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Incident infection during the first year of treatment – A comparison of clozapine and paliperidone palmitate long-acting injection
Incident infection during the first year of treatment – A comparison of clozapine and paliperidone palmitate long-acting injection
Background:To examine the risk of infection in patients prescribed clozapine compared with patients prescribed paliperidon...
A phase 1 study to assess potential interaction between ASP8062 and alcohol in healthy adult subjects
A phase 1 study to assess potential interaction between ASP8062 and alcohol in healthy adult subjects
Background:ASP8062 is a novel orally active GABAB receptor positive allosteric modulator in clinical development for the t...
Refractory delirium tremens treated with ketamine
Refractory delirium tremens treated with ketamine
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
MDMA/ecstasy use and psilocybin use are associated with lowered odds of psychological distress and suicidal thoughts in a sample of US adults
MDMA/ecstasy use and psilocybin use are associated with lowered odds of psychological distress and suicidal thoughts in a sample of US adults
Background:Suicide is one of the leading causes of death worldwide and rates within the United States have risen over the ...
Validation of the Psychological Insight Scale: A new scale to assess psychological insight following a psychedelic experience
Validation of the Psychological Insight Scale: A new scale to assess psychological insight following a psychedelic experience
Introduction:As their name suggests, ‘psychedelic’ (mind-revealing) compounds are thought to catalyse processes of psychol...
Lifetime use of MDMA/ecstasy and psilocybin is associated with reduced odds of major depressive episodes
Lifetime use of MDMA/ecstasy and psilocybin is associated with reduced odds of major depressive episodes
Background:Depression is a major mental health issue worldwide, with high rates of chronicity and non-recovery associated ...
The effects of psilocybin on cognitive and emotional functions in healthy participants: Results from a phase 1, randomised, placebo-controlled trial involving simultaneous psilocybin administration and preparation
The effects of psilocybin on cognitive and emotional functions in healthy participants: Results from a phase 1, randomised, placebo-controlled trial involving simultaneous psilocybin administration and preparation
Background:Psilocybin, a psychoactive serotonin receptor partial agonist, has been reported to acutely reduce clinical sym...
Activation of the aryl hydrocarbon receptor by clozapine induces preadipocyte differentiation and contributes to endothelial dysfunction
Activation of the aryl hydrocarbon receptor by clozapine induces preadipocyte differentiation and contributes to endothelial dysfunction
Background:The superior therapeutic benefit of clozapine is often associated with metabolic disruptions as obesity, insuli...
Impact of drug-induced Parkinsonism and tardive dyskinesia on health-related quality of life in schizophrenia
Impact of drug-induced Parkinsonism and tardive dyskinesia on health-related quality of life in schizophrenia
Background:Both drug-induced Parkinsonism (DIP) and tardive dyskinesia (TD) have been shown to be associated with lower he...
Sex-dependent metabolism of ketamine and (2R,6R)-hydroxynorketamine in mice and humans
Sex-dependent metabolism of ketamine and (2R,6R)-hydroxynorketamine in mice and humans
Background:Ketamine is rapidly metabolized to norketamine and hydroxynorketamine (HNK) metabolites. In female mice, when c...
Psilocybin microdosing does not affect emotion-related symptoms and processing: A preregistered field and lab-based study
Psilocybin microdosing does not affect emotion-related symptoms and processing: A preregistered field and lab-based study
Background:Microdoses of psychedelics (i.e. a sub-hallucinogenic dose taken every third day) can reduce symptoms of depres...
Debunking the myth of ‘Blue Mondays’: No evidence of affect drop after taking clinical MDMA
Debunking the myth of ‘Blue Mondays’: No evidence of affect drop after taking clinical MDMA
Background:Incorporating 3,4-methylenedioxymethamphetamine (MDMA) as an adjunct to psychotherapy has shown promise in rece...
Repurposing psychopharmacology: A two-way street?
Repurposing psychopharmacology: A two-way street?
Batistela, M, Vilela-Costa, H, Frias, A, et al. (2021) Enhanced responsiveness to hypoxic panicogenic challenge in femal...
Habitual caffeine consumption moderates the antidepressant effect of dorsomedial intermittent theta-burst transcranial magnetic stimulation
Habitual caffeine consumption moderates the antidepressant effect of dorsomedial intermittent theta-burst transcranial magnetic stimulation
Background:Potentiating current antidepressant treatment is much needed. Based on animal studies, caffeine may augment the...
The effects of atorvastatin on emotional processing, reward learning, verbal memory and inflammation in healthy volunteers: An experimental medicine study
The effects of atorvastatin on emotional processing, reward learning, verbal memory and inflammation in healthy volunteers: An experimental medicine study
Background:Growing evidence from clinical trials and epidemiological studies suggests that statins can have clinically sig...
Enhanced responsiveness to hypoxic panicogenic challenge in female rats in late diestrus is suppressed by short-term, low-dose fluoxetine: Involvement of the dorsal raphe nucleus and the dorsal periaqueductal gray
Enhanced responsiveness to hypoxic panicogenic challenge in female rats in late diestrus is suppressed by short-term, low-dose fluoxetine: Involvement of the dorsal raphe nucleus and the dorsal periaqueductal gray
Background:Acute hypoxia, which is panicogenic in humans, also evokes panic-like behavior in male rats. Panic disorder is ...
The epidemiology of mescaline use: Pattern of use, motivations for consumption, and perceived consequences, benefits, and acute and enduring subjective effects
The epidemiology of mescaline use: Pattern of use, motivations for consumption, and perceived consequences, benefits, and acute and enduring subjective effects
Background:Mescaline is a naturally occurring psychoactive phenethylamine found in several cacti and historically used cer...
Association study of BDNF Val66Met gene polymorphism with bipolar disorder and lithium treatment response in Indian population
Association study of BDNF Val66Met gene polymorphism with bipolar disorder and lithium treatment response in Indian population
Background:The association of the Val66Met (rs6265) polymorphism in the brain-derived neurotrophic factor (BDNF) gene with...
Award winning abstracts presented at The 11th Annual International College of Mental Health Pharmacy (CMHP) Conference. Manchester, UK on 8th and 9th October 2021
Award winning abstracts presented at The 11th Annual International College of Mental Health Pharmacy (CMHP) Conference. Manchester, UK on 8th and 9th October 2021
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Prospective memory deficits following acute alcohol consumption
Prospective memory deficits following acute alcohol consumption
Background:Prospective memory is a critical neurocognitive capacity that refers to the ability to execute delayed intentio...
Altered amygdala-cortical connectivity in individuals with Cannabis use disorder
Altered amygdala-cortical connectivity in individuals with Cannabis use disorder
Background:Cannabis is one of the most commonly used substances in the United States. Prior literature using task-based fu...
Effects of 31 recombinant CYP2C19 variants on clomipramine metabolism in vitro
Effects of 31 recombinant CYP2C19 variants on clomipramine metabolism in vitro
Background:CYP2C19 is an important member of the cytochrome P450 enzyme superfamily. We recently identified 31CYP2C19 alle...
Evaluation of the effectiveness and acceptability of the long-acting oral antipsychotic penfluridol: Illustrative case series
Evaluation of the effectiveness and acceptability of the long-acting oral antipsychotic penfluridol: Illustrative case series
Aim:In this study, we sought to determine clinical outcomes at 1 year for patients prescribed penfluridol in an inner Lond...
Relationship between depression, prefrontal creatine and grey matter volume
Relationship between depression, prefrontal creatine and grey matter volume
Background:Depression and low mood are leading contributors to disability worldwide. Research indicates that clinical depr...
Utility of a controlled amphetamine withdrawal paradigm among adults who use methamphetamine: A pilot clinical trial
Utility of a controlled amphetamine withdrawal paradigm among adults who use methamphetamine: A pilot clinical trial
Background:The continued increase in prevalence of methamphetamine use in the United States has resulted in a significant ...
Neuropsychological performance in young adults with cannabis use disorder
Neuropsychological performance in young adults with cannabis use disorder
Background and Aims:Cannabis is a commonly used recreational drug in young adults. The worldwide prevalence in 18- to 25-y...
Cevimeline co-treatment attenuates olanzapine-induced metabolic disorders via modulating hepatic M3 muscarinic receptor: AMPKα signalling pathway in female rats
Cevimeline co-treatment attenuates olanzapine-induced metabolic disorders via modulating hepatic M3 muscarinic receptor: AMPKα signalling pathway in female rats
Background:Olanzapine is one of the most commonly used antipsychotic drugs; however, its metabolic disorders are the main ...
Aberrant inhibitory processing in the somatosensory cortices of cannabis-users
Aberrant inhibitory processing in the somatosensory cortices of cannabis-users
Background:Delta-9 tetrahydrocannabinol (THC) is a major exogenous psychoactive agent, which acts as a partial agonist on ...
Intoxication without anticipation: Disentangling pharmacological from expected effects of alcohol
Intoxication without anticipation: Disentangling pharmacological from expected effects of alcohol
Background:The pharmacological effects of alcohol on executive function, craving and subsequent alcohol-seeking have been ...
A narrative synthesis of research with 5-MeO-DMT
A narrative synthesis of research with 5-MeO-DMT
Background:5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring, short-acting psychedelic tryptamine, pro...
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