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Keratinocytes take part in the regulation of substance P in melanogenesis through the HPA axis
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, ChinaState Key Laboratory of Na...
Nicotinamide mononucleotide reduces melanin production in aged melanocytes by inhibiting cAMP/Wnt signaling
Phillip J.M. Aifuwa I. Walston J. Wirtz D. The mechanobiology of aging.Annu. Rev. Biomed. Eng. 17: 113-141Hakozaki T. Swan...
Increase in inhibin beta A/Activin-A expression in the human epidermis and the suppression of epidermal stem/progenitor cell proliferation with aging
Giangreco A. Qin M. Pintar J.E. Watt F.M. Epidermal stem cells are retained in vivo throughout skin aging.Aging Cell. 7: 2...
Novel GSK-3 kinase inhibitor Pym-5 induces GSK-3β rather than GSK-3α-dependent melanogenesis in murine melanoma cells
Pym-5 promotes MIFT-dependent melanogenesis in vitro.The hallmark of differentiated melanocytes is the presence of melanin...
Evaluating differential expression of fibrosis-related genes and their correlation with blood vessel density in chronic cutaneous graft-versus-host disease
Background Sclerodermoid graft-versus-host disease (GVHD) is the most severe form of chronic GVHD (c...
TRPA1 promotes melanosome phagocytosis in keratinocytes via PAR-2/CYLD axis
Microtubules are involved in melanosome redistribution from dispersed to clustered (centripetal transport) [[18]Evans R.D....
Tiamulin inhibits TNF-α and alleviates psoriasis-like dermatitis
Griffiths C.E.M. Armstrong A.W. Gudjonsson J.E. J. Bark. Psoriasis Lancet. 397: 1301-1315Parisi R. Iskandar I.Y.K. Kontopa...
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Anti-inflammatory effects of differential molecular weight Hyaluronic acids on UVB-induced calprotectin-mediated keratinocyte inflammation
Highlights•uLMW-HA decreased UVB-induced IL-6 secretion.•uLMW-HA downregulated Calprotectin-induced TRAF6 expression.•CD44...
Impaired holocrine secretion and intracellular retention of autophagosomal components in comedones
Comedo, a clogged hair follicle, is one of the predisposing factors of acne. Comedo formation has been known to resu...
Aberrant serine protease activities in atopic dermatitis
New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity.J. D...
Actinic lentigines from Japanese and European volunteers share similar impaired biological functions
Bastiaens M. Hoefnagel J. Westendorp R. Vermeer B.J. Bouwes J.N. Bavinck, Solar lentigines are strongly related to sun exp...
Staphylococcus aureus phenol-soluble modulins induce itch sensation
Atopic dermatitis (AD) is one of the most common debilitating inflammatory skin diseases and often results in lifelo...
Yohimbine hydrochloride inhibits skin melanin synthesis by regulating wnt/β-catenin and p38/MAPK signal pathways
Background Yohimbine hydrochloride (YH) is a prescription drug to treat erectile dysfunction. It als...
Abnormal inflammatory traits and downregulated caveolin-1 expression in monocytes of psoriasis patients may be associated with psoriatic inflammation and atherosclerosis
Background Monocytes and macrophages are implicated in inflammation and atherosclerosis, whereas mon...
Plasma metabolomic profiling reflects the malnourished and chronic inflammatory state in recessive dystrophic epidermolysis bullosa
Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, T...
The role of HMGB1 in inflammatory skin diseases
Harris H.E. Andersson U. Pisetsky D.S. HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease.Nat. R...
Risk factors for sepsis and effects of pretreatment with systemic steroid therapy for underlying condition in SJS/TEN patients: Results of a nationwide cross-sectional survey in 489 Japanese patients
Background Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening ...
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