessing xenobiotic metabolites and metabolomes: implications for maternal health and preeclampsia
Saliva as a non-invasive matrix for assessing xenobiotic metabolites and metabolomes: implications for maternal health and preeclampsia
Chemical exposure during prenatal development has significant implications for both maternal and child health. Compared to...
Single-cell transcriptomics identifies PDGFRA+ progenitors orchestrating angiogenesis and periodontal tissue regeneration
Single-cell transcriptomics identifies PDGFRA+ progenitors orchestrating angiogenesis and periodontal tissue regeneration
Periodontal bone defects, primarily caused by periodontitis, are highly prevalent in clinical settings and manifest as bon...
c-Kit signaling confers damage-resistance to sweet taste cells upon nerve injury
c-Kit signaling confers damage-resistance to sweet taste cells upon nerve injury
Taste buds relay taste sensory information to the primary taste neurons but depend on those same neurons for essential com...
Expert consensus on digital restoration of complete dentures
Expert consensus on digital restoration of complete dentures
Digital technologies have become an integral part of complete denture restoration. With advancement in computer-aided desi...
Persistent accumulation of therapy-induced senescent cells: an obstacle to long-term cancer treatment efficacy
Persistent accumulation of therapy-induced senescent cells: an obstacle to long-term cancer treatment efficacy
In the ever-evolving landscape of cancer therapy, while cancer treatments such as chemotherapy, radiotherapy, and targeted...
Single-cell spatial atlas of smoking-induced changes in human gingival tissues
Single-cell spatial atlas of smoking-induced changes in human gingival tissues
Smoking is a well-established risk factor for periodontitis, yet the precise mechanisms by which smoking contributes to pe...
CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B
CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B
Odontoblasts are primarily responsible for synthesizing and secreting extracellular matrix proteins, which are crucial for...
Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches
Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches
Periodontitis is a chronic inflammatory disease initiated by biofilm microorganisms and mediated by host immune imbalance....
An unexpected role of Nogo-A as regulator of tooth enamel formation
An unexpected role of Nogo-A as regulator of tooth enamel formation
Neurite outgrowth inhibitor A (Nogo-A) is a major player in neural development and regeneration and the target of clinical...
Personalized bioceramic grafts for craniomaxillofacial bone regeneration
Personalized bioceramic grafts for craniomaxillofacial bone regeneration
The reconstruction of craniomaxillofacial bone defects remains clinically challenging. To date, autogenous grafts are cons...
Organoids in the oral and maxillofacial region: present and future
Organoids in the oral and maxillofacial region: present and future
The oral and maxillofacial region comprises a variety of organs made up of multiple soft and hard tissue, which are anatom...
Correction: An unexpected role of Nogo-A as regulator of tooth enamel formation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Cuproptosis-related lncRNA JPX regulates malignant cell behavior and epithelial-immune interaction in head and neck squamous cell carcinoma via miR-193b-3p/PLAU axis
Cuproptosis-related lncRNA JPX regulates malignant cell behavior and epithelial-immune interaction in head and neck squamous cell carcinoma via miR-193b-3p/PLAU axis
The development, progression, and curative efficacy of head and neck squamous cell carcinoma (HNSCC) are influenced by com...
A blood glucose fluctuation-responsive delivery system promotes bone regeneration and the repair function of Smpd3-reprogrammed BMSC-derived exosomes
A blood glucose fluctuation-responsive delivery system promotes bone regeneration and the repair function of Smpd3-reprogrammed BMSC-derived exosomes
Blood glucose fluctuation leads to poor bone defect repair in patients with type 2 diabetes (T2DM). Strategies to safely a...
Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral
Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral
Ameloblasts are specialized cells derived from the dental epithelium that produce enamel, a hierarchically structured tiss...
Expert consensus on digital guided therapy for endodontic diseases
Expert consensus on digital guided therapy for endodontic diseases
Digital guided therapy (DGT) has been advocated as a contemporary computer-aided technique for treating endodontic disease...
Dental impact of anti-fibroblast growth factor 23 therapy in X-linked hypophosphatemia
Dental impact of anti-fibroblast growth factor 23 therapy in X-linked hypophosphatemia
Elevated fibroblast growth factor 23 (FGF23) in X-linked hypophosphatemia (XLH) results in rickets and phosphate wasting, ...
Mesenchymal stem cell-derived apoptotic bodies alleviate alveolar bone destruction by regulating osteoclast differentiation and function
Mesenchymal stem cell-derived apoptotic bodies alleviate alveolar bone destruction by regulating osteoclast differentiation and function
Periodontitis is caused by overactive osteoclast activity that results in the loss of periodontal supporting tissue and me...
Molecular mechanisms of cellular metabolic homeostasis in stem cells
Molecular mechanisms of cellular metabolic homeostasis in stem cells
Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-r...
Titanium particles in peri-implantitis: distribution, pathogenesis and prospects
Titanium particles in peri-implantitis: distribution, pathogenesis and prospects
Peri-implantitis is one of the most important biological complications in the field of oral implantology. Identifying the ...
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