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Deep-Learning Solution Providing Molecular Marker Subtyping of Breast Cancer Whole Slide Images: Protocol for a UK Clinical Service Evaluation Study
Deep-Learning Solution Providing Molecular Marker Subtyping of Breast Cancer Whole Slide Images: Protocol for a UK Clinical Service Evaluation Study
Background: As the histopathology workforce continues to struggle and service demand continues to increase, it has become ...
Prevalence of and Risk Factors for Metabolic Syndrome, Vascular Damage, and Accelerated Aging (MetVasA) After Pediatric Hematopoietic Stem Cell Transplantation for Hematological Malignancy: Protocol for a Cross-Sectional Cohort Study
Prevalence of and Risk Factors for Metabolic Syndrome, Vascular Damage, and Accelerated Aging (MetVasA) After Pediatric Hematopoietic Stem Cell Transplantation for Hematological Malignancy: Protocol for a Cross-Sectional Cohort Study
Background: Survivors of hematopoietic stem cell transplantation (HSCT) in childhood face a high risk of metabolic and car...
Comparing 2-Hz and 100-Hz Electroacupuncture for Postoperative Musculoskeletal Pain: Protocol for a 2 × 2 Prospective Randomized Crossover Trial
Comparing 2-Hz and 100-Hz Electroacupuncture for Postoperative Musculoskeletal Pain: Protocol for a 2 × 2 Prospective Randomized Crossover Trial
Background: Postoperative pain after musculoskeletal surgery impedes early rehabilitation and reduces quality of life. Ele...
Prognostic Performance of C-Reactive Protein for Tuberculosis Outcome: Protocol for a Systematic Review and Meta-Analysis
Prognostic Performance of C-Reactive Protein for Tuberculosis Outcome: Protocol for a Systematic Review and Meta-Analysis
Background: Tuberculosis (TB) remains a major global health challenge, with substantial mortality despite the availability...
Early vs Late Initiation of Extracorporeal Membrane Oxygenation: Protocol for a Prospective, Randomized, Multicenter Study
Early vs Late Initiation of Extracorporeal Membrane Oxygenation: Protocol for a Prospective, Randomized, Multicenter Study
Background: Acute respiratory distress syndrome (ARDS) is characterized by severe inflammatory lung injury leading to life...
Dovramilast for Erythema Nodosum Leprosum in Patients With Leprosy in Nepal: Protocol for a Phase 2 Open-Label Pilot Study
Dovramilast for Erythema Nodosum Leprosum in Patients With Leprosy in Nepal: Protocol for a Phase 2 Open-Label Pilot Study
Background: Erythema nodosum leprosum (ENL) is an immunological complication affecting up to 10% of borderline lepromatous...
Understanding Motor Adaptation in the Transition to Sustained Pain: Protocol for a Longitudinal Experimental Study
Understanding Motor Adaptation in the Transition to Sustained Pain: Protocol for a Longitudinal Experimental Study
Background: Chronic pain affects over 30% of the global population and remains a major public health issue due to limited ...
Evaluation of the Psychometric Properties and Applicability of Agni Assessment Tools in Ayurveda: Protocol for a Systematic Review
Evaluation of the Psychometric Properties and Applicability of Agni Assessment Tools in Ayurveda: Protocol for a Systematic Review
Background: Agni (digestive or metabolic factors) is a fundamental concept in Ayurveda that governs digestion, metabolism,...
Advancing Discussions Using a Video-Based Support Tool About End-of-Life Care (ADVISE): Protocol for a Single-Center Randomized Controlled Trial
Advancing Discussions Using a Video-Based Support Tool About End-of-Life Care (ADVISE): Protocol for a Single-Center Randomized Controlled Trial
Background: More than 950,000 adults over 65 years of age are hospitalized each year after injury. Recommended care for th...
Design, Development, and Validation of a Chatbot to Support Health Care Professionals Experiencing Workplace Aggression: Protocol for a Mixed Methods Study
Design, Development, and Validation of a Chatbot to Support Health Care Professionals Experiencing Workplace Aggression: Protocol for a Mixed Methods Study
Background: Workplace violence against health care professionals has increased worldwide, leading to negative psychologica...
Moderating Role of State and Trait Positive Affect in Virtual Reality Exposure for Public Speaking Anxiety: Protocol for a Multisite Experimental Study
Moderating Role of State and Trait Positive Affect in Virtual Reality Exposure for Public Speaking Anxiety: Protocol for a Multisite Experimental Study
Background: The identification of moderators of exposure-based cognitive behavior therapy (EXCBT) outcome has the potentia...
Effects of Aerobic Training Versus Behavioral Intervention to Increase Physical Activity for Disease Control in Patients With Asthma: Protocol for a Randomized Trial
Effects of Aerobic Training Versus Behavioral Intervention to Increase Physical Activity for Disease Control in Patients With Asthma: Protocol for a Randomized Trial
Background: Aerobic training (AT) and behavioral intervention (BI) aimed at increasing physical activity provide numerous ...
Assessing the Ability of an Online Education Program to Modify Patient Expectations of Total Knee Arthroplasty Outcomes: Protocol for a Randomized Controlled Trial
Assessing the Ability of an Online Education Program to Modify Patient Expectations of Total Knee Arthroplasty Outcomes: Protocol for a Randomized Controlled Trial
Background: Patient satisfaction with total knee arthroplasty (TKA) is strongly influenced by alignment between expectatio...
Artificial Intelligence–Assisted Image Extraction in Neonatal Echocardiography for Congenital Heart Disease Diagnosis in Sub-Saharan Africa: Protocol for Model Development
Artificial Intelligence–Assisted Image Extraction in Neonatal Echocardiography for Congenital Heart Disease Diagnosis in Sub-Saharan Africa: Protocol for Model Development
Background: Sub-Saharan Africa (SSA) bears the highest global burden of under-5 mortality, with congenital heart disease (...
Efficacy of a Ready-to-Feed Starter Liquid Infant Formula Containing 2-Fucosyllactose and Lacto-N-Neotetraose in Chinese Infants: Protocol for a Double Blind, Randomized Controlled Trial
Efficacy of a Ready-to-Feed Starter Liquid Infant Formula Containing 2-Fucosyllactose and Lacto-N-Neotetraose in Chinese Infants: Protocol for a Double Blind, Randomized Controlled Trial
Background: Bioactive compounds, such as human milk oligosaccharides (HMOs), impact the development of the intestinal micr...
Effect of TikTok on Self-Harm and Suicidal Behavior in the Adolescent Population: Protocol for a Systematic Review
Effect of TikTok on Self-Harm and Suicidal Behavior in the Adolescent Population: Protocol for a Systematic Review
Background: Social media use among adolescents and young adults has increased exponentially over the last decade, with Tik...
Implementation, Experiences, Impact, and Costs of Artificial Intelligence in Chest Diagnostics: Protocol for a Mixed Methods Evaluation
Implementation, Experiences, Impact, and Costs of Artificial Intelligence in Chest Diagnostics: Protocol for a Mixed Methods Evaluation
Background: The ability to perform complex tasks has seen artificial intelligence (AI) used to support radiology in clinic...
Development of an Intervention for Managing Adolescent Anxiety Using Community-Based Participatory Methods: Protocol
Development of an Intervention for Managing Adolescent Anxiety Using Community-Based Participatory Methods: Protocol
Background: Youth of color that live in urban communities, face disproportionate anxiety levels due to systemic inequities...
Moringa oleifera Supplementation for Reducing Heavy Metal Toxicity and Oxidative Stress in Pregnant Women: Protocol for a Nonrandomized Trial Study
Moringa oleifera Supplementation for Reducing Heavy Metal Toxicity and Oxidative Stress in Pregnant Women: Protocol for a Nonrandomized Trial Study
Background: Heavy metals present in the environment, including lead, cadmium, and mercury, pose significant health risks t...
Developing a Core Outcome Set and a Core Outcome Measurement Set for Studies Evaluating Interventions to Minimize Physical Restraint Use in Adult Intensive Care Units: Protocol for a Modified Delphi Study
Developing a Core Outcome Set and a Core Outcome Measurement Set for Studies Evaluating Interventions to Minimize Physical Restraint Use in Adult Intensive Care Units: Protocol for a Modified Delphi Study
Background: Heterogeneity in outcome selection and measurement methods has been noted in studies examining the minimizatio...
Developing a Multisensor-Based Machine Learning Technology (Aidar Decompensation Index) for Real-Time Automated Detection of Post–COVID-19 Condition: Protocol for an Observational Study
Developing a Multisensor-Based Machine Learning Technology (Aidar Decompensation Index) for Real-Time Automated Detection of Post–COVID-19 Condition: Protocol for an Observational Study
Background: Post–COVID-19 condition is emerging as a new epidemic, characterized by the persistence of COVID-19 symptoms b...
Stress and Hypertension Among African American Female Family Caregivers of Persons Living With Alzheimer Disease and Related Dementias: Protocol for a Pilot Internet-Based Randomized Controlled Trial
Stress and Hypertension Among African American Female Family Caregivers of Persons Living With Alzheimer Disease and Related Dementias: Protocol for a Pilot Internet-Based Randomized Controlled Trial
Background: Caregivers of persons with Alzheimer disease and related dementias (ADRD) neglect their health, including by i...
Efficacy of a Web-Based Integrated Growth Mindset Intervention on Reducing Anxiety Among Social Work and Counseling Practicum Trainees: Protocol for a 2-Arm Randomized Controlled Trial
Efficacy of a Web-Based Integrated Growth Mindset Intervention on Reducing Anxiety Among Social Work and Counseling Practicum Trainees: Protocol for a 2-Arm Randomized Controlled Trial
Background: Practicum is indispensable for the development of professional practitioners; yet, trainees may encounter psyc...
Lung Cancer Screening in Family Members and Peers of Patients With Lung Cancer: Protocol for a Prospective Cohort Study
Lung Cancer Screening in Family Members and Peers of Patients With Lung Cancer: Protocol for a Prospective Cohort Study
Background: Low-dose computed tomography (LDCT) screening is promising for the early detection of lung cancer (LC) and the...
Development of a Framework for Youth- and Family-Specific Engagement in Research: Proposal for a Scoping Review and Qualitative Descriptive Study
Development of a Framework for Youth- and Family-Specific Engagement in Research: Proposal for a Scoping Review and Qualitative Descriptive Study
Background: Youth and families play an indispensable role in health research, given their unique lived experiences and exp...
Evaluation of the Clinical Nursing Effects of a Traditional Chinese Medicine Nursing Program Based on Care Pathways for Patients With Type 2 Diabetes: Protocol for a Randomized Controlled Clinical Trial
Evaluation of the Clinical Nursing Effects of a Traditional Chinese Medicine Nursing Program Based on Care Pathways for Patients With Type 2 Diabetes: Protocol for a Randomized Controlled Clinical Trial
Background: To improve the performance of health care institutions, reduce overmedication, and minimize the waste of medic...
Ayurveda Management of Menorrhagia (Raktapradara): Protocol for a Randomized Controlled Trial
Ayurveda Management of Menorrhagia (Raktapradara): Protocol for a Randomized Controlled Trial
Background: In India, heavy menstrual bleeding or menorrhagia (Raktapradara) constitutes about 15% to 20% of all gynecolog...
Examining Quality of Work Life in Atlantic Canadian Long-Term Care Homes: Protocol for a Cross-Sectional Survey Study
Examining Quality of Work Life in Atlantic Canadian Long-Term Care Homes: Protocol for a Cross-Sectional Survey Study
Background: The Canadian long-term care (LTC) workforce cares for increasingly complex residents. With greater care needs ...
Assessment and Intervention for Diabetes Distress in Primary Care Using Clinical and Technological Interventions: Protocol for a Single-Arm Pilot Trial
Assessment and Intervention for Diabetes Distress in Primary Care Using Clinical and Technological Interventions: Protocol for a Single-Arm Pilot Trial
Background: Diabetes distress (DD) is a common emotional response to living with diabetes. If not addressed, DD can have n...
Treatments for Trauma-Induced Coagulopathy: Protocol for a Systematic Review and Meta-Analysis
Treatments for Trauma-Induced Coagulopathy: Protocol for a Systematic Review and Meta-Analysis
Background: Trauma-induced coagulopathy (TIC) is a common and potentially life-threatening coagulopathy as a result of tra...
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