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RNA multi-omics in single cells reveal rhythmical RNA reshaping during human and mouse oocyte maturation
RNA multi-omics in single cells reveal rhythmical RNA reshaping during human and mouse oocyte maturation
Omics technologies are widely applied in assisted reproductive technology (ART), such as embryo selection, investigation o...
annATAC: automatic cell type annotation for scATAC-seq data based on language model
annATAC: automatic cell type annotation for scATAC-seq data based on language model
Cell type annotation serves as the cornerstone for downstream analysis of single cell data. Nevertheless, scATAC-...
NeuroScale: evolutional scale-based protein language models enable prediction of neuropeptides
NeuroScale: evolutional scale-based protein language models enable prediction of neuropeptides
Neuropeptides (NPs) are critical signaling molecules involved in various physiological and behavioral processes, including...
p53-mediated suppression of the SLC7 A11/GPX4 signaling pathway promotes trophoblast ferroptosis in preeclampsia
p53-mediated suppression of the SLC7 A11/GPX4 signaling pathway promotes trophoblast ferroptosis in preeclampsia
Ferroptosis is an iron-dependent form of non-apoptotic cell death that occurs through increased plasma membrane phospholip...
How much do we know about the function of mammalian genes?
How much do we know about the function of mammalian genes?
The last two decades have seen impressive advances in functional genomics, but we are still a long way from understanding ...
Single-sample network modeling on omics data
Single-sample network modeling on omics data
Modeling networks for single samples can facilitate discoveries in biology that go beyond those found when analyzing an &#...
A muscle exercise research revolution powered by -omics at single cell and nucleus resolution
A muscle exercise research revolution powered by -omics at single cell and nucleus resolution
In the last few years, single cell and single nucleus RNA-sequencing technologies have been leveraged in exercised adult s...
Lessons in immune adaptations to hypoxia revealed by comparative and evolutionary physiology
Lessons in immune adaptations to hypoxia revealed by comparative and evolutionary physiology
Recent findings from comparative and evolutionary physiologists reveal novel insights into the regulation of inflammation ...
Evolution beyond DNA: epigenetic drivers for evolutionary change?
Evolution beyond DNA: epigenetic drivers for evolutionary change?
Epigenetics has been a buzzword in science for many years, but 20 years ago, the idea that epigenetic gene regula...
DNA polymerases in precise and predictable CRISPR/Cas9-mediated chromosomal rearrangements
DNA polymerases in precise and predictable CRISPR/Cas9-mediated chromosomal rearrangements
Recent studies have shown that, owning to its cohesive cleavage, Cas9-mediated CRISPR gene editing outcomes at junctions o...
Imputation strategies for genomic prediction using nanopore sequencing
Imputation strategies for genomic prediction using nanopore sequencing
Genomic prediction describes the use of SNP genotypes to predict complex traits and has been widely applied in humans and ...
Geroprotector drugs and exercise: friends or foes on healthy longevity?
Geroprotector drugs and exercise: friends or foes on healthy longevity?
Physical activity and several pharmacological approaches individually combat age-associated conditions and extend healthy ...
Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation
Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation
Immature cumulus-oocyte complexes are retrieved to obtain mature oocytes by in vitro maturation (IVM), a laboratory tool i...
New chromosome-scale genomes provide insights into marine adaptations of sea snakes (Hydrophis: Elapidae)
New chromosome-scale genomes provide insights into marine adaptations of sea snakes (Hydrophis: Elapidae)
Sea snakes underwent a complete transition from land to sea within the last ~ 15 million years, yet they remai...
Diversity across organisational scale emerges through dispersal ability and speciation dynamics in tropical fish
Diversity across organisational scale emerges through dispersal ability and speciation dynamics in tropical fish
Biodiversity exists at different levels of organisation: e.g. genetic, individual, population, species, and community. The...
Identification of FtfL as a novel target of berberine in intestinal bacteria
Identification of FtfL as a novel target of berberine in intestinal bacteria
Berberine (BBR) is a commonly used anti-intestinal inflammation drug, and its anti-cancer activity has been found recently...
FGF-independent MEK1/2 signalling in the developing foetal testis is essential for male germline differentiation in mice
FGF-independent MEK1/2 signalling in the developing foetal testis is essential for male germline differentiation in mice
Disrupted germline differentiation or compromised testis development can lead to subfertility or infertility and are stron...
Plasmodium yoelii iron transporter PyDMT1 interacts with host ferritin and is required in full activity for malarial pathogenesis
Plasmodium yoelii iron transporter PyDMT1 interacts with host ferritin and is required in full activity for malarial pathogenesis
The rapid reproduction of malaria parasites requires proper iron uptake. However, the process of iron absorption by parasi...
Fruit bats adjust their decision-making process according to environmental dynamics
Fruit bats adjust their decision-making process according to environmental dynamics
One of the main functions of behavioral plasticity lies in the ability to contend with dynamic environments. Indeed, while...
Cisplatin exposure alters tRNA-derived small RNAs but does not affect epimutations in C. elegans
Cisplatin exposure alters tRNA-derived small RNAs but does not affect epimutations in C. elegans
The individual lifestyle and environment of an organism can influence its phenotype and potentially the phenotype of its o...
Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1
Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1
Estrogen receptor beta (ERβ, Esr2) plays a pivotal role in folliculogenesis and ovulation, yet its exact mechanism of...
Lipid bilayer properties potentially contributed to the evolutionary disappearance of betaine lipids in seed plants
Lipid bilayer properties potentially contributed to the evolutionary disappearance of betaine lipids in seed plants
Many organisms rely on mineral nutrients taken directly from the soil or aquatic environment, and therefore, developed mec...
Different mechanisms of X-ray irradiation-induced male and female sterility in Aedes aegypti
Different mechanisms of X-ray irradiation-induced male and female sterility in Aedes aegypti
Aedes aegypti (Ae. aegypti) is the major vector that transmits many diseases including dengue, Zika, and filariasis in tro...
Muscle miRNAs are influenced by sex at baseline and in response to exercise
Muscle miRNAs are influenced by sex at baseline and in response to exercise
Sex differences in microRNA (miRNA) expression profiles have been found across multiple tissues. Skeletal muscle is one of...
Convergent evolution of the sensory pits in and within flatworms
Convergent evolution of the sensory pits in and within flatworms
Unlike most free-living platyhelminths, catenulids, the sister group to all remaining flatworms, do not have eyes. Instead...
Benchmarking MicrobIEM – a user-friendly tool for decontamination of microbiome sequencing data
Benchmarking MicrobIEM – a user-friendly tool for decontamination of microbiome sequencing data
Microbiome analysis is becoming a standard component in many scientific studies, but also requires extensive quality contr...
The function of wing bullae in mayflies (Insecta: Ephemeroptera) reveals new insights into the early evolution of Pterygota
The function of wing bullae in mayflies (Insecta: Ephemeroptera) reveals new insights into the early evolution of Pterygota
Mayflies are basal winged insects of crucial importance for the understanding of the early evolution of Pterygota. Unlike ...
Evidence for widespread existence of functional novel and non-canonical human transcripts
Evidence for widespread existence of functional novel and non-canonical human transcripts
Fraction of functional sequence in the human genome remains a key unresolved question in Biology and the subject of vigoro...
Author Correction: Genetic evidence of tri-genealogy hypothesis on the origin of ethnic minorities in Yunnan
Author Correction: Genetic evidence of tri-genealogy hypothesis on the origin of ethnic minorities in Yunnan
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Cellular reprogramming is driven by widespread rewiring of promoter-enhancer interactions
Cellular reprogramming is driven by widespread rewiring of promoter-enhancer interactions
Long-range interactions between promoters and cis-regulatory elements, such as enhancers, play critical roles in gene regu...
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