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Amelioration of hepatic steatosis in male obese rats by high-protein diet is dependent upon protein source
The liver plays an essential role in lipid homeostasis. Lipid uptake, de novo synthesis, metabolism, and export contribute...
NCOA4-dependent ferritinophagy: A key mechanism of selenium deficiency-induced ferroptosis and porcine phlebitis via the AMPK-mTOR pathway
Selenium (Se) is an essential trace element required for maintaining redox homeostasis and cellular antioxidant defenses t...
Ketogenic diet modulates AMPK-mTOR pathway in breast cancer
Breast cancer (BC) is the most common cancer among women [1]. The more aggressive triple-negative breast cancer (TNBC), a ...
The protective role of Astaxanthin against the central and peripheral detrimental effects for chronic administration of sweeteners in a rat model: Involvement of multiple signaling axes
Obesity and diabetes mellitus (DM) are pressing global health issues, largely driven by excessive sugar consumption and ca...
(Poly)phenol and methylxanthine metabolites and their association with cognitive and cardiometabolic health in older people
Dietary (poly)phenols and methylxanthines may help lower the risk of developing neurodegenerative diseases. However, the r...
Isoquercitrin attenuates osteoarthritis progression by targeting P53-mediated ferroptosis: A mechanistic study integrating network pharmacology and experimental validation
Osteoarthritis (OA) is a prevalent degenerative joint disorder featured by articular cartilage deterioration, synovitis, s...
Iron overload activates NF-κB-driven hepatic inflammation in suckling rats
Iron requirements are especially high during early stages of life as infants need a large amount of iron to meet the deman...
Nutritional and metabolic signatures in pediatric phenylketonuria and hyperphenylalaninemia: Insights from untargeted urinary metabolomics
Dietary interventions are essential for managing phenylketonuria (PKU) and may influence metabolic regulation beyond pheny...
Transcriptomics and metabolomics reveal the alleviating effect of lycopene on di-(2-ethylhexyl) phthalate-induced hepatotoxicity in mice
Di(2-ethylhexyl) phthalate is the most prevalent phthalic acid ester, acting as a plasticizer by noncovalently binding to ...
Bioactive metabolites in neonates of mothers supplemented with Bifidobacterium animalis are linked to microbiota-related compounds in milk and maternal plasma in mice
Volume 153, July 2026, 110301Author links open overlay panel, , , , , , , Highlights•Maternal Bifidobacterium may enrich n...
Guaiacol counters renal fibrosis via BMP/ERK/Smad1/5/9 signaling in UUO-induced chronic kidney disease
Chronic kidney disease (CKD) is one of the most frequent long-term disorders globally, with increasing morbidity and morta...
Dietary fucoxanthin alleviates skin aging and modulates systemic aging markers in naturally aged C57BL/6J mice
Aging is an unavoidable biological process characterized by a gradual deterioration of structural integrity and physiologi...
Integrated metagenomic and metabolomic profiling in an in vitro colonic fermentation study to assess the impacts of conventional, unconventional, and whole edible beet (Beta vulgaris L.) parts on the composition and metabolic responses of the intestinal microbiota of hypertensive individuals
Beet (Beta vulgaris L.) has been widely studied as a functional food, particularly for its bioactive compounds. This study...
Time-restricted feeding improves cognitive function in Alzheimer’s mice through GCK/NPY/apoptosis pathway
Alzheimer's disease (AD) is a degenerative disorder of the central nervous system characterized by the deposition of amylo...
Salvia plebeia R. Br. extract delays cellular senescence and promotes healthy aging via Atg7-dependent autophagy, with rosmarinic acid as a major bioactive constituent
Aging is an intricate biological process that unfolds gradually over time, leading to progressive deterioration in the str...
Dietary sulforaphane glucosinolate alleviates stress–induced depression and demyelination through gut–brain axis modulation
Volume 153, July 2026, 110328Author links open overlay panel, , , , , , , , Highlights•SGS diet prevents depression-like b...
Selenium accumulated exposure aggravates the progression of type 2 diabetes mellitus via activating the IRF2/Caspase-4/GSDMD pyroptosis pathway
The International Diabetes Federation reports that the global prevalence of diabetes among individuals aged 20–79 reached ...
Subacute ruminal acidosis induces inflammation, autophagy, and apoptosis by disrupting Ca2+ homeostasis via STIM1/ORAI1 upregulation in mammary gland tissues
High-concentrate diets, which are rich in essential nutrients, effectively meet the nutritional requirements for ruminant ...
Hesperetin alleviates high-fat diet-induced NAFLD by activating FXR to modulate ferroptosis homeostasis and suppress inflammation
When more than 5% of liver cells exhibit bullous steatosis without secondary factors like alcohol or drugs, the condition ...
Curdione alleviates renal fibrosis through Fblim1-dependent inhibition of the TGF-β1/Smad3 signaling pathway
Chronic kidney disease (CKD) represents a significant global public health crisis, characterized by the progressive and ir...
Untargeted metabolomics reveals the mechanisms of luteolin and exercise combination treatment against cognitive impairments in AD mice through modulating autophagy
Due to the complexity of Alzheimer's disease (AD), its treatment is extremely challenging. However, the multifaceted natur...
Myo-inositol supplementation in diet-induced obese lactating rats mitigates metabolic dysregulation and improves offspring health in early life
Volume 145, November 2025, 110012Author links open overlay panel, , , , , Highlights•Myo-inositol (MI) supplementation mit...
The modulation of mTOR signaling on dietary carbohydrate utilization in largemouth bass (Micropterus salmoides)
Fish, particularly carnivorous species, are often considered to exhibit diabetic-like characteristics due to their limited...
Mechanisms of astragalus polysaccharide alleviated experimental colitis involved mTreg cells and the mTOR/HIF-1α pathway
Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease (IBD) that results in recurrent inflammation and ulcer...
Leucine and glutamic acid attenuate the dextran sulfate sodium-induced colitis in mice by modulating the inflammatory response and energy metabolism processes
Inflammatory bowel disease (IBD) is a chronic relapsing - remitting inflammatory disease of the gastrointestinal tract, wh...
Calycosin-7-O-β-D-glucoside alleviates nonalcoholic fatty liver disease by regulating short-chain fatty acids metabolism and metabolic regulators
Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease in the world, with a prevalence rate o...
Impact of infant nutrition on gut and brain nitrogenous metabolomes: Comparison of human milk and infant formula feeding in the minipiglet model
Human milk (HM) is a complex fluid containing a myriad of bioactive compounds, providing the nutritional requirements of i...
Baseline 25-hydroxyvitamin D as a stronger protector against type 2 diabetes in the context of hyperuricemia and gout: a cohort study based on the UK biobank
To elucidate the association between Vitamin D and the risk of Type 2 diabetes (T2D) in individuals with hyperuricemia or ...
Naringin attenuates myocardial ischemia-reperfusion injury by promoting mitochondrial translocation of NDUFS1 and suppressing cardiac microvascular endothelial cell ferroptosis
Acute myocardial infarction (AMI), an ischemic heart disease caused by coronary artery blockage, reduces blood flow to the...
Integrated multiomics analysis reveals the effect of glucose selenol improves rat immunity
Selenium (Se), a well-known micronutrient, plays a critical role in biological function of plants and animals. Se possesse...
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